致力于衰老的功能基因组学研究，综合运用多组学技术解析衰老及相关疾病的发生发展机制，挖掘新型衰老干预靶标，其工作加深了对灵长类干细胞与器官衰老的认识。

071010-生物化学与分子生物学
071009-细胞生物学
0710J6-再生医学

衰老功能基因组学

2012-09--2017-06   北京大学   博士
2008-09--2012-06   河北农业大学   学士

   

2019-09~现在, 中科院动物研究所, 副研究员
2017-07~2019-08,中国科学院生物物理研究所, 项目副研究员

2022-06-01-今,Life Medicine期刊, 助理编辑
2022-01-01-今,中国老年学和老年医学学会抗衰老分会, 委员
2021-02-01-今,中国老年医学学会基础与转化医学分会, 常务委员

   

（1） 中华医学科技奖医学科学技术奖, 二等奖, 部委级, 2021
（2） 中国科学院杰出科技成就奖, 部委级, 2020
（3） 北京市科学技术奖, 二等奖, 省级, 2018

（ 1 ） 一种评价或辅助评价卵巢细胞的方法及其使用的标志物, 发明专利, 2022, 第 6 作者, 专利号: CN110938700B

（ 2 ） 一种评价或辅助评价胰岛细胞身份及衰老的标志物, 发明专利, 2022, 第 5 作者, 专利号: CN111471771B

（ 3 ） 结直肠癌的DNA甲基化标志物以及利用其检测结直肠癌的方法和试剂盒, 发明专利, 2021, 第 5 作者, 专利号: CN111662978B

（ 4 ） HIGH-THROUGHPUT SEQUENCING DETECTION METHOD FOR METHYLATED CPG ISLANDS, 发明专利, 2016, 第 2 作者, 专利号: EP3015552(A4)

（ 5 ） HIGH-THROUGHPUT SEQUENCING DETECTION METHOD FOR METHYLATED CPG ISLANDS, 发明专利, 2016, 第 2 作者, 专利号: US20160298183A1

（ 6 ） 甲基化CpG岛的高通量测序检测方法, 发明专利, 2014, 第 2 作者, 专利号: CN104250663A

   

