General
Yuguo Du 
Professor of Organic Chemistry
College of Chemistry and Chemical Engineering
Email: duyuguo@gucas.ac.cn
Telephone: 010-88256161
Address: Graduate University of the Chinese Academy of Sciences
19A Yuquanlu, Beijing, P. R. China
Postcode: 100049

Research Areas

Carbohydrate based drug design, synthesis, and bioactivity studies.

Education



1982-1987 Tsinghua University, Beijing, China B.S.
1987-1990 Chinese Academy of Sciences M.S.
1992-1995 Chinese Academy of Sciences  Ph.D. 

Experience

   
Work Experience
1990-1992 Research assistant, Research center for eco-environmental sciences, Chinese Academy of Sciences
1995-1998 Postdoc, College of Pharmacy, Iowa University
1995-2001 Associate professor, Research center for eco-environmental sciences, Chinese Academy of Sciences
2001-now Professor, Research center for eco-environmental sciences, Chinese Academy of Sciences
2008-now, Professor, Graduate University of Chinese Academy of Sciecnes
Teaching Experience
2008-now Professor of Organic Chemistry, College of Chemistry and Chemical Engineering

Honors & Distinctions

   

Publications

   
Papers
Publications (Since 1995)

1. Xing Ma, Jing Wang, Qiuli Shan, Zhuowei Tan, Guohua Wei, Dongbin Wei, Yuguo Du, A “Turn-on” Fluorescent Hg2+ Chemosensor Based on Ferrier Carbocyclization, Org. Lett., 2012, 14(3), 820-823.
2. Xing Ma, Guohua Wei, Dongbin Wei, Yuguo Du, Solvent controlled sugar-rhodamine fluorescence sensor for Cu2+ detection, Analyst, 2012, 137, 1436-1439.
3. Xing Ma, Jun Liu, Yuguo Du, Guohua Wei, Dongbin Wei, Highly sensitive and selective chemosensor for Cu2+ detection based on a N-propargyl rhodamine 6G-hydrazide derivative, Sci China Chem doi: 10.1007/s11426-011-4418-4.
4. Jing Wang, Shouyi Yu, Shouhai Jiao, Xiaowen Lv, Ben-zhan Zhu, Yuguo Du, Characterization of TCHQ-induced genotoxicity and mutagenesis using a shuttle vector pSP189 in mammalian cells. Mutation Research, 2012, 729 (1-2):16-23. (IF3.2)
5. Jing Wang, Xiaowen Lv, Jieping Shi, Xiaosong Hu, Yuguo Du, Troglitazone induces apoptosis via PPARγ activated POX-induced ROS formation in HT29 cells. Biomedical and environmental sciences, 2011,24(4):391-399.
6. Guofeng Gu, Min Fang, Yuguo Du, Efficient and selective removal of chloroacetyl group promoted with tetra-n-butylammonium fluoride (TBAF), Carbohydr. Res. 2011, 346, 2801–2804.
7. Guohua Wei, Dongbin Wei, Yuguo Du, An alternative total synthesis of solamargine, Sci China Chem doi: 10.1007/s11426-011-4476-7.
8. Guohua Wei, Junxia Yin, Xing Ma, Shouyi Yu, Dongbin Wei, Yuguo Du*, A carbohydrate modified fluoride ion sensor and its applications, Analytica Chimica Acta 2011, 703, 219-225. (IF4.31)
9. Dongbin Wei, Yanling Sun, Junxia Yin, Guohua Wei, Yuguo Du, Design and application of Fe3+ probe for “naked-eye” colorimetric detection in fully aqueous system, Sensors and Actuators B, 2011, 160, 1316-1321.(IF3.37)
10. Xing Ma, Jun Liu, Yuguo Du, Guohua Wei, Dongbin Wei, New rhodamine derivative as OFF-ON fluorescent chemosensor for detection of Cu2+, Sci China Chem 2011, 54, 1635–1639.
11. Dongbin Wei, Zhuowei Tan, Yuguo Du, A biological safety evaluation on reclaimed water reused as scenic water using a bioassay battery, J. Environ. Sci. 2011, 23, 1611-1618.
12. Guohua Wei, Jing Wang, Yuguo Du*, Total synthesis of solamargine, Bioorg. Med. Chem. Lett. 2011, 21, 2930-2933.
