生物力学

生物医学工程

   

080101-一般力学与力学基础

生物力学
生物医学工程

2006-04--中国科学院力学研究所生物力学与生物工程中心   主任
2000-07--中国科学院力学研究所   研究员
1995-03--2000-07   重庆大学生物工程研究院   教授
1992-04--1995-03   重庆大学生物工程研究中心   副研究员
1990-07--1992-04   重庆大学生物工程研究中心   讲师
1984-07--1990-07   重庆大学生物工程研究中心   工学博士
1980-09--1984-07   上海交通大学动力机械工程系   学士

2002年获国家杰出青年基金

2004年入选新世纪百千万人才工程国家级人选

研究兴趣为蛋白质相互作用的力学-化学耦合、细胞互作与组织构建的力学-生物学耦合、空间细胞-分子生物力学工程，发表论文130余篇（含Nature Plants, Hepatology, Science Bulletin, Biomaterials等）。

（1）Shear flow alleviates spaceflight-induced hepatic lipid dysregulation via suppression of SREBP mechanotransduction. Science Bulletin, 2026, 通讯作者

（2） Unraveling the formation and stabilization of vesicle penetration pore by molecular dynamics simulations, Acta Mechanica Sinica, 2025, 通讯作者

（3） Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions, BIOPHYSICAL JOURNAL, 2025, 通讯作者

（4） E-cadherin negatively regulates hESCs endodermal differentiation under varied substrate stiffnesses, CELLULAR AND MOLECULAR LIFE SCIENCES, 2025, 通讯作者

（5） Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight, NPJ MICROGRAVITY, 2025, 通讯作者

（6） Neutrophils exhibit flexible migration strategies and trail formation mechanisms on varying adhesive substrates, Biomaterials, 2025, 通讯作者

（7） Stretch-induced hepatic endothelial mechanocrine promotes hepatocyte proliferation, HEPATOLOGY, 2024, 通讯作者

（8） Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation, BMC BIOLOGY, 2024, 通讯作者

（9） Real-time structural signatures of protein allostery by electrically- and mechanically-coupled sensing, NANO TODAY, 2024, 通讯作者

（10） FAK-p38 signaling serves as a potential target for reverting matrix stiffness-modulated liver sinusoidal endothelial cell defenestration, Biomaterials, 2024, 通讯作者

（11） Direct mechanical exposure initiates hepatocyte proliferation, JHEP REPORTS, 2023, 通讯作者

（12） Trail Formation Alleviates Excessive Adhesion and Maintains Efficient Neutrophil Migration, ACS Applied Materials & Interfaces, 2023, 通讯作者

（12） Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer, Advanced Drug Delivery Reviews, 2022, 通讯作者

（13） Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes, Biophysical Journal, 2022, 通讯作者

（14） E-selectin negatively regulates polymorphonuclear neutrophil transmigration through altered endothelial junction integrity, FASEB JOURNAL, 2021, 通讯作者

（15） Mechanomics analysis of hESCs under combined mechanical shear, stretch, and compression, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 2021, 通讯作者

（16） Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation, BIOPHYSICAL JOURNAL, 2021, 通讯作者

（17） Mapping the morphological identifiers of distinct conformations via the protein translocation current in nanopores, NANOSCALE, 2021, 通讯作者

（18） Hepatic differentiation of human embryonic stem cells by coupling substrate stiffness and microtopography, BIOMATERIALS SCIENCE, 2021, 通讯作者

（19） Mechanically Regulated Outside-In Activation of an I-Domain-Containing Integrin, BIOPHYSICAL JOURNAL, 2020, 通讯作者

（20） Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2020, 通讯作者

（21） Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2020, 通讯作者

（22） Regulation of hepatic differentiation of human embryonic stem cells by calcium silicate extracts for liver injury repairing, APPLIED MATERIALS TODAY, 2020, 通讯作者

（23） Impact of real-time shedding on binding kinetics of membrane-remaining L-selectin to PSGL-1, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2019, 通讯作者

（24） An integration design of gas exchange, bubble separation, and flow control in a space cell culture system on board the SJ-10 satellite, REVIEW OF SCIENTIFIC INSTRUMENTS, 2019, 通讯作者

（25） Mechanical Point Loading Induces Cortex Stiffening and Actin Reorganization, BIOPHYSICAL JOURNAL, 2019, 通讯作者

（26） Mechanical features of endothelium regulate cell adhesive molecule-induced calcium response in neutrophils, APL BIOENGINEERING, 2019, 通讯作者

（27） Microgravity-induced hepatogenic differentiation of rbmscs on board the sj-10 satellite, FASEB JOURNAL, 2019, 通讯作者

（18） Flow-enhanced priming of hESCs through H2B acetylation and chromatin decondensation, STEM CELL RESEARCH & THERAPY, 2019, 通讯作者

（29） Binding of intercellular adhesion molecule 1 to beta(2)-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2018, 通讯作者

（30） Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite, FRONTIERS IN PHYSIOLOGY, 2018, 通讯作者

（31） Mechanical remodeling of normally sized mammalian cells under a gravity vector, THE FASEB JOURNAL, 2017, 通讯作者

（32） Mechanical regulation of organ asymmetry in leaves, NATURE PLANTS, 2017, 第 11 作者 通讯作者

（33） Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip, LAB ON A CHIP, 2017, 通讯作者

（34） Dynamic contributions of P- and E-selectins to beta(2)-integrin-induced neutrophil transmigration, FASEB JOURNAL, 2017, 通讯作者

（35） Mechanical remodeling of normally sized mammalian cells under a gravity vector, FASEB JOURNAL, 2017, 通讯作者

（36） Improving the Gene Transfection in Human Embryonic Stem Cells: Balancing with Cytotoxicity and Pluripotent Maintenance., ACS APPLIED MATERIALS & INTERFACES, 2016, 通讯作者

（37） Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels., MOLECULAR NEUROBIOLOGY, 2016, 通讯作者

（38） Mechano-Biological Coupling of Cellular Responses to Microgravity, MICROGRAVITY SCIENCE AND TECHNOLOGY, 2015, 通讯作者

（39） Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography, BIOMATERIALS, 2014, 通讯作者

（40） Mechanomics: an emerging field between biology and biomechanics, PROTEIN & CELL, 2014, 通讯作者

（41） Differential Regulation of Stiffness, Topography, and Dimension of Substrate on Rat Mesenchymal Stem Cells, Biomaterials, 2013, 通讯作者

（42） Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation, JOURNAL OF IMMUNOLOGY, 2013, 通讯作者

（43） Tyrosine Replacement of PSGL-1 Reduces Association Kinetics with P- and L-Selectin on the Cell Membrane, BIOPHYSICAL JOURNAL, 2012, 通讯作者

（44） Shear- and stretch-induced dissociation of P-selectin/PSGL-1 complex using molecular dynamics simulation, Biophysical Journal, 2012, 通讯作者

（45） The Cytosolic GH Loop Regulates the Phosphatidylinositol 4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 通讯作者

（46） Determining beta(2)-Integrin and Intercellular Adhesion Molecule 1 Binding Kinetics in Tumor Cell Adhesion to Leukocytes and Endothelial Cells by a Gas-driven Micropipette Assay, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 通讯作者

（47）Direct observation of catch bonds involving cell-adhesion molecules, Nature, 2003, 第2作者

生物医学工程概论

生物力学

博士生综合基础课（生物力学）

生物力学进展