基本信息
丁文军  男  博导  生命科学学院
电子邮件: dingwj@ucas.ac.cn
通信地址: 北京市石景山区玉泉路19号(甲)
邮政编码:

研究领域

生物化学与分子生物学、细胞生物学(Biochemistry and Molecular Biology, Cell Biology)

招生信息

   
招生专业
071010-生物化学与分子生物学
071009-细胞生物学
070202-粒子物理与原子核物理
招生方向
环境与健康、糖尿病
细胞生物学/环境与健康
核技术应用

教授课程

细胞生物学实验
分子细胞生物学
细胞生物学技术及应用
细胞生物学技术及应用讨论课
免疫组织化学实验
文献阅读课
免疫组织化学实验技术
细胞生物学实验技术
污染物质归趋与生态毒理学
文献阅读课(限京外所环境工程,环境科学专业的学生选修)
细胞生物学实验课
细胞生物学技术与应用
细胞生物学技术与应用讨论课
生物化学研究方法
环境毒理学研究进展
毒理学概论
细胞生物学实验技术概论

出版信息

   
发表论文
(1) Perfluorooctane sulphonate induces oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway., Chemosphere, 2018, 通讯作者
(2) Effect of perfluorooctane sulphonate-induced Kupffer cell activation on hepatocyte proliferation through the NF-κB/TNF-ɑ/IL-6-dependent pathway, Chemosphere, 2018, 通讯作者
(3) IL-9 and Th9 cells in health and diseases-From tolerance to immunopathology, Cytokine and Growth Factor Reviews., 2017, 第 5 作者
(4) Airborne PM2.5 induced hepatic insulin resistance by Nrf2/JNK-mediated signaling pathway, Int. J. Environ. Res. Public Health, 2017, 通讯作者
(5) 2-deoxy-D-glucose treatment decreases anti-inflammatory M2 macrophage polarization in mice with tumor and allergic airway inflammation, Frontiers in Immunology, 2017, 通讯作者
(6) PM2.5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells, BBA-General Subjects, 2017, 通讯作者
(7) Association of mannose-binding lectin polymorphisms with Tuberculosis susceptibility among Chinese, Scientific Reports, 2016, 第 10 作者
(8) Vanadium(IV)-chlorodipicolinate inhibits 3T3-L1 preadipocyte adipogenesis by activating LKB1/AMPK signaling pathway, Journal of Inorganic Biochemistry, 2016, 通讯作者
(9) Effects of protein corona on intracellular uptake and cytotoxicity of PM1, Progress in Biochemistry and Biophysics, 2016, 通讯作者
(10) DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells, BBA-General Subjects, 2016, 第 9 作者
(11) PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through ERK/AKT/NF-κB-dependent pathway., Journal of Applied Toxicology, 2016, 通讯作者
(12) Role of miR-155 in fluorooctane sulfonate-induced oxidative hepatic damage via the Nrf2-dependent pathway, Toxicology and Applied Pharmacology, 2016, 通讯作者
(13) 肝脏脂质代谢与自噬, 中国科学院大学学报, 2016, 通讯作者
(14) Direct effects of airborne PM2.5 exposure on macrophage polarizations, BBA-General Subjects, 2016, 通讯作者
(15) Comparative study of the effects of PM1-induced oxidative stress on autophagy and surfactant protein B and C expressions in lung alveolar type II epithelial MLE-12 cells, BBA-General Subjects, 2016, 通讯作者
(16) Effects of Size-Fractionated Particulate Matter on Cellular Oxidant Radical Generation in Human Bronchial Epithelial BEAS-2B Cells, International Journal of Envionmental Research and Public Health, 2016, 通讯作者
(17) TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway., Cellular & Molecular Immunology, 2015, 通讯作者
(18) 巨噬细胞极化与细胞代谢的相互调控, 细胞与分子免疫学杂志, 2015, 第 3 作者
(19) Oxidovanadium(IV) Sulfate-induced glucose uptake in HepG2 cells through IR/Akt pathway and hydroxyl radicals, Journal of Inorganic Biochemistry, 2015, 通讯作者
(20) Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation, J Neurochem, 2015, 通讯作者
(21) Cellular metabolism and macrophage functional polarization, International Reviews of Immunology, 2015, 通讯作者
(22) Nrf2抵抗胰岛β细胞氧化损伤的作用机制, 中国科学院大学学报, 2015, 通讯作者
(23) Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells, Apoptosis, 2014, 通讯作者
(24) Effects of vanadium(III, IV, V)-chlorodipicolinate on glycolysis and antioxidant status in the liver of STZ-induced diabetic rats, J Inorg Biochem, 2014, 通讯作者
(25) Water-insoluble fraction of airborne particulate matter (PM10) induces oxidative stress in human lung epithelial A549 cells, Environmental Toxicology, 2014, 通讯作者
(26) Polymorphisms in the interleukin 18 receptor 1 gene and Tuberculosis susceptibility among Chinese, PLoS One, 2014, 通讯作者
(27) ZnO nanoparticles-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes, Nanoscale Res Lett, 2014, 通讯作者
(28) Tetrabromobisphenol A (TBBPA) induced oxidative stress in hepatoma HepG2 cells, International Journal of Applied Environmental Sciences, 2014, 第 4 作者
(29) V5dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究, 中国科学院研究生院学报, 2013, 通讯作者
(30) 可吸入颗粒物与血管内皮细胞功能紊乱的关系, 环境与健康杂志, 2013, 通讯作者
(31) PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells, Toxicology in Vitro, 2013, 通讯作者
(32) PM2.5诱导肺上皮MLE-12细胞的氧化应激和自噬, PM2.5 induces autophagy in lung epithelial A549 and MLE-12 cells, 中国药理与毒理学杂志, 2013, 第 2 作者
(33) 可吸入颗粒物与血管内皮细胞功能紊乱的关系, The Relationship between Inhaled Particulate Matter and Dysfunction of Vascular Endothelial Cells, 环境与健康杂志, 2013, 通讯作者
(34) 纳米金属化合物的神经毒性效应研究进展, 神经药理学报, 2013, 通讯作者
(35) Effect of VIVO(dipic-Cl)(H2O)2 on lipid metabolism disorders in the liver of STZ-induced diabetic rats, Journal of Diabetes Research, 2013, 通讯作者
