NMR studies on biomedicine and the related fields

Ph. D (1997-2000): Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, P. R. China
M.S. (1994-1997): Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, P. R. China
B.Sc. (1989-1993): Chemistry Department, University of Heilongjiang, P. R. China

   

2008 until now: Professor, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, P. R. China 
2004 -2008: Associate Professor, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, P. R. China 
2001 - 2003: Postdoctoral Research Assistant, University of Dundee, United Kingdom 
1993 - 1994: Assistant, Mudanjiang Medicine College, P. R. China

The third Prize in 2006 China Association for Instrument Analysis (CAIA ) Science and Technology Prize

   

1. Y. Xiao，Y. J. Wu, W. J. Zhang, X. J. Li, F. K. Pei, Research Progress of Magnetic Resonance Imaging Contrast Agents, Chin. J. Anal. Chem., 2011, 39, 757-764.
2. L. Wei, P. Q. Liao, H. F. Wu, X. J. Li, F. K. Pei, W. S. Li. Toxicological Effects of Cinnabar in Rats by NMR-based Metabolic Profiling of Urine and Serum. Toxicol. Appl. Pharm., 2009, 234:314-325.
3. P. Q. Liao, L. Wei, H. F. Wu, W. S. Li, X. J. Li, F. K. Pei. Biochemical effects of Gadolinium chloride in rats liver and kidney studied by 1H NMR metabolomics. J. Rare Earth., 2009, 27: 280-287.
4. P. Q. Liao, L. Wei, W. Liu, Y. J. Wu, X. J. Li, F. K. Pei, Metabonomic Studies on Intact Livers and Liver Extracts from Rats Treated with Neodymium Nitrate, Chem. J. Chin. Univ., 2009, 30, 1116-1120.
5. L. Wei, P. Q. Liao, H. F. Wu, X. J. Li, F. K. Pei, W. S., Li. Toxicological Effects of Cinnabar in Rats by NMR-based Metabolic Profiling of Urine and Serum. Toxicol. Appl. Pharm., 2008, 227(3):417-429
6. W. S. Li, Z. F. Li, F. Y. Jing, X. J. Li, F. K. Pei, X. X. Wang, H. Lei. Synthesis and Evaluation of Gd-DTPA-labeled Arabinogalactans as Potential MRI Contrast Agents. Carbohyd Res., 2008, 343：685-694.
7. P. Q. Liao, L. Wei, Y. J. Wu, X. J. Li, F. K. Pei, Studies on the Acute Biochemical Effects of Nd(NO3)3 by Nuclear Magnetic Resonance based Metabonomics, Chin. J. Anal. Chem., 2008, 36, 426-432.
8. W. J. Zhang, J. L. Feng, H.F . Wu, P. Q. Liao, X. J. Li, X. Zhao,Studies on the Toxicity of Model Toxins by Nuclear Magnetic Resonance Spectroscopy of Serum Combined with Fisher Distinguish Analysis, Chin. J. Anal. Chem., 2008, 36: 1338-1342.
9. Z. F. Li, W. S., Li, P. Q. Liao, L. Wei, X. J. Li, F. Y. Jing, F. K. Pei, X. X. Wang, H. Lei. Study of Two Sandwich-type Manganese Polyoxometalates as Potential MRI Contrast Agents. Chem. J. Chin. Univ., 2007, 28, 2021~2025
10. W. S., Li, Z. F. Li, F. Y. Jing, X. G. Yang, X. J. Li, F. K. Pei, X. X. Wang, H. Lei. Zeolites Mn2+-NaY as Oral Gastrointestinal Tract Contrast Agents in Magnetic Resonance Imaging. Acta Chim. Sinica., 2007, 65, 2029~2033
11. P. Q. Liao, L. Wei, X. Y. Zhang, X. J. Li, H. F. Wu, Y. J. Wu, J. Z. Ni, F. K. Pei. Metabolic Profiling of Serum From Gadolinium Chloride-treated Rats by 1H NMR Spectroscopy. Anal. Biochem., 2007, 364, 112~121
12. Z. F. Li, W. S., Li, X. J. Li, F. K. Pei, X. X. Wang, H. Lei. Mn(II)-monosubtituted Polyoxometalates as Candidates for Contrast Agents in Magnetic Resonance Imaging. J. Inorgan. Biochem., 2007, 101, 1036~1042
