Dr. Haiyun Gan received PhD in Developmental Biology from Institute of Zoology, Chinese Academy of Sciences in 2011. He was a post-doctoral fellow at Zhiguo Zhang's lab in the Columbia University before joining St. Jude Children's Research Hospital in 2018. In 2019, he joined the faculty at SIAT. His work has been published in Science, Molecular Cell, Nature Communications, eLife and other top international academic journals.
Research Areas
The research fields include:
1) Using system biology and synthetic biology to study the regulation mechanism of epigenetic inheritance;
2) The function of epigenetic inheritance regulation in stem cell differentiation, embryonic development, tumorigenesis and drug resistance;
3) Development and application of the synthetic epigenome-related technologies.
Publications
Yu, C#, H. Gan#, A. Serra-Cardona, L. Zhang, S. Gan, S. Sharma, E. Johansson, A. Chabes, R. M. Xu, Z. Zhang. A mechanism for preventing asymmetric histone segregation onto replicating DNA strands, Science, 2018, 361: 1386-1389. (Highlighted in Science and F1000)
H. Gan#, A. Serra-Cardona#, X. Hua, H. Zhou, K. Labib, C. Yu, Z. Zhang. The Mcm2-Ctf4-Polalpha Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands, Molecular Cell, 2018, 72(1): 140-151.
H. Gan#, C. Yu#, S. Devbhandari, S. Sharma, J. Han, A. Chabes, D. Remus, Z. Zhang*, Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress, Molecular Cell, 2017, 68: 446-455. (Highlighted in Cell Cycle)
Zhang, H#, H. Gan#, Z. Wang#, J. H. Lee, H. Zhou, T. Ordog, M. S. Wold, M. Ljungman and Z. Zhang*, RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells, Molecular Cell, 2017, 65: 272-284. (Highlighted in F1000)
Fang, D#, H. Gan#, J. H. Lee#, J. Han#, Z. Wang#, S. M. Riester, L. Jin, J. Chen, H. Zhou, J. Wang, H. Zhang, N. Yang, E. W. Bradley, T. H. Ho, B. P. Rubin, J. A. Bridge, S. N. Thibodeau, T. Ordog, Y. Chen, A. J. van Wijnen, A. M. Oliveira, R. M. Xu, J. J. Westendorf, Z. Zhang*, The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas, Science, 2016, 352: 1344-1348. (Highlighted in F1000)