研究方向将主要聚焦于有机合成化学及其在药物发现中的应用。通过发展合成化学中的新催化剂、新概念、新策略，实现原子间的高效、高选择性成键、手性药物分子的规模化制备、类药性化合物库的快速构建及新药发现，积极探索不对称催化面向药物合成、药物发现的应用，以基础研究带动原始创新的应用研究，促进基础研究的成果产业化转化。

主要研究方向包括：

（1）发展高效、高选择性催化剂和合成策略合成药用天然产物及药物分子（有机合成方法学及全合成）

（2）针对重要生理活性分子进行修饰、结构优化和构效关系研究，开发药物先导化合物和药物候选化合物（药物化学）;

（3）基于氮杂环的串联反应高效构筑多样性杂环化合物库并开展表型筛选，挖掘苗头和先导化合物（药物化学）；

（4）发展药物合成关键技术及绿色合成工艺开发（药物合成工艺）。

   

0703Z1-化学生物学
070304-物理化学

创新药物发现；药物合成
有机合成

2009-09--2014-07   中科院上海有机化学研究所   博士
2005-09--2009-06   湖南师范大学   学士

   

2021-07~现在, 中科院深圳先进技术研究院, 研究员
2017-06~2021-06,南方科技大学, 副教授
2014-11~2017-06,德国柏林工业大学, 博士后

   

（1） Thieme Chemistry Journals Award, 其他, 2023
（2） 深圳市自然科学奖, 一等奖, 市地级, 2021
（3） 德国洪堡奖学金, 其他, 2014

（ 1 ） 手性α-胺基缩醛类化合物及其衍生物的制备方法, 发明专利, 2021, 第 3 作者, 专利号: CN113816865A

（ 2 ） 二茂铁含硼手性双膦配体及其制备方法和应用, 发明专利, 2021, 第 2 作者, 专利号: CN113121615A

（ 3 ） 二茂铁衍生物及其制备方法和应用, 发明专利, 2014, 第 3 作者, 专利号: CN103804430A

   