13. Xun Lv, Shouyi Yu, Jing Wang, Yuguo Du*, Synthesis of stryphnoside A, a triterpene saponin isolated from the pericarps of Stryphnodendron fissuratum, Carbohydr. Res. 2011, 346, 1786-1791.
14. Chao Cai, Jun Liu, Yuguo Du*, and Robert J. Linhardt*, Stereoselective Total Synthesis of (-)-Cleistenolide, J. Org. Chem. 2010, 75, 5754–5756.
15. Xun Lv, Shuihong Chen, Guohua Wei, Yuguo Du*, Synthesis of the pentasaccharide repeating unit of Escherichia coli O128 antigen, Carbohydr. Res. 2010, 345, 2272-2276.
16. Chao Cai, Guohua Wei, Yuguo Du*, Methyl 2,3-di-O-acetyl-4-O-levulinoyl-1-O-(2,2,2,-trichloro-2-iminoethyl)-L-idopyranosiduronate. Acta. Cryst. 2010, E66, o949.
17. Lei Zhang, Guohua Wei, Yuguo Du*, Synthesis and Crystal structure of (1R,2S,3S,4S)-(6-O-acetyl-1,2-O-isoproplidene-3,5-dideoxy-?-D-glucofuranoso)-1,3,5-trihydro-2,3-oxathiaindene-2,2-dioxide, Chinese J. Struct. Chem. 2010, 29, 134-137.
18. Sijin Liu, Shitao Li, Yuguo Du, Polychlorinated Biphenyls (PCBs) Enhance Metastatic Properties of Breast Cancer Cells by Activating Rho-Associated Kinase (ROCK), Plos One, 2010, 5, 1-8.
19. Sijin Liu, Shuping Zhang, Chen Qu, Wei Liu, Yuguo Du, The associations between the environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk and progression, Sci China Chem, 2010, 53, 974-979.
20. Marie-Jeanne Clément, Bérangère Tissot, Lionel Chevolot, Elisabeth Adjadj, Yuguo Du, Patrick A Curmi, and Régis Daniel, NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide branching in its anticomplementary activity, Glycobiology 2010, 20, 883-894.
21. Lei Zhang, Guohua Wei, Yuguo Du*, Total synthesis of apigenin-4’-yl 2-O-(p-coumaroyl)-?-D-glucopyranoside, Carbohydr. Res. 2010, 345, 2714-2417.
22. Jing Wang, Xiaowen Lv, Yuguo Du, Inflammatory response and insulin signaling alteration induced by PCB77, J. Environ. Sci. 2010, 22, 1086–1090.
23. Lei Zhang, Guohua Wei, Yuguo Du*, Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles, Carbohydr. Res. 2009, 344, 2083-2087.
24. Qiangmin Zhang, Feng Gao, Hao Peng, Hao Cheng, Yiwei Liu, Jiaqi Tang, John Thompson, Guohua Wei, Jingren Zhang, Yuguo Du, Jinghua Yan, and George F. Gao*, Crystal Structures of Streptococcus suis Mannonate Dehydratase (ManD) and Its Complex with Substrate: Genetic and Biochemical Evidence for a Catalytic Mechanism, J. Bacteriology, 2009, 191, 5832–5837.
25. Shuihong Cheng, Yuguo Du,* Baiping Ma and Dawei Tan, Total synthesis of a furostan saponin, timosaponin BII, Org. Biomol. Chem., 2009, 7, 3112–3118.
26. Jianghong Dai, Zhisheng Yu, Yongzhi He, Ling Zhang, Zhihui Bai, Zhiyang Dong, Yuguo Du, Hongxun Zhang, Cloning of a novel levoglucosan kinase gene from Lipomyces starkeyi and its expression in Escherichia coli, World J Microbiol Biotechnol 2009, 25, 1589-1595.
27. Xing Huang, Shuihong Cheng, Yuguo Du,* Feihong Bing, Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu, Carbohydr. Res. 2009, 344, 1153-1158.
28. Guohua Wei, Chao Cai, Yuguo Du*, Highly Efficient and Versatile Synthesis of Some Important Precursors from 1,6-Anhydrous-β-D-glucopyranose as a Green Starting Material, Chinese Journal of Chemistry 2009, 1589-1592.
29. Shuihong Cheng, Guohua Wei, Yuguo Du, Facile synthesis of protected pentasaccharide repeat unit of E. coli O86 antigen, Chemical Journal of Chinese Universities 2009, 30, 919-922.
