基本信息

张长生 男 博导 南海海洋研究所
电子邮件：czhang@scsio.ac.cn；czhang2006@gmail.com
通信地址：广州市新港西路164号
邮政编码：510301

ORCID: https://orcid.org/0000-0003-2349-3138

研究领域和科研项目

研究领域

围绕海洋微生物源药物分子的发现、生物合成、代谢工程和开发应用开展研究，探究多组学指导下海洋微生物源药物分子发现的新方法，解析复杂的生物合成途径和独特的酶催化机制，开展药物分子的生物活性和成药性评价研究，将合成生物学和代谢工程应用于海洋微生物源药物分子开发应用的实践和创新。

1. 生物大数据指导下的海洋微生物活性物质的发现。基于生物大数据，探究组学指导下的海洋微生物源药物分子发现的新方法，从中发现具有应用前景的先导分子，开展生物活性和成药性评价研究。

2. 药源分子生物合成及新功能酶的作用机制研究。阐明新药物分子的生物合成途径，揭示药物分子生物合成中包含的独特酶学机制和结构基础，定向改造开发具有高效催化功能的酶。

3. 合成生物学与代谢工程的实践和创新。采用合成生物学和代谢工程的技术手段，实现有应用前景的药物分子的产量提升和结构优化，为实现海洋微生物源药物分子的绿色制造奠定基础。


科研项目

国家重点研发计划项目，2023.12-2028.11

国家自然科学基金委

              重大项目（参与）2022-2026

              杰出青年基金 2012-2015

              重点项目 2017-2021

              重点国际（地区）合作研究项目 2019-2023

              面上项目（3）

广州市南沙区重点领域科技计划项目 2023.12-2026.11

广东省海洋经济发展（海洋六大产业）专项资金项目 2021.4-2023.3

中国科学院王宽诚率先人才计划“卢嘉锡国际团队项目” 2021-2023

海南省科技厅重大项目 2020.12-2023.12

国家重点基础研究发展计划（973计划）课题  2010-2014

中科院前沿领域重点项目 2016-2022

重要方向性项目 2009-2011

中科院先导专项重点任务 2013-2017

广东省海洋经济创新发展区域示范项目，课题 2013-2017

广东省自然基金重大培育项目 2015-2018

广东省特支计划人才项目（2） 2015-2019

广东省渔港建设和渔业产业发展专项 2016-2018


代表性文章

Liu et al Journal of the American Chemical Society, 2023, 145 (50): 27886–27899. DOI: 10.1021/jacs.3c11772. 

Jiang et al Angewandte Chemie International Edition, 2023, 62 (51): e202310728. DOI: 10.1002/anie.202310728.

Tan et al Angewandte Chemie International Edition, 2023, 62 (27): e202302043. DOI: 10.1002/anie.202302043.

Yang et al Nature Communications, 2022, 13: 5386. DOI: 10.1038/s41467-022-33131-0. 

De et al Nature Communications, 2022, 13: 4896. DOI: 10.1038/s41467-022-32641-1.

Zhang et al Science China Chemistry, 2021, 64 (10): 1736–1742. DOI: 10.1007/s11426-021-1072-6.

Zhu et al Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069. DOI: 10.1002/anie.202004978.

Huang et al Nature Communications, 2018, 9 (1): 2088. DOI: 10.1038/s41467-018-04487-z.

Zhang et al Science, 2006, 313(5791): 1291-1294. DOI: 10.1126/science.1130028. 

招生信息

招生专业

070703-海洋生物学

070321-化学生物学

071005-微生物学

招生方向

海洋生物学、海洋天然产物化学、海洋微生物学

教育背景

1998-09--今 德国乌帕塔尔大学 博士
1994-09--今 华东理工大学 硕士
1990-08--今 上海交通大学 学士

工作经历

2020/07  --  今                 中国科学院南海海洋研究所，副所长

2015/04  --  2020/07       中国科学院南海海洋研究所，所长助理

2012/08  --  2020/04       中国科学院南海海洋研究所，科研与规划处处长

2008/03  --  今                 中国科学院南海海洋研究所， 研究员

2003/01  --  2008/03       美国威斯康星大学药学院博士后，assistant Scientist

1997/07  --  1998/08      上海太平洋生物高科技有限公司，助理研究员       

教授课程

海洋生物资源可持续利用讲座

获得荣誉

2024年：  Editor, Marine Life Science & Technology

2023年： 2022年度中国海洋与湖沼十大科技进展

2022年：  Associate Editor，Microbiome 

2022年：  Associate Editor，Environmental Microbiome

2021年：  中国科学院南海海洋研究所优秀研究生指导教师荣誉称号

2021年：  英国皇家化学学会会士（Fellow of Royal Society of Chemistry, FRSC)

2020年：  中国科学院南海海洋研究所优秀研究生指导教师荣誉称号

2020年：  编委，Molecules

2019年：  Editorial board member, Natural Product Reports

2018年：  2018年度"中国科学院优秀导师奖"

2018年：  2018年度中国科学院广州教育基地"优秀研究生导师"

2018年：  中国科学院南海海洋研究所优秀研究生指导教师荣誉称号

2017年：  享受“国务院政府特殊津贴”

2016年：  国家科技创新领军人才

2016年：   第四届曾呈奎海洋科技奖--青年科技奖，中国海洋湖沼学会

2015年：  广东特支计划“杰出人才（南粤百杰）”

2014年：  有突出贡献中青年专家

2014年：  中青年科技创新领军人才

2014年：  广东特支计划”领军人才”

2013年：  择优终期评估”优秀”，中国科学院

2012年：   全国优秀科技工作者，中国科协

2011年：   国家杰出青年基金获得者（终期评估优秀），国家自然科学基金委员会

2009年：   择优支持入选者，中国科学院 

2005年： “First Midwest Carbohydrate Symposium”, Anatrace Best Poster Award  

出版信息

# (co-first author), * (corresponding author)

2024


180. Liangliang Bai,# Linping Wu,# Changsheng Zhang, Zhiwen Liu, Liang Ma, Jing Ni, Dezhen He, Mingxuan Zhu, Shaoyong Peng, Xiaoxia Liu, Huichuan Yu, Yuhe Lei, Yanxin Luo, Yu Zhang, Xiaolin Wang,* Gang Wei,* Yingjie Li.*  Replenishment of mitochondrial Na+ and H+ by ionophores potentiates cutaneous wound healing in diabetes. Materials Today Bio, 2024, DOI: 10.1016/j.mtbio.2024.101056. Available online 16 April 2024;

179. Yanqin Li,# Mengjing Cong,# Xiufeng Zhang, Yiguang Zhu, Wenjun Zhang, Yonghong Liu, Changsheng Zhang,* Junfeng Wang,* and Yan Yan.* An Enzymatic Carbon-Carbon Bond Cleavage and Aldol Reaction Cascade Converts an Angular Scaffold into the Linear Tetracyclic Core of Ochraceopones. Angewandte Chemie International Edition, 2024, 63, e202403365. DOI: 10.1002/anie.202403365. Accepted manuscript online: 07 March 2024; Version of Record online: 26 March 2024;

178. 姚景龙，陈海涛，张长生*，杨敏，王卫强，魏源送，潘刚，王亚炜，罗耀，钟慧，张镇秋。践行“一带一路”新发展理念，推动“中国-斯里兰卡联合科教中心”高质量发展。中国科学院院刊，2024, 39 (2): 381-386. DOI: 10.16418/j.issn.1000-3045.20230908002. Published 21 Feb 2024.

