(1) 海洋特境微生物药用资源的收集与挖掘

(2) 海洋微生物药物功效分子发现及其生物代谢潜能研究

(3) 海洋来源抗肿瘤、抗病毒先导化合物的机制研究及成药性评价

招生专业：

海洋生物学

生物技术与工程

接受本科院校药学、化学和生物等相关专业硕士推免生和联合培养博士/硕士研究生。

2009-09--2012-06   中国海洋大学   博士
2006-09--2009-06   青岛科技大学   硕士
2002-09--2006-06   青岛科技大学   学士

博士研究生

博士学位

工作简历

2022-12~至今, 中国科学院南海海洋研究所, 研究员

2019-03~2020-03,美国加州大学洛杉矶分校, 访问学者

2016-12~2022-12, 中国科学院南海海洋研究所, 副研究员

2012-09~2016-12,中国科学院南海海洋研究所, 助理研究员

社会兼职

​2022-01-01-至今，Natural Products and Bioprospecting期刊青年编委

2021-11-14-至今，中国药学会海洋药物专业委员会青委会委员

2018-07-01-至今，中国菌物学会菌物化学专业委员会委员

2018-06-13-至今，中国菌物学会终身会员

2018-05-28-至今，中国化学会会员

​

（ 1 ） 一种具有抗前列腺癌活性的四氢喹啉生物碱及其制备方法和应用, 发明专利, 2020, 第 1 作者, 专利号: 202011437854.8

（ 2 ） 一种水杨醇类化合物及其在制备抗肠道病毒药物中的应用, 发明专利, 2019, 第 1 作者, 专利号: ZL201710052984.1

（ 3 ） 一类新颖结构倍半萜化合物及其在制备抗炎药物中的应用, 发明专利, 2019, 第 1 作者, 专利号: ZL201610578329.5

（ 4 ） 海洋曲霉SCSIO 05879制备Versicoloids A 和B及在抗胶孢炭疽菌药物中的应用, 发明专利, 2018, 第 1 作者, 专利号: ZL201710505896.2

（ 5 ） 抗生素Versicoloids A 和B及其制备方法和在制备抗植物病原菌药物中的应用, 发明专利, 2017, 第 1 作者, 专利号: ZL201610046509.9

（ 6 ） 一种α-吡喃酮混源萜及其制备方法和应用, 发明专利, 2017, 第 1 作者, 专利号: ZL201510244085.2

（ 7 ） 吡啶酮生物碱类化合物及其制备方法和在制备抗肿瘤药物中的应用, 发明专利, 2016, 第 1 作者, 专利号: ZL201410021280.4

（ 8 ） 生物碱类化合物在制抗肠道病毒及乙酰胆碱酯酶抑制剂药物中的应用, 发明专利, 2015, 第 1 作者, 专利号: ZL201410021315.4

在Org. Lett., Acta Pharm Sin B, Cell Death Dis., Pharmacol. Res., Org. Chem. Front., Bioorg. Chem., J. Nat. Prod.等药物化学主流刊物上发表SCI论文122篇，近年来第一/通讯作者文章如下：

60. Song Y^#, Tan Y^#, She J, Chen C, Wang J, Hu Y, Pang X, Wang J*, Liu Y*. Tanzawaic Acid Derivatives from the Marine-Derived Penicillium steckii as Inhibitors of RANKL-Induced Osteoclastogenesis. J. Nat. Prod., 2023, Doi: 10.1021/acs.jnatprod.2c00865. (Front Cover Article).

59. Cong M^#, Ren X^#, Song Y, Pang X, Tian X, Liu Y*, Guo P*, Wang J*. Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production. Phytochemistry, 2023, 208, 113593.

58. Qi X, Chen W, Chen L, Hu Y, Wang X, Han W, Xiao J, Pang X, Yao X, Liu S, Li Y, Yang J*,  Wang J*, Liu Y*. Structurally various p-terphenyls with neuraminidase inhibitory from a sponge derived fungus Aspergillus sp. SCSIO41315. Bioorg. Chem., 2023, 132, 106357.