30. Guohua Wei, Yuguo Du, K. L. Matta, Highly Efficient Synthesis of Two Hyaluronan Trisaccharide Analogues for Potential Hyaluronic Acid Synthases Inhibitors, Chemical Journal of Chinese Universities 2009, 30, 2199-2203.
31. Qi Chen, Yonghua Xu, Yuguo Du, Bao-Hang Han, Triphenylamine-based fluorescent conjugated glycopolymers: Synthesis, characterization and interactions with lectins, Polymer 2009, 50, 2830–2835.
32. Ben-Zhan Zhu, Guo-Qiang Shan, Chun-Hua Huang, Balaraman Kalyanaraman, Li Mao, Yuguo Du, Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical, Proc Natl Acad Sci USA 2009, 106, 11466-11471.
33. Jing Wang, Xiao-Wen Lv, Yuguo Du, Potential Mechanisms Involved in Ceramide-induced Apoptosis in Human Colon Cancer HT29 Cells, BIOMED. ENVIRON. SCI. 2009, 22, 76-85.
34. Dongbin Wei, Zhifen Lin, Yuguo Du, Application of biological safety index in two Japanese watersheds using a bioassay battery. Chemosphere. 2008, 72(9), 1303-1308.
35. Guohua Wei, Xun Lv, Yuguo Du,* FeCl3-catalyzed ?-glycosidation of glycosamine pentaacetates, Carbohydr. Res. 2008, 343, 3096-3099.
36. Soraya Fermas, Florence Gonnet, Angela Sutton, Nathalie Charnaux, Barbara Mulloy, Yuguo Du, Françoise Baleux, and Régis Daniel, Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (sdf-1/cxcl 12) are coupled as evidenced by affinity CE-MS analysis, Glycobiology 2008, 18(12), 1054-1064.
37. Yuguo Du,* Qi Chen, Jun Liu, C–C Bond Formation, 305-342. In Glycoscience: Chemistry and Chemical Biology. Bertram O. Fraser-Reid, Kuniaki Tatsuta, Joachim Thiem (Eds.), 2008.
38. Hongmei Liu, Shuihong Cheng, Jun Liu, Yuguang Du, Zhihui Bai, Yuguo Du*, Synthesis of Pentasaccharide and Heptasaccharide Derivatives and Their Effects on Plant Growth, J. Agric. Food Chem. 2008, 56, 5634–5638.
39. Shuihong Cheng, Yuguo Du,* Feihong Bing and Guobin Zhang, Synthesis of flaccidoside II, a bidesmosidic triterpene saponin isolated from Chinese folk medicine Di Wu, Carbohydr. Res. 2008, 343, 462-469.
40. Guohua Wei, Lei Zhang, Chao Cai, Shuihong Cheng, Yuguo Du*, Selective cleavage of sugar anomeric O-acyl groups using FeCl3?6H2O, Tetrahedron Lett. 2008, 49, 5488–5491.
41. Ben-Zhan Zhu, Hong-Tao Zhao, Balaraman Kalyanaraman, Jun Liu, Guo-Qiang Shan, Yuguo Du, Balz Frei, Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinines, Proc Natl Acad Sci USA 2007, 104, 3698-3702.
42. Lijian Cheng, Qi Chen, Jun Liua, Yuguo Du*, Synthesis of a fluorescence-labeled K30 antigen repeating unit using click chemistry, Carbohydr. Res. 2007, 342, 975-981.
43. Qi Chen, Yuguo Du*, Synthesis of sporiolide B from D-glucal, Carbohydr. Res. 2007, 342, 1405-1411.
44. Lijian Cheng, Qi Chen, Jun Liu, Yuguo Du*, Facile synthesis of cleistetroside-2, a partially acetylated oligorhamnoside from Cleistopholis glauca and patens, Carbohydr. Res. 2007, 342, 1496-1501.
45. Yuguo Du*, Jun Liu, Robert J. Linhardt, Facile Synthesis of (?)-Paeonilide, J. Org. Chem. 2007, 72, 3952-3954.
46. Qi Chen, Yuguo Du*, The first total synthesis of sporiolide B, Tetrahedron Lett. 2006, 47, 8489-8492.
47. Jun Liu, Yuguo Du*, Xiaomin Dong, Shucong Meng, Junjun Xiao, Lijian Cheng, Stereoselective synthesis of jaspine B from D-xylose, Carbohydr. Res. 2006, 341, 2653–2657.
48. Yuguo Du,* Qi Chen, Robert J. Linhardt, The First Total Synthesis of Sporiolide A, J. Org. Chem. 2006, 71, 8446-8451.
