菌群在生态系统中处于非常重要的地位，不但参与环境中能量和物质的循环，同时也对宿主（如动物）的健康和疾病至关重要。这为利用菌群预测或控制农业有害动物爆发、保护生物多样性、改善人类健康和生活质量等提供了新思路。本课题组将通过研发和应用基于大数据采集与分析的精确技术，特别是基于测序和成像的单细胞技术，从环境或共生菌群发现重要的功能微生物并研究其生物学，在此基础上结合人工智能和生物技术实现对菌群的精准调控，同时为调控动物的繁殖与行为、改善环境或宿主健康等提出理论或开发具体技术。

本研究组以交叉学科研究为主，欢迎生物学，化学，物理学，计算机科学，工学，数学等不同背景的有志青年报考。

0710Z1-基因组学

菌群生物学，菌群调控技术，单细胞技术

2009-09--2014-06   北京大学前沿交叉学科研究院/BIOPIC   博士学位
2005-09--2009-06   南京大学化学化工学院   学士学位

博士研究生毕业

博士学位

   

（1） 日本理化学研究所樱舞奖, 研究所（学校）, 2023
（2） 北京大学优秀博士论文奖, 研究所（学校）, 2014

[1] SHIROGUCHI Katsuyuki, JIN Jianshi, YAMAMOTO Reiko. METHOD FOR TREATING CELL POPULATION AND METHOD FOR ANALYZING GENES INCLUDED IN CELL POPULATION. JP: WO2021241721-A1, 2021-12-02.

   

[1] Jianshi Jin, Taisaku Ogawa, Nozomi Hojo, Kirill Kryukov, Kenji Shimizu, Tomokatsu Ikawa, Tadashi Imanishi, Taku Okazaki, Katsuyuki Shiroguchi. Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic states. Proceedings of the National Academy of Sciences USA[J]. 2023, 120(1): https://www.pnas.org/doi/10.1073/pnas.2210283120.
[2] Cui, Guangwei, Shimba, Akihiro, Jin, Jianshi, Ogawa, Taisaku, Muramoto, Yukiko, Miyachi, Hitoshi, Abe, Shinya, Asahi, Takuma, TaniIchi, Shizue, Dijkstra, Johannes M, Iwamoto, Yayoi, Kryukov, Kirill, Zhu, Yuanbo, Takami, Daichi, Hara, Takahiro, Kitano, Satsuki, Xu, Yan, Morita, Hajime, Zhang, Moyu, Zreka, Lynn, Miyata, Keishi, Kanaya, Takashi, Okumura, Shinya, Ito, Takashi, Hatano, Etsuro, Takahashi, Yoshimasa, Watarai, Hiroshi, Oike, Yuichi, Imanishi, Tadashi, Ohno, Hiroshi, Ohteki, Toshiaki, Minato, Nagahiro, Kubo, Masato, Hollander, Georg A, Ueno, Hideki, Noda, Takeshi, Shiroguchi, Katsuyuki, Ikuta, Koichi. A circulating subset of iNKT cells mediates antitumor and antiviral immunity. SCIENCE IMMUNOLOGY[J]. 2022, 7(76): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000933997800001.
[3] Jin, Jianshi, Yamamoto, Reiko, Takeuchi, Tadashi, Cui, Guangwei, Miyauchi, Eiji, Hojo, Nozomi, Ikuta, Koichi, Ohno, Hiroshi, Shiroguchi, Katsuyuki. High-throughput identification and quantification of single bacterial cells in the microbiota. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-28426-1.
[4] Li, Yanmeng, Jin, Jianshi, Bai, Fan. Cancer biology deciphered by single-cell transcriptomic sequencing. PROTEIN & CELL[J]. 2022, 13(3): 167-179, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000685793200002.
[5] Tao, Jianli, Zhang, XiaoWei, Jin, Jianshi, Du, XiaoXia, Lian, Tengfei, Yang, Jing, Zhou, Xiang, Jiang, Zhengfan, Su, XiaoDong. Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation. JOURNAL OF IMMUNOLOGY[J]. 2017, 198(9): 3627-3636, http://dx.doi.org/10.4049/jimmunol.1601909.
[6] Jianshi Jin, Tengfei Lian, Chan Gu, Kai Yu, Yi Qin Gao, Xiao-Dong Su. The effects of cytosine methylation on general transcriptional factors. Scientific Reports[J]. 2016, 6: https://www.nature.com/articles/srep29119.
[7] Jianshi Jin, Tengfei Lian, X. Sunney Xie, Xiao-Dong Su. High-accuracy mapping protein binding stability on nucleosomal DNA using single-molecule method. Journal of Molecular Cell Biology[J]. 2014, 6(5): 438-440, https://doi.org/10.1093/jmcb/mju033.
[8] Kim, Sangjin, Brostroemer, Erik, Xing, Dong, Jin, Jianshi, Chong, Shasha, Ge, Hao, Wang, Siyuan, Gu, Chan, Yang, Lijiang, Gao, Yi Qin, Su, Xiaodong, Sun, Yujie, Xie, X Sunney. Probing Allostery Through DNA. SCIENCE[J]. 2013, 339(6121): 816-819, [9] Juan Zhao, Jianshi Jin, Chunhui Wu, Hui Jiang, Yanyan Zhou, Jinglin Zuo, Xuemei Wang. Highly sensitive identification of cancer cells by combining the new tetrathiafulvalene derivative with a β-cyclodextrin/multi-walled carbon nanotubes modified GCE. Analyst[J]. 2010, 135(11): 2965-2969, [10] 苏晓东, 金坚石, 谢晓亮. 单分子水平的酶催化与基因表达研究. 物理化学学报[J]. 2010, 1976-1987, http://lib.cqvip.com/Qikan/Article/Detail?id=34508431.
[11] Chen, Ya, Liu, Wei, Jin, JianShi, Liu, Bin, Zou, ZhiGang, Zuo, JingLin, You, XiaoZeng. Rhenium(I) tricarbonyl complexes with bispyridine ligands attached to sulfur-rich core: Syntheses, structures and properties. JOURNAL OF ORGANOMETALLIC CHEMISTRY[J]. 2009, 694(5): 763-770, http://dx.doi.org/10.1016/j.jorganchem.2008.12.018.

   

（1）BarBIQ: high-throughput identification and quantification of single bacterial cells in the microbiota   2023 的国际基因节暨生物医药产业大会   金坚石   2023-04-27
（2）BarBIQ: high-throughput identification and quantification of single bacterial cells in the microbiota   第45回日本分子生物学会年会   Jianshi Jin, Katsuyuki Shiroguchi   2022-12-01
（3）Decoding single-cell transcriptomic states from cell images enabled by robotic data acquisition and deep learning   第59回日本生物物理学年会   Jianshi Jin, Katsuyuki Shiroguchi   2021-11-27