57. Song Y, Song M, Chen W, Pang X, Wang F, Tian X,  Wang J*, Liu Y*. One new furanone analogue from the deep-sea fungus Purpureocillium sp. SCSIO 06693. Nat Prod Res, 2022, Doi: 10.1080/14786419.2022.2089671.

56. Xu F^*,#, Chen W^#, Ye Y, Qi X, Zhao K, Long J, Pang X, Liu Y,  Wang J*. A New Quinolone and Acetylcholinesterase Inhibitors from a Sponge-Associated Fungus Penicillium sp. SCSIO41033. Nat Prod Res, 2022, Doi: 10.1080/14786419.2022.2139694.

55. Cong M, Zhang Y, Feng X, Pang X, Liu Y, Zhang X*, Yang Z*, Wang J*. Anti‑infammatory alkaloids from the cold‑seep‑derived fungus Talaromyces helicus SCSIO41311. 3 Biotech, 2022, 12, 161.

54. Cong M, Pang X, Zhao K, Song Y, Liu Y, Wang J*. Deep-Sea Natural Products from Extreme Environments: Cold Seeps and Hydrothermal Vents. Mar. Drugs 2022, 20, 404.

53. Xie Y, Song Y, Cong Z, Zhao K, Pang X, Liu Y, Huang X*, Wang J*. New Diterpene and Indole Alkaloid Analogs from the Streptomyces malaysiensis SCSIO 41397. Chem. Biodiversity 2022, 19, e202200731.

52. Pang X, Wang P, Liao SR, Zhou X, Lin X, Yang B, Tian X, Wang J*, Liu Y*. Three unusual hybrid sorbicillinoids with anti-inflammatory activities from

51. Chen J^#,  Hu Y^#,  Zhang J, Wang Q, Wu X, Huang W, Wang Q, Cai G, Wang H, Ou T, Feng W, Liu P, Liu Y, Wang J*, Huang J, Wang J*.  Therapeutic targeting RORγ with natural product N-hydroxyapiosporamide for small cell lung cancer by reprogramming neuroendocrine fate. Pharmacol. Res., 2022, 178, 106160.

50. Zhong L^#,  Yang B^#,  Zhang Z^#,  Wang J*, Wang X, Guo Y, Huang W, Wang Q, Cai G, Zhou S, Ma S, Nie Y, Lei J, Liu P, Deng W, Liu Y, Han F*, Wang J*. Targeting autophagy peptidase ATG4B with a novel natural product inhibitor Azalomycin F4a for advanced gastric cancer. Cell Death Dis., 2022, 13, 161.

49. Xie Y^#, Guo L^#, Huang J^#, Huang X*, Cong Z, Liu Q, Wang Q, Pang X, Xiang S, Zhou X, Liu Y*, Wang J*, Wang J*. Cyclopentenone-Containing Tetrahydroquinoline and Geldanamycin Alkaloids from Streptomyces malaysiensis as Potential Anti-Androgens against Prostate Cancer Cells. J. Nat. Prod., 2021, 84, 2004−2011. (Top 20 Most Read Articles in August, 2021)

48. Chen W^#, Zhang J^#, Qi X, Zhao K, Pang X, Lin X, Liao S, Yang B, Zhou X, Liu S, Wang J*, Yao X*, Liu Y*. p‑Terphenyls as Anti-HSV-1/2 Agents from a Deep-Sea-DerivedPenicillium sp. J. Nat. Prod., 2021, 84, 2822−2831. (Front Cover Article)

47. Pang X, Chen W, Wang X, Zhou X, Yang B, Tian X, Wang J*, Xu S*, Liu Y*. New Tetramic Acid Derivatives From the Deep-Sea-Derived FungusPenicillium sp. SCSIO06868 With SARS-CoV-2 M^pro Inhibitory Activity Evaluation. Front Microbiol, 2021, 12, 730807.