177. Youzhe Chen,# Hongbo Jin,# Weiliang Xiong, Zhuangjie Fang, Weiguang Sun,Yiguang Zhu, Liping Zhang, Yonghui Zhang, Wenjun Zhang,* Changsheng Zhang.* Discovery of Aburatubolactams Reveals Biosynthetic Logic for Distinct 5/5-Type Polycyclic Tetramate Macrolactams. Organic Letters, 2024, 26 (8): 1677–1682. DOI: 10.1021/acs.orglett.4c00168. Publication Date: February 16, 2024; Published in issue 1 March 2024.

176. Wei Liu,# Shilan Zhai,# Liang Ma,* Liping Zhang, Yuchan Chen, Zhiyong Liu, Tianyu Zhang, Weimin Zhang, Changsheng Zhang,* Wenjun Zhang.* Expanding the Chemical Diversity of Grisechelins via Heterologous Expression. Journal of Natural Products, 2024, 87 (2): 371-380. DOI: 10.1021/acs.jnatprod.3c01132. Published online 1 February 2024; Published in issue 23 February 2024.

175. Bidhan Chandra De, Chunfang Yang, Chunshuai Huang, Changsheng Zhang, and Wenjun Zhang.* Non-enzymatic synthesis of C-methylated fluostatins: discovery and reaction mechanism. Organic & Biomolecular Chemistry, 2024, 22 (6): 1152-1156. DOI: 10.1039/d3ob01920a. first published on 03 Jan 2024; advance article 12 Jan 2024; in issue 7 Feb 2024.

Graphical abstract: Non-enzymatic synthesis of C-methylated fluostatins: discovery and reaction mechanism

174. Bin Tan, Qingbo Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Naturally Occurring and Widespread Resistance to Bioactive Natural Products. ChemMedChem, 2024, 19 (3): e202300619. DOI: 10.1002/cmdc.202300619 (invited review). Accepted manuscript online: 16 December 2023; Version of Record online: 12 January 2024; Issue Online: 01 February 2024.  


2023

173. Kai Liu,# Jinyan Zhang,# Guangtao Zhang,#* Liping Zhang, Zhen Meng, Liang Ma, Wenjun Zhang, Weiliang Xiong, Yiguang Zhu, Binju Wang,* Changsheng Zhang.* Deciphering Deoxynybomycin Biosynthesis Reveals Fe(II)/α-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition. Journal of the American Chemical Society, 2023, 145 (50): 27886–27899. DOI: 10.1021/jacs.3c11772. Publication online 6 December, 2023. ("Hot off the press" in Natural Product Reports, 2024, DOI: 10.1039/d4np90005g 41 (2): 157–161.)

172. Peng Jiang,# Hongbo Jin,# Guangtao Zhang, Wenjun Zhang, Wei Liu, Yiguang Zhu, Changsheng Zhang,* Liping Zhang.* A Mechanistic Understanding of the Distinct Regio- and Chemo-selectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angewandte Chemie International Edition, 2023, 62 (51): e202310728. DOI: 10.1002/anie.202310728; Angewandte Chemie, 2023, 135 (51):  e202310728. DOI: 10.1002/ange.202310728. Accepted manuscript online: 02 November 2023; Version of Record online: 14 November 2023; Issue Online: 11 December 2023.



171. Zhuangjie Fang, Qingbo Zhang,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin. Organic Letters, 2023, 25 (34): 6346-6351. DOI: 10.1021/acs.orglett.3c02231. Published online 22 August 2023; Published inissue 1 September 2023. ("Hot off the press" in Natural Product Reports, 2023, 40 (10): 1590-1594. DOI: 10.1039/D3NP90045B). 

170. Xiaoyang Zhao#, Youzhe Chen#, Ting Long, Zhiying Liu, Qingbo Zhang, Haibo Zhang, Yan Yan, Changsheng Zhang*, Yiguang Zhu*. Genome Mining and Biosynthetic Reconstitution of Fungal Depsidones Reveal a Dual Functional Cytochrome P450 for Ether Formation. Journal of Natural Products, 2023,  86 (8): 2046–2053. DOI: 10.1021/acs.jnatprod.3c00609. Published online 11 August 2023; Published inissue 25 August 2023.

169. Ke-Gang Linghu, Tian Zhang, Guang-Tao Zhang, Peng Lv, Wen-Jun Zhang, Guan-Ding Zhao, Shi-Hang Xiong, Qiu-Shuo Ma, Ming-Ming Zhao, Meiwan Chen, Yuan-Jia Hu, Changsheng Zhang,* Hua Yu.* Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy. Journal of Pharmaceutical Analysis, 2023, DOI: 10.1016/j.jpha.2023.07.009. Pre-proof Available online 17 July 2023; corrected proof online 7 Feb 2024;

168. Mengyi Zhu,# Lijuan Wang,# Haibo Zhang, Liping Zhang, Bin Tan, Qi Huang, Yiguang Zhu, and Changsheng Zhang*. Biosynthesis and engineered overproduction of everninomicins with promising activity against multidrug-resistant bacteria. ACS Synthetic Biology, 2023, 12 (5): 1520–1532. DOI: 10.1021/acssynbio.3c00055. Published online 21 April 2023; Published inissue 19 May 2023. (Featured in 中国科学院，中科院之声V，粤科网，科学网， 南海所)

167. Bin Tan#, Liping Zhang#, Qingbo Zhang#, Siqiang Chen, Weiliang Xiong, Yiguang Zhu*, Changsheng Zhang*. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, 2023, 62 (27): e202302043. DOI: 10.1002/anie.202302043; Angewandte Chemie, 2023, 135 (27): e202302043. DOI: 10.1002/ange.202302043. First published online 19 April 2023; Version of Record online: 09 May 2023; Issue Online: 27 June 2023; "Hot paper" in Angew Chem. (Featured in 中国科学院，中科院之声V，粤科网，X-MOL， 南海所, )

166. Lijuan Wang#, Mengyi Zhu#, Qingbo Zhang, Shilan Zhai, Yiguang Zhu, Haibo Zhang*, and Changsheng Zhang*. Biosynthetic diversification of fidaxomicin aglycones by heterologous expression and promoter refactoring. Journal of Natural Products, 2023, 86 (4): 986–993. DOI: 10.1021/acs.jnatprod.3c00001. Published online 12 April 2023; Published in issue April 28 2023.

165. Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang*, Qingbo Zhang*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979–985. DOI: 10.1021/acs.jnatprod.2c01169. Published online 15 March 2023; Published in issue April 28 2023.

164. Ziqian Cheng, Qingbo Zhang, Jing Peng, Xiaoyang Zhao, Liang Ma, Changsheng Zhang*, Yiguang Zhu*. Genomics-Driven Discovery of Benzoxazole Alkaloids from the Marine-Derived Micromonospora sp. SCSIO 07395. Molecules, 2023, 28 (2): 821. DOI:  10.3390/molecules28020821. Published 13 January 2023.

163. Bin Tan,# Qingbo Zhang,# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu*, and Changsheng Zhang*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, 41 (12): 1478–1484. DOI: 10.1002/cjoc.202200818. First Published 17 January 2023; Version of Record online: 30 March 2023; Issue Online: 15 May 2023. (Preprint January 06 2023, DOI: 10.22541/au.167303804.43320409/v)

162. Bin Tan, Qingbo Zhang*, Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84. DOI: 10.1021/acs.jnatprod.2c00772. Published online 6 January 2023; Published in issue 27 January 2023.