[1] 荣念新, 殷勤. Asymmetric Hydrogenation of Racemic 2-Substituted Indoles via Dynamic Kinetic Resolution: An Easy Access to Chiral Indolines Bearing Vicinal Stereogenic Centers. J. Am. Chem. Soc[J]. 2024, 146(8): 5081-5087, [2] Wu, KeQin, Li, Hui, Zhou, Ao, Yang, WeiRan, Yin, Qin. Palladium-Catalyzed Chemo- and Regioselective C-H Bond Functionalization of Phenols with 1,3-Dienes. JOURNAL OF ORGANIC CHEMISTRY. 2023, [3] 史永杰, 荣念新, 张绪穆, 殷勤. Synthesis of Chiral Primary Amines via Enantioselective Reductive Amination: from Academy to Industry. Synthesis[J]. 2023, 55: 1053-1068, [4] 胡乐安, 殷勤, 张绪穆. Highly Enantioselective Synthesis of N‐Unprotected Unnatural α‐Amino Acid Derivatives by Ruthenium‐Catalyzed Direct Asymmetric Reductive Amination. Angewandte Chemie[J]. 2022, 61: e202202552-, [5] 代增进, 张绪穆, 殷勤. Advances on Asymmetric Reductive Amination with Ammonium Salts as Amine Sources. Chin. J. Org. Chem.[J]. 2022, 42: [6] 代增进, 张绪穆, 殷勤. 铵盐为胺源的不对称还原胺化反应研究进展. 有机化学[J]. 2022, 42(8): 2261-2274, http://lib.cqvip.com/Qikan/Article/Detail?id=7108214181.
[7] Yin, Congcong, Pan, Yingmin, Zhang, Xumu, Yin, Qin. Catalytic Asymmetric Hydrogenation of Tetrasubstituted Unsaturated Lactams: An Efficient Approach to Enantioenriched 3,4-Disubstituted Piperidines. ORGANIC LETTERS[J]. 2022, 24(2): 675-680, http://dx.doi.org/10.1021/acs.orglett.1c04132.
[8] Shi, Yongjie, Wang, Jingxin, Yang, Feifan, Wang, Chenhan, Zhang, Xumu, Chiu, Pauline, Yin, Qin. Direct asymmetric reductive amination of alpha-keto acetals: a platform for synthesizing diverse alpha-functionalized amines. CHEMICAL COMMUNICATIONS[J]. 2022, 58(4): 513-516, http://dx.doi.org/10.1039/d1cc06601c.
[9] Tian, Yingying, Hu, Lean, Wang, YuanZheng, Zhang, Xumu, Yin, Qin. Recent advances on transition-metal-catalysed asymmetric reductive amination. ORGANIC CHEMISTRY FRONTIERSnull. 2021, 8(10): 2328-2342, http://dx.doi.org/10.1039/d1qo00300c.
[10] Shi, Yongjie, Wang, Jingxin, Yin, Qin, Zhang, Xumu, Chiu, Pauline. Copper-Catalyzed Enantioselective 1,2-Reduction of Cycloalkenones. ORGANIC LETTERS[J]. 2021, 23(15): 5658-5663, http://dx.doi.org/10.1021/acs.orglett.1c01744.
[11] Dai, Zengjin, Pan, YingMin, Wang, ShouGuo, Zhang, Xumu, Yin, Qin. Direct reductive amination of ketones with ammonium salt catalysed by Cp*Ir(iii) complexes bearing an amidato ligand. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(41): 8934-8939, http://dx.doi.org/10.1039/d1ob01710a.
[12] Hu, Lean, Zhang, Yao, Zhang, QingWen, Yin, Qin, Zhang, Xumu. Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H-2. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(13): 5321-5325, http://dx.doi.org/10.1002/anie.201915459.
[13] Yin, Qin, Shi, Yongjie, Wang, Jingxin, Zhang, Xumu. Direct catalytic asymmetric synthesis of alpha-chiral primary amines. CHEMICAL SOCIETY REVIEWSnull. 2020, 49(17): 6141-6153, https://www.webofscience.com/wos/woscc/full-record/WOS:000570357800001.
[14] Shi, Yongjie, Tan, Xuefeng, Gao, Shuang, Zhang, Yao, Wang, Jingxin, Zhang, Xumu, Yin, Qin. Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters. ORGANIC LETTERS[J]. 2020, 22(7): 2707-2713, https://www.webofscience.com/wos/woscc/full-record/WOS:000526335800040.
[15] Zhang, Yao, Liu, YunQi, Hu, Lean, Zhang, Xumu, Yin, Qin. Asymmetric Reductive Amination/Ring-Closing Cascade: Direct Synthesis of Enantioenriched Biaryl-Bridged NH Lactams. ORGANIC LETTERS[J]. 2020, 22(16): 6479-6483, http://dx.doi.org/10.1021/acs.orglett.0c02282.
[16] Hu, Lean, Zhang, Yao, Chen, GenQiang, Lin, BiJin, Zhang, QingWen, Yin, Qin, Zhan, Xumu. CuH-Catalyzed Atropoenantioselective Reduction of Bringmann's Lactones via Dynamic Kinetic Resolution. ORGANIC LETTERS[J]. 2019, 21(14): 5575-5580, [17] Lou Yazhou, Hu Yutao, Lu Jiaxiang, Guan Fanfu, Gong Gelin, Yin Qin, Zhang Xumu. Dynamic Kinetic Asymmetric Reductive Amination: Synthesis of Chiral Primary -Amino Lactams. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(43): 14193-14197, [18] Tao Yang, Xiaochong Guo, Qin Yin, Xumu Zhang. Intramolecular asymmetric reductive amination: synthesis of enantioenriched dibenz c , e azepines † †Electronic supplementary information (ESI) available. See DOI: 10.1039. CHEMICAL SCIENCE. 2018, 10(8): 2473-2477, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385856/.
