基本信息

杨镜奎  男 有机化学博士  教授 博导  化学科学学院
电子邮件: jkyang_AT_ucas.edu.cn
通信地址: 北京市石景山区玉泉路19号(甲)中国科学院大学,化学科学学院

电    话:  010-88256421/69672535

邮政编码: 100049

部门/实验室:化学科学学院

研究兴趣

以有机合成为主导,开展以下研究:

)有机合成(合成、机理、催化、立体选择性)\

特殊大环及大共轭体系、杂环及药物分子合成、天然产物分离与研究(中草药、腐植酸等)、不对称合成

)有机物结构与性能(构效关系)研究

纳米材料、有机光//磁功能材料(含荧光材料)、超分子自组装及器件合成、生物活性分子及生物功能材料、化学/化学生物学信息学(Chemoinfomatics, Biochemoinformatics)(构效关系、波谱模拟与结构预测、神经网络在化学性能及生物活性研究中的应用)

)分子识别: 

   有机分子、金属离子的高灵敏度快速可视化识别(非昂贵仪器测试,与仪器测试优势互补);

   应用范围: 化学及生物传感器,及其在疾病早期诊断、水资源及环境安全、食品安全(用量及与环境条件如温度、时间、对象的关系)、反应机理及生物分子代谢过程等研究领域的应用



招生信息

一)2020招生方向

有机及生物功能分子的合成、结构与性能研究    (硕士生

有机合成及有机功能分子的结构信息学          (博士生)



二) 欢迎所有对有机化学感兴趣,能积极主动与老师同学交流沟通/合作, 并愿意在有机化学领域有所发展的同学报考,

1)请提供个人详细简历(含学习成绩);及与化学特别是有机化学学习科研有关的具体材料;

2)提供A4纸一页说明:为何对有机化学有兴趣,以及仔细了解本实验室的研究内容,确认你对本实验室研究的兴趣


教育背景及工作经历

教育背景
1980.9-1984.7 华中师范大学化学系 (理学学士)
1984.9-1987.7 北京理工大学力学工程系 (工学硕士)
1987.9-1990.9 中国科院学院化学研究所(有机化学专业, 理学博士)
2001.1-2002.7 Computer Sciences, Texas State University, San Macros, TX, USA (Master Student)

工作经历
2012年9月起-: 至今:  教授,中国科学院大学,化学科学学院( 2017.10前为化学与化工学院) 
2004年-2012:教授,中国科学院研究生院化学与化学工程学院 
2002年- 2004年: Research Fellow,美国Texas州,Texas大学Austin分校,化学与生物化学系(合作教授: Prof.N.L.Bauld / Prof. M.J.Krische)                 
1997年 - 2000年: 博士后,美国Texas州, Texas大学Austin分校,化学与生物化学系        (合作教授: Prof.N.L.Bauld)                       
1995年 - 1997年: 副研究员,中国科学院北京化学研究所                     
1992年 - 1995年: 助理研究员,中国科学院北京化学研究所
1990年 - 1992年: 博士后, 北京医科大学药学院天然药物与仿生药物国家重点实验室             (合作教授:张礼和院士)  
1989年 - 1990年: 客座研究学者,中国天津南开大学元素有机化学国家重点实验室

专利

1)一种有机分子二维有序结构及其制备方法,申请号:201610444711.7 (2016/6/20),


奖励信息
(1) 年度优秀个人 (2005,2006,2007,2008,2009,2016), , 研究所(学校), 2016
(2) 《高等有机及高分子化学合成与分离实验》, 一等奖, 研究所(学校), 2011
(3) 化学教学实验室课程及教学实验室建设, 二等奖, 部委级, 2008
(4) 《杂环化学》, 二等奖, 研究所(学校), 2005

学术论文

   
含会议文章及综述

Including reviews and conference papers: 
       More than 60 papers published on J.Am.Chem.Soc., Chem.Sci., Green Chem., Organic Lett.,  J.Org. Chem.,Adv. Synth. Catal .,Anal.Chem., Microchim Acta ,Chem.Asian J., Euro J.Inorg.Chem., Acta Biochimica et Biophysica Sinica, Synlett, Synthesis, Tetrahedron Lett., Phys. Chem. Lett., J.Phys.Org.Chem., J.Chem. Soc.Perkin Trans. 2, , Heteroatom Chem. , Chin.J.Chem.and others,


65.Yueguang Lv, Hua Bai, Jingkui Yang  , Yujian He, and Qiang Ma* ,Direct Mass Spectrometry Analysis Using In-Capillary Dicationic Ionic Liquid-Based in Situ Dispersive Liquid–Liquid Microextraction and  Sonic-Spray Ionization Anal. Chem., DOI: 10.1021/acs.analchem.9b005972019/04/19 online

      https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.analchem.9b00597


64.Yuan-Bo Tong, Zheng-Fang Tian,Hai-Bao Duan,Zhong-Peng Zhu,Tian-Yu Hong,Shun-Ping Zhao*and Jing-Kui Yang* Dielectric Relaxation and Beyond Limiting Behavior of Alternating Current Conductivity in A Supermolecular FerroelectricChem.Asian J. 2019,14(4),582-591(VIP paper) https://onlinelibrary.wiley.com/doi/pdf/10.1002/asia.201801853


63.吕悦广 , 白桦 , 李文涛 , 杨镜奎 , 何裕建* , 马强*,声波喷雾离子化质谱技术及其应用研究进展分析化学,2019, 47(1): 1-12.   doi: 10.19756/j.issn.0253-3820.181411