46. Han W^#, Song M^#, Hu Y, Pang X, Liao S, Yang B, Zhou X, Liu Y, Liu Q*, Wang J*. Citrinin and α-pyrone derivatives with pancreatic lipase inhibitory activities from Penicillium sp. SCSIO 41302. J Asian Nat Prod Res, 2021, Doi: 10.1080/10286020.2021.1998009.

45. Hu Y, Chen W, Song M, Pang X, Tian X, Wang F, Liu Y, Wang J*. Indole diketopiperazine alkaloids and aromatic polyketides from the Antarctic fungus Penicilliumsp. SCSIO 05705. Nat Prod Res, 2021, Doi: 10.1080/14786419.2021.1973460.

44. Qi X, Chen W, Lin X, Liao S, Yang B, Zhou X, Liu Y, Wang J*, Li Y*. A glyoxylate-containing benzene derivative and butenolides from a marine algicolous fungusAspergillus sp. SCSIO 41304. Nat Prod Res, 2021, Doi: 10.1080/14786419.2021.1978994.

43. Guo T^#, Song M^#, Han, W, Zhu, J, Liu Q*, Wang J*. New N-methyl-4-quinolone alkaloid and citrinin dimer derivatives from the sponge-derived fungus Penicillium sp. SCSIO 41303. Phytochem. Lett. 2021, 46, 29–35.

42. Song M^#,  Xie Y^#, Chen W, Hu Y, Zhao K, Liu Y, Huang X*, Liu Q*, Wang J*. Diketopiperazine and enterotoxin analogues from the mangrove derived-soil Streptomyces sp. SCSIO 41400 and their biological evalution. Nat Prod Res, 2021, Doi: 10.1080/14786419.2020.1864632.

41. Guo C, Wang P, Pang X, Lin X, Liao S, Yang B, Zhou X, Wang J*, Liu Y*. Discovery of a dimeric Zinc complex and five cyclopentenone derivatives from the sponge-associated fungus Aspergillus ochraceopetaliformis. ACS Omega, 2021, 6, 8942.

40. Pang X, Zhou X, Lin X, Yang B, Tian X, Wang J*, Xu S*, Liu Y*. Structurally various sorbicillinoids from the deep-sea sediment derived fungus Penicillium sp. SCSIO06871. Bioorg Chem, 2021, 107, 104600.

39. Zhu Y^#, Wang J^#, Mou P, Yan Y, Chen M, Tang Y*. Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22. Org Biomol Chem, 2021, 19,1985. (Highlighted by Natural Products Reports)

38. Chen W, Chen C, Long J, Lan S, Lin X, Liao S, Yang B, Zhou X, Wang J*, Liu Y*. Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029. J Antibiot, 2021, 74, 156.

37. Li T, Yin J, Ji Y, Lin P, Li Y, Yang Z, Hu S, Zhang B, Koshti S, Wang J*, Ji C*, Guo S*. Setosphapyrones C and D accelerate macrophages cholesterol efflux by promoting LXRa/ABCA1 pathway. Arch Pharm Res, 2020, 43, 788.

36. Zheng J^#, Wang J^#, Wang Q, Zou H, Wang H, Zhang Z, Chen, J, Wang P, Zhao Y, Lu J, Zhang X, Xiang S, Wang H, Lei J, Chen H, Liu P, Liu Y*, Han F*, Wang J*. Targeting castration-resistant prostate cancer with a novel ROR-gama antagonist elaiophylin. Acta Pharm Sin B, 2020, 10, 2313.

35. Han W, Cai J, Zhong W, Xu G, Wang F, Tian X, Zhou X*, Liu Q*, Liu Y, Wang J*.  Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007. Bioorg Chem, 2020, 96, 103646.

34. Chen W, Li K, Lin X, Liao S, Yang B, Zhou X, Wang J, Liu Y*, Wang J*.  Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Nat Prod Res, 2020, doi: 10.1080/14786419.2020.1749614.