49. S. A. Mousa, X. Feng, J. Xie, Yuguo. Du, Y. Hua, H. He, L. O’Connor, R. J. Linhardt, Synthetic Oligosaccharide Stimulates and Stabilizes Angiogenesis: Structure–Function Relationships and Potential Mechanisms, J. Cardiovasc. Pharmacol. 2006, 48, 6-13.
50. Yuguo Du*, Jun Liu, Robert J. Linhardt, Stereoselective Synthesis of Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B) from D-Xylose, J. Org. Chem. 2006, 71, 1251-1253.
51. Yuguo Du,* Guohua Wei, Shuihong Cheng, Yuxia Hua and Robert J. Linhardt, HClO4–SiO2 catalyzed glycosylation using sugar trichloroacetimidates as glycosyl donors, Tetrahedron Lett. 2006, 47, 307-310.
52. Yuxia Hua, Junjun Xiao, Yingshen Huang, Yuguo Du*, Synthesis of the pentasaccharide repeating unit of latosillan, Carbohydr. Res. 2006, 341, 191-197.
53. Qi Chen, Feng Yang, Yuguo Du*, Synthesis of a C3-symmetric (1?6)-N-acetyl-?-D-glucosamine octadecasaccharide using click chemistry, Carbohydr. Res. 2005, 340, 2476-2482.
54. Lijun Wei, Guohua Wei, Houcheng Zhang, Peng G. Wang and Yuguo Du*, Synthesis of new, potent avermectin-like insecticidal agents, Carbohydr. Res. 2005, 340, 1583-1590.
55. Guisheng Zhang, Jie Shen, Hao Cheng, Lizhi Zhu, Lanyan Fang, Sanzhong Luo, Mark T. Muller, Gun Eui Lee, Lijun Wei, Yuguo Du, Duxin Sun, and Peng George Wang, Syntheses and Biological Activities of Rebeccamycin Analogues with Uncommon Sugars, J. Med. Chem. 2005, 48, 2600-2611.
56. Guohua Wei, Yuguo Du* and R. J. Linhardt, New Potent Insecticidal Agent: 4’-Fucosyl Avermectin Derivative, Tetrahedron Lett. 2004, 45, 6895-6898.
57. Yuxia Hua, Yuguo Du*, Gangli Yu, Shidong Chu, Synthesis and biological activities of octyl 2,3-di-O-sulfo-?-L-fucopyranosyl-(1?3)-2-O-sulfo-?-L-fucopyranosyl-(1?4)-2,3-di-O-sulfo-?-L-fucopyranosyl-(1?3)-2-O-sulfo-?-L-fucopyranosyl-(1?4)-2,3-di-O-sulfo-?-L-fucopyranoside, Carbohydr. Res. 2004, 339, 2083-2090.
58. Guofeng Gu, Yuguo Du*, R.J. Linhardt, Facile Synthesis of Saponins Containing 2,3-Branched Oligosaccharides by Using Partially Protected Glycosyl Donors, J. Org. Chem. 2004, 69, 5497-5500.
59. Yuguo Du*, Guofeng Gu, Yuxia Hua, Guohua Wei, Xinshan Ye, Guangli Yu, Synthesis and antitumor activities of glucan derivatives, Tetrahedron 2004, 60, 6345-6351.
60. Zhenqing Zhang, Guangli Yu, Huashi Guan, Xia Zhao, Yuguo Du*, Xiaolu Jiang, Preparation and structure determination of alginate oligosaccharides, Carbohydr. Res. 2004, 339, 1475-1481.
61. Guofeng Gu, Guohua Wei, Yuguo Du*, Synthesis of a 6V-sulfated mannopentasaccharide analogue related to PI-88, Carbohydr. Res. 2004, 339, 1155-1162.
62. Yuguo Du*, Guohua Wei, R.J. Linhardt, Total synthesis of Quercetin 3-Sophorotrioside, J. Org. Chem. 2004, 69, 2206-2209.
63. Yuxia Hua, Guofeng Gu, Yuguo Du*, Synthesis and biological activities of sulfated octyl (1→3)-?-L-fucopyranosyl tetrasaccharide, Carbohydr. Res. 2004, 867-872.
64. Ying Kang, Yan Mei, Yuguo Du, Zhengdong Jin, Total Synthesis of the highly potent anti-HIV natural product daurichromenic acid along with its two chromane derivatives, rhododaurichromanic acids A and B, Org. Lett. 2003, 5, 4481-4484.
65. Yuguo Du*, Guofeng Gu, Guohua Wei, Yuxia Hua, R. J. Linhardt, Synthesis of Saponins Using Partially Protected Glycosyl Donors, Org. Lett. 2003, 5, 3627-3630.