62. Yuan-Bo Tong; Zheng-Fang Tian; Hai-Bao Duan; Zhong-Peng Zhu; Tian-Yu Hong; Jing-Kui Yang, Monocycle-like Molecular Rotor Induce a Dielectric Relaxation and Dielectric Phase Transformation in an Inorganic-Organic Hybrid Supermolecule,European Journal of Inorganic Chemistry, 2018, 2018(29),3427-3432 ,  http://dx.doi.org/10.1002/ejic.201800588 2018/6/14(online)


61.Yuan-Bo Tong; Zheng-Fang Tian; Hai-Bao Duan; Zhong-Peng Zhu; Wei He; Tian-Yu Hong; Gui Yu; Yu-Jian He; Jing-Kui YANG*, [(18-crown-6)K][Fe(1)Cl(1)4]0.5[Fe(2)Cl(2)4]0.5: A Multifunctional Molecular Switch of Dielectric, Conductivity and Magnetism",Chemistry - An Asian Journal, 2018, 13(6), 656-663  http://dx.doi.org/10.1002/asia.201701794

                                                                                                           


60.Zhongpeng Zhu, Haoyuan Wang, Christopher Simmons, Po-Sen Tseng, Xiang Qiu, Yu Zhang,Xiyan Duan, Jing-Kui YANG  and Weiping Tang*, Iridium-Catalyzed Dynamic Kinetic Stereoselective Allylic Etherification of Achmatowicz Rearrangement Products, Adv. Synth. Catal. 2018, 360(3), 595-599. http://dx.doi.org/10.1002/adsc.201700950

                                                              


59.吕悦广,郭项雨,马强*,白桦,孟宪双,胡明珠,马龙华,吴青,何裕建,杨镜奎*,常压敞开式离子化-离子迁移谱法快速筛查玩具中14种致癌致敏染料,分析测试学报,2017,36(8),949-954.


58.Wei He, Yue-Guang Lv, Tian-Yu Hong, Yuan-Bo Tong, Zhong-Peng Zhu, Qian Wei, Cun-Yue Guo, Gui Yu, Jing-Kui Yang*,Hydrogen Peroxide-Induced Oxidative Dimerization of Wittig Reagents: Improving the Selectivity, Yield  and Expanding to the Aryl System, ChemistrtySelect, 2017,2(24),7273-7277. http://onlinelibrary.wiley.com/doi/10.1002/slct.201701434/abstract

                                                            


57.Zhanhui Yang, Zhongpeng Zhu, Renshi Luo, Xiang Qiu, Ji-tian Liu, Jing-Kui Yang and Weiping Tang*,Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source  ,Green Chem., 2017,19(14), 3296-3301 , http://pubs.rsc.org/en/content/articlelanding/2017/gc/c7gc01289f#!divAbstract  (2017/06/14 online)

                                

56. Qian Wei, Wei Wang, Er-Jun Zhou, Xiao-Ping Liu, Ming-Hui Liang, Ke Deng *, Jing-Kui Yang*, and Peng Jiang*. Positioned Substituent Effect on Self-assembly Behaviors of Perylene Diimde Derivatives on Graphite. Joural of Colloid and Interface Science, 2017,504, 58-67. https://doi.org/10.1016/j.jcis.2017.05.029

                                    

 

55. Jing Peng, Yongchao Geng, Hai-Jian Yang*, Wei He, Zidong Wei*, Jing-Kui Yang, Cun-Yue Guo*, Efficient solvent-free fixation of CO2 into cyclic carbonates catalyzed by Bi(III) porphyrin/TBAI at atmospheric pressure, Mol. Catal. 2017, 432, 37-46.    http://dx.doi.org/10.1016/j.mcat.2017.01.019

                                 

 

54.Bibai Du, Xiaoou Su, Kunhao Yang, Long Pan, Qingju Liu, Lingling Gong, Peilong Wang*, Jingkui Yang*, and Yujian He*. Antibody-Free Colorimetric Detection of Total Aflatoxins in Rice Based on a Simple Two-Step Chromogenic Reaction. Anal. Chem.,2016,88(7),3775-3780.  (2016/3/3online)

http://pubs.acs.org/doi/abs/10.1021/acs.analchem.5b04720

                                           

 53. Bibai Du,Peilong Wang, Can Xiao, Ying Zhou, Li Wu,Hong Zhao,Xiaoou Su,Jingkui Yang*, Yujian He*. Antibody-free colorimetric determination of total aflatoxins by mercury(II)-mediated aggregation of lysine-functionalized gold nanoparticles.Microchim Acta.  2016, 183(4),1493-1500. (http://link.springer.com/article/10.1007/s00604-016-1786-7

                                        

52.张桐,贺伟,朱忠朋,杨镜奎*,环庚三烯酮与邻二甲氧基苯在浓硫酸作用下的缩合重排反应机理.中国科学院大学学报,2016, 33(1), 65-69. http://journal.ucas.ac.cn/CN/abstract/abstract12313.shtml

                                     

 

51 杨镜奎* 伟, 朱忠朋, 杜碧柏, 吕悦广。《腐植酸采样、分析、应用及标准制定中存在的问题》,2015土壤可持续发展论坛暨第十三届全国绿色环保肥料(农药)新技术、新产品交流会,论文集,第56-61页及191页,腐植酸工业协会, 山东,泰安,2015.11.30-2015.12.3(大会邀请报告)

 

50.杜碧柏, 刘庆菊, 周影, 肖亚婷, 杨镜奎,* 何裕建.* 不同标记物质在黄曲霉毒素快速检测中的应用。《食品安全质量检测学报》 2015693504-3516

http://www.chinafoodj.com/ch/reader/view_abstract.aspx?file_no=20150626001&flag=1  

 

