基本信息
戴建武 男 博导 遗传与发育生物学研究所
实验室主页:http://dailab.genetics.ac.cn
电子邮件:jwdai@genetics.ac.cn
通信地址:北京市海淀区中关村南一条三号 中科院遗传发育所103室
邮政编码:100190

研究领域

主要研究方向:
1.生物材料与组织再生
2.干细胞自我更新与定向分化
3.干细胞微环境重建与组织工程

招生信息

   
招生专业
071009-细胞生物学
071006-神经生物学
080502-材料学
招生方向
再生医学,生物材料,干细胞
生物材料
再生医学

教育背景

1998-09--2000-05 美国哈佛大学医学院 博士后
1996-09--1998-09 美国杜克大学 博士
1988-09--1991-07 北京医科大学 硕士
1984-09--1988-07 武汉大学 学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2003-08--今 中国科学院遗传与发育生物学研究所 研究员
1993-09--1996-08 美国杜克大学 访问学者
1991-09--1993-07 北京医科大学 任教
社会兼职
   

教授课程

干细胞研究进展系列讲座、 组织工程

专利与奖励

   
奖励信息
(1) CCTV年度科技创新人物,其他级,2014
(2) 国家科技进步二等奖,二等奖,国家级,2012
(3) 遗传发育所益海嘉里优秀导师奖,其他级,2010
专利成果
(1) 一种脱钙骨支架材料及其制备方法,发明,2008,第2作者,专利号:ZL 200610080609.X
(2) 与胶原特异结合的神经生长因子及其编码基因与应用,发明,2008,第3作者,专利号:ZL 200610081506.5
(3) 一种胶原蛋白膜及其制备方法,发明,2007,第1作者,专利号:ZL 200410096629.7
(4) 活化的胶原骨修复材料及其专用融合活性骨修复因子,发明,2007,第2作者,专利号:ZL 200510132791.4
(5) 用于捕捉干细胞的生物材料及其制备方法与应用,发明,2014,第5作者,专利号:ZL 201110026096.5
(6) 一种融合蛋白TAT‐NANOG及其编码基因与应用,发明,2013,第1作者,专利号:ZL 201110084055.1
(7) Activated Collagen Scaffold Materials and Their Special Fused Active Restoration Factors,发明,2011,第1作者,专利号:EP 1970382 B1 (欧洲)
(8) 一种表达人骨形态发生蛋白的方法及其专用表达载体,发明,2008,第4作者,专利号:ZL 200410096493.X
(9) 一个人源的Nanog基因及其编码蛋白与应用,发明,2008,第3作者,专利号:ZL 200510098452.9
(10) 一种生物修复材料及其制备方法与应用,发明,2007,第3作者,专利号:ZL 200510098731.5
(11) 活化胶原蛋白支架材料及其专用融合活性修复因子,发明,2007,第2作者,专利号:ZL 200510132792.9
(12) 修复脊髓损伤的生物材料及其制备方法与应用,发明,2013,第4作者,专利号:ZL 201010528622.3
(13) 一种融合蛋白TAT‐OCT4及其编码基因与应用,发明,2014,第1作者,专利号:ZL 201110084049.6
(14) 与胶原蛋白特异结合的血管内皮生长因子及其应用,发明,2012,第1作者,专利号:ZL 200810222219.0
(15) 一种骨支架材料及其制备方法与应用,发明,2012,第3作者,专利号:ZL 200810056972.7
(16) 与层粘连蛋白结合的神经生长因子及其编码基因与应用,发明,2013,第4作者,专利号:ZL 200910089716.2
(17) Reprogramming cells by three-dimensional cultivation.,发明,2012,第5作者,专利号:PCT/CN2012/072284
(18) 肝素、胶原材料和生长因子的交联物及其制备方法,发明,2013,第4作者,专利号:ZL 200910089730.2
(19) 胶原材料与生长因子的交联物及其制备方法,发明,2013,第4作者,专利号:ZL 200910089728.5
(20) 一种与纤维蛋白特异结合的重组蛋白及其应用,发明,2013,第1作者,专利号:ZL 201110322657.6
(21) 一种用成纤维细胞制备神经干细胞的方法,发明,2012,第5作者,专利号:201210552280.8
(22) miR-7及其应用,发明,2013,第5作者,专利号:201310311571.2
(23) 一种诱导成熟细胞去分化的方法.,发明,2014,第5作者,专利号:ZL 201310017486.5
(24) OCT4B蛋白异构体的用途,发明,2014,第5作者,专利号:ZL 201210001826.0
(25) Activated collagen scaffold materials and their special fused active restoration factors.,发明,2014,第1作者,专利号:US 8,802,396 B2 (美国)
(26) 含双因子的外周神经损伤修复胶原材料及其制备方法,发明,2015,第1作者,专利号:ZL 201410234129.9
(27) Activated collagen scaffold materials and their special fused active restoration factors.,发明,2014,第1作者,专利号:14/320,191 (美国)
(28) Activated collagen scaffold materials and their special fused active restoration factors,发明,2014,第1作者,专利号:14/320,105 (美国)
(29) 一种修饰组织工程支架的方法,发明,2015,第2作者,专利号:ZL 201210509347.X
(30) 一种用于修复脊髓损伤的圆柱体支架及其应用方法,发明,2015,第2作者,专利号:ZL 201310045578.4
(31) 一种在组织工程支架上定量装载生长因子的方法及其应用,发明,2014,第2作者,专利号:ZL 201210508762.3
(32) 一种引导外周神经再生的功能生物材料及其制备方法,发明,2014,第1作者,专利号:201410553525.8
(33) 一种有序胶原材料及其制备方法与应用,发明,2014,第1作者,专利号:201410389082.3