66. Feng Yang, Yuxia Hua, Yuguo Du*, Synthesis of biantennary β-D-(1→6) glucosamine oligosaccharides, Carbohydr. Res. 2003, 338, 1313-1318.
67. Yuguo Du*, Guohua Wei, R.J. Linhardt, The first total synthesis of calabricoside A, Tetrahedron Lett. 2003, 44, 6887-6890.
68. Guohua Wei, Guofeng Gu, Yuguo Du*, Silver triflate, a mild alternative catalyst for glycosylation conditions using trichloroacetimidates as glycosyl donors, J. Carbohydr. Chem. 2003, 22, 385-393.
69. Guofeng Gu, Yuguo Du*, H. Hu, C. Jin, Synthesis of 2-chloro-4-nitro-phenyl ?-L-fucopyranoside: the substrate of ?-L-fucosidase (AFU), Carbohydr. Res. 2003, 338, 1603-1607.
70. Hongmei He, Guofeng Gu, Yuguo Du*, Synthesis of laminarin oligosaccharide derivatives having D-arabinofuranosyl side-chains, J. Carbohydr. Chem. 2003, 22, 265-273.
71. Feng Yang, Yuguo Du*, A practical synthesis of β-D-(1→6) glucosamine nonasaccharide, Carbohydr. Res. 2003, 338, 495-502.
72. Guofeng, Gu, Yuguo Du*, Synthesis of a pentasaccharide derivative corresponding to triterpenoid saponins isolated from Spergularia ramose, J. Chem. Soc., Perkin Trans. I. 2002, 2075-2079.
73. Hongmei He, Feng Yang, Yuguo Du*, Synthesis of natural ?-D-(1?3) glucopyranosyl oligosaccharides, Carbohydr. Res. 2002, 337, 1673-1678.
74. Feng Yang, Hongmei He, Yuguo Du*, Synthesis of (1?6)-?-D-linked glucosamine hexsaccharide, a potential antitumor and immunostimulating agent, Tetrahedron Lett. 2002, 43, 7561-7563.
75. Guofeng Gu, Yuguo Du*, Jingqi Pan, Concise synthesis of a buffalo milk pentasaccharide derivative, Carbohydr. Res. 2002, 337, 1313-1317.
76. Feng Yang, Hongmei He, Yuguo Du*, Unexpected ?-stereochemical outcomes of attempted ?-glycosylations Mujian Lu, Carbohydr. Res. 2002, 337, 1165-1169.
77. Feng Yang, Yuguo Du*, Synthesis of oligosaccharide derivatives related to those from sanqi, a Chinese herbal medicine from Panax notoginseng, Carbohydr. Res. 2002, 337, 485-491.
78. Yuguo Du, M. Zhang, F. Kong, Efficient and practical synthesis of three pentasaccharides core structures corresponding to N-glycan Tetrahedron 2001, 57, 1757-1763.
79. Yuguo Du, M. Zhang, F. Kong, A concise synthesis of Julibroside I related neosaponin, J. Chem. Soc., Perkin Trans. I. 2001, 2289-2293.
80. Q. Pan, Yuguo Du, F. Kong, J. Pan, M. Lu, Synthesis of 3-O-arabinosylated (1?6)-?-D-galactan Epitopes, J. Carbohydr. Chem. 2001, 20, 297-306.
81. M. Zhang, Yuguo Du, F. Kong, Practical synthesis of tetrasaccharide derivative corresponding to ristomycin A and ristocetin A, Carbohydr. Res. 2001, 330, 319-324.
82. G. Gu, F. Yang, Yuguo Du*, F. Kong, Synthesis of a hexasaccharide that relates to the arabinogalactan epitope Carbohydr. Res. 2001, 336, 99-106.
83. Yuguo Du*, M. Zhang, F. Yang, G. Gu, A facile access to 3,6-branched oligosaccharides: Synthesis of a glycopeptide derivative that relates to Lycium Barbarum L., J. Chem. Soc., Perkin Trans. I. 2001, 3122-3127.
84. Yuguo Du, M. Zhang, F. Kong, Highly efficient and practical synthesis of 3,6-branched oligosaccharides, Organic Lett. 2000, 2, 3797-3800.
85. Yuguo Du, Q. Pan, F. Kong, Synthesis of a tetrasaccharide representing a minimal epitope of arabinogalactan, Carbohydr. Res. 2000, 323, 28-35.
86. Yuguo Du, Q. Pan, F. Kong, An efficient and concise regioselective synthesis of ?-L-arabinofuranosyl octamer, Carbohydr. Res. 2000, 329, 17-24.