[19] Chen, GenQian, Lin, BiJin, Huang, JiaMing, Zhao, LingYu, Chen, QiShu, Jia, ShiPeng, Yin, Qin, Zhang, Xumu. Design and Synthesis of Chiral oxa-Spirocyclic Ligands for Ir-Catalyzed Direct Asymmetric Reduction of Bringmann's Lactones with Molecular H-2. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(26): 8064-8068, https://www.webofscience.com/wos/woscc/full-record/WOS:000438309400003.
[20] Tan, Xuefeng, Gao, Shuang, Zeng, Weijun, Xin, Shan, Yin, Qin, Zhang, Xumu. Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H-2. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(6): 2024-2027, http://dx.doi.org/10.1021/jacs.7b12898.
[21] Lang, Qiwei, Gu, Guoxian, Cheng, Yaoti, Yin, Qin, Zhang, Xumu. Highly Enantioselective Synthesis of Chiral gamma-Lactams by Rh-Catalyzed Asymmetric Hydrogenation. ACS CATALYSIS[J]. 2018, 8(6): 4824-4828, http://dx.doi.org/10.1021/acscatal.8b00827.
[22] Gu, Guoxian, Lu, Jiaxiang, Yu, Ouran, Wen, Jialin, Yin, Qin, Zhang, Xumu. Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of alpha-Substituted beta-Ketoesters via Dynamic Kinetic Resolution. ORGANIC LETTERS[J]. 2018, 20(7): 1888-1892, [23] Yin, Qin, Klare, Hendrik F T, Oestreich, Martin. Catalytic Friedel-Crafts C-H Borylation of Electron-Rich Arenes: Dramatic Rate Acceleration by Added Alkenes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(13): 3712-3717, https://www.webofscience.com/wos/woscc/full-record/WOS:000397339400051.
[24] Yin, Qin, Oestreich, Martin. Photocatalysis Enabling Acceptorless Dehydrogenation of Benzofused Saturated Rings at Room Temperature. ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONnull. 2017, 56(27): 7716-7718, https://www.doi.org/10.1002/anie.201703536.
[25] Yin, Qin, Klare, Hendrik F T, Oestreich, Martin. Friedel-Crafts-Type Intermolecular C-H Silylation of Electron-Rich Arenes Initiated by Base-Metal Salts. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(9): 3204-3207, https://www.webofscience.com/wos/woscc/full-record/WOS:000370656200044.
[26] Yin, Qin, Wang, ShouGuo, Liang, XiaoWei, Gao, DeWei, Zheng, Jun, You, ShuLi. Organocatalytic asymmetric chlorinative dearomatization of naphthols. CHEMICAL SCIENCE[J]. 2015, 6(7): 4179-4183, https://www.webofscience.com/wos/woscc/full-record/WOS:000356176200064.
[27] Wang, ShouGuo, Yin, Qin, Zhuo, ChunXiang, You, ShuLi. Asymmetric Dearomatization of beta-Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(2): 647-650, https://www.webofscience.com/wos/woscc/full-record/WOS:000347238800048.
[28] Liu, Chuan, Yin, Qin, Dai, LiXin, You, ShuLi. Synthesis of pyrroloindolines and furoindolines via cascade dearomatization of indole derivatives with carbenium ion. CHEMICAL COMMUNICATIONS[J]. 2015, 51(27): 5971-5974, http://dx.doi.org/10.1039/c5cc00780a.
[29] 殷勤, 游书力. Asymmetric Chlorination/Ring Expansion for the Synthesis of alpha-Quaternary Cycloalkanones. ORG. LETT.[J]. 2014, 16(6): 1810-1813, http://ir.sioc.ac.cn/handle/331003/39048.
[30] Shi, YanChao, Wang, ShouGuo, Yin, Qin, You, ShuLi. N-alkylation of indole via ring-closing metathesis/isomerization/Mannich cascade under ruthenium/chiral phosphoric acid sequential catalysis. ORGANIC CHEMISTRY FRONTIERS[J]. 2014, 1(1): 39-43, https://www.webofscience.com/wos/woscc/full-record/WOS:000364422700005.
[31] Duan Dehe, Yin Qin, Wang Shouguo, Gu Qing, You Shuli. Chiral Phosphoric Acid-Catalyzed Asymmetric Cascade Reaction Of C(3) Substituted Indoles and Methyl Vinyl Ketone. ACTA CHIMICA SINICA[J]. 2014, 72(9): 1001-1004, https://www.webofscience.com/wos/woscc/full-record/WOS:000343965100002.
[32] Gao, DeWei, Yin, Qin, Gu, Qing, You, ShuLi. Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C-H Bond Arylation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 136(13): 4841-4844, https://www.webofscience.com/wos/woscc/full-record/WOS:000333947900012.
