基本信息

牛丽丽  女    中国科学院深圳先进技术研究院
电子邮件: ll.niu@siat.ac.cn
通信地址: 深圳市南山区西丽镇学苑大道1068号
邮政编码:518055

部门/实验室:医工所

研究领域

超声神经调控;超声生物力学成像


招生信息

   
招生专业
083100-生物医学工程
081203-计算机应用技术
081002-信号与信息处理
招生方向
超声血流成像,超声弹性成像,超声神经调控
超声成像算法
超声信号处理

教育背景

2009-09--2012-11   中国科学院大学   博士
2007-09--2009-07   东北大学   硕士
2003-09--2007-07   沈阳师范大学   学士
学历
博士

学位
博士

专利与奖励

代表性专利:

(1)   郑海荣; 周慧; 牛丽丽; 郭瑞彪; 孟龙; 李永川; 苏敏; 黄继卿; 钱明;清醒动物超声神经调控装置,授权日:2019/6/4,授权号:ZL201710138442.6

(2)   郑海荣;牛丽丽;王丛知;钱明;肖杨;孟龙,一种获得用于发射穿颅聚焦超声的超声发射序列的方法及系统,授权日:2018-03-23,授权号:ZL201410829230.9

(3)   郑海荣;黄小伟;牛丽丽;孟龙;周伟;钱明;肖杨,一种多阵元换能器的阵元选择装置、方法和超声刺激系统,授权日:2019/3/12,授权号:ZL201610289024.2

(4)   郑海荣;周慧;牛丽丽;孟龙;夏向向;张金钮;郭瑞彪;苏敏,一种自动收线的超声神经调控装置,申请号:CN201710636418.5

(5)   郑海荣;周伟;孟龙;王凯悦;牛丽丽;黄小伟;蔡飞燕;李飞;王辰,一种超声神经调控系统,授权日:2019-07-19,授权号:ZL201610803573.7

奖励:

·         2016          广东省科学技术奖

·         2015          中科院科技促进发展奖

奖励信息
(1) 基于剪切波的定量超声弹性成像技术与应用, 一等奖, 省级, 2016
(2) 高端医学影像技术与装备及其产业化团队, 二等奖, 部委级, 2015

出版信息

   
发表论文
(1) Ultrasound neuromodulation inhibits seizures in acute epileptic monkeys, iScience, 2020, 通讯作者
(2) Transcranial Ultrasound Stimulation of Hypothalamus in Aging Mice, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2020, 通讯作者
(3) Ultrasound stimulation of periaqueductal gray induces defensive behaviors, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2020, 通讯作者
(4) Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance, SCIENCE CHINA Life Sciences, 2020, 第 1 作者
(5) Noninvasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy, Theranostics, 2020, 通讯作者
(6) Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson's Disease Model Mouse, Research, 2019, 第 2 作者
(7) Sonoporation of Cells by a Parallel Stable Cavitation Microbubble Array, Advanced Science, 2019, 通讯作者
(8) Transcranial Low-intensity Pulsed Ultrasound Modulates Structural and Functional Synaptic Plasticity in Rat Hippocampus, IEEE Transactions on Ultrasonics, Ferroelectrics, Frequency Control, 2019, 通讯作者
(9) Ultrasound Improves Motor Function in an MPTP Mouse Model of Parkinson's Disease, IEEE Transactions on Biomedical Engineering, 2019, 第 2 作者
(10) Non-invasive Low-Intensity Pulsed Ultrasound Modulates Primary Cilia of Rat Hippocampal Neurons, Ultrasound in Medicine & Biology, 2019, 通讯作者
(11) Identification of Ultrasonic Echolucent Carotid Plaques Using Discrete Fréchet Distance Between Bimodal Gamma Distributions, IEEE Transactions on Biomedical Engineering, 2018, 通讯作者
(12) Influence of vascular geometry on local hemodynamic parameters: phantom and small rodent study, Biomed Eng Online, 2018, 第 1 作者
(13) Sorting of tumour cells in a microfluidic device by multi-stage surface acoustic waves, Sens. Actuators B: Chem, 2018, 通讯作者
(14) Evaluation of carotid plaque echogenicity based on the integral of the cumulative probability distribution using gray-scale ultrasound images, PLoS ONE, 2017, 通讯作者
(15) Computational and experimental assessment of influences of hemodynamic shear stress on carotid plaque, Biomedical engineering online, 2017, 通讯作者
(16) The relationship between HbA1c and ultrasound plaque textures in atherosclerotic patients, Cardiovascular Diabetology, 2016, 通讯作者
(17) Spatial selective manipulation of microbubbles by tunable surface acoustic waves, Biomicrofluidics, 2016, 第 1 作者
(18) Classification of carotid plaque echogenicity by combining texture features and morphological characteristics, Journal of Ultrasound in Medicine, 2016, 通讯作者
(19) Journal of Ultrasound in Medicine, Clinical Physiology and Functional Imaging, 2016, 第 1 作者
(20) A Disposable Microfluidic Device for Controlled Drug Release from Thermal-Sensitive Liposomes by High Intensity Focused Ultrasound, Theranostics, 2015, 第 1 作者
(21) Stress phase angle depicts differences in arterial stiffness: phantom and in vivo study, Physics in Medicine and Biology, 2015, 第 1 作者
(22) Detection of subclinical atherosclerosis in asymptomatic subjects using ultrasound radiofrequency-tracking technology, PLoS ONE, 2014, 第 1 作者
(23) Pulsatile flow characterization in a Vessel Phantom With Elastic Wall Using Ultrasonic Particle Image Velocimetry Technique: The Impact of Vessel Stiffness on Flow Dynamics, IEEE Trans Biomed Eng, 2014, 第 1 作者
(24) Impact of multiple cardiovascular risk factors on carotid intima-media thickness and elasticity, PLoS ONE, 2013, 第 1 作者
(25) Surface Roughness Detection of Arteries via Texture Analysis of Ultrasound Images for Early Diagnosis of Atherosclerosis, PLoS One, 2013, 第 1 作者
(26) A Texture Matching Method Considering Geometric Transformations in Non-invasive Ultrasonic Measurement of Arterial Elasticity, Ultrasound in Medicine and Biology, 2012, 第 1 作者
(27) A 2-D Noninvasive Ultrasonic Method for Simultaneous Measurement of Arterial Strain and Flow Pattern, Clinical Physiology and Functional Imaging, 2012, 第 1 作者
(28) “Real Time Texture Analysis for Identifying Optimum Microbubble Concentration in 2D Ultrasonic Particle Image Velocimetry, Ultrasound in Medicine and Biology, 2011, 第 1 作者
(29) Ultrasonic particle image velocimetry for Improved Flow Gradient Imaging: Algorithms, Methodology and Validation, Physics in Medicine and Biology, 2010, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于超声生物力学成像方法的血管斑块力学特性研究, 主持, 国家级, 2016-01--2019-12
( 2 ) 血管壁周向应力和血流剪切应力相位角的高分辨超声实验研究, 主持, 国家级, 2014-01--2016-12
( 3 ) 超声无创心血管疾病早期检测技术, 主持, 省级, 2013-10--2015-10
( 4 ) 血管早期病变超声无创检测方法研究, 主持, 省级, 2016-01--2017-12