161. Xuemin Ding, Weixia Ye, Bin Tan, Qiaoyun Song, Yuchan Chen, Wei Liu, Lili Sun, Wei Tang, Yulei Qiao, Qingbo Zhang, Haibo Zhang, Ying Wang, Weimin Zhang, Changsheng Zhang*, Wenjun Zhang*. Talachalasins A-C, undescribed cytochalasans with a 16β-methyl or 2-oxabicyclo­[3.3.1]nonan-3-one unit from the deep-sea-derived fungus Talaromyces muroii sp. SCSIO 40439. Chinese Journal of Chemistry, 2023, 41 (8): 915–923. DOI: 10.1002/cjoc.202200744. First published: 05 January 2023; Version of Record online: 23 February 2023; Issue Online: 15 March 2023.



2022

160. Chunyan Fang, Qingbo Zhang, Wenjun Zhang,  Changsheng Zhang*, and Yiguang Zhu*. Discovery of efrotomycin congeners and heterologous expression-based insights into the self-resistance mechanism. Journal of Natural Products, 2022, DOI: 10.1021/acs.jnatprod.2c00986. Epub 29 November 2022.


159. Bin Tan, Qingbo Zhang*, Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis. Tetrahedron, 2022, 127: 133103. DOI: 10.1016/j.tet.2022.133103. Epub 29 October 2022.

158.  Tingting Xu,# Qingqing Gan,# Qiang Liu, Ruidong Chen, Xuhui Zhen, Changsheng Zhang and Jinsong Liu*. Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel activator-dependent form of GT family. Acta Crystallographica Section D Structural Biology, 2022,  78 (10): 1235-1248. DOI: 10.1107/S2059798322008658. Epub 27 September 2022.

157. Chunfang Yang,# Liping Zhang,# Wenjun Zhang, Chunshuai Huang, Yiguang Zhu, Xiaodong Jiang, Wei Liu, Mengran Zhao, Bidhan Chandra De, Changsheng Zhang*. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. Nature Communications, 2022, 13, 5386. DOI: 10.1038/s41467-022-33131-0. Epub 2022 Sept 14.

156. Bidhan Chandra De#, Wenjun Zhang#, Chunfang Yang, Attila Mándi, Chunshuai Huang, Liping Zhang, Wei Liu, Mark W Ruszczycky, Yiguang Zhu, Ming Ma, Ghader Bashiri, Tibor Kurtán, Hung-wen Liu*, Changsheng Zhang*. Flavin-enabled reductive and oxidative epoxide ring opening reactions. Nature Communications, 2022, 13: 4896. DOI: 10.1038/s41467-022-32641-1. Epub 2022 Aug 20.

155. Wei Liu, Liang Ma, Li-Ping Zhang, Yu-Chan Chen, Qing-Bo Zhang, Hai-Bo Zhang, Wei-Min Zhang, Changsheng Zhang*, Wen-Jun Zhang*. Two new phenylhydrazone derivatives from the Pearl River estuary sediment-derived Streptomyces sp. SCSIO 40020. Marine Drugs, 2022, 20 (7): 449. DOI: 10.3390/md20070449. Epub 2022 Jul 09.

154. 张海波, Imran Khan, Kumar Saurav, 张丽萍, 方壮杰, 张鑫雅, 彭方, 张长生. 鲸鱼骨来源真菌Penicillium sp. S2014503的生物活性成分[J]. 热带海洋学报, 2023, 42 (2): 132-140. DOI: 10.11978/2022074. Epub 2022 May 16.

153. 朱义广，牟鹏云，张庆波，张长生。中国南海来源真菌Penicillium sp. SCSIO 40438次级代谢产物研究。热带海洋学报, 2022, DOI: . Epub 2022 May 10.10.11978/2022079

152. Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang*. Antifungal Macrolides Kongjuemycins from Coral-associated Rare Actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic Letters, 2022, 24 (19): 3482–3487. DOI: 10.1021/acs.orglett.2c01089. (selected as Supplementary cover article) Epub 2022 April 27.

            

151. 龙婷，张庆波，牟鹏云，王俊锋，张长生*，朱义广*。海洋来源节菱孢菌ZSDS1-F3中PKS-NRPS类天然产物挖掘。微生物学报，2022, 62 (8): 3224-3235. DOI:  10.13343/j.cnki.wsxb.20210783. Epub 2022 Apr 21.

150. 王璐，叶伟霞，赵梦冉，张庆波，张丽萍，张长生，张文军*。湛江红树林内生真菌分离筛选及Stemphyliums sp. SCSIO 40436代谢产物研究。微生物学通报，2022, 49 (8): 2995-3007. DOI: 10.13344/j.microbiol.china.211223. Epub 2022 Apr 01.

149. 赵梦冉，王璐，叶伟霞，张庆波，马亮，张丽萍，张文军，张长生，杨春芳*。湛江高桥红树林沉积物放线菌多样性及其中一株链霉菌产生的germicidins类化合物的鉴定。微生物学报， 2022, 62 (5): 1740-1753. DOI: 10.13343/j.cnki.wsxb.20210531  ; CNKI. Epub 2022 Feb 23.

148. 徐慧欣，王 璐，张丽萍，刘威，张庆波，张海波，张长生，张文军*。Malfilamentoside A 的构型确定与新呋喃糖苷类化合物malfilamentoside D。 有机化学，2022, DOI: 10.6023/cjoc2021110038. Epub 2021 Dec 30.

147. 叶伟霞，赵梦冉，王璐，蒋晓东，张文军，张长生，田海妍*。南海珊瑚来源真菌Aspergillus sp. SCSIO 40435的分离鉴定及其次级代谢产物研究。微生物学报，2022, .62 (5): 1819–1831. DOI: ; . 10.13343/j.cnki.wsxb.20210568CNKIEpub 2021 Nov 25


2021


146. Xiao-Zhen Wu, Wen-Jun Huang, Wei Liu, Attila Mándi, Qingbo Zhang, Liping Zhang, Wenjun Zhang, Tibor Kurtán, Cheng-Shan Yuan,* Changsheng Zhang.* Penicisteckins A‒F, Isochroman-Derived Atropisomeric Dimers from Penicillium steckii HNNU-5B18. Journal of Natural Products, 2021, 84 (11): 2953–2960. DOI: 10.1021/acs.jnatprod.1c00787. Epub 2021 Nov 17.

145. Ruoxuan Bao,# Yongmei Meng,# Haibo Zhang, Chen Yang, Wei Li, Cheng Zhang, Jinye Zhang, Renqiang Sun, Zengxia Li, Wei Jiang, Chensong Zhang, Changsheng Zhang,* Hai-Xin Yuan,* Yongjun Dang.* Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death & Disease, 2021,12, Article number: 972. DOI: 10.1038/s41419-021-04264-9. Epub 2021 Oct 20.