[33] 石延超, 王守国, 殷勤, 游书力. N-Alkylation of Indole via Ring-Closing Metathesis/Isomerization/Mannich Cascade under Ruthenium/Chiral Phosphoric Acid Sequential Catalysis. ORG. CHEM. FRONT.[J]. 2014, 1: 39-43, http://ir.sioc.ac.cn/handle/331003/39037.
[34] Cai, Quan, Yin, Qin, You, ShuLi. Chiral- Amine- Catalyzed Asymmetric Bromocyclization of Tryptamine Derivatives. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 3(4): 408-411, https://www.webofscience.com/wos/woscc/full-record/WOS:000334789100011.
[35] Yin, Qin, You, ShuLi. Asymmetric Chlorocyclization of Indole-3-yl-benzamides for the Construction of Fused Indolines. ORGANIC LETTERS[J]. 2014, 16(9): 2426-2429, https://www.webofscience.com/wos/woscc/full-record/WOS:000335491000033.
[36] 段德河, 殷勤, 王守国, 顾庆, 游书力. 手性磷酸催化的C3取代吲哚和甲基乙烯基酮的不对称串联反应. 化学学报[J]. 2014, 72(9): 1001-1004, http://ir.sioc.ac.cn/handle/331003/39120.
[37] Gao Dewei, Yin Qin, Gu Qing, You Shuli. Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C-H Bond Arylation. J. AM. CHEM. SOC.[J]. 2014, 136(13): 4841-4844, http://ir.sioc.ac.cn/handle/331003/39052.
[38] Yin, Qin, You, ShuLi. Asymmetric Chlorination/Ring Expansion for the Synthesis of alpha-Quaternary Cycloalkanones. ORGANIC LETTERS[J]. 2014, 16(6): 1810-1813, https://www.webofscience.com/wos/woscc/full-record/WOS:000333477400070.
[39] Yin, Qin, Wang, ShouGuo, You, ShuLi. Asymmetric Synthesis of Tetrahydro-beta-carbolines via Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation Reaction. ORGANIC LETTERS[J]. 2013, 15(11): 2688-2691, http://www.irgrid.ac.cn/handle/1471x/898888.
[40] Yin, Qin, You, ShuLi. Enantioselective Chlorocyclization of Indole Derived Benzamides for the Synthesis of Spiro-indolines. ORGANIC LETTERS[J]. 2013, 15(16): 4266-4269, http://www.irgrid.ac.cn/handle/1471x/898875.
[41] 殷勤, 游书力. Enantioselective Chlorocyclization of Indole Derived Benzamides for the Synthesis of Spiro-indolines. ORG. LETT.[J]. 2013, 15(16): 4266-4269, http://www.irgrid.ac.cn/handle/1471x/898875.
[42] 殷勤, 王守国, 游书力. Asymmetric Synthesis of Tetrahydro-beta-carbolines via Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation Reaction. ORG. LETT.[J]. 2013, 15(11): 2688-2691, http://www.irgrid.ac.cn/handle/1471x/898888.
[43] Yin, Qin, You, ShuLi. Intramolecular Alkene Electrophilic Bromination Initiated ipso-Bromocyclization for the Synthesis of Functionalized Azaspirocyclohexadienones. ORGANIC LETTERS[J]. 2012, 14(13): 3526-3529, http://www.irgrid.ac.cn/handle/1471x/682007.
[44] Yin, Qin, You, ShuLi. Chiral phosphoric acid-catalysed Friedel-Crafts alkylation reaction of indoles with racemic spiro indolin-3-ones. CHEMICAL SCIENCE[J]. 2011, 2(7): 1344-1348, http://202.127.28.38/handle/331003/22536.
[45] Tang, BoXiao, Yin, Qin, Tang, RiYuan, Li, JinHeng. Electrophilic ipso-Cyclization of N-(p-Methoxyaryl)propiolamides Involving an Electrophile-Exchange Process. JOURNALOFORGANICCHEMISTRY[J]. 2008, 73(22): 9008-9011, https://www.webofscience.com/wos/woscc/full-record/WOS:000260923000037.
[46] Yu, QuanFu, Zhang, YueHua, Yin, Qin, Tang, BoXiao, Tang, RiYuan, Zhong, Ping, Li, JinHeng. Electrophilic ipso-iodocyclization of N-(4-methylphenyl)propiolamides: Selective synthesis of 8-methyleneazaspiro4,5trienes. JOURNAL OF ORGANIC CHEMISTRY[J]. 2008, 73(9): 3658-3661, https://www.webofscience.com/wos/woscc/full-record/WOS:000255339600059.

（1） Synthesis by Addition to π-Type C-C Bonds (Update), Thieme, 2014-09, 第 1 作者
（2） Industrial Applications of Asymmetric Reduction of C=C Bonds (Update), Elsevier, 2023-04, 第 1 作者

   

（ 1 ） 手性Cp金属络合物设计、合成及其在不对称氢转移还原胺化中的应用, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） 金属催化不对称合成, 负责人, 地方任务, 2021-01--2024-12
（ 3 ） 过渡金属催化酮直接不对称还原胺化合成伯胺及其衍生物, 负责人, 国家任务, 2019-01--2021-12
（ 4 ） Bringmann内酯高效转化合成 轴手性化合物, 负责人, 地方任务, 2020-05--2023-05
（ 5 ） 新型氮杂环卡宾-铜催化体系的设计、合成及应用, 负责人, 国家任务, 2023-01--2026-12

（1）铵盐参与的不对称还原胺化   中国化学会第32届学术年会   2021-04-19