49.Zhikun Zhang, Ying Zhou, Jing-Kui Yang, Peilong Wang, Xiaoou Su, Hong Zhao, Yujian He, Zhiqin Cao, Maoqiang Luo, Colorimetric Detection of Cr3+ in Aqueous Solution Based on Cofunctionalized Silver Nanoparticles Modified with 4-Nitrobenzenethiol and 4-Mercaptobenzoic Acid. 
Nano, 2015,1550095 [8 pages].http://www.worldscientific.com/doi/abs/10.1142/S1793292015500952  

 

48.  GuoFu Dong, HongYao Wang, JianBo Cong, ChangZhen Wang, JunWang Guo, Tong Zhang, JingKui Yang*, Guo Shan *, Ke Wu*.  Calibration ruler for CW-EPR distance measurement using diradical molecule of rigid structure,Acta Biochimica et Biophysica Sinica, 2015, 47(5), 342-348. https://doi.org/10.1093/abbs/gmv021

              

47.Wu Ke, Wang ChangZhen,Zhou Yu,Cong Jianbo,Donf Guofu, Tang Li, Hu Xiangjun, Wang Hongyao, Yang Jingkui, Application of SDSL-EPR technique in study of mobility of selected sites in CRD domain of LSECtin,生物物理学报。2012,28(增刊),首届世界华人自由基医学学术大会论文集,2012年8月7-9日, 兰州:33.

    

46.张志昆, 袁龙飞, 刘庆菊, 蔡波太, 李向军, 赵红, 董亚蕾, 杨镜奎*, 何裕建*,  赵亮, 董树清,基于手性D-氨基酸的毒理性对转基因食品安全性的研究,《中国科学:化学》,2015 451, 98-108. http://chem.scichina.com:8081/sciB/CN/abstract/abstract516122.shtml   

45. Wei Lu, Juan Gao,Jing-Kui Yang*, Lei Liu,Yuliang Zhao and Hai-Chen Wu*,Regioselective alkyl transfer from phosphonium ylides to functionalized polyfluoroarenes.Chem. Sci., 2014, 5, 1934–1939.  (Jan.28,2014 online),DOI: 10.1039/C4SC00221K, http://pubs.rsc.org/en/content/articlelanding/2014/sc/c4sc00221k#!divAbstract

                                                

 

44. Hong-Yao Wang, Jing-Kui YANG,

2-Benzyl-3-hydroxy-3-methyl-2,3-dihydro-1H-isoindol-1-one, Acta Cryst. (2012). E68,part 6, o1795. http://scripts.iucr.org/cgi-bin/paper?nr2026  

 

43. Sang, Qiuguang(桑秋光) Yang, Jingkui(杨镜奎)*,An Efficient Way for the Recognition of Zinc Ion via the Fluorescence Enhancement, Chin.J.Chem.2012, 30(7), 1410-1414. Online http://onlinelibrary.wiley.com/doi/10.1002/cjoc.201200057/abstract 

                                                    

42. Peng Zhang, Dongqing Sun, Mingwei Wen, Jingkui Yang, Kebin Zhou*, and Zhixiang Wang*, Hydroxyl Radical Promotes Direct Iodination of Aromatic Compounds with Iodine in Water: A Combined Experimental and Theoretical Study, Adv. Synth. Catal .2012, 354(4), 720-729. Online http://onlinelibrary.wiley.com/doi/10.1002/adsc.201100765/abstract 

                                           

41. Dong-Qing SUN, Jing-Kui YANG* ,Unique Effects of Sulfur and Water on the Syntheses of Thiaheterocycles, Heteroatom Chem. ,2012, 23(1), 84-90.  Online   http://onlinelibrary.wiley.com/doi/10.1002/hc.20755/abstract

                                                    

 

40. Dong-Qing SUN, Jing-Kui YANG*, An Economical Approach for the Synthesis of Unsaturated Thiacrown Ethers, Synthesis,2011, No. 15, 2454-2458.  Online  https://www.thieme-connect.de/DOI/DOI?10.1055/s-0030-1260066

                                          

39. Dong-Qing Sun and Jing-Kui Yang,(15-Crown-5-κ5O)[S -(E )-1,2-dichlorovinylthiosulfato- κO]sodium, Acta Cryst. E, 2011. E67(Pt.7) , m934. Online  http://scripts.iucr.org/cgi-bin/paper?S1600536811022252

 

38. Li-Qiang LIU, Dong-Qing SUN and Jing-Kui YANG*Efficient Additives to Improve the Catalytic Effects of Ferric (III) Chloride on the Reaction of N-Vinylcarbazole (NVC): Hydroquinone for Methanolysis, Hydrogen Peroxide for Cyclobutanation Respectively, J.Phys. Org. Chem., 2012, 25(4), 272-277. Online  http://onlinelibrary.wiley.com/doi/10.1002/poc.1892/abstract

                                                    

37. Qiu-Guang Sang, Jing-Kui YANG , 14,54-Dichloro-3(2,7),7(2,7)-dinaphthalena-2,4,6,8-tetraoxa- 1(2,6), 5(2,6)-di(1,3,5-triazina)octaphane.Acta Cryst.E. 2011,E67,o2525. Online 

[ http://dx.doi.org/10.1107/S160053681103460X   ]

 

36. HUANG Bi-Yu , WU Hai-Chen* ,YANG Jing-Kui*, Mechanistic studies of hydrogenation of electron-rich substrates with electron-deficient Rh-BINAP catalyst, Journal of Graduate University of Chinese Academy of Sciences, 2012, 29(4), 571-575. Online http://journal.ucas.ac.cn/CN/abstract/abstract11623.shtml   

 