出版信息

   
发表论文
(1) Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord.,ACS Appl Mater Interfaces,2015,通讯作者
(2) Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction.,J Control Release,2015,通讯作者
(3) Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats.,ACS Appl Mater Interfaces,2015,通讯作者
(4) Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model.,Biomaterials,2015,通讯作者
(5) Electrospun Collagen Fibers with Spatial Patterning of SDF1α for the Guidance of Neural Stem Cells.,Adv Healthc Mater.,2015,通讯作者
(6) Directed osteogenic differentiation of mesenchymal stem cell in three-dimensional biodegradable methylcellulose-based scaffolds.,Colloids and Surfaces B: Biointerfaces,2015,通讯作者
(7) The collagen scaffold with collagen binding BDNFenhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transaction.,Spinal Cord.,2015,通讯作者
(8) Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model.,Tissue Eng Part A,2015,通讯作者
(9) Regeneration of uterine horns in rats using collagen scaffolds loaded with human embryonic stem cell-derived endometrium-like cells. ,Tissue Eng Part A ,2015,通讯作者
(10) Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis.,Mol Med Rep.,2015,通讯作者
(11) Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model. ,Artif Organs,2015,通讯作者
(12) Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs.,J Biomed Mater Res A,2015,通讯作者
(13) A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy.,J Control Release,2015,通讯作者
(14) The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine.,Biomaterials,2015,通讯作者
(15) Transplantation of hBMSCs loaded on collagen scaffolds for the regeneration of canine tissue-engineered urethras.,J Genet Genome Res.,2015,通讯作者
(16) Keep warm and get success: The role of postischemic temperature in the mouse middle cerebral artery occlusion model, Brain Res Bull.,2014,通讯作者
(17) The miR-7 identified from collagen biomaterial based 3-D cultured cells regulates neural stem cell differentiation.,Stem Cells Dev.,2014,通讯作者
(18) Linear ordered collagen scaffolds loaded with collagen-binding basic fibroblast growth factor facilitate recovery of sciatic nerve injury in rats.,Tissue Eng Part A,2014,通讯作者
(19) Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair.,Biomaterials,2014,通讯作者
(20) Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model. ,Tissue Eng Part A.,2014,通讯作者
(21) Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs.,Biomaterials,2014,通讯作者
(22) The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells. ,Biomaterials,2014,通讯作者
(23) Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs.,J Biomed Mater Res A,2014,通讯作者
(24) Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model.,Artif Organs,2014,通讯作者
(25) Accelerated postero-lateral spinal fusion by collagen scaffolds modified with engineered collagen-binding human bone morphogenetic protein-2 in rats. ,PLoS One,2014,通讯作者
(26) The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification. ,Biomaterials,2014,通讯作者
(27) Use of natural neural scaffolds consisting of engineered vascular endothelial growth factor immobilized on ordered collagen fibers filled in a collagen tube for peripheral nerve regeneration in rats.,Int J Mol Sci.,2014,通讯作者
(28) Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model.,Sci China Life Sci.,2014,通讯作者
(29) Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds.,Colloids and Surfaces B: Biointerfaces,2014,通讯作者
(30) Accelerating proliferation of neural stem/progenitor cells in collagen sponges immobilized with engineered basic fibroblast growth factor for nervous system tissue engineering., Biomacromolecules,2014,通讯作者
(31) In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent.,Int J Mol Med.,2014,通讯作者
(32) The invitro and invivo toxicity of graphene quantum dots. Biomaterials.,Biomaterials,2014,通讯作者
(33) Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus.,Biomaterials,2014,通讯作者
(34) The interplay of T1- and T2-relaxation on T1-weighted MRI of hMSCs induced by Gd-DOTA-peptides.,Biomaterials,2014,通讯作者
(35) Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway.,Biomaterials,2013,通讯作者
(36) Three-dimensional culture may promote cell reprogramming.,Organogenesis,2013,通讯作者
(37) Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats.,Biomaterials,2013,通讯作者
(38) Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces.,Biomaterials,2013,通讯作者
(39) Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair.,Biomaterials,2013,通讯作者
(40) Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in diabetic rat model.,J Tissue Eng Regen Med.,2013,通讯作者
(41) Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells.,Sci. Rep.,2013,通讯作者
(42) Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at 11.7 T.,Biomaterials,2013,通讯作者