144. Bidhan Chandra De, Wenjun Zhang, Guangtao Zhang, Zhiwen Liu, Bin Tan, Qingbo Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Host-dependent Heterologous Expression of Berninamycin Gene Cluster Leads to Linear Thiopeptide Antibiotics. Organic & Biomolecular Chemistry, 2021, 19 (41): 8940-8946. DOI:  10.1039/D1OB01759D. Epub 2021 Oct 1. ("Hot off the press" in Natural Product Reports, 2021, 38 (12): 2139-2144. DOI: 10.1039/D1NP90046C)

143. 翟诗岚，刘威，吴正超，朱义广，张文军，张长生，马亮*。 珠江口沉积物来源链霉菌SCSIO 40020中bafilomycins的鉴定及其生物合成基因簇的异源表达。微生物学报, 2021, 61 (12): 3991-4005. 摘要 DOI: 10.13343/j.cnki.wsxb.20210121. Epub 2021 Sept 14.

142. Haibo Zhang, Liping Zhang, Imran Khan, Guangtao Zhang, Yiguang Zhu & Changsheng Zhang.* A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds. SCIENCE CHINA Chemistry, 2021, DOI: 10.1007/s11426-021-1072-6. Epub 2021 Aug 31.

141. Chunshuai Huang, Chunfang Yang,* Wenjun Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of An Unexpected 1,4-Oxazepine-Linked Seco-Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP. Journal of Natural Products, 2021,  84 (8): 2336–2344. DOI: 10.1021/acs.jnatprod.1c00461. Epub 2021 Aug 12.

140. Lu Wang,# Yanbing Huang,# Liping Zhang, Zhiwen Liu, Wei Liu, Huixin Xu, Qingbo Zhang, Haibo Zhang, Yan Yan, Zhiyong Liu, Tianyu Zhang, Wenjun Zhang,* Changsheng Zhang.* Structures and Absolute Configurations of Phomalones from Coral-associated fungus Parengyodontium album sp. SCSIO 40430.  Organic & Biomolecular Chemistry, 2021, 19 (27): 6030-6037. DOI: 10.1039/d1ob00869b. Epub 2021 Jun 29.

139. Pengyun Mou, Qingbo Zhang, Jing Peng, Xiaodong Jiang, Liping Zhang, Zhongbo Zhou,* Changsheng Zhang, Yiguang Zhu*. Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434. Fitoterapia, 2021, 152: 104937. DOI: 10.1016/j.fitote.2021.104937. Epub 2021 May 15.

138. 金红波，张丽萍，张文军，张光涛，朱义广，刘威，张长生*。斑鸠霉素氧化酶CftA体外生物活性研究。微生物学通报，2021，48 (7): 2389-2397. DOI:  10.13344/j.microbiol.china.210150. Epub 2021 Apr 27.

137. Xiaodong Jiang, Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang.* Discovery of a New Asymmetric Dimer Nenestatin B and Implications of Dimerizing Enzyme in a Deep Sea Actinomycete. Organic & Biomolecular Chemistry, 2021,19 (19): 4243-4247. DOI: 10.1039/d1ob00310k. Epub 2021 Apr 22. ("Hot off the press" in Natural Product Reports, 2021, 38 (8): 1418-1422. DOI: 10.1039/D1NP90030G)


136. Jing Peng, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Ting Long, Ziqian Cheng, Changsheng Zhang,* Yiguang Zhu*. New piericidin derivatives from a marine-derived Streptomyces sp. SCSIO 40063 with cytotoxicity activity. Natural Product Research, 2021, DOI:  10.1080/14786419.2021.1901699. Epub 2021 Mar 19.

135. Xinya Zhang,# Siqiang Chen,# Liping Zhang, Qingbo Zhang, Wenjun Zhang, Yuchan Chen, Weimin Zhang, Haibo Zhang,* and Changsheng Zhang.* Dassonmycins A and B, Polycyclic thioalkaloids from a marine sponge-derived Nocardiopsis dassonvillei SCSIO 40065. Organic Letters, 2021, 23 (8): 2858–2862. DOI: 10.1021/acs.orglett.1c00328. ( Front Cover paper ). Epub 2021 Mar 11. ("Hot off the press" in Natural Product Reports, 2021, 38 (6): 1053-1057. DOI: 10.1039/D1NP90020J).

          


134. Imran Khan, Jing Peng, Zhuangjie Fang, Wei Liu, Wenjun Zhang, Qingbo Zhang, Liang Ma, Guangtao Zhang, Changsheng Zhang* and Haibo Zhang.* Cylindromicin from arctic-derived fungus Tolypocladium sp. SCSIO 40433. Molecules, 2021, 26(4): 1080. DOI: 10.3390/molecules26041080. Epub 2021 Feb 18.

133. Hui-Xin Xu, Ting Yang, Li-Ping Zhang, Wei Liu, Hai-Bo Zhang, Qing-Bo Zhang, Chang-Sheng Zhang*, Wen-Jun Zhang*. Ocauxarthrol A from Auxarthron umbrinum SCSIO 40432 and configurational reassignment of chrysoqueen and auxarthrols. Tetrahedron Letters, 2021, 66: 152842. DOI:  10.1016/j.tetlet.2021.152842. Epub 2021 Feb 4.

132. Chunfang Yang,# Chunshuai Huang,# Chunyan Fang, Liping Zhang, Siqiang Chen, Qingbo Zhang, Changsheng Zhang*, Wenjun Zhang*. Inactivation of flavoenzyme-encoding gene flsO1 in fluostatin biosynthesis leads to diversified angucyclinone derivatives. Journal of Organic Chemistry, 2021,  86 (16): 11019–11028. DOI: 10.1021/acs.joc.0c02517. (Supplementary cover article) ("Hot off the press" in Natural Product Reports, 2021,  DOI: 10.1039/d1np90037d). Epub 2021 Feb 3.

https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/joceah/2021/joceah.2021.86.issue-16/acs.joc.0c02517/20210812/images/medium/jo0c02517_0005.gif

131. Liang Ma, Wenjun Zhang, Zhiwen Liu, Yanbing Huang, Qingbo Zhang, Xinpeng Tian, Changsheng Zhang, Yiguang Zhu.* Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment,  producing diverse bioactive natural products. Marine Genomics, 2021, 55: 100803. DOI: 10.1016/j.margen.2020.100803. Epub 2020 Jul 9.

130. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, and Changsheng Zhang. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research, 2021, 35(2):188-194. DOI: 10.1080/14786419.2019.1616729 .Epub 2019 May 29.



2020


129. Siqiang Chen, Qingbo Zhang, Xinya Zhang, Xiaodong Jiang, Haibo Zhang, Yiguang Zhu, Changsheng Zhang, and Liping Zhang.* A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064. Natural Product Research, 2020, DOI: 10.1080/14786419.2020.1867131. Epub 2020 Dec 30.

128. 方春艳, 朱义广, 张长生, 张庆波*。PPtase高表达海洋放线菌Streptomyces sp. SCSIO 40060的次级代谢产物研究。中国海洋药物，2020, 39 (6): 12-18.  HTML Epub 2020 Dec 15.

127. Liping Zhang,# Bidhan Chandra De,# Wenjun Zhang,* Attila Mándi, Zhuangjie Fang, Chunfang Yang, Yiguang Zhu, Tibor Kurtán, and Changsheng Zhang.* Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U. Journal of Biological Chemistry, 2020, 295 (50): 16987-16997. DOI: 10.1074/jbc.RA120.015563 . Epub 2020 Oct 1.

126. Zhuangjie Fang,# Xiaodong Jiang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu,Changsheng Zhang.* S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130. DOI: 10.1021/acs.jnatprod.0c00719. Epub 2020 Sep 24.