35 Li-Qiang LIU, Jing-Kui YANG*, The Syntheses of 1, 3-Bis (Aryl Butadienyl Ketone) Propane Derivatives and Their Visible Light Photocatalytic [4+4] and [2+2] Cycloadditions, Journal of Graduate University of Chinese Academy of Sciences, 2012 29(2), 180-191.  http://journal.ucas.ac.cn/CN/abstract/abstract11565.shtml  syntheses of (2E,4E,9E,11E)-1,13-di(naphthalen-2-yl)trideca-2,4,9,11-tetraene- 1, 13 – dione(5a); (4Z,8Z-2,3,3a,6,7,9a-hexahydro-1H-cyclopenta[8]annulene-6,7-diyl)bis[naphthalen-2 -ylmethanone] (6a) and (2E,2’E)-3,3’-(bicyclo[3.2.0] heptane- 6,7-diyl)bis[1-(naphthalen-2-yl)prop-2-en-1-one] (7a) and others

                            

34. Li-Qiang Liu, Jing-Kui Yang, rac-2,2’-(Tetrahydro-2H-thiopyran-2,6-diyl) -bis[1- (4-bromophenyl) ethanone], Acta Cryst. E, 2011. E67, o1047.

 

33. Wen-Yuan Xu, Yue-Mei Jia, Jing-Kui Yang*, Zhi-Tang Huang, Chu-Yi Yu*. Reactions of Heterocyclic Ketene Aminals with 2-[3-Oxoisobenzofuran-1(3H)- ylidene]malononitrile: Synthesis of Novel Polyfunctionalized 1,4-Dihydropyridine-Fused 1,3-Diazaheterocycles. Synlett. 2010, 1682-1684. Online  https://www.thieme-connect.de/DOI/DOI?10.1055/s-0029-1220126

                                      

 

32. 杨镜奎,腐植酸类物质化学研究的独特性及新进展,《腐植酸》,2009,(5),6-17.

 

31. 邢丽, 向军辉, 张复实, 杨镜奎,碳纳米管膜的制备及其研究进展(Preparation and Research Progress of Carbon Nanotube Film),世界科技研究与发展,200931(3),390-393

 

30. 杨镜奎,如何探讨中医中药理论思路在现代药物设计中的应用。《中医药的科学研究》第54-56 页,,新观点新学说学术沙龙文集,中国科学技术协会学会学术部,中国科学技术出版社,北京,20074月出版。(200716-7日,天津)。

 

29. 邢丽, 张复实, 向军辉, 杨镜奎, 自组装技术及其研究进展 Technology and Research Progress based on Self-assembly 世界科技研究与发展,2007 293),39-44

 

28. 杨镜奎,中医系统、规范、标准和全球化,中药必须面对西药现代化的挑战。《新时期中医药发展战略与政策论坛》,中国软科学研究会等主办,2005417-18日,北京。(会议文章)

 

27. Jingkui Yang, Greg A.N.Felton, Nathan L.Bauld *, and Michael J. Krische*,Chemically Induced Anion Radical Cycloadditions: Intramolecualr Cyclobutanation of bis(Enones) via Homogeneous Electron transfer , J. Am. Chem. Soc.,2004, 126(6), 1634-1635. Online http://pubs.acs.org/doi/abs/10.1021/ja030543j   

 

26. Jingkui Yang, David F. Caube, Adam Berro, Nathan L.Bauld* , Michael J. Krische* , Anion Radical [2+2] Cycloaddition as a Mechanistic Probe:Stoichiometry-and Concentration-Dependent Partitioning of Electron Transfer and Alkylation Pathways in the Reaction of the Gilman Reagent Me2CuLi.LiI with Bis(enones), J.Org.Chem. (Article) ,2004, 69(23), 7979-7984. Online  http://pubs.acs.org/doi/abs/10.1021/jo048499t   

 

25. JingKui YANG collaborated with Nathan L.Bauld*, J. Am. Chem. Soc., 2003, 125(52), 16463. Addition /correction to(更正他人文章) : a) Hole-Catalyzed Epoxidation [J. Am. Chem. Soc. 1991, 113, 3613-3614]. Bauld, N. L.; Mirafzal, G. A.; b) Is Hole Transfer Involved in Metalloporphyrin-Catalyzed Epoxidation? [J. Am. Chem. Soc. 1993, 115, 7653-7664]. Kim, T.; Mirafzal, G. A.; Liu, J.; Bauld, N. L.; Online-1 , Online-2 http://pubs.acs.org/doi/abs/10.1021/ja033463o  http://pubs.acs.org/doi/abs/10.1021/ja0334659   

 

24. N.L.Bauld*, Jingkui Yang and Daxin Gao,Diels-Alder cycloadditions of N-vinyl carbazole radical cation,J.Chem.Soc., Perkin Trans. 2, 2000, (2), 207-210.Online http://pubs.rsc.org/en/content/articlelanding/2000/p2/a908659e   

 

23. N.L.Bauld* and J.K.Yang,Intramolecualr site selectivity in cation radical Diels-Alder cycloadditions of difunctional and trifunctional dienophiles, J.Phys.Org.Chem., 2000, 13, 518~522. Online  http://onlinelibrary.wiley.com/doi/10.1002/1099-1395(200009)13:9%3C518::AID-POC288%3E3.0.CO;2-9/abstract   

 

22. N.L.Bauld* and Jingkui Yang,The Stereospecificity and mechanism cation radical Diels-Alder and cyclobutanation reactions,Org. Lett., 1999, 1(5),773-774.  Online  http://pubs.acs.org/doi/abs/10.1021/ol9907567 

 

21. Jingkui Yang and Nathan L.Bauld* ,Synthesis of cis- and trans- 1,2-diphenoxyethenes and p,p’-disubstituted diaryloxy ethenes, J.Org. Chem., 1999, 64(25),9251-9253.Online  http://pubs.acs.org/doi/abs/10.1021/jo9812577   

 

20. N.L.Bauld* and Jingkui Yang, A two step non-sterospecific cation radical Diels-Alder reaction, Tetrahedron Lett., 1999, 40, 8519~8522. Online http://www.sciencedirect.com/science/article/pii/S0040403999018420   

 

19. Xu, Juhua, Li,Yuliang; Zheng, Dagui; Yang, Jing-kui; Mao, Zhong ; Zhu, Dao-Ben,An unexpected reaction:[2+1] cycloaddition of [60]fullerene with 4,4,5,5-tetra-methylimidazolidine-2-thione and DL-valine, Tetrahedron Lett., 1997, 38(37),6613-6616 .