(36) PM2.5 induces nrf2-mediated defense mechanisms against oxidative stress by activating pik3/akt signaling pathway in human lung alveolar epithelial A549 cells, Cell Biology and Toxicology, 2013, 通讯作者
(37) The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications, Journal of Molecular Medicine, 2012, 通讯作者
(38) Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes, Cellular Molecular Immunology, 2012, 通讯作者
(39) The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term, Journal of Cellular Physiology, 2012, 通讯作者
(40) 冬季和夏季PM10和PM2.5对人肺上皮细胞A549毒性的比较, 中国科学院研究生院学报, 2012, 第 2 作者
(41) CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway, Stem Cells, 2012, 通讯作者
(42) Anti-diabetic effects of a series of vanadium dipicolinate complexes in rats with streptozotocin-induced diabetes, Coordination Chemistry Reviews, 2011, 通讯作者
(43) Oxidative stress induced by urban fine particles in cultured EA.hy926 cells, Human and Experimental Toxicology, 2011, 通讯作者
(44) 全氟辛烷磺酸对SD大鼠肝毒性及其肝脏细胞色素P450 mRNA表达的影响, Hepatotoxicity of PFOS in SD rats and its effect on the expression of CYP450 mRNA in liver, 毒理学杂志, 2010, 通讯作者
(45) 生物降解介导的表面变化的聚合物分子及其对细胞生长的影响, Biodegradation-induced surface change of polymer microspheres and its influence on cell growth, Polymer Degradation and Stability, 2010, 通讯作者
(46) 姜黄素激活PPAR对降低高脂膳食糖尿病小鼠血糖的作用, Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice, Fitoterapia, 2010, 通讯作者
(47) PM2.5对肺泡II型上皮细胞MLE-12的毒性研究, 毒理学杂志, 2010, 
(48) Acute Toxicity of Ferric Oxide and Zinc Oxide Nanoparticles in Rats , Journal of Nanoscience and Nanotechnology, 2010, 
(49) 血管紧张素转化酶基因I/D多态性与高血压脑梗塞发病的相关性, 中科院研究生院学报, 2010, 
(50) 血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性, 中科院研究生院学报, 2010, 
(51) Evaluation of inhibition of fatty acid synthase by ursolic acid: Positive cooperation mechanism, Biochemical and Biophysical Research Communications, 2010, 
(52) Anti-diabetic effects of vanadium(III, IV, V)–chlorodipicolinate complexes in streptozotocin-induced diabetic rats, Biometals, 2009, 
(53) Efficient fabrication of transparent antimicrobial poly(vinyl alcohol) thin films, J Nanopart Res, 2009, 
(54) Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats, Journal of Inorganic Biochemistry, 2009, 
(55) 基于代谢组学方法研究纳米二氧化钛对大鼠肾功能的影响, 毒理学杂志, 2009, 
(56) 纳米氧化锌对人肺腺癌细胞A549的毒性, 中国科学院研究生院学报, 2009, 
(57) 钒化合物抗糖尿病作用的研究进展, 化学进展, 2009, 
(58) Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats, Journal of Inorganic Biochemistry, 2009, 
(59) Chloro-substituted dipicolinate vanadium complexes: Synthesis, solution, solid-state, and insulin-enhancing properties, Journal of Inorganic Biochemistry, 2009, 
(60) Biodegradable Polymeric Microcarriers with Controllable Porous Structure for Tissue Engineering, Macromol. Biosci, 2009, 
(61) Anti-diabetic Effects of Cesium Aqua (N,N′-ethylene (salicylideneiminato)-5-sulfonato) Oxovanadium (IV) Dihydrate in Streptozotocin-induced Diabetic Rats, Biol Trace Elem Res, 2008, 
(62) Reversal of Osteoporotic Changes of Mineral Composition in Femurs of DiabeticRats by Insulin , Biol Trace Elem Res, 2008, 
(63) The association of psychological symptoms with unintentional injuries among retired employees of a university in China, International Journal of Injury Control and Safety Promotion, 2008, 
(64) Inhibition of protein tyrosine phosphatase 1B and alkaline phosphatase by bis(maltolato)oxovanadium (IV), Journal of Inorganic Biochemistry, 2008, 
(65) Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term, J Mol Med, 2008, 
(66) 钒对遗传性Ⅱ型糖尿病KK小鼠降糖作用的实验研究, 中国科学院研究生院学报, 2008, 
(67) Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats, J Biol Inorg Chem, 2007, 
(68) Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe , Micron, 2007, 
(69) 纳米毒理研究进展, 中国药理学与毒理学杂志, 2007, 
(70) 4-氯-2, 6-双吡啶双氧钒化合物降低1型糖尿病大鼠血糖的生物学作用, 中国科学院研究生院学报, 2007, 
(71) 口服富铬啤酒酵母对链脲佐霉素诱导糖尿病大鼠的生物效应, 中国科学院研究生院学报, 2007, 
(72) STZ诱导的糖尿病对骨密度和血清睾酮的影响(英文), 中国科学院研究生院学报, 2007, 
发表著作
( 1 ) 国家污染物环境健康风险名录-化学第一分册, Directory of National Environment and Health: Chemical Pollutant Part I, 中国环境科学出版社, 2009-02, 第 1 作者
Comprhensive Handbook of Iodine, Oxford: Academic Press, 2009-11, ( 3 ) 国内外化学污染物环境与健康风险排序比较研究, Overview of Risk Assessment for Chemcial Pollution and Human Health in the World , 科学出版社, 2010-09, 第 2 作者
( 4 ) 国家污染物环境健康风险名录(化学第二分册), Directory of National Environment and Heath: Chemical Pollutant II, 中国环境科学出版社, 2011-08, 第 1 作者
( 5 ) 有毒生物, 人民卫生出版社, 2013-11, 第 3 作者
( 6 ) 国家污染物环境健康风险名录(生物分册), Directory of National Environment and Heath: Biological Pollutant, 中国环境科学出版社 , 2013-12, 第 1 作者
( 7 ) 营养组学, Nutriomics, 中国协和医科大学出版社, 2015-11, 第 3 作者
Nanomaterials in Energy and Environmental Applications, Pan Stanford Publishing Pte. Ltd, 2016-10, 第 1 作者