125. Jinxin Xu,#,* Xiaowen Tang,# Yiguang Zhu, Zhijun Yu, Kai Su, Yulong Zhang, Yan Dong, Weiming Zhu, Changsheng Zhang, Ruibo Wu, Jinsong Liu.* Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition. Communications Biology, 2020, 3(1): 455. DOI: 10.1038/s42003-020-01184-w. Epub 2020 Aug 19.

124. Imran Khan, Haibo Zhang,* Wei Liu,  Liping Zhang, Fang Peng, Yuchan Chen, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, and Changsheng Zhang.* Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019.  RSC Advances, 2020, 10 (35): 20738-20744. DOI:  10.1039/D0RA03529G. Epub 2020 Jun 2.

123. Ling Liu, Sainan Li, Runze Sun, Xiangjing Qin, Jianhua Ju, Changsheng Zhang, Yanwen Duan,* and Yong Huang.* Activation and characterization of bohemamine biosynthetic gene cluster from Streptomyces sp. CB02009. Organic Letters, 2020, 22 (12): 4614–4619. DOI: 10.1021/acs.orglett.0c01224. Epub 2020 May 28.

122. Yuanqi Wang, Changsheng Zhang, Yilei Zhao*, Rosalinda Zhao, Kendall Houk.  Understand the specific regio- and enantioselectivity of fluostatin  conjugation in the post-biosynthesis. Biomolecules, 2020, 10 (6): 815. DOI: 10.3390/biom10060815. Epub 2020 May 26.

121. Yiguang Zhu,# Qingbo Zhang,# Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu,* and Changsheng Zhang.* Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069. DOI: 10.1002/anie.202004978 and 10.1002/ange.202004978. Epub 2020 Apr 23.


120. Wei Liu,‡ Vinay Gopal Jannu,‡ Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang* and Yiguang Zhu*. Heterologous expression of the trichostatin gene cluster and functional characterization of the N-methyltransferase TsnB8. Organic & Biomolecular Chemistry, 2020, 18 (19): 3649-3653. DOI: 10.1039/d0ob00617c. Epub 2020 Apr 23.

119. Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan,* and Shoudeng Chen.* Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharmaceutica Sinica B (APSB), 2020, DOI: 10.1016/j.apsb.2020.04.009. Epub 2020 Apr 20.

118. Chunyan Fang, Qingbo Zhang, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Liang Ma, Haibo Zhang, and  Changsheng Zhang.* Proximicins F and G and diproximicin A: aminofurans from the marine-derived Verrucosispora sp. SCSIO 40062 by overexpression of PPtase genes. Journal of Natural Products, 2020, 83 (4): 1152-1156. DOI:  10.1021/acs.jnatprod.9b01185. Epub 2020 Mar 19.


117. Bin Tan,# Qingbo Zhang,# Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang.* Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides.  ACS Chemical Biology, 2020, 15 (3): 766-773. DOI: 10.1021/acschembio.9b00997.  Introducing Our Authors for Bin Tan (DOI: 10.1021/acschembio.0c00202). Epub 2020 Mar 9.

116. Mahder S. Manenda, Marie-Ève Picard, Liping Zhang, Normand Cyr, Xiaojun Zhu, Julie Barma, Manon Couture, Changsheng Zhang, and Rong Shi.* Structural analyses of the group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. Journal of Biological Chemistry, 2020, 295 (14): 4709-4722. DOI: 10.1074/jbc.RA119.011212. Epub 2020 Feb 28.

115. Hongbo Jin, Wenjun Zhang, Guangtao Zhang, Liping Zhang, Wei Liu, and Changsheng Zhang.* Engineered biosynthesis of 5/5/6 type polycyclic tetramate macrolactams in an ikarugamycin (5/6/5 type)-producing chassis.  Organic Letters, 2020, 22 (5): 1731-1735. DOI: 10.1021/acs.orglett.9b04672. Epub 2020 Feb 13. ("Hot off the press" in Natural Product Reprots, 2020, 37 (4): 472-476. DOI: 10.1039/D0NP90014A) 

114. Bin Tan,# Siqiang Chen,# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang, and Changsheng Zhang.* Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066. DOI: 10.1021/acs.orglett.9b04597.  Epub 2020 Jan 23.


113. Liang Ma, Qingbo Zhang, Chunfang Yang, Yiguang Zhu, Liping Zhang, Lijuan Wang, Zhiwen Liu, Guangtao Zhang, and Changsheng Zhang*. Assembly line and post-PKS modifications in the biosynthesis of marine polyketide natural products. Book chapter in: Comprehensive Natural Products III: Chemistry and Biology. Book editor, Begley, T. P. & H.-w. Liu; Volume editor, Y. Tang, 2020, Volume 1: 139-197. DOI: 10.1016/B978-0-12-409547-2.14711-0. Epub 2019 Nov 23.


2019


112. Wei Liu, Wenjun Zhang, Hongbo Jin, Qingbo Zhang, Yuchan Chen, Xiaodong Jiang, Guangtao Zhang, Liping Zhang, Weimin Zhang, Zhigang She, and Changsheng Zhang.* Genome mining of marine-derived Streptomyces sp. SCSIO 40010 leads to cytotoxic new polycyclic tetramate macrolactams. Marine Drugs, 2019, 17 (12): 663. DOI: 10.3390/md17120663. Epub 2019 Nov 25. ( See also in the printed book, "Genome Mining and Marine Microbial Natural Products",  Kui Hong, Changsheng Zhang, Alan Dobson  (Eds.). ISBN 978-3-03928-090-2 (Pbk); ISBN 978-3-03928-091-9 (PDF)

         

111. Liujuan Zheng,# Xiaodong Jiang,# Qingbo Zhang, Yiguang Zhu, Haibo Zhang, Wenjun Zhang, Kumar Saurav, Jinsong Liu, and Changsheng Zhang.* Discovery and biosynthesis of neoenterocins indicate a skeleton rearrangement of enterocin. Organic Letters, 2019, 21 (22): 9066-9070. DOI: 10.1021/acs.orglett.9b03460. Epub 2019 Oct 28. ("Hot off the press" in Natural Product Reprots, 2020, 37 (2): 145-149. DOI: 10.1039/D0NP90004D) 

110. Ziquan Yu, Haibo Zhang, Chengshan Yuan, Qingbo Zhang, Imran Khan, Yiguang Zhu, and Changsheng Zhang.* Characterizing two cytochrome P450s in tiacumicin biosynthesis reveals reaction timing for tailoring modifications. Organic Letters, 2019, 21 (18): 7679-7683.  DOI: 10.1021/acs.orglett.9b03100. Epub 2019 Sep 11. ("Hot off the press" in Natural Product Reprots, 2019, 36 (12): 1614-1618. DOI: 10.1039/C9NP90045D) 

109. Chunshuai Huang, Chunfang Yang, Zhaungjie Fang, Liping Zhang, Wenjun Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of stealthin derivatives and Implication of the amidotransferase FlsN3 in the biosynthesis of nitrogen-containing fluostatins. Marine Drugs, 2019, 17 (3): 150. DOI: 10.3390/md17030150. Epub 2019 Mar 4.

 

108. Chunshuai Huang, Chunfang Yang, Wenjun Zhang, Yiguang Zhu, Liang Ma, Zhuangjie Fang, and Changsheng Zhang*. Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster. The Journal of Antibiotics, 2019, 72 (5): 311-315. DOI: 10.1038/s41429-019-0161-4. Epub 2019 Feb 28.

