081703-生物化工

细菌生物材料

2016-09--2021-06   武汉大学   博士
2012-09--2016-06   湖北大学   学士

   

2023-09~现在, 中国科学院过程工程研究所, 项目研究员 博导
2021-09~2023-08,武汉大学, 特聘副研究员 博导

2024-02-06-今,Aggregate期刊, Next Generation Board
2024-01-01-今,Smart Mater. Med.期刊, 编委
2023-06-07-今,Exploration期刊, 青年编委
2023-06-01-今,View期刊, 青年编委
2023-04-28-今,中国抗癌协会纳米肿瘤学专委会, 青年委员

   

（1） 中国生物材料学会科学技术奖, 二等奖, 部委级, 2023
（2） 中国生物物理学会纳米生物学分会优秀青年学者, 其他, 2023
（3） 中国化学会化学化工与材料京博优秀博士奖铜奖, , 部委级, 2022
（4） 湖北省长江学子, 省级, 2021
（5） 武汉大学十大杰出青年, 研究所（学校）, 2018
（6） 中国生物材料大会青年学者奖, 其他, 2017
（7） 中国青少年科技创新奖, 国家级, 2016

[1] 张先正, 曾思敏, 郑迪威, 曾旋. 一种鼻炎预防或治疗用抗菌消炎微凝胶及其制备方法和应用. CN: CN112220740B, 2023-01-10.
[2] 张先正, 曾思敏, 李瑞琳, 郑迪威, 曾旋. 一种带壁细胞表面修饰高分子的方法、被修饰后的细胞及其应用. CN: CN114958712A, 2022-08-30.
[3] 张先正, 郑迪威, 张昱, 曾旋. 一种可室温保存的一体化含蛋白药物注射器. CN: CN213852507U, 2021-08-03.
[4] 张先正, 丁兴兰, 郑迪威, 曾旋. 一种多糖包埋的细菌芽孢的制备方法及其应用. CN: CN113046342A, 2021-06-29.
[5] 张先正, 高凡, 郑迪威. 用于高响应性抗肿瘤免疫疗法的HPV疫苗改性材料及其制备方法. CN: CN111228477B, 2021-06-04.
[6] 张先正, 郑迪威, 严雨, 曾旋. 一种调节菌群激活免疫应答的银纳米水凝胶及其制备方法和应用. CN: CN112494515A, 2021-03-16.
[7] 张先正, 曾思敏, 郑迪威, 曾旋. 一种鼻炎预防或治疗用抗菌消炎微凝胶及其制备方法和应用. CN: CN112220740A, 2021-01-15.

   