 

18. Yuliang Li, Zhong Mao, Juhua Xu, Jingkui Yang, Zhixin Guo, Daoben Zhu, Jingwei Li, Bo Yin,Preparation of a novel stable nitroxide based on [60]fulleropyrrolidine and its magnetic properties, Chem. Phys. Lett., 1997, 265, 361-364 .

 

17. Jingkui Yang, Yuliang Li and Daoben Zhu, Synthesis of a series novel functional materials for potential uses in electronic devices, applied development & research for Phoenix Corporate Research Lab., Motorola, Inc., USA, unpublished results .

 

16. Yu-Liang Li, Ju-Hua Xu, Da-Gui Zheng, Jing-Kui Yang, Cai-Yuan Pan and Dao-Ben Zhu, Synthesis and Characterization of stable nitroxides based on fullerenes (C60, C70) and their magnetic study, Solid State Commun., 1997, 101(2) 123~128.

 

15. Bin Zhang, Yu-Liang Li, Hong-Xian Han, Jing-Kui Yang, Dao-Ben Zhu and Yu-Sei Maruyama, Bis(methylthio)ethylenedithiotetrathiafulvalene, 1996, Acta Cryst., C52, 400~403.

 

14. Dagui Zheng, Yuliang Li, Jingkui Yang and Daoben Zhu,Preparation of Two Novel C60 and C70 Fullerene Pyrrolidine Derivatives, , Fullerene Science & Technology, 1996, 4(50) , 1067~1072.

 

13. Da Gui Zheng, Yu Liang Li, Jingkui Yang and Dao Ben Zhu, A [70]Fulleropyrrolidine: Derived from C70, keton and a-Aminoacid, Chin. Chem. Lett.1996,7(6) 571~572.

 

12. Li,Yuliang, Zheng, Dagui, Xu,Juxua, Mao, Zhong, Yang, Jingkui, Bai Fenglian and Zhu, Daoben ,Study on the synthesis of [60]fulleropyrrolidines ,Chin. Sci. Bull., 1996, 42(7) 704~707.

 

11. 李玉良,郑大贵,徐菊华,毛忠,杨镜奎,白风莲,朱道本.C60富勒烯吡咯烷衍生物的合成研究. 科学通报, 1997, 42(7): 704-707.

 

10. Yuliang Li, Dagui Zheng, Jingkui Yang and Daoben Zhu,Synthesis and Characterization of two C70-fused pyrrolidine derivatives, The Second International Interdisciplinary Colloquiumon on the Sciences and Technology of Fullerenes, London,  UK,July 7~10, 1996, Abstract book.p.77~78 .

 

9. Wang, Heting, Yang, Jingkui and Huang , Zhi Tang,The reaction of heterocyclic ketene Aminals with isothiocyanates, 15th International Congress of Heterocyclic Chemistry, PO3-245(ISHC), Taipei International Convention Center,August 6-11, 1995. (会议文章)

 

8. 李玉良,杨镜奎,朱道本,明星分子C60及家族化合物的物理化学性质及前景(邀请文章),高技术与产业化,1995, (4),4-8.

 

7. 李玉良,杨镜奎,朱道本,富勒烯的化学与物理性质(邀请文章), 杨镜奎,李玉良,朱道本,自然杂志,1995, 17(3) 123-132.

 

6. Jingkui Yang, Yuliang Li and Daoben Zhu,The Preparation and Characterization of Fused BEDT-TTF, the 5th China-Japan Symposium on Conduction and Photo-conduction in Organic Solids and Related Phenomena, CJJS5, Oct.5~10 , 1995, HangZhou, PRC. (会议文章)

 

5. Juhua Xu, Yuliang Li,Jingkui Yang and Daoben Zhu, A Novel way to synthesize C60 Derivatives C60[C(NO2)2]nClm and their magnetic properties, Solid State Commun.1996, 97(6), 451~453( 1996), Proceedings, 1995, 95(10) 1102~1110.

 

4. Yuliang Li, Hongxian Han, Jingkui Yang, Fenglian Bai, Yiming Mo, Yongfang Li, Mingyong Han, Juhua Xu, Zi Wu, Daoben Zhu, Preparation and Characterization of three pyrrolidine derivatives of C60, Electrochem. Soc. Proc., 1995,95(10),1111~1115.

 

3. Jingkui Yang and Lihe Zhang ,The Synthesis of the Precursors to the cyclobutyl sugar ring nucleosides with potentials use as Antiviral Antitumor and Antibacterial Drugs. ,unpublished results.

 

2. Zhi-Tang Huang, Jing-Kui Yang, Reaction of Heterocyclic ketene Aminals with Aryl Isothiocyanates and Synthesis of Sulfur Containing Heterocycles Therefrom, Heteroatom Chemistry,1992, 3(5/6) 487-493.

1. Jingkui Yang , Zhitang Huang ,(a) Reaction of Isocyanates with 2-Nitromethylene Imidazolidine or 2-Benzoyl Methylene Imidazolidine. (b)A   Convenient Way for the Synthesis of 2- [(Nitro)(phenylcarmoyl)methylene]- hexahydropyridines and 2-[(Benzoyl)(Phenylcarmoyl)methylene]-hexahydro- pyridines, unpublished.