107. Zhiwen Liu,# Liang Ma,# Liping Zhang, Wenjun Zhang, Yiguang Zhu, Yuchan Chen, Weimin Zhang, and Changsheng Zhang*. Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers. Organic & Biomolecular Chemistry, 2019, 17 (5): 1053-1057. Epub 2018 Dec 6. DOI:  10.1039/C8OB02775G (contribution to the themed collection: "Biosynthesis" as an outside front cover. PDF)

             


2018

106. Chunshuai Huang, Chunfang Yang, Yiguang Zhu*, Wenjun Zhang, Cheng-shan Yuan, and Changsheng Zhang*. Marine bacterial aromatic polyketides from host-dependent heterologous expression and fungal mode of cyclization. Frontiers in Chemistry, 2018, 6 (10): 528. DOI: 10.3389/fchem.2018.00528. Epub 2018 Oct 30. (contribution to section Medicinal and Pharmaceutical Chemistry of research topic "Natural Products from Marine Microorganisms")

105. Wenjun Zhang, Guangtao Zhang, Liping Zhang, Wei Liu, Xiaodong Jiang, Hongbo Jin, Zhiwen Liu, Haibo Zhang, Aihua Zhou, Changsheng Zhang*.  New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060. Tetrahedron, 2018, 74 (47): 6839-6845. DOI: 10.1016/j.tet.2018.10.007. Epub 2018 Oct 11.

104. 黄艳冰, 蒋晓东, 刘威, 黄春帅, 张丽萍, 诸晗宁, 张长生, 张文军*。叶状蔷薇珊瑚来源真菌Parengyodontium album SCSIO 40430次级代谢产物研究。微生物学通报，2018, 45(9): 1881-1888. DOI: 10.13344/j.microbiol.china.180226. Epub 2018 Jun 6.

103. 张长生, 李文利。海洋微生物学：新机遇，新挑战。微生物学通报，2018, 45 (9): 1841-1842. DOI: 10.13344/j.microbiol.china.189009. Epub 2018 Sep 20.


102. Chunshuai Huang,# Chunfang Yang,# Wenjun Zhang, Liping Zhang, Bidhan Chandra De, Yiguang Zhu, Xiaodong Jiang, Chunyan Fang, Qingbo Zhang, Cheng-Shan Yuan, Hung-wen Liu*, Changsheng Zhang*.  Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines.  Nature Communications, 2018, 9 (1): 2088. DOI: 10.1038/s41467-018-04487-z  . Epub 2018 May 25. (Featured in a Nature Communications  Editors' Highlights Webpage of recent research on Organic Chemistry and Chemical Biology by Julia Eckhoff)

101. Haibo Zhang, Xiaoxing Tian, Xiaohui Pu, Qingbo Zhang, Wenjun Zhang, Changsheng Zhang*.  Tiacumicin congeners with improved antibacterial activities from a halogenase-inactivated mutant. Journal of Natural Products, 2018, 81 (5): 1219–1224. DOI: 10.1021/acs.jnatprod.7b00990. Epub 2018 Apr 20.

100. Wei Lin,# Kalyan Das,# David Degen,# Abhishek Mazumder, Diego Duchi, Dongye Wang, Yon W. Ebright, Richard Y. Ebright, Elena Sineva, Matthew Gigliotti, Aashish Srivastava, Sukhendu Mandal, Yi Jiang, Yu Liu, Ruiheng Yin, Zhening Zhang, Edward T. Eng, Dennis Thomas, Stefano Donadio, Haibo Zhang, Changsheng Zhang, Achillefs N. Kapanidis, Richard H. Ebright*. Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3). Molecular Cell, 2018, 70 (1): 60-71. DOI: 10.1016/j.molcel.2018.02.026. Epub 2018 Mar 29.


2017

99. Ruidong Chen,# Qingbo Zhang,# Bin Tan, Liujuan Zheng, Huixian Li, Yiguang Zhu, Changsheng Zhang*. Genome mining and activation of a silent PKS/NRPS gene cluster direct the production of totopotensamides. Organic Letters, 2017, 19(20): 5697-5700. DOI: 10.1021/acs.orglett.7b02878. Epub 2017 Oct 11.

98. Liang Ma, Wenjun Zhang, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Qingbo Zhang, Liping Zhang, Chengshan Yuan & Changsheng Zhang*. Identification and characterization of a gene cluster for tryptophan dimers in deep sea-derivedStreptomyces sp. SCSIO 03032. Applied Microbiology and Biotechnology, 2017, 101 (15): 6123–6136. DOI: 10.1007/s00253-017-8375-5. Epub 2017 Jun 15.

97. Qingbo Zhang,# Huixian Li,# Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu* and Changsheng Zhang*. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science, 2017, 8(7): 5067-5077. DOI: 10.1039/C7SC01182B. ("Hot off the press" in Natural Product Reports, 2017, 34 (10): 1180-1184. DOI: 10.1039/C7NP90040F.  Epub 2017 May 4. Selected in Themed collection "In celebration of Chinese New Year", a special online collection of articles to celebrate Chinese New Year. This collection includes some of most popular articles from China and highlights a number of outstanding contributions)


96. 田小杏, Kumar Saurav, 张庆波, 张文军, 蒲晓辉, 张长生, 张海波*。2株南极来源放线菌所产的二酮哌嗪类化合物研究。中国海洋药物，2017, 36 (3): 67-72. Epub 2017 Jun 15.

95. Xiaodong Jiang, Qingbo Zhang, Yiguang Zhu, Fangling Nie, Zhengchao  Wu, Chunfang Yang, Liping Zhang, Xinpeng Tian, Changsheng Zhang*. Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089. Tetrahedron, 2017, 73 (26): 3585–3590. (Dedicated to the Tetrahedron Young Investigator Prize Special Issue in honor of Professor Ang Li). DOI: 10.1016/j.tet.2017.03.054. Epub 2017 Mar 23.

94. Wenjun Zhang,# Chunfang Yang,# Chunshuai Huang, Liping Zhang, Haibo Zhang, Qingbo Zhang, Cheng-Shan Yuan, Yiguang Zhu, Changsheng Zhang*. Pyrazolofluostatins A-C,  pyrazole-fused nenzo[a]fluorenes from South China Sea-derived Micromonospora rosaria SCSIO N160. Organic Letters, 2017, 19 (3): 592–595. ("Hot off the press" in Natural Product Reports, 2017, 34 (4) : 338-342). DOI: 10.1021/acs.orglett.6b03745. Epub 2017 Jan 11.

93. Subhasish Saha,# Wenjun Zhang,# Guangtao Zhang,# Yiguang Zhu, Yuchan Chen, Wei Liu, Chengshan Yuan, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang, Changsheng Zhang.* Activation and characterization of a cryptic gene cluster reveal a cyclization cascade for polycyclic tetramate macrolactams. Chemical Science, 2017,8 (2): 1607-1612. DOI: 10.1039/C6SC03875A. Epub 2016 Oct 28.



2016

92. 郑六眷, 蒋晓东, 谭彬, 袁呈山, 张长生, 张庆波*。海洋来源放线菌Streptomyces sp. SCSIO BEMM34的次级代谢产物研究。中国海洋药物，2016,35(6):38-45. Epub 2016 Dec 15.