科研活动

   
科研项目
( 1 ) 钒诱导的氧化应激效应, 主持, 国家级, 2009-01--2011-12
( 2 ) 纳米颗粒的跨膜分子机制研究, 主持, 国家级, 2007-01--2011-12
( 3 ) 《健康风险名录》生物分册, 主持, 国家级, 2011-01--2012-12
( 4 ) 机动车污染健康影响评价方法, 主持, 国家级, 2010-01--2013-09
( 5 ) 国内外POPs优控名录比较研究, 主持, 国家级, 2010-01--2012-09
( 6 ) POPs的机体负荷与健康效应评价, 主持, 国家级, 2008-01--2012-09
( 7 ) 除草剂抗体的制备纯化与筛选, 主持, 国家级, 2009-01--2012-08
( 8 ) 铍及其化合物检测排放, 主持, 国家级, 2009-01--2014-12
( 9 ) 海外创新团队, 主持, 部委级, 2014-01--2017-12
( 10 ) PM2.5暴露诱发胰岛素抵抗的分子作用机制, 主持, 国家级, 2014-01--2017-12
( 11 ) 同步辐射技术研究PM2.5迁移转化及其诱导细胞氧化损伤的分子作用机制, 主持, 国家级, 2015-01--2018-12
( 12 ) 钒化合物诱导的自噬及其调节糖尿病肝脏脂代谢紊乱的分子作用机制, 主持, 部委级, 2015-06--2017-06
( 13 ) 大气细颗粒物毒性组分在呼吸道的定位分布及其引发呼吸道损伤及保护/适应性反应的分子作用机制, 主持, 国家级, 2017-01--2020-12
( 14 ) 突发生物危害发展及模型, 主持, 国家级, 2016-07--2018-12
参与会议
(1)Role of miR-155 in Fluorooctane Sulphonate-induced Oxidative Hepatic Damage via the Nrf2-dependent Pathway   第三届生态毒理学学术研讨会   2016-04-27
(2)Relationship Between Particulate Matter-induced oxidative stress and Insulin Resistance   2015-11-07
(3)PM2.5介导的氧化应激通过ERK/AKT/NF-κB通路调控 内皮细胞粘附分子的表达   第十二届全国气溶胶会议暨第十三届海峡两岸气溶胶技术研讨会   2015-10-22
(4)Vanadium compounds: in vivo and in vitro effects on lipid metabolism   2015-07-20

合作情况

   
项目协作单位

中国科学院理化技术研究所、中国科学院生态环境研究中心、中国科学院动物所、中国环境科学研究院、中国疾病控制与预防中心、中国医科院基础医学研究所、中国科学院高能物理研究所、中国科学院化学所、美国科罗拉多州立大学、日本理化学研究所、日本山梨县环境科学研究所、美国内布拉斯加大学医学中心