13. Z. F. Li, W. S., Li, X. J. Li, F. K. Pei, Y. X. Li, H. Lei. The gadolinium complexes with polyoxometalates as potential MRI contrast agents. Magn. Reson Imag., 2007, 25, 412~417
14. Z. F. Li, X. J. Li, W. S., Li, P. Q. Liao, L. Wei, Fengying Jing, F. K. Pei. Synthesis, Characterization, Stability and Relaxation Behaviours of Bis-1:11 Series Gadolinium Heteropolymetalates. J. Molecular Sci., 2006, 22, 76~79
15. H. F. Wu, X. Y. Zhang, X. J. Li, P. Q. Liao, W. S., Li, Z. F. Li, Y. J. Wu, F. K. Pei. Studies on the Acute Toxicity of Model Toxins by Proton Magnetic Resonance Spectroscopy of Urine Combined with Two-step Cluster Analysis. Chin. J. Anal. Chem., 2006, 34, 21~25
16. Z. F. Li, H. F. Wu, X. Y. Zhang, X. J. Li, P. Q. Liao, W. S., Li, F. K. Pei. Investigation on the Acute Biochemical Effects of Light Rare Earths(Lanthanum and Cerium) by NMR-Based Metabonomic Approaches. Chem. J. Chin. Univ., 2006, 27, 438~442
17. P. Q. Liao, H. F. Wu, X. Y. Zhang, X. J. Li, Z. F. Li, W. S., Li, Y. J. Wu, F. K. Pei. Comparative Investigation on Acute Biochemical Effect of Lanthanum and Cerium by MAS 1H NMR-based Metabonomic Approach. Chem. J. Chin. Univ., 2006, 27, 1448~1452
18. Z. F. Li, H. F. Wu, X. Y. Zhang, X. J. Li, P. Q. Liao, W. S., Li, F. K. Pei. Investigation on the acute biochemical effects of light rare earths on rat serum by NMR-based metabonomic approaches. Front. Chem. China, 2006, 4, 443~447
19. X. Y. Zhang, H. F. Wu, P. Q. Liao, X. J. Li, J. Z. Ni, Fengkui Pei, NMR-Based Metabonomic Study on the Sub-Acute Biochemical Effects of Aristolochic Acid. Food Chem.. Toxicol., 2006, 44, 1006~1014
20. H. F. Wu, X. Y. Zhang, X. J. Li, W. S., Li, Z. F. Li, P. Q. Liao, Y. J. Wu, F. K. Pei. Investigation on the Acute Biochemical Effects of Ce(NO3)3 on Liver and Kidney Tissues by MAS 1H NMR Spectroscopic-Based Metabonomic Approach. J. Rare Earth., 2006, 24, 357~363
21. H. F. Wu, X. J. Li, W. S. Li, Z. F. Li, P. Q. Liao, Y. J. Wu, F. K. Pei, Comparison of Biochemical Effects Induced by Changle between Male and Female Rats Using NMR and ICP-MS Techniques. J. Rare Earth., 2006, 24, 108~114
22. H. F. Wu, X. Y. Zhang, X. J. Li, Z. F. Li, Y. J. Wu, F. K. Pei, Studies on the Acute Biochemical Effects of La(NO3)3 Using 1H NMR Spectroscopy of Urine Combined with Pattern Recognition. J. Inorgan. Biochem., 2005, 99, 644~650
23. H. F. Wu, X. J. Li, P. Q. Liao, Y. J. Wu, F. K. Pei, Y. X. Nie, Bioeffects of Rare Earth Complex on Rats Studied by NMR and ICP-MS Spectroscopy. J. Rare Earth., 2005, 23, 245~250
24. H. F. Wu, X. Y. Zhang, X. J. Li, Y. J. Wu, F. K. Pei, Acute Biochemical Effects of La(NO3)3 on Liver and Kidney Tissues by MAS 1H NMR and Pattern Recognition. Anal. Biochem. 2005, 340, 99~105
25. H. F. Wu, X. Y. Zhang, X. J. Li, Z. F. Li, Y. J. Wu, F. K. Pei, Comparison of metabolic profiles from serum for the hepatotoxin-treated rats by NMR spectroscopic-based metabonomic analysis. Anal. Biochem., 2005, 339, 242~248
26. H. F. Wu, X. Y. Zhang, P. Q. Liao, Z. F. Li, W. S. Li, X. J. Li, Y. J. Wu, F. K. Pei, NMR Spectroscopic-Based Metabonomic Investigation on the Acute Biochemical Effects Induced by Ce(NO3)3 in Rats. J. Inorgan. Biochem., 2005, 99, 2150~2160