91. Xinpeng Tian, Zhewen Zhang, Tingting Yang, Meili Chen, Jie Li, Fei Chen, Jin Yang, Wenjie Li, Bing Zhang, Zhang Zhang, Jiayan Wu, Changsheng Zhang, Lijuan Long,* Jingfa Xiao*. Comparative genomics analysis ofStreptomycesspecies reveals their adaptation to the marine environment and their diversity at the genomic level. Frontiers in Microbiology, 2016, 10.3389/fmicb.2016.00998. Epub 2016 Jun 27.
90. Haibo Zhang,# Kumar Saurav,# Ziquan Yu, Attila Mándi, Tibor Kurtán, Jie Li, Xinpeng Tian, Qingbo Zhang, Wenjun Zhang, Changsheng Zhang*. α-Pyrones with diverse hydroxy substitutions from three marine-derived Nocardiopsis strains. Journal of Natural Products, 2016, 79(6): 1610–1618. DOI: 10.1021/acs.jnatprod.6b00175. Epub 2016 Jun 14.

89. Yiguang Zhu,# Marie-Ève Picard,# Qingbo Zhang, Julie Barma, Xavier Murphy Després, Xiangui Mei, Liping Zhang, Jean-Baptiste Duvignaud, Manon Couture, Weiming Zhu, Rong Shi* and Changsheng Zhang.*  Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis. Chemical Science, 2016,7(8): 4867-4874. DOI: 10.1039/c6sc00771f. Epub 2016 Apr 13.

Graphical abstract: Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis


88. Yiguang Zhu,# Jinxin Xu,# Xiangui Mei,# Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu,* Jinsong Liu,* Changsheng Zhang*. Biochemical and structural insights into the aminotransferase CrmG in caerulomycin biosynthesis. ACS Chemical Biology, 2016,11 (4): 943–952. DOI: 10.1021/acschembio.5b00984. Epub 2016 Jan 12.


87. Guangtao Zhang, Wenjun Zhang, Subhasish Saha, Changsheng Zhang*. Recent advances in discovery, biosynthesis and genome mining of medicinally relevant polycyclic tetramate macrolactams. Current Topics in Medicinal Chemistry, 2016, 16 (15): 1727-1739. (invited review). DOI: 10.2174/1568026616666151012112818. Epub 2015 Oct 11.



2015

86. Chunfang Yang, Chunshuai Huang, Wenjun Zhang*, Yiguang Zhu, Changsheng Zhang*. Heterologous expression of fluostatin gene cluster leads to a bioactive heterodimer. Organic Letters, 2015, 17(21): 5324-5327. DOI:  10.1021/acs.orglett.5b02683.  Epub 2015 Oct 14. ("Hot off the press" in Natural Product Reports, 2016, 33(2): 122-126. DOI: 10.1039/C5NP90052B)

85. Medema MH*, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. Minimum information about a biosynthetic gene cluster. Nature Chemical Biology, 2015, 11(9): 625-631. DOI:  10.1038/nchembio.1890. Epub 2015 Aug 18.

84. 聂方玲, 陈玉婵, 张庆波, 田新朋, 章卫民, 张长生, 张文军*。深海链霉菌SCSIO 03032芳酰胺类代谢产物的研究。中国海洋药物，2015, 34 (4): 49-55. Epub 2015 Aug 15.

83. Yiguang Zhu,# Wenjun Zhang,# Yaolong Chen, Chengshan Yuan, Haibo Zhang, Guangtao Zhang, Liang Ma, Qingbo Zhang, Xinpeng Tian, Si Zhang, Changsheng Zhang*. Characterization of heronamide biosynthesis reveals a tailoring hydroxylase and indicates migrated double bonds. ChemBioChem, 2015, 16(14): 2086-2093. DOI: 10.1002/cbic.201500281. Epub 2015 Aug 6.


82. Huixian Li,# Yu Sun,# Qingbo Zhang, Yiguang Zhu, Shu-Ming Li, Ang Li, Changsheng Zhang*. Elucidating the cyclization cascades in xiamycin biosynthesis by substrate synthesis and enzyme characterizations. Organic Letters, 2015, 17(2): 306-309. DOI: 10.1021/ol503399b. Epub 2014 Dec 22. ("Hot off the press" in Natural Product Reports, 2015, 32(4): 512-516. DOI: 10.1039/C5NP90013A)


2014


81. Wenjun Zhang, Liang Ma, Sumei Li, Zhong Liu, Yuchan Chen, Haibo Zhang, Guangtao Zhang, Qingbo Zhang, Xinpeng Tian, Chengshan Yuan, Si Zhang, Weimin Zhang, and Changsheng Zhang*. Indimicins A–E, Bisindole Alkaloids from the Deep Sea-Derived Streptomyces sp. SCSIO 03032. Journal of Natural Products, 2014, 77 (8): 1887-1892. DOI: 10.1021/np500362p. Epub 2014 Aug 22. (Featured as "Key Drug Discovery Article" by Global Medical Discovery)


80. Peng Fu,# Yiguang Zhu,# Xiangui Mei, Yi Wang, Haijian Jia, Changsheng Zhang*, Weiming Zhu*. Acyclic Congeners fromActinoalloteichus cyanogriseusProvide Insights into Cyclic Bipyridine Glycoside Formation. Organic Letters, 2014, 16 (16): 4264-4267. DOI: 10.1021/ol5019757. Epub 2014 Aug 4.

79. Guangtao Zhang,# Wenjun Zhang,# Qingbo Zhang, Ting Shi, Liang Ma, Yiguang Zhu, Sumei Li, Haibo Zhang, Yi-Lei Zhao, Rong Shi, Changsheng Zhang*. Mechanistic Insights Into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis. Angewandte Chemie International Edition, 2014, 53 (19): 4840-4844. DOI:  10.1002/anie.201402078. Epub 2014 Apr 6. (Recommended by Faculty of 1000; "Hot off the press" in Natural Product Reports, 2014, 31 (9): 1083-1087. DOI: 10.1039/C4NP90023E).


78. Wenjun Zhang, Sumei Li, Yiguang Zhu, Yuchan Chen, Yaolong Chen, Haibo Zhang, Guangtao Zhang, Xinpeng Tian, Yu Pan, Si Zhang, Weimin Zhang, and Changsheng Zhang*. Heronamides D–F, Polyketide Macrolactams from the Deep-Sea Derived Streptomyces sp. SCSIO 03032. Journal of Natural Products, 2014, 77(2): 388–391. DOI: 10.1021/np400665a. Epub 2014 Feb 18.


77. 吴正超, 郑六眷, 陈耀龙, 李洁, 陈玉婵, 章卫民, 张长生, 李苏梅*。海洋源放线菌Streptomyces sp. SCSIO 10428中吩嗪生物碱类抗生素的分离鉴定。中国海洋药物，2014, 33 (1): 45-52. Epub 2014 Feb 15.

76. Yaolong Chen,# Wenjun Zhang,# Yiguang Zhu,* Qingbo Zhang, Xinpeng Tian, Si Zhang, Changsheng Zhang*. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis. Organic Letters, 2014, 16(3): 736-739. DOI: 10.1021/ol4034176. Epub 2014 Jan 10.




2013

75. Yiguang Zhu, Qingbo Zhang, Sumei Li, Qinheng Lin, Peng Fu, Guangtao Zhang, Haibo Zhang, Rong Shi, Weiming Zhu*, and Changsheng Zhang*. Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation. Journal of the American Chemical Society, 2013, 135(50): 18750-18753. DOI: 10.1021/ja410513g. ("Hot off the press" inNatural Products Reports, 2014, 31(4): 414-418. DOI: 10.1039/c4np90007c). Epub 2013 Dec 5.