科研活动

中国国内参与或主持的科研基金:

2014年-          :  中国国家自然科学基金
                        [双链(或单链)极性共轭多烯化合物的合成及其多环化反应]
2010
年-2012年:中国国家自然科学基金
                         (用EPR技术测量蛋白质分子内选定位点之间的距离)
2008年-2010年:中国国家自然科学基金
                     (极性大共轭有机烯杂醚光电功能体系的合成及物化性质研究)
2008年-2009年: 教育部留学回国人员科研启动基金
2007年-2008年:中国科学院研究生院人才启动基金
                     (活性中间体离子自由基的性质及其化学反应的实验和计算研究)
2006年-2007年: 中国军事医学科学院合作基金
                       (生物活性分子的合成与性能测试)
2005年-2007年: 中国科学院有机固体重点实验室开放基金
                     (特殊环状功能性高分子聚合物的离子自由基合成)
1996年-1997年: 中国国家自然科学基金 (富勒烯化学和物理基础研究 ) 
1994年-1997年: 中国科学院“八五”重大基础研究项目
                        “分子电子学”有机导体子课题
1995年-1997年: 美国摩托罗拉 Phoenix 研究实验室合作基金(荧光材料)
1990年-1992年: 中国国家人事部博士后基金(小环核甘药物前体的合成) 
1989年-1990年: 天津南开大学元素有机化学国家重点实验室开放基金(杂环化学)


美国参与的科研基金项目:
1997年-2000年: Robert A.Welch 基金 ( F-149, 离子自由基化学 )
                       美国国家自然科学基金 ( CHE-9610227,溶液中的阳离子自由基)
2002年-2004年: Robert A. Welch基金 ( F-149,离子自由基化学) 
                      美国国家卫生研究院基金(RO1GM65149-01,催化碳-碳键的形成,催化[2+2]环加成)

合作情况

合作单位:

1)   中国检验检疫科学研究院; (食品安全及日用品安全: 有机污染物及重金属富集与快速高通量检测)

2)   国家纳米科学中心;                   (超分子自组装)

3)   中国科学院化学所;           (有机功能材料, 有机杂环小分子合成)

4)   美国School of Pharmacy,University of Wisconsin Madison,Madison, WI, United States.

                                                (有机共轭分子合成及机理研究)

5)   中国科学院高能物理研究所;(有机不对称合成)

6)   北京放射医学研究所(Beijing Institute of Radiation Medicine): 自由基在生物体系中的作用与检测。

化学信息连接

免费杂志,热点文章,图书信息,专题俱乐部       


http://chemweb.com  
     ChemWeb.com provides access to the information chemists need to   enhance their research, product development, self-development, education, and/or their businesses in Chemistry and related disciplines. Easy access to abstracts, papers, books, conferences, news, forums and the Alchemist newsletter
IUPAC: 国际纯粹与应用化学会 International Union of Pure and Applied Chemistry
http://www.iupac.org/publications/ci/2001/november/arkivoc.html 


Chemistry Guide(Sigmaaldrich)         https://www.sigmaaldrich.com  ((含各种实验方法, 及文献综述Aldrichimica Acta期刊)

web of sciences                                http://www.webofknowledge.com
Science 杂志                                     http://www.sciencemag.org

Nature 杂志                                      https://www.nature.com/

美国化学会                                             
http://pubs.acs.org/  
欧洲英国皇家化学会,英国                         
http://www.rsc.org/  
中國化學會                                             
http://www.ccs.ac.cn/  
(台灣)中國化學會                                    
http://www.ccs.sinica.edu.tw  
美国科学院院刊                                      
http://www.pnas.org  
威利国际科学(公司) Wiley InterScience
http://www3.interscience.wiley.com/  
     介绍了该公司的情况及其出版物。该公司拥有超过300种科学,技术医学和专 业杂志,有几十种涉及生命科学和医学的相关期刊,还有最新实验室程序手册。
威勒出版社wiley-vch                            
http://www.wiley-vch.de/publish/en/
     威勒出版社是著名的出版商,选题精良,是科学和商业上的最新信息
斯普林格(公司)Springer                 
http://www.springerlink.com/ 
     提供该公司出版物电子期刊的每期目录。该网站收录数百种电子期刊
加拿大国家研究委员会(NRC)研究出版社
http://pubs.nrc-cnrc.gc.ca/rp2_home_e.html  

American Association for Clinical Chemistry
http://www.aacc.org/  

中国科学院国家科学图书馆                      
http://www.las.ac.cn/index.jsp  
国家科学数字图书馆                               
http://www.csdl.ac.cn  
中国国家图书馆                                      
http://www.nlc.gov.cn  
化学学科信息门户                                   
http://www.chinweb.com  
中国科学院化学研究所理论与计算化学平台
http://cftcc.iccas.ac.cn  
Journal of Heterocyclic Chemistry (杂环化学杂志)
http://www.jhetchem.com  
Thieme Chemistry ( Journals, Books, etc.)
http://www.thieme-chemistry.com  
More info. For organic Reactions           
http://www.organic-chemistry.org/  
Free Online for Organic Chemistry         
http://www.arkat-usa.org  
The Chemical Engineer Online       
http://www.tcetoday.com/tce/mainframe.htm  
Materials Research Society              
http://www.mrs.org/  

中国医药数字图书馆                   
http://www.pharmadl.com/pharmadl/index.aspx 

多学科免费文献检索                   http://www.scirus.org/  

貝爾化學獎 Nobel Prize in Chemistry Winners 1901~ :
http://nobelprizes.com/nobel/chemistry/chemistry.html

