Regulation of neuronal function

Neuronal deficit and underlying mechanism during the early stage of neurodegeneration

1999-2003          Tsinghua University   B.S

2004-2009          University of Maryland College Park Ph.D

2015-present        Interdisciplinary Research Center on Biology and Chemistry, Investigator

2011-2015            Johns Hopkins University, Postdoc / Assistant research scientist

2009-2010           University of Maryland College Park, Postdoc   

2019: Material application in Neuroscience, instructor (Shanghai University)

2018: Introductin to brain disorder, instructor (IRCBC, CAS)

Oct, 2015-present: Current research frontier, instructor (IRCBC, CAS)

Oct 19^th, 21^st, 2009: Cell biology, substitute instructor (University of Maryland, College Park)

Aug-Dec, 2007: Neurophysiology, teaching asistant (University of Maryland, College Park)

Feb-Jun, 2006: Mammalian Physiology, teaching asistant (University of Maryland, College Park)  

1.       Long H*, Zheng W*, Liu Y, Sun Y, Zhao K, Liu Z, Xia W, Lv S, Liu Z, Li D, He KW^#, Liu C^#. Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2012435118. doi: 10.1073/pnas.2012435118. PMID: 33972418..

2.       M Bridi*, F-J Zong*, X Min N Luo, T Tran, J Qiu, D Severin, X-T Zhang, G Wang, Z-J Zhu, K-W He^#, A Kirkwood^# (2020) Daily Oscillations in the Excitation-Inhibition Balance in Visual Cortical Circuits, Neuron, 105(4):621-629.e4. doi: 10.1016/j.neuron.2019.11.011

3.       Fang-Jiao Zong*, Zhaorong Chen, Xueting Zhang, Yang Liu, Xia Min, Haishan Yao, Kai-Wen He^#. Functional modulation of PV+ interneuron by natural sleep/wake cycle and its impact on microcircuit and cognition (To be submitted)

4.       Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A^# (2018) Two distinct mechanisms for experience-dependent homeostasis. Nat Neurosci. 21(6):843-850

5.       He K, Huertas M, Hong S, Tie X, Hell J.W, Shouval H, Kirkwood A^# (2015) Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron, 88(3): 528-38

6.    Ikrar T, Guo N, He K, Besnard A, Levinson S, Hill A, Lee HK, Hen R, Xu X, Sahay A^# (2013) Adult neurogenesis modulates excitability of the dentate gyrus. Frontiers in Neural Circuits. 7:204

7.    Wang H*, Megill A*, He K, Kirkwood A, Lee HK^# (2012) Consequences of inhibiting amyloid precursor protein (APP) processing enzymes on synaptic function and plasticity. Neural Plasticity. 2012:272374

8.    He K, Petrus E, Gammon N, Lee HK^#, (2012) Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. Journal of Neuroscience. 32(25):8469-74

9.    Huang S*, Treviño M*, He K*, Ardiles A, Pasquale R, Guo Y, Palacios A, Huganir R, Kirkwood A^# (2012) Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron. 73(3):497-510 (Recommended by F1000Prime)

10.      Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee HK, Hell JW^# (2012) The β2 Adrenergic Receptor Supports Prolonged Theta Tetanus - induced LTP. J Neurophysiol.

11.     He K, Goel A, Ciarkowski CE, Song L, Lee HK^# (2011) Brain area specific regulation of synaptic AMPA receptors by phosphorylation. Commun Integr Biol. 4(5):569-72

12.     He K, Lee A, Song L, Kanold PO, Lee HK^# (2011) AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression. Journal of Neurophysiology. 105(4):1897-907

13.     Lee HK, Takamiya K, He K, Song L, Huganir RL^# (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. Journal of Neurophysiology. 103(1):479-89

14.     He K, Song L, Cummings LW, Goldman J, Huganir RL, Lee HK^# (2009) Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. PNAS, 106(47):20033-8(Recommended by F1000Prime)

15.     Lee HK, Takamiya K, Kameyama K, He K, Yu S, Rossetti L, Wilen D, and Huganir RL ^# (2007) Idenfication and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Mol Cell Neuroscience, 36(1):86-94.

16.     Laird FM*, Cai H*, Savonenko AV*, Farah MH*, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC^# (2005) BACE1, a major determinant of selective vulnerability of the brain to amyloid- amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. Journal of Neuroscience, 25(50):11693-11709.