[1] Zheng, DiWei, Qiao, JiYan, Ma, JunChi, An, JiaXin, Yang, ChiHui, Zhang, Yu, Cheng, Qian, Rao, ZhiYong, Zeng, SiMin, Wang, Lin, Zhang, XianZheng. A Microbial Community Cultured in Gradient Hydrogel for Investigating Gut Microbiome-Drug Interaction and Guiding Therapeutic Decisions. ADVANCED MATERIALS[J]. 2023, 35(22): http://dx.doi.org/10.1002/adma.202300977.
[2] Zheng, DiWei, Chen, KeWei, Yan, JianHua, Rao, ZhiYong, Yang, ChiHui, Li, RuiLin, Tang, Ying, Cheng, Han, Zhang, XianZheng. A seed-like hydrogel with metabolic cascade microbiota for oral treatment of liver failure. MATERIALS TODAY[J]. 2022, 58: 30-40, http://dx.doi.org/10.1016/j.mattod.2022.07.014.
[3] Zheng, DiWei, Deng, WeiWei, Song, WenFang, Wu, CongCong, Liu, Jie, Hong, Sheng, Zhuang, ZeNan, Cheng, Han, Sun, ZhiJun, Zhang, XianZheng. Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma. NATURE BIOMEDICAL ENGINEERING[J]. 2022, 6(1): 32-+, http://dx.doi.org/10.1038/s41551-021-00807-9.
[4] Hong, Sheng, Zheng, DiWei, Zhang, QiuLing, Deng, WeiWei, Song, WenFang, Cheng, SiXue, Zhi, ZhiSun, Zhang, XianZheng. An RGB-emitting molecular cocktail for the detection of bacterial fingerprints. CHEMICAL SCIENCE[J]. 2020, 11(17): 4403-4409, [5] Li Bin, Ji Ping, Peng SiYuan, Pan Pei, Zheng DiWei, Li ChuXin, Sun YunXia, Zhang XianZheng. Nitric Oxide Release Device for Remote-Controlled Cancer Therapy by Wireless Charging. ADVANCED MATERIALS[J]. 2020, 32(16): https://www.webofscience.com/wos/woscc/full-record/WOS:000529881300028.
[6] Zheng, DiWei, Li, RunQing, An, JiaXin, Xie, TianQiu, Han, ZiYi, Xu, Rui, Fang, Yu, Zhang, XianZheng. Prebiotics-Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer. ADVANCED MATERIALS[J]. 2020, 32(45): https://www.webofscience.com/wos/woscc/full-record/WOS:000574137300001.
[7] Chen, Si, Fan, JinXuan, Zheng, DiWei, Liu, Fan, Zeng, Xuan, Yan, GuoPing, Zhang, XianZheng. A multi-functional drug delivery system based on polyphenols for efficient tumor inhibition and metastasis prevention. BIOMATERIALS SCIENCE[J]. 2020, 8(2): 702-711, https://www.webofscience.com/wos/woscc/full-record/WOS:000509549500013.
[8] DiWei Zheng, Fan Gao, Qian Cheng, Peng Bao, Xue Dong, JinXuan Fan, Wen Song, Xuan Zeng, SiXue Cheng, XianZheng Zhang. A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-15927-0.
[9] Zheng, DiWei, Pan, Pei, Chen, KeWei, Fan, JinXuan, Li, ChuXin, Cheng, Han, Zhang, XianZheng. An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure. NATURE BIOMEDICAL ENGINEERING[J]. 2020, 4(9): 853-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000547609200002.
[10] DiWei Zheng, Sheng Hong, QiuLing Zhang, Xue Dong, Pei Pan, WenFang Song, Wen Song, SiXue Cheng, XianZheng Zhang. Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18493-7.
[11] Zheng, DiWei, Dong, Xue, Pan, Pei, Chen, KeWei, Fan, JinXuan, Cheng, SiXue, Zhang, XianZheng. Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy. NATURE BIOMEDICAL ENGINEERING[J]. 2019, 3(9): 717-728, [12] Zou, MeiZhen, Liu, WenLong, Li, ChuXin, Zheng, DiWei, Zeng, JinYue, Gao, Fan, Ye, JingJie, Zhang, XianZheng. A Multifunctional Biomimetic Nanoplatform for Relieving Hypoxia to Enhance Chemotherapy and Inhibit the PD-1/PD-L1 Axis. SMALL[J]. 2018, 14(28): https://www.webofscience.com/wos/woscc/full-record/WOS:000438368300012.
[13] Zheng, DiWei, Chen, Ying, Li, ZiHao, Xu, Lu, Li, ChuXin, Li, Bin, Fan, JinXuan, Cheng, SiXue, Zhang, XianZheng. Optically-controlled bacterial metabolite for cancer therapy. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/d16bc80f86904250a7bda65fe7249261.