(43) Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds., Colloids and Surfaces B: Biointerfaces,2013,通讯作者
(44) Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model.,Tissue Engineering and Regenerative Medicine,2013,通讯作者
(45) Induction of rat facial nerve regeneration by functional collagen scaffolds.,Biomatierials,2013,通讯作者
(46) Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates.,Biomaterials,2013,通讯作者
(47) The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties.,Biomaterials,2013,通讯作者
(48) Assembled 3D cell niches in chitosan hydrogel network to mimic extracellular matrix.,Colloids and Surfaces A: Physicochem. Eng. Aspects,2013,通讯作者
(49) Evaluation of abioactivebone-inducingmaterialconsistingofcollagenscaffolds andcollagen-binding BMP2.,J Biomed Mater Res A,2013,通讯作者
(50) One-step self-assembly of ZnPc/NaGdF4:Yb,Er nanoclusters for simultaneous fluorescence imaging and photodynamic effects on cancer cells.,Journal of Materials Chemistry B,2013,通讯作者
(51) Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity.,Biomaterials. 33(6):1714-21.,2012,通讯作者
(52) The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs.,Biomaterials. 33(5):1437-44,2012,通讯作者
(53) The Novel Function of OCT4B Isoform-265 in Genotoxic Stress.,Stem Cells. 30(4):665-72,2012,通讯作者
(54) Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model.,Biomaterials. 33(5):1386-95,2012,通讯作者
(55) Extrahepatic bile duct regeneration in pigs using collagen scaffolds loaded with human collagen-binding bFGF. ,Biomaterials,2012,通讯作者
(56) MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin.,BMC Neurosci.,2012,通讯作者
(57) The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury.,Biomaterials. 33(6):1801-7.,2012,通讯作者
(58) The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats. ,Biomaterials. 32(16):3939-48,2011,通讯作者
(59) Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. ,Acta Biomaterialia. 7(3):1084-93,2011,通讯作者
(60) Regeneration of full-thickness abdominal wall defects in rats using collagen scaffolds loaded with collagen-binding basic fibroblast growth factor., Biomaterials. 32(3): 753-9.,2011,通讯作者
(61) Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration., Biomaterials. 32(10):2508-15.,2011,通讯作者
(62) The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor. ,Biomaterials. 32(12):3244-52,2011,通讯作者
(63) Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor. ,Biomaterials,2011,通讯作者
(64) A Myocardial Patch Made of Collagen Membranes Loaded with Collagen-Binding Human Vascular Endothelial Growth Factor Accelerates Healing of the Injured Rabbit Heart.,Tissue Engineering Part A. 17(21-22):2739-47.,2011,通讯作者
(65) Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transaction. ,J Biomed Mater Res B Appl Biomater. 97(2):271-7.,2011,通讯作者
(66) The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies.,J Controlled Release. 141(1):30-7.,2010,通讯作者
(67) Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing., J Biomed Mater Res A. 92(3):887-95.,2010,通讯作者
(68) Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts.,Frontiers in Biology,2010,通讯作者
(69) Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells., Stem Cells Dev. 19(1):53-60,2010,通讯作者
(70) Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. ,J Mater Sci Mater Med. 21(1):309-17,2010,通讯作者
(71) Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA., Biochem Biophys Res Commun. 394(3):750-4.,2010,通讯作者
(72) The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B., J Genet Genomics. 37(7):461-5,2010,通讯作者
(73) Isoforms of OCT4 contribute to the confusing diversity in stem cell biology,Stem Cells. 28(5):885-93.,2010,通讯作者
(74) Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. ,J Urol. 183(6):2432-9.,2010,通讯作者
(75) Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promotes axonal regeneration and partial functional recovery after complete spinal cord transaction. ,J Neurotrauma. 27(9):1671-83.,2010,通讯作者
(76) Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model. ,Diabetes Research and Clinical Practice. 90(1):66-72.,2010,通讯作者
(77) The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF., Biomaterials. 31(33):8634-41,2010,通讯作者
(78) The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. ,Biomaterials. 31(35):9212-20,2010,通讯作者
(79) The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development., Oncology Letters. 1(3): 457-63,2010,通讯作者
(80) Stem cell research is coming of age in China.,J Genet Genomics. 37(7):413.,2010,第1作者
(81) Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction., Circulation. 119(13):1776-84.,2009,通讯作者
(82) Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization. ,Biomacromolecules. 10(12):3193-8.,2009,通讯作者
发表著作
   

