Innate immunity 

Protein synthesis 

Virus infection

1) Li Wan, Szymon Juszkiewicz, Daniel Blears, Prashanth Kumar Bajpe, Zhong Han, Peter Faull, Richard Mitter, Ambrosius. Snijders, Aengus Stewart, Ramanujan S. Hegde, and Jesper Q. Svejstrup. (2021) Translation stress and collided ribosomes are co-activators of cGAS. Molecular Cell.

2)  Szymon Juszkiewicz, Shaun Speldewinde, Li Wan, Jesper Svejstrup, and Ramanujan S Hegde. (2020) The ASC-1 complex disassembles collided ribosomes. Molecular Cell, 79: 603-614.

3)  Jinhua Han*, Li Wan*, Guixing Jiang, Liping Cao, Tian Tian, Feiyu Xia, Yi Luo, Yi Wang, Michael S.Y. Huen, Ting Liu, and Jun Huang. (2021) ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. Proc Natl Acad Sci USA  (* co-first author)

4)  Li Wan, and Jun Huang. (2014) The PSO4 complex associates with RPA and modulates the activation of ATR. J Biol Chem, 289: 6619-6626

5)  Li Wan*, Jiangman Lou*, Yisui Xia*, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, and Jun Huang. (2013) hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Reports, 14: 1104-1112. (* co-first author)

6)  Li Wan*, Jinhua Han*, Ting Liu*, Shunli Dong, Feng Xie, Hongxia Chen, and Jun Huang. (2013) Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proc Natl Acad Sci USA, 110: 10646-10651. (* co-first author)

7) Ting Liu*, Li Wan*, Yue Wu, Junjie Chen, Jun Huang. (2011) hSWS1-SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem, 286: 41758-41766. (* co-first author)

1) Li Wan, Szymon Juszkiewicz, Daniel Blears, Prashanth Kumar Bajpe, Zhong Han, Peter Faull, Richard Mitter, Ambrosius. Snijders, Aengus Stewart, Ramanujan S. Hegde, and Jesper Q. Svejstrup. (2021) Translation stress and collided ribosomes are co-activators of cGAS. Molecular Cell.

2)  Szymon Juszkiewicz, Shaun Speldewinde, Li Wan, Jesper Svejstrup, and Ramanujan S Hegde. (2020) The ASC-1 complex disassembles collided ribosomes. Molecular Cell, 79: 603-614.

3)  Jinhua Han*, Li Wan*, Guixing Jiang, Liping Cao, Tian Tian, Feiyu Xia, Yi Luo, Yi Wang, Michael S.Y. Huen, Ting Liu, and Jun Huang. (2021) ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. Proc Natl Acad Sci USA  (* co-first author)

4)  Li Wan, and Jun Huang. (2014) The PSO4 complex associates with RPA and modulates the activation of ATR. J Biol Chem, 289: 6619-6626

5)  Li Wan*, Jiangman Lou*, Yisui Xia*, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, and Jun Huang. (2013) hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Reports, 14: 1104-1112. (* co-first author)

6)  Li Wan*, Jinhua Han*, Ting Liu*, Shunli Dong, Feng Xie, Hongxia Chen, and Jun Huang. (2013) Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proc Natl Acad Sci USA, 110: 10646-10651. (* co-first author)

7) Ting Liu*, Li Wan*, Yue Wu, Junjie Chen, Jun Huang. (2011) hSWS1-SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem, 286: 41758-41766. (* co-first author)

1) Li Wan, Szymon Juszkiewicz, Daniel Blears, Prashanth Kumar Bajpe, Zhong Han, Peter Faull, Richard Mitter, Ambrosius. Snijders, Aengus Stewart, Ramanujan S. Hegde, and Jesper Q. Svejstrup. (2021) Translation stress and collided ribosomes are co-activators of cGAS. Molecular Cell.

2)  Szymon Juszkiewicz, Shaun Speldewinde, Li Wan, Jesper Svejstrup, and Ramanujan S Hegde. (2020) The ASC-1 complex disassembles collided ribosomes. Molecular Cell, 79: 603-614.

3)  Jinhua Han*, Li Wan*, Guixing Jiang, Liping Cao, Tian Tian, Feiyu Xia, Yi Luo, Yi Wang, Michael S.Y. Huen, Ting Liu, and Jun Huang. (2021) ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. Proc Natl Acad Sci USA  (* co-first author)

4)  Li Wan, and Jun Huang. (2014) The PSO4 complex associates with RPA and modulates the activation of ATR. J Biol Chem, 289: 6619-6626

5)  Li Wan*, Jiangman Lou*, Yisui Xia*, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, and Jun Huang. (2013) hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Reports, 14: 1104-1112. (* co-first author)

6)  Li Wan*, Jinhua Han*, Ting Liu*, Shunli Dong, Feng Xie, Hongxia Chen, and Jun Huang. (2013) Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proc Natl Acad Sci USA, 110: 10646-10651. (* co-first author)

7) Ting Liu*, Li Wan*, Yue Wu, Junjie Chen, Jun Huang. (2011) hSWS1-SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem, 286: 41758-41766. (* co-first author)

In 2016, I joined the Jesper Svejstrup laboratory expecting to continue to work in this broad area of research, and to supplement my biochemical skills with expertise in modern molecular cell biology techniques. As a starting point, I decided to pursue an intriguing observation made during the group's previous work on the ASCC3 gene/protein, namely that depletion of ASCC3 results in dramatic upregulation of interferon-stimulated genes, especially after DNA damage (Williamson et al., Cell 2017). Given what we knew about ASCC3 at that point, we fully expected that I would be working on the mechanisms of DNA damage-regulated transcription, in the nucleus. However, things developed in a completely different direction, and I was instead interested in the molecular mechanisms of innate immune response; how it interfaces with the protein synthesis machinery; and responds to virus infection from a translation regulation perspective.
In 2022, I joined the Guangzhou Institutes of Biomedicine and Health, affiliated with the Chinese Academy of Sciences, as a group leader. My lab seeks to understand how innate immune response is required to sense translation stress and thus likely for host cells to fight virus infection from a completely new and previously unappreciated perspective, using a powerful combination of biochemical, and molecular cell biological techniques.