Nobel Prize in all Fields:  https://www.nobelprize.org/
ChemWeb : 
http://www.chemweb.com
chemweb: very useful in the teaching of chemistry and biology
化学物质安全数据库 MSDS.com  free info(registered required要注册)
MSDS: Material Safety Data Sheets Resources (University of California)
Sdbs: 收录了常见化合物的nmr、ms数据, 结果比较可靠;
http://www.aist.go.jp/riodb/sdbs/sdbs/owa/sdbs_sea.cre_frame_sea  

Chemfinder: 收录了常见化合物的理化数据;
http://chemfinder.cambridgesoft.com/  
Nist: 收录了常见化合物的理化数据,ir、ms谱图;
http://webbook.nist.gov/chemistry/  
免费在线检索美国专利
http://www.uspto.gov/patft/index.html  可看全文,可下载,可打印;需要安装软件。
免费在线检索欧洲专利、世界专利
http://www.european-patent-office.org/index.en.php  ,可看PDF全文,下载,可打印;
免费在线检索中国专利
http://www.sipo.gov.cn/sipo/default.htm  可看全文,可下载,可打印;
organic syntheses(有机合成)
http://www.orgsyn.org/  检索o.s.上的所有文章,免费看到全文,安装chemdraw插件。
synthetic.pages (合成网站)
http://www.syntheticpages.com/ 在线检索合成文章,可免费看到全文;
http://www.organic-chemistry.org/

Collection of Czechoslovak Chemical Communications http://cccc.uochb.cas.cz/


光谱及波谱数据库:

 常见溶剂化学位移(1H-NMR, 13C-NMR)/及氘代溶剂中不同杂质的化学位移动

 Organomettlics,2010,29(9),2176-2179 (DOI: 10.1021/om100106e https://pubs.acs.org/doi/abs/10.1021/om100106e

NIAIST(AISAT), Japan ( MS, CNMR, HNMR, IR, Raman, ESR)
 
http://riodb01.ibase.aist.go.jp/sdbs/cgi-bin/direct_frame_top.cgi 

  Datebase of NMR :
http://www.nmrdb.org ( NMR predicting)

  http://www.internetchemistry.com/chemistry/nmr-spectroscopy.htm  (NMR spectra)https://pubs.acs.org/doi/abs/10.1021/om100106e

 

 结构及性质查询数据库
    
http://www.chemspider.com/ ( in Namse, Structures, CAS No. and others)
    
http://zinc.docking.org/         ZINC: A Free Tool to Discover Chemistry for Biology  (J. Chem. Inf. Model. 2012, 52, 1757−1768,J. Chem. Inf. Model. 2005;45(1):177-82)
    
http://www.3d-qsar.com/ 3-D QSAR methods are nowadays used widely in drug design, since they are computationally not demanding and afford fast generation of QSARs from which the biological activity of molecules can be predicted.

   蛋白质园二色谱:http://pcddb.cryst.bbk.ac.uk/home.php

  蛋白质结构:        http://www.pdb.org/pdb/home/home.do



国内数据库

  http://www.nmrdata.com/Default.aspx (上海微谱,NMR)


化学软件信息网站

SWissADME    http://www.swissadme.ch/index.php    free web tools for physicochemical descriptors as well as to predict ADME    parameters, pharmacokinetic properties, druglike nature and medicinal chemistry friendliness of one or multiple small molecules to support drug discovery.

ACORN NMR  http://www.acornnmr.com/

Virtual NMR   http://gandalf.umd.edu /

UPSTREAM   http://www.upstream.com  Software Tools to Generate Information from Chemical Data. 可線上預測 1H-NMR and 13C-NMR shift.
SPARTAN     
http://www.wavefun.com  
HyperChem   
http://www.hyper.com  
Chem3D          
http://www.camsoft.com  
Alchemy2000
http://www.tripos.com  
Gaussian        
http://www.gaussian.com  
Molden          
http://www.caos.kun.nl/~schaft/molden/molden.html  
Gamess          
http://www.msg.ameslab.gov/GAMESS/GAMESS.html  
ChemDraw     
http://www.camsoft.com  
ChemWindow
http://www.compuchem.com/chemwin.htm  
ISIS/Draw       
http://www.mdli.com/download/idraw.html  
chemsketch   
http://www.acdlabs.com  
acd公司提供的一个画分子式软件,功能齐全,注册以后还可利用其网络数据库在线模拟化合物的各种nmr数据,计算化合物的理化数据(如pka、沸点、饱和蒸汽压等),对复杂化合物进行iupac命名。


http://www.chirality.com.cn/study.asp(手性会议)


课程信息

​高等物理有机化学(原高等有机化学二)

高等杂环化学

高等有机及高分子化学合成与分离实验(研究生)

有机化学实验(本科生)

有机理论及合成前沿研究中存在的问题及解决思路探讨

色谱与光谱实验(部分内容)

学生信息


已有(含毕业)硕士博士来源:  硕士生含推免生、统考生; 博士生含硕转博、统考生。

     (各位同学可以提供新信息/照片更新)

已经毕业的博士生

桑秋光(2005-2010)   刘立强(2005-2011)      孙冬青(2006-2011)      卢伟(2010-2014)       张志昆(2012-2015) 

  

    杜碧柏(2013-2016)      贺 伟 (2012-2017)        朱忠朋  (2013-2018)    童元柏(2016-2019)


已毕业硕士生

 黄碧玉(2008-2011 )        徐文远(2010-2013)      王洪耀(2009-2012)       张  桐(2011-2015)      魏 倩 (2014-2017)


在学博士生

     吕悦广(2015-至今)          洪天宇(2016-至今)           李修明(2019.9-)