87. Q. Wang, M. Wolff, T. Polat, Yuguo Du, R. J. Linhardt, Inhibition of Neuraminidase with Neuraminic Acid C-glycosides, Bioorg. Med. Chem. Lett. 2000, 10, 941-944.
88. Yuguo Du, Q. Pan, F. Kong, Regio- and stereoselective synthesis of 1?5 linked ?-L-arabinofuranosyl oligosaccharide, Synlett 1999, 1648-1650.
89. Yuguo Du, F. Kong, The Regio- and Stereoselective Synthesis Of ?-L- Rhamnopyanosyl Oligosaccharides Via Sugar-Sugar Orthoester Formation And Rearrangment, J. Carbohydr. Chem. 1999, 18, 655-667.
90. H.G. Bazin, Yuguo Du, T. Polat, R. J. Linhardt, Synthesis of a versatile Neuraminic Acid “C”-disaccharide precusor for the synthesis of C-glycoside analogues of Gangliosides, J. Org. Chem. 1999, 64, 7254-7259.
91. Yuguo Du, R. J. Linhardt, I. R. Vlahov, Recent advances in stereoselective C-glycoside synthesis, Tetrahedron 1998, 54, 9913-9961.
92. Yuguo Du, T. Polat, R. J. Linhardt, The stereospecific synthesis of KDN ?-C-glycosides by samarium mediated reductive desulfonylation of glycosyl phenylsulfone, Tetrahedron Lett. 1998, 39, 5007-5010.
93. Yuguo Du, I. R. Vlahov, R. J. Linhardt, New strategy for the synthesis of D-glucopyranosiduronic acid glycosyl donors containing a latent C-4 acceptor, Carbohydr. Lett. 1998, 3, 53-58.
94. Yuguo Du, R. J. Linhardt, Stereospecific synthesis of ?-C-glycosyl derivatives (?-C-glycosides) of N-acetylneuraminic acid by samarium-mediated reductive desulfonylation of glycosyl phenylsulfone, Carbohydr. Res. 1998, 308, 161-164.
95. T. Polat, Yuguo Du, R. J. Linhardt, A general method for the synthesis of ?-C-glycosides of ulosonic acid by samarium-mediated reductive dechloronation Synlett 1998, 1195-6.
96. Yuguo Du, J. Lin, R. J. Linhardt, Regioselective synthesis of L-idopyranuronic acid derivatives: intermolecular aglycon transfer of dithioacetal under standard glycosylation conditions, J. Carbohydr. Chem. 1997, 16, 1327-1344.
97. Yuguo Du, I. R. Vlahov, R. J. Linhardt, An unusual ring contraction of silyl glucopyranosides to silyl glucofuranosides, Carbohydr. Lett. 1996, 2, 165-168.
98. Yuguo Du, W. Mao, F. Kong, Synthesis of 1,2-anhydro-altro- and -allopyranose ether, Carbohydr. Res. 1996, 282, 315-323.
99. Yuguo Du, F. Kong, Synthesis, conformation and glycosylation of 1,2-anhydro-manno-, -gluco-, -lyxo- and -xylo-furanose benzyl ether, J. Carbohydr. Chem. 1996, 15, 797-817.
100. Yuguo Du, F. Kong, A facile synthesis of 1,2-anhydro glycofuranose benzyl ether, Tetrahedron Lett. 1995, 36, 427-430.
101. Yuguo Du, F. Kong, Stereoselective glycosylation of fully benzylated 1,2- and 1,3-anhydrosugar- pyranose with protected serine methyl ester, J. Carbohydr. Chem. 1995, 14, 341-352.
102. Yuguo Du, F. Kong, Synthesis and unusual ring opening of 1,2-anhydro-3,4-di-O-benzyl- D-fucopyranose, Carbohydr. Res. 1995, 275, 413-420.
103. Yuguo Du, F. Kong, Synthesis and glycosylation of 1,3-anhydro-2,4-di-O-benzyl-L-arabinopyranose Carbohydr. Res. 1995, 275, 259-273.
Patents
1) R.J. Linhardt, H.G. Bazin, Yuguo Du, T. Polat, US 6,245,902 B1, 2001, Synthesis of ?-C-glycoside of ulosonic acid by samarium mediated reductive desulfonylation or dechloronation.
2) R.J. Linhardt, H.G. Bazin, Yuguo Du, T. Polat, PCT, WO 01/10877 A1, 2001, Synthesis of ganlioside (GM4) C-derivatives using SmI2 chemistry.
3) R. J. Linhardt, T. Tulay, Yuguo Du, US 6,590,110 B1, 2003, Method for synthesizing C-glycosides of ulosonic acids.