33. Chen W, Liu H, Long J, Tao H, Lin X, Liao S, Yang B, Zhou X, Liu Y*, Wang J*.  Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Phytochem Lett, 2020, 35: 99–102. (Highlighted by Natural Products Reports)

32. Pang X, Lin X, Zhou X, Yang B, Tian X, Wang J*, Xu S*, Liu Y*. New quinoline alkaloid and bisabolane-type sesquiterpenoid derivatives from the deep-sea-derived fungus Aspergillus sp. SCSIO06786. Fitoterapia, 2020, 140: 104406.

31. Guo C, Wang P, Lin X, Salendra L, Kong F, Liao S, Yang B, Zhou X, Wang J*, Liu Y*. Phloroglucinol heterodimers and bis-indolyl alkaloids from the Sponge-Derived Fungus Aspergillus sp. SCSIO 41018. Org Chem Front, 2019, 6: 3053–3059. (Front Cover Article, Best Cover Winner in 2019)

30. Liu N, Peng S, Yang J, Cong Z, Lin X, Liao S, Yang B, Zhou X, Zhou X, Liu Y*, Wang J*. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301. Fitoterapia, 2019, 135: 27-32.

29. Guo C, Lin X, Liao S, Yang B, Zhou X, Yang X, Tian X, Wang J*, Liu Y.* Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720. Nat Prod Res, 2019, doi: 10.1080/14786419.2018.1553880.

28. Cong Z, Huang X*, Liu Y, Liu Y, Wang P, Liao S, Yang B, Zhou X, Huang D, Wang J*. Cytotoxic anthracycline and antibacterial tirandamycin analoguesfrom a marine-derived Streptomyces sp. SCSIO 41399. J Antibiot, 2019, 72: 45–49.

27. Pang X, Cai G, Lin X, Salendra L, Zhou X, Yang B, Wang J, Wang J*, Xu S*, Liu Y*. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. Mar. Drugs, 2019, 17, 398.

26. Wang J, Qing L, Zhao B, Cai L, Zhong Z, Liu Y, Zhou X*. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium. Org Biomol Chem, 2019, 17(1): 195–202.

25. Wang J, Cong Z, Huang X, Hou C, Chen W, Tu Z, Huang D, Liu Y*. Soliseptide A, acyclic hexapeptidepossessing piperazicacid groups from Streptomyces solisilvae HNM30702. Org Lett, 2018,  20(5): 1371–1374.

24. Pang X, Lin X, Yang J, Zhou X, Yang B, Wang J*, Liu Y*. Spiro-Phthalides and isocoumarinsisolated from the marine-sponge-derived fungus Setosphaeria sp. SCSIO41009. J Nat Prod, 2018, 81(8), 1860−1868. (Top 20 Most Read Articles in August, 2018)

23. Pang X, Lin X, Wang P, Zhou X, Yang B, Wang J*, Liu Y*. Perylenequione derivatives with anticancer activities isolated from the marine sponge-derived fungus, Alternaria sp. SCSIO41014. Mar. Drugs, 2018, 16(8), 280.

22. Wang J*, Zhou L, Chen S, Yang B, Liao S, Kong F, Lin X, Wang F, Zhou X, Liu Y*. New chlorinated diphenyl ethers and xanthones from a deep-sea-derivedfungus Penicillium chrysogenum SCSIO 41001. Fitoterapia, 2018, 125, 49–54.

21. Pang X, Lin X, Wang J*, Liang R, Tian Y, Salendra L, Luo X, Zhou X, Yang B, Tu Z, Liu Y*. Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007. Steroids, 2018, 129, 41–46.

20. Wang J, He W, Kong F, Tian T, Wang P, Zhou X*, Liu Y*. Ochracenes A−I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis. J Nat Prod, 2017, 80(6): 1725–1733. (Highlighted by Natural Products Reports)

19. Wang J, Liang R, Liao S, Yang B, Tu Z, Lin X, Wang B, Liu Y*. Vaccinols J–S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii. Fitoterapia, 2017, 120: 164–170.