在学硕士生

    杨旭(2017-至今)    严良(2017-至今)          何 玉(2018-)          赵俊博(2019.9-)


-----------------------------------------------------------------------------------------------------------

             

        孙冬青博士答辩(2011.11.09,玉泉路)          卢伟博士答辩(2014.3.27玉泉路)           张志昆博士答辩(2015.5玉泉路)        

                                                                          

                             

         贺伟博士(2012.9-2017.9)                朱忠朋博士(2013.9-2018.7)            童元柏博士2019.7

中文期刊杂志

1)物理化学学报  http://www.whxb.pku.edu.cn/CN/volumn/current.shtml

化学及其它科学领域重要参考文献或资料

一) 合成领域:

   1)天然产物全合成策略:Divergent Strategy in Natural Product Total Synthesis,Chem. Rev., 2018, 118 (7), pp 3752–3832

   2)不同方法合成多取代烯烃合成的效率Mass Efficiency of Alkene Syntheses with Tri- and  Tetrasubstituted Double Bonds,

      ACS Sustainable Chem. Eng., 2017, 5 (11), pp 10459–10473 http://pubs.acs.org/doi/abs/10.1021/acssuschemeng.7b02479

   3) Enantioselective semireduction of alenes https://www.nature.com/articles/s41467-017-00793-0

   4) C-H活化Direct arylation of strong aliphatic C–H bonds, Nature, 2018, 560,p70-75 (20180801) https://www.nature.com/articles/s41586-018-0366-x ,

   5) Cerorubenic acid-III 全合成J.AM.Chem.Soc. 2019 ASAP.: link1link2


二)人工智能与合成(machine learning,AI)


   4) 深度学习设计电子材料: npj Computational Materials,2018, 4,67 (中文简介)

   3)人工智能_算出来的酶_绿色合成B-氨基酸:Nature Chemical Biology, 2018, May 21

      https://www.nature.com/articles/s41589-018-0053-0 (2018/5/21)

   2)像化学家一样探索新反应的“AI”机器人.Nature,2018,559,p377-381.

    https://www.nature.com/articles/s41586-018-0307-8 (reports:in Chin)

   1)高精度AI诊断工具 Cell, 2018, 172(5), 1122-1131.(2018023), https://www.sciencedirect.com/science/article/pii/S0092867418301545 http://www.whb.cn/zhuzhan/kjwz/20180223/190193.html


三)电池含太阳能电池领域:

   1)太阳能电池17.3%效率: Science, 2018/8/9 online  link1  (Organic and solution-processed tandem solar cells with 17.3% efficiency)

   2)有机太阳能电池效率达15% (Nature Energy, 2018, 3, pp 422-427)https://www.nature.com/articles/s41560-018-0134-z

   3) 非C60类受体太阳能电池(综述) No-fullerene acceptors for organic solar cells,Nature Reviews Materials,2018,3,18003 (19 pages)https://www.nature.com/articles/natrevmats20183

   4)基于非C60的有机太阳能电池 Organic solar cells based on non-fullerene acceptors Nature Materials ,2018,1,p119128

         https://www.nature.com/articles/nmat5063/|


四)科学与艺术

   化学与建筑学:The Chemist and the Architect Angew.Chem. Int.Ed. 2018, 57,4177 –4191    

                https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.201708325


五)结构与性能关系(药物活性,食品特性,功能关系)

   1)乙烯与水果软化 Ethylene and fruit softening, Food Quality and Safety, 2017,1(4),p253-267 , https://doi.org/10.1093/fqsafe/fyx024

   2)化学键键能新关系Recent Advances and Advisable Applications of Bond Energetics in Organic Chemistry J. Am. Chem. Soc., 2018, 140 (28),  pp 8611–8623.https://pubs.acs.org/doi/10.1021/jacs.8b04104   (link1, link2)

    3) 配体参数化指导立体构型控制的Suzuki偶联反应Enantiodivergent Pd-catalyzed CC bond formation enabled through ligand parameterization(Science, 2018, 362, 670-674)(link1,link2)


五)、特殊分子合成及性能研究

    1)石墨炔 (Chem. Commun., 2010,46, 3256-325  https://doi.org/10.1039/B922733D

    2)全炔大环(C18), Sciences,2019/8/15, DOI: 10.1126/science.aay1914  https://science.sciencemag.org/content/early/2019/08/14/science.aay1914


六)功能材料

  1)碳纤维材料汇总 : link

  2)石墨烯气凝胶: Science,2019,link1  link2 

   3)MOF link  link2


七)生物医学

  1)单染色体体酵母(Creating a functional single-chromosome yeast)Nature, 2018, 0801. https://www.nature.com/articles/s41586-018-0382-x ( Eng) http://www.stdaily.com/index/kejixinwen/2018-08/02/content_696013.shtml (in Chinese) 

Entire yeast genome squeezed into one lone chromosome


八)实验技能及规范

   1) 实验记录(或报告)参考资料 6H-Benzo[c]chromen-6-one合成,Org.Synth.2018, 95, 97-111)

      http://www.orgsyn.org/demo.aspx?prep=v95p0097 .


九)其它

  1)Welcome To Periodic Graphics:   A monthly collaboration between C&EN and Andy Brunning, chemistry educator and author of  the   popular graphics blog Compound Interest. To see more of Brunning’s work, go to http://compoundchem.com.

http://cen.acs.org/sections/periodicgraphics.html

 2)快速算法/指数级加速: https://arxiv.org/abs/1807.04271  Ewin Tang ( A quantum-inspired classical algorithm for recommendation systems ( 2018/07/10) . https://www.itcodemonkey.com/article/6926.html

 3)深度生成模型 https://www.itcodemonkey.com/article/6795.html