[14] Gao, Fan, Zhang, Chi, Qiu, WenXiu, Dong, Xue, Zheng, DiWei, Wu, Wei, Zhang, XianZheng. PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug. SMALL[J]. 2018, 14(37): https://www.webofscience.com/wos/woscc/full-record/WOS:000444473300013.
[15] Zheng, Diwei, Li, Bin, Xu, Lu, Zhang, QiuLing, Fan, JinXuan, Li, ChuXin, Zhang, XianZheng. Normalizing Tumor Microenvironment Based on Photosynthetic Abiotic/Biotic Nanoparticles. ACS NANO[J]. 2018, 12(6): 6218-6227, https://www.webofscience.com/wos/woscc/full-record/WOS:000436910200121.
[16] Song, Wen, Kuang, Jing, Li, ChuXin, Zhang, Mingkang, Zheng, Diwei, Zeng, Xuan, Liu, Chuanjun, Zhang, XianZheng. Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication. ACS NANO[J]. 2018, 12(2): 1978-1989, http://dx.doi.org/10.1021/acsnano.7b09112.
[17] Zheng, DiWei, Xu, Lu, Li, ChuXin, Dong, Xue, Pan, Pei, Zhang, QiuLing, Li, Bin, Zeng, Xuan, Zhang, XianZheng. Photo-Powered Artificial Organelles for ATP Generation and Life-Sustainment. ADVANCED MATERIALS[J]. 2018, 30(52): https://www.webofscience.com/wos/woscc/full-record/WOS:000454124800007.
[18] Fan, JinXuan, Li, ZiHao, Liu, XinHua, Zheng, DiWei, Chen, Ying, Zhang, XianZheng. Bacteria-Mediated Tumor Therapy Utilizing Photothermally-Controlled TNF-alpha Expression via Oral Administration. NANO LETTERS[J]. 2018, 18(4): 2373-2380, https://www.webofscience.com/wos/woscc/full-record/WOS:000430155900026.
[19] Zhu, Jingyi, Zhang, Mingkang, Zheng, Diwei, Hong, Sheng, Feng, Jun, Zhang, XianZheng. A Universal Approach to Render Nanomedicine with Biological Identity Derived from Cell Membranes. BIOMACROMOLECULES[J]. 2018, 19(6): 2043-2052, https://www.webofscience.com/wos/woscc/full-record/WOS:000435226200027.
[20] Peng, MengYun, Zheng, DiWei, Wang, ShiBo, Cheng, SiXue, Zhang, XianZheng. Multifunctional Nanosystem for Synergistic Tumor Therapy Delivered by Two-Dimensional MoS2. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(16): 13965-13975, https://www.webofscience.com/wos/woscc/full-record/WOS:000400321800018.
[21] Zheng, DiWei, Lei, Qi, Zhu, JingYi, Fan, JinXuan, Li, ChuXin, Li, Cao, Xu, Zushun, Cheng, SiXue, Zhang, XianZheng. Switching Apoptosis to Ferroptosis: Metal-Organic Network for High-Efficiency Anticancer Therapy. NANO LETTERS[J]. 2017, 17(1): 284-291, http://dx.doi.org/10.1021/acs.nanolett.6b04060.
[22] Peng, Mengyun, Qin, Siyong, Jia, Huizhen, Zheng, Diwei, Rong, Lei, Zhang, Xianzheng. Self-delivery of a peptide-based prodrug for tumor-targeting therapy. NANO RESEARCH[J]. 2016, 9(3): 663-673, https://www.webofscience.com/wos/woscc/full-record/WOS:000371797000007.
[23] Chen, WeiHai, Luo, GuoFeng, Qiu, WenXiu, Lei, Qi, Liu, LiHan, Zheng, DiWei, Hong, Sheng, Cheng, SiXue, Zhang, XianZheng. Tumor-Triggered Drug Release with Tumor-Targeted Accumulation and Elevated Drug Retention To Overcome Multidrug Resistance. CHEMISTRY OF MATERIALS[J]. 2016, 28(18): 6742-6752, https://www.webofscience.com/wos/woscc/full-record/WOS:000384399000041.
[24] Zheng, DiWei, Li, JiangLan, Li, Cao, Xu, ZuShun, Cheng, SiXue, Zhang, XianZheng. Viscosity enhanced release (VER) effect in nanoporous drug delivery systems: phenomenon and mechanism. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2015, 3(17): 3483-3489, http://dx.doi.org/10.1039/c5tb00267b.

   

（ 1 ） 可口服的仿生菌群微生态系统用于肝/肾衰竭中的代谢毒素清除, 负责人, 国家任务, 2023-01--2026-12
（ 2 ） 智能微生物材料用于恶性肿瘤治疗, 负责人, 中国科学院计划, 2023-10--2026-10
（ 3 ） 过程杰青-郑迪威, 负责人, 研究所自主部署, 2023-09--2027-12