科研活动

   
科研项目
(1) 面向干细胞微环境构建的低温细胞3D重建系统,主持,院级级,2014-01--2015-12
(2) 基于快速成型技术的新型神经组织工程支架材料研发,参与,国家级,2013-06--2016-06
(3) 功能生物材料与组织器官工程产品研究,参与,部委级,2012-01--2015-12
(4) 三维培养干细胞自我更新与定向分化的调控网络,主持,国家级,2011-01--2015-12
(5) 胶原结合能力的血管内皮生长因子对猪心肌损伤的治疗作用及安全性评价,主持,部委级,2011-01--2013-12
(6) 人工组织器官构建,主持,院级级,2011-01--2015-12
(7) 神经再生环境的构建,主持,部委级,2010-01--2013-12
(8) OCT4 异构体的表达、功能和调节机制的研究,主持,部委级,2010-01--2012-12
(9) 骨损伤定向修复活性骨材料的研制,主持,院级级,2009-01--2011-12
参与会议
   

合作情况

   
项目协作单位
   

指导学生

已指导学生

索广力   博士研究生  071008-发育生物学  

王霞  博士研究生  071009-细胞生物学  

王斌  博士研究生  071008-发育生物学  

赵文学  博士研究生  071008-发育生物学  

赵艳红  博士研究生  071008-发育生物学  

林航  博士研究生  071009-细胞生物学  

张经余   博士研究生  071008-发育生物学  

陈冰  博士研究生  071008-发育生物学  

孙文杰  博士研究生  071009-细胞生物学  

赵燕南  博士研究生  071009-细胞生物学  

张晶  博士研究生  071009-细胞生物学  

高健  硕士研究生  071009-细胞生物学  

高原  博士研究生  071009-细胞生物学  

韩津  博士研究生  071009-细胞生物学  

韩倩倩  博士研究生  071009-细胞生物学  

施春英  博士研究生  071009-细胞生物学  

曹佳妮  博士研究生  071009-细胞生物学  

陈磊  博士研究生  071009-细胞生物学  

韩素芳  博士研究生  071009-细胞生物学  

苏冠男  博士研究生  071009-细胞生物学  

肖汉山  硕士研究生  071009-细胞生物学  

魏建树  博士研究生  071007-遗传学  

牟辰辰  硕士研究生  071009-细胞生物学  

杨赟  博士研究生  071009-细胞生物学  

梁辉  博士研究生  071009-细胞生物学  

现指导学生

李星  博士研究生  071008-发育生物学  

范彩霞  博士研究生  071009-细胞生物学  

刘素梅  博士研究生  071008-发育生物学  

徐白  博士研究生  071009-细胞生物学  

薛伟伟  博士研究生  071006-神经生物学  

杨颖  博士研究生  071006-神经生物学