74. 马亮, 张文军, 朱义广, 吴正超, Kumar Saurav, 黄晖, 张长生*。永兴岛白穗软珊瑚共附生放线菌筛选及部分活性次级代谢产物的鉴定。微生物学报，2013, 53(10):1061-1071. Epub 2013 Oct 4.

73. Ruidong Chen,# Haibo Zhang,# Gaiyun Zhang, Sumei Li, Guangtao Zhang, Yiguang Zhu, Jinsong Liu, and Changsheng Zhang*. Characterizing Amosamine Biosynthesis in Amicetin Reveals AmiG as a Reversible Retaining Glycosyltransferase. Journal of the American Chemical Society, 2013, 135 (33): 12152–12155. DOI: 10.1021/ja401016e. Epub 2013 Aug 9.


72. Ji Xiao, Qingbo Zhang, Yiguang Zhu, Sumei Li, Guangtao Zhang, Haibo Zhang, Kumar Saurav & Changsheng Zhang*. Characterization of the Sugar-O-Methyltransferase LobS1 in Lobophorin Biosynthesis. Applied Microbiology and Biotechnology, 2013, 97(20): 9043-9053. DOI: 10.1007/s00253-013-5083-7. Epub 2013 Jul 20.

71. Zhengchao Wu, Sumei Li, Jie Li, Yuchan Chen, Kumar Saurav, Qingbo Zhang, Haibo Zhang, Wenjun Zhang, Weimin Zhang, Si Zhang and Changsheng Zhang*. Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428. Marine Drugs, 2013, 11(6): 2113-2125. DOI: 10.3390/md11062113. Epub 2013 Jun 14.
70. Zheng-Chao Wu, Sumei Li, Sang-Jip Nam, Zhong Liu, and Changsheng Zhang. Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp. CNX037. Journal of Natural Products, 2013, 76 (4): 694–701. DOI: 10.1021/np400009a. Epub 2013 Apr 15.

69. 张文军，李苏梅，张海波，张庆波，张改云，张光涛，朱义广，张长生*。海洋来源小单孢菌Micromonospora rosaria SCSIO N160中大环内酯类化合物的分离鉴定。天然产物研究与开发, 2013, 25 (4): 466-469。Epub 2013 Apr 15.

68. Sumei Li,# Ji Xiao,# Yiguang Zhu, Guangtao Zhang, Chunfang Yang, Haibo Zhang, Liang Ma, and Changsheng Zhang*. Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase. Organic Letters, 2013, 15 (6): 1374-1377. DOI: 10.1021/ol400342e. Epub 2013 Feb 22.

67. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Si Zhang, Weimin Zhang & Changsheng Zhang *. New Diketopiperazine Derivatives from a Deep-Sea-Derived Nocardiopsis alba SCSIO 03039. The Journal of Antibiotics, 2013, 66 (1): 31-36. DOI: 10.1038/ja.2012.88. Epub 2012 Oct 24.
66. Xin-Peng Tian, Li-Juan Long, Su-Mei Li, Jing Zhang, Ying Xu , Jie He, Jie Li, Fa-Zuo Wang, Wen-Jun Li, Chang-Sheng Zhang, Si Zhang*. Pseudonocardia antitumoralis sp. nov., a new deoxynyboquinone-producing actinomycete isolated from a deep-sea sedimental sample in South China Sea. International Journal of Systematic and Evolutionary Microbiology, 2013, 63 (Pt 3):893-899. DOI: 10.1099/ijs.0.037135-0. Epub  2012 May 25.



2012


65. 林钦恒; 肖吉; 陈瑞东; 张长生*。微生物糖苷类抗生素糖基转移酶的体外研究进展。中国抗生素杂志，2012, 37 (12): 881-895. DOI: 10.13461/j.cnki.cja.005109. Epub 2012 Dec 25.

64. Qingbo Zhang, Huixian Li, Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang*. Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis. Organic Letters, 2012, 14 (24): 6142–6145. DOI: 10.1021/ol302782u. Epub 2012 Dec 3. ("Hot off the press" in Natural Product Reports, 2013, 30 (4): 485-489. DOI: 10.1039/c3np90007j.)



63. Wenjun Zhang,# Zhong Liu,# Sumei Li, Yongzhi Lu, Yuchan Chen, Haibo Zhang†, Guangtao Zhang, Yiguang Zhu, Gaiyun Zhang, Weimin Zhang, Jinsong Liu, and Changsheng Zhang*. Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160. Journal of Natural Products, 2012, 75(11): 1937–1943. DOI: 10.1021/np300505y. Epub 2012 Nov 8.


62. 田新朋, 黄洪波, 朱义广, 张长生,* 鞠建华, 龙丽娟, 张偲。海洋放线菌资源与代谢产物及其组合生物合成研究进展。2012年工业生物技术发展报告，科学出版社，2012: 107-122. Epub 2012 Oct 15.

61. Qingbo Zhang, Attila Mándi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtán,* Changsheng Zhang*.  N–N-coupled indolosesquiterpene atropo-diastereomers from a marine-derived actinomycete. European Journal of Organic Chemistry, 2012, 2012(27): 5256-5262. DOI: 10.1002/ejoc.201200599. Epub 2012 Aug 13.


60. Xin-Peng Tian, Li-Juan Long, Su-Mei Li, Jing Zhang, Ying Xu, Jie He, Jie Li, Fa-Zuo Wang, Wen-Jun Li, Chang-Sheng Zhang, Si Zhang*. Streptomyces oceanisp. nov., a new obligate marine actinomycete isolated from a deep-sea sample of seep authigenic carbonate nodule in South China Sea. Antonie Van Leeuwenhoek, 2012 , 102(2): 335-343. DOI: 10.1007/s10482-012-9743-x. Epub 2012 Jun 14.

59. Wenjun Zhang, Zhong Liu, Sumei Li, Tingting Yang, Qingbo Zhang, Liang Ma, Xinpeng Tian, Haibo Zhang, Caiguo Huang, Si Zhang, Jianhua Ju, Yuemao Shen, and Changsheng Zhang*. Spiroindimicins A–D: New Bisindole Alkaloids from a Deep-Sea Derived Actinomycete. Organic Letters, 2012, 14(13): 3364-3367. DOI: 10.1021/ol301343n. Epub 2012 Jun 13. ("Hot off the press" in Natural Product Reports, 2012, 29: 1033-1037. DOI: 10.1039/c2np90033e.)

58. Yiguang Zhu,# Peng Fu,# Qinheng Lin, Guangtao Zhang, Haibo Zhang, Sumei Li, Jianhua Ju, Weiming Zhu*, and Changsheng Zhang*. Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase. Organic Letters, 2012, 14 (11): 2666-2669. DOI: 10.1021/ol300589r. Epub 2012 May 16. ("Hot off the press" in Natural Product Reports, 2012, 29 (8): 829-833. DOI: 10.1039/C2NP90024F).


57. Huixian Li,# Qingbo Zhang,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, and Changsheng Zhang*. Identification and Characterization of Xiamycin A and Oxiamycin Gene Cluster Reveals an Oxidative Cyclization Strategy Tailoring Indolosesquiterpene Biosynthesis. Journal of the American Chemical Society, 2012, 134 (21): 8996-9005. DOI: 10.1021/ja303004g. Epub 2012 May 16.


56. 肖吉, 张光涛, 朱义广, 张长生*。海洋微生物次