27. X. Y. Zhang, H. F. Wu, X. J. Li, F. K. Pei, J. Z. Ni, NMR Studies on the Sub-Acute Biochemical Effects of Aristolochic Acid on Rat Serum. Chin. Chem. Lett., 2005, 16, 1507~1510
28. H. F. Wu, X. Y. Zhang, X. J. Li, G. Y. Sun, Y. J. Wu, F. K. Pei, Studies on the Acute Toxicity of Lu(NO3)3 by 1H NMR and Pattern Recognition Method. Chem. J. Chin. Univ., 2005, 26, 1321~1324
29. J. H. Feng, X. J. Li, F. K. Pei, Y. X. Niu, Evaluation of bioeffects of a long-term administering ChangLe on rat by proton NMR method and biochemical examination. Chin. J. Chem. 2003, 21, 320~326.
30. J. H. Feng, X. J. Li, F. K. Pei, X. Chen, S. L. Li, Y. X. Nie, 1H NMR Analysis for Metabolites in Serum and Urine from Rats Administrated Chronically with La(NO3)3. Anal. Biochem., 2002, 301, 1~7.
31. J. H. Feng, X. J. Li, F. K. Pei, G. Y. Sun, X. Zhang, M. L. Liu, An Evaluation of Gadolinium Polyoxometalates as Possible MRI Contrast Agent. Magn. Reson Imag., 2002, 20, 407~412.
32. X. J. Li, J. H. Feng, F. K. Pei, X. Chen, S. L. Li, Y. X. Nie, Nuclear Magnetic Resonance Studies on the Toxicological Effects of Rare Earth in Urine. Chem J. Chin. Univ., 2001, 22, 1904~1906.
33. J. H. Feng, X. J. Li, X. Y. Li, F. K. Pei, Studies on the Solution Structures of Lanthanide(III) Complexes of DTPA-BIN by NMR. Chem. J. Chin. Univ., 2001, 22, 1615~1619.
34. X. J. Li, J. H. Feng, F. K. Pei, X. Chen, Y. X. Nie, 1H NMR Studies on the Effect of Rare Earth on the Metabolism in Wistar Rats. Chin. J. Anal. Chem. 2000, 28, 1472~1475.
35. X. J. Li, J. H. Feng, X.Y. Li, Y. J. Wu, F. K. Pei, Studies of Gd-Diethtylenetriamine Pentaacetic Acid in Bovine Serum Albumin Solution by Nuclear Magnetic Resonance Spectroscopy. Chin. J. Anal. Chem., 2000, 28, 269~272.
36. J. H. Feng, X. J. Li, F. Y. Jing, F. K. Pei, Synthesis, Characterization, Stability and Relaxation Behaviors of Rare Earth Heteropolymetalates. Acta Chim. Sinica., 2000, 58, 423~426.
37. J. H. Feng, S. L. Li, X. J. Li, F. K. Pei, X. Chen, Y. X. Nie, 1H NMR Studies of Biofluids of Rats on Long-term Toxicity of Rare Earth. Chin. J. Magn. Reson. 2000, 17, 442~447.
38. X. J. Li, J. H. Feng, F. Y. Jing, X. Y. Li, F. K. Pei, NMR Studies of Gd (DTPA-BIN) in Bovine Serum Albumin Solution and Its Thermodynamic Properties. Chin. J. Magn. Reson. 1999, 16, 525~531.
39. X. J. Li, S. R. Zhang, S.G. Zhang, F. K. Pei. Studies on the Interaction of Rare Earth Ions with BSA. Chem J. Chin. Univ., 1999, 20, 127~131.
40. X.Y. Li, X. J. Li, S. R. Zhang, F. K. Pei, NMR Relaxation Studies of GdDTPA in Human Serum Albumin Solution. Polyhedron 1999, 18, 695~697.
41. X. J. Li, Z. Q. Wang, J. Chen, S. G. Zhang, UV Spectral Study on the Interaction of RE Ions with BSA. Chin. J. Appl. Chem. 1998, 15, 5~8.
42. J. Chen, G. X. Ma, X. J. Li, S. G. Zhang, D. Q. Li, The Suppression of Ge-132 on Maillard Reaction of BSA by Fluorescence Spectrum. Chem. J. Chin. Univ. 1998, 18, 1937~1939.
43. J. Chen, G. X. Ma, X. J. Li, S. G. Zhang, D. Q. Li, Study on the Regulation of Diorganogermanium Compounds on the Maillard Reaction of Histidine and Glycine by Fluorescence Spectrum. Chin. Chem. Lett. 1998, 9, 1091~1092.
44. J. Chen, G. X. Ma, X. J. Li, S. G. Zhang, D. Q. Li, Fluorescence Spectrometric Study on the Suppression of Ge-132 on Maillard Reaction of Phenylalanine. Chin. J. Appl. Chem. 1998, 15, 89~91.