[1] Zunpeng Liu, Wei Li, Lingling Geng, Liang Sun, Qiaoran Wang, Yang Yu, Pengze Yan, Chuqian Liang, Jie Ren, Moshi Song, Qian Zhao, Jinghui Lei, Yusheng Cai, Jiaming Li, Kaowen Yan, Zeming Wu, Qun Chu, Jingyi Li, Si Wang, Chunyi Li, JingDong J Han, Reyna HernandezBenitez, Ng ShyhChang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, GuangHui Liu. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. CELL DISCOVERY[J]. 2022, 8: [2] Hongkai Zhao, Qianzhao Ji, Zeming Wu, Si Wang, Jie Ren, Kaowen Yan, Zehua Wang, Jianli Hu, Qun Chu, Huifang Hu, Yusheng Cai, Qiaoran Wang, Daoyuan Huang, Zhejun Ji,, Juan Carlos Izpisua Belmonte, Jingyi Li, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging[J]. 2022, [3] Yusheng Cai, Wei Song, Jiaming Li, Ying Jing, Chuqian Liang, Liyuan Zhang, Xia Zhang, Wenhui Zhang, Beibei Liu, Yongpan An, Jingyi Li, Baixue Tang, Siyu Pei, Xueying Wu, Yuxuan Liu, ChengLe Zhuang, Yilin Ying, Xuefeng Dou, Yu Chen, FuHui Xiao, Dingfeng Li, Ruici Yang, Ya Zhao, Yang Wang, Lihui Wang, Yujing Li, Shuai Ma, Si Wang, Xiaoyuan Song, Jie Ren, Liang Zhang, Jun Wang, Weiqi Zhang, Zhengwei Xie, Jing Qu, Jianwei Wang, Yichuan Xiao, Ye Tian, Gelin Wang, Ping Hu, Jing Ye, Yu Sun, Zhiyong Mao, QingPeng Kong, Qiang Liu, Weiguo Zou, XiaoLi Tian, ZhiXiong Xiao, Yong Liu, JunPing Liu, Moshi Song, JingDong J Han, GuangHui Liu. The landscape of aging. Science China Life Sciences[J]. 2022, 1-101, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446657/.
[4] Li, Jingyi, Zheng, Yuxuan, Yan, Pengze, Song, Moshi, Wang, Si, Sun, Liang, Liu, Zunpeng, Ma, Shuai, Belmonte, Juan Carlos Izpisua, Chan, Piu, Zhou, Qi, Zhang, Weiqi, Liu, GuangHui, Tang, Fuchou, Qu, Jing. A single-cell transcriptomic atlas of primate pancreatic islet aging. National Science Review[J]. 2021, 8(2): 12-26, http://lib.cqvip.com/Qikan/Article/Detail?id=7104077533.
[5] Wang, Wei, Zheng, Yuxuan, Sun, Shuhui, Li, Wei, Song, Moshi, Ji, Qianzhao, Wu, Zeming, Liu, Zunpeng, Fan, Yanling, Liu, Feifei, Li, Jingyi, Esteban, Concepcion Rodriguez, Wang, Si, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, Tang, Fuchou, Liu, GuangHui. A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence. SCIENCE TRANSLATIONAL MEDICINE[J]. 2021, 13(575): http://dx.doi.org/10.1126/scitranslmed.abd2655.
[6] Wang, Si, Zheng, Yuxuan, Li, Jingyi, Yu, Yang, Zhang, Weiqi, Song, Moshi, Liu, Zunpeng, Min, Zheying, Hu, Huifang, Jing, Ying, He, Xiaojuan, Sun, Liang, Ma, Lifang, Esteban, Concepcion Rodriguez, Chan, Piu, Qiao, Jie, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Qu, Jing, Tang, Fuchou, Liu, GuangHui. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. CELL[J]. 2020, 180(3): 585-+, http://dx.doi.org/10.1016/j.cell.2020.01.009.
[7] Weiqi Zhang, Shu Zhang, Pengze Yan, Jie Ren, Moshi Song, Jingyi Li, Jinghui Lei, Huize Pan, Si Wang, Xibo Ma, Shuai Ma, Hongyu Li, Fei Sun, Haifeng Wan, Wei Li, Piu Chan, Qi Zhou, GuangHui Liu, Fuchou Tang, Jing Qu. A single-cell transcriptomic landscape of primate arterial aging. Nature Communications[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-15997-0.
[8] Li, Jingyi, Zhou, Xin, Liu, Xiaomeng, Ren, Jie, Wang, Jilian, Wang, Wendong, Zheng, Yuxuan, Shi, Xinyun, Sun, Tao, Li, Zhifei, Kang, Anding, Tang, Fuchou, Wen, Lu, Fu, Wei. Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing. CLINICAL CHEMISTRY[J]. 2019, 65(7): 916-926, [9] Liu, Xiaomeng, Ren, Jie, Luo, Nan, Guo, Huahu, Zheng, Yuxuan, Li, Jingyi, Tang, Fuchou, Wen, Lu, Peng, Jirun. Comprehensive DNA methylation analysis of tissue of origin of plasma cell-free DNA by methylated CpG tandem amplification and sequencing (MCTA-Seq). CLINICAL EPIGENETICS[J]. 2019, 11(1): http://gooa.las.ac.cn/external/index?type=-1&pid=1500929.