Research Interests

The current research interests are focusing on:
1) Degradation mechanism of organic pollutants; interaction between organic pollutants and bio-molecules.
2) Carbohydrate-based drug design and synthesis.

Conferences

   

Collaboration

   

Students

已指导学生

陈琦  博士研究生  083001-环境科学  

刘军  博士研究生  083001-环境科学  

华玉夏   博士研究生  083001-环境科学  

黄星  硕士研究生  083001-环境科学  

程水红  博士研究生  083001-环境科学  

张磊  博士研究生  083001-环境科学  

蔡超  博士研究生  083001-环境科学  

喻守益  硕士研究生  083001-环境科学  

吕迅  博士研究生  083001-环境科学  

杜萌  博士研究生  083001-环境科学  

张朝立  博士研究生  070303-有机化学  

阴俊霞  博士研究生  083001-环境科学  

高阳光  博士研究生  070321-化学生物学  

刘林  硕士研究生  085216-化学工程  

王元成  硕士研究生  070303-有机化学  

王琳琳  博士研究生  070303-有机化学  

高剑  博士研究生  070321-化学生物学  

刘义  博士研究生  070321-化学生物学  

肖铭  博士研究生  083001-环境科学  

杨炳海  硕士研究生  070321-化学生物学  

黄风尘  硕士研究生  083001-环境科学  

单秋丽  博士研究生  083001-环境科学  

马兴  博士研究生  070303-有机化学  

李敏  博士研究生  083001-环境科学  

张幸  博士研究生  070303-有机化学  

李金山  硕士研究生  070303-有机化学  

毕晶晶  博士研究生  070303-有机化学  

孙雪  博士研究生  070303-有机化学  

张扬  硕士研究生  0703Z1-化学生物学  

现指导学生

乔俊飞  博士研究生  083001-环境科学  

闫帅虎  硕士研究生  070303-有机化学  

余彩霞  硕士研究生  0703Z1-化学生物学  

文青  硕士研究生  077601-环境科学  

贺鹏  博士研究生  070303-有机化学  

赵传芳  博士研究生  070303-有机化学  

孙雪凤  硕士研究生  070303-有机化学  

赵翠霞  硕士研究生  085216-化学工程  

尚呈翔  博士研究生  070303-有机化学  

刘银鑫  博士研究生  070303-有机化学  

耿佳琳  硕士研究生  0703Z1-化学生物学