18. He W, Zhou X, Qin X, Mai Y, Lin X, Liao S, Yang B, Zhang T, Tu Z, Wang J*, Liu Y*. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derivedfungus Gliomastix sp. ZSDS1-F7. Nat Prod Res, 2017, 31(5): 604–609.

17. Wang J, Wei X, Qin X, Tian X, Liao L, Li K, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y*. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702, J Nat Prod, 2016, 79(1): 59–65. (Highlighted by Natural Products Reports)

16. Wang J, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou X, Liu Y*. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879, J Agric Food Chem, 2016, 64(16): 2910–2916.

15. Wang J, Qin X, Chen Z, Ju Z, He W, Tan Y, Zhou X, Tu Z, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni), Phytochem Lett, 2016, 15: 13–15.

14. Zhao B^#, Peng S^#, He W, Liu Y, Wang J*, Zhou X*. Antitubercular and cytotoxic tigliane-type diterpenoidsfrom Croton tiglium, Bioorg Med Chem Lett, 2016, 26(20): 4996–4999.

13. Xu G^#, Wang Z^#, Zhao B, Liu N, Yang S, Liu Y, Wang J*, Zhou X*. Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-inducednitric oxide release, Phytochem Lett, 2016, 18: 35–38.

12. Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, pyridine alkaloids from a sponge-derivied fungus Arthrinium arundinis ZSDS1-F3. Org Lett, 2015, 17(3): 656–659. (ACS Editors' Choice, Highlighted by Natural Products Reports)

11. Wang J, He W, Qin X, Wei X, Tian X, Liao L, Liao S, Yang B, Tu Z, Chen B, Wang F, Zhou X*, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp. SCSIO 05705, RSC Adv, 2015, 5(84): 68736–68742.

10. Wang J, Wang Z, Ju Z, Wan J, Liao S, Lin X, Zhang T, Zhou X, Chen H, Tu Z*, Liu Y*. Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis. Planta Med, 2015, 81(2): 160–166.

9. Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimer icsesquiterpene from Carpesium abrotaoides L. Bioorg Med Chem Lett, 2015, 25(19): 4082–4084.

8. Wang J^#, Yang S^#, Liu Y, Li D, He W, Zhang X, Liu Y*, Zhou X*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium. Bioorg Med Chem Lett, 2015, 25(9): 1986–1989.

7. Yang S^#, Liu Y^#, Wang J*, Wang Y, Pan W, Sheng W, Cai R, Zhou X*. Isoquinoline alkaloids from Zanthoxylum simulans and their biological evaluation, J Antibiot, 2015, 68(4): 289–292.

6. Wang J, Wei X, Qin X, Chen H, Lin X, Zhang T, Yang X, Liao S, Yang B, Liu J, Zhou X, Tu Z*, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochem Lett, 2015, 12: 59–62.

5. Wang J^#, Qin X^#, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z*, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation. Nat Prod Res, 2015, 29(18): 1761–1765.

4. Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y*. Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel(L.) Druce. Tetrahedron, 2014, 70(51): 9695–9701.

3. Wang J, Deng Y, Yang S, Liu Y, Wang Y, Pan W, Zhou X*. Characterization and biological evaluation of six new dimericlignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulans, Bioorg Med Chem Lett, 2014, 24(19): 4667–4671.

2. Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y*. A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. Nat Prod Res, 2014, 28(14): 1070–1074.

1. Wang J^#, Lin X^#, Qin C, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang B, Zhou X, Yang X, Tu Z*, Liu Y*. Antimicrobial and antiviral sesquiterpenoids from sponge-associated fungus, Aspergillus sydowii ZSDS1-F6. J Antibiot, 2014, 67(8): 581–583.

   

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现指导学生

胡怡伟  硕士研究生  070703-海洋生物学  

丛梦静  硕士研究生  070703-海洋生物学  

宋悦  硕士研究生  086000-生物与医药