1. X. J. Li, W. S. Li, Z. F. Li, F. K. Pei, Arabinogalactan as carriers for contrast agents in magnetic resonance imaging. Chinese National Invention Patent No: 200610131639.9
2. X. J. Li, W. S. Li, Z. F. Li, F. K. Pei, Glycyrrhizic acid as carriers for contrast agents in magnetic resonance imaging. Chinese National Invention Patent No: 200610130884.8
3. F. K. Pei, Z. F. Li, X. J. Li, W. S. Li, Manganese polyoxotungstenic complexes as MRI contrast agents. Chinese National Invention Patent No: 200610016823.9.
4. F. K. Pei, G. Y. Sun, Z. F. Li, X. J. Li, W. P. Su, W. S. Li, Paramagnetic complexes labeled elaeagnus angustifalial polysaccharide as MRI contrast agents. Chinese National Invention Patent No: 200610016948.1.

Studies on the biochemical effects of lanthanide ions and traditional Chinese mineral medicine in rats on kidney and liver by NMR spectroscopic-based metabonomic approach
NMR relaxation properties and synthesis of MRI contrast agents (Lanthanide complexes of polyamino-polycarboxylates and gadolinium complexes with polyoxometalates)
Biological analysis of biofluids (serum and urine), intact tissues (liver and kidney), and tissue extracts (from liver, kidney or cerebrum) using NMR technology combined with pattern recognition methods (metabonomics/metabolomics)

1. Lai Wei, Peiqiu Liao, Xiaojing Li, Fengkui Pei, 1H NMR-based metabolomics investigation on the nephrotoxicity induced by cinnabar, Proceedings of International 13th Beijing Conference and Exhibition on Instrumental Analysis，2009，Beijing，E25.
2. Weisheng LI, Xiaojing Li, Fengkui Pei, Synthesis and Evaluation Of Gd-Dtpa-Labled Glycyrrhizic Acid as MRI Contrast Agent , Proceedings of International 13th Beijing Conference and Exhibition on Instrumental Analysis，2009，Beijing，E45.
3. Peiqiu Liao, Lai Wei, Xiaojing Li, Fengkui Pei, An Integrated Metabonomic Investigation on the Acute Biochemical Effects of Praseodymium Nitrate, Proceedings of International 13th Beijing Conference and Exhibition on Instrumental Analysis，2009，Beijing，E46.
4. Fengkui Pei, Zhongfeng Li, Weisheng Li, Xiaojing Li. Investigation of two sandwich-type manganese polyoxometalates as potential MRI contrast agents. The 16th Triennial Conference for the International Society of Magnetic Resonance, 2007, Taiwan, P3-01.
5. Weisheng Li, Zhongfeng Li, Xiaojing Li, Fengkui Pei. Synthesis and evaluation of Gd-DTPA-Labled Arabinogalactan Polymer as MRI Contrast Agents. The 2nd Asia-Pacific NMR Symposium, 2007, Taiwan, CP1.
6. H. F. Wu, P. Q. Liao, X. J. Li, X. Y. Zhang, Z. F. Li, W. S. Li, F. K. Pei. NMR Spectroscopic-Based Metabonomic Investigation on the Acute Biochemical Effects Induced by Ce(NO3)3, Proceedings of the 11th International Beijing Conference and Exhibition on Instrumental Analysis. 2005, Beijing, E18.
7. X. Y. Zhang, P. Q. Liao, X. J. Li, H. F. Wu, F. K. Pei, The Metabolic Profiles of Serum for Nephrotoxin Treated Rats by NMR-Based Metabonomic Approach, Proceedings of the 11th International Beijing Conference and Exhibition on Instrumental Analysis. 2005, Beijing, E16.
8. Z. F. Li, H. F. Wu, X. Y. Zhang, X. J. Li, P. Q. Liao, W. S. Li, Y. J. Wu, F. K. Pei, Comparison of Metabolic Profiles from Serum for La(NO3)3- and Ce(NO3)3-treated Rats by NMR-Based Metabonomic Approach, Proceedings of the 11th International Beijing Conference and Exhibition on Instrumental Analysis. 2005, Beijing, E19.

Postdoctor: Xue Rong

Doctor: Wu Huifeng, Zhang Xiaoyu, Li Zhongfeng, Liao Peiqiu, Li Weisheng, Wei Lai

Master: Xiao Yan, Zhang Xiaohui, Pan Hongkai