[10] Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, GuangHui Liu. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-16, http://dx.doi.org/10.1038/s41467-019-10831-8.
[11] Wang, Ping, Liu, Zunpeng, Zhang, Xiaoqian, Li, Jingyi, Sun, Liang, Ju, Zhenyu, Li, Jian, Chan, Piu, Liu, GuangHui, Zhang, Weiqi, Song, Moshi, Qu, Jing. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-B/RelA in maintaining the homeostasis of human vascular cells. PROTEIN & CELL[J]. 2018, 9(11): 945-965, http://lib.cqvip.com/Qikan/Article/Detail?id=676820273.
[12] Yang, Jiping, Li, Jingyi, Suzuki, Keiichiro, Liu, Xiaomeng, Wu, Jun, Zhang, Weiqi, Ren, Ruotong, Zhang, Weizhou, Chan, Piu, Belmonte, Juan Carlos Izpisua, Qu, Jing, Tang, Fuchou, Liu, GuangHui. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. CELL RESEARCH[J]. 2017, 27(9): 1178-1181, https://www.webofscience.com/wos/woscc/full-record/WOS:000408916300011.
[13] Pan, Huize, Guan, Di, Liu, Xiaomeng, Li, Jingyi, Wang, Lixia, Wu, Jun, Zhou, Junzhi, Zhang, Weizhou, Ren, Ruotong, Zhang, Weiqi, Li, Ying, Yang, Jiping, Hao, Ying, Yuan, Tingting, Yuan, Guohong, Wang, Hu, Ju, Zhenyu, Mao, Zhiyong, Li, Jian, Qu, Jing, Tang, Fuchou, Liu, GuangHui. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. CELL RESEARCH[J]. 2016, 26(2): 190-205, https://www.webofscience.com/wos/woscc/full-record/WOS:000372062300007.
[14] Duan, Shunlei, Yuan, Guohong, Liu, Xiaomeng, Ren, Ruotong, Li, Jingyi, Zhang, Weizhou, Wu, Jun, Xu, Xiuling, Fu, Lina, Li, Ying, Yang, Jiping, Zhang, Weiqi, Bai, Ruijun, Yi, Fei, Suzuki, Keiichiro, Gao, Hua, Esteban, Concepcion Rodriguez, Zhang, Chuanbao, Belmonte, Juan Carlos Izpisua, Chen, Zhiguo, Wang, Xiaomin, Jiang, Tao, Qu, Jing, Tang, Fuchou, Liu, GuangHui. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. NATURE COMMUNICATIONS[J]. 2015, 6: http://dx.doi.org/10.1038/ncomms10068.
[15] Wen, Lu, Li, Jingyi, Guo, Huahu, Liu, Xiaomeng, Zheng, Shengmin, Zhang, Dafang, Zhu, Weihua, Qu, Jianhui, Guo, Limin, Du, Dexiao, Jin, Xiao, Zhang, Yuhao, Gao, Yun, Shen, Jie, Ge, Hao, Tang, Fuchou, Huang, Yanyi, Peng, Jirun. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. CELL RESEARCH[J]. 2015, 25(11): 1250-1264, https://www.webofscience.com/wos/woscc/full-record/WOS:000365049100010.
[16] Zhang, Weiqi, Li, Jingyi, Suzuki, Keiichiro, Qu, Jing, Wang, Ping, Zhou, Junzhi, Liu, Xiaomeng, Ren, Ruotong, Xu, Xiuling, Ocampo, Alejandro, Yuan, Tingting, Yang, Jiping, Li, Ying, Shi, Liang, Guan, Dee, Pan, Huize, Duan, Shunlei, Ding, Zhichao, Li, Mo, Yi, Fei, Bai, Ruijun, Wang, Yayu, Chen, Chang, Yang, Fuquan, Li, Xiaoyu, Wang, Zimei, Aizawa, Emi, Goebl, April, Soligalla, Rupa Devi, Reddy, Pradeep, Esteban, Concepcion Rodriguez, Tang, Fuchou, Liu, GuangHui, Belmonte, Juan Carlos Izpisua. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. SCIENCE[J]. 2015, 348(6239): 1160-1168, http://dx.doi.org/10.1126/science.aaa1356.

   

（ 1 ） 中国健康长寿大人群多队列的系统研究, 参与, 国家任务, 2018-01--2022-12
（ 2 ） 人心血管类器官研究体系建立及功能机制研究, 参与, 国家任务, 2020-09--2025-08
（ 3 ） 非线粒体定位Sirtuins在人类干细胞稳态和衰老中的作用及机制研究, 负责人, 国家任务, 2019-01--2021-12
（ 4 ） 可注射的抗病纳米机器人, 参与, 中国科学院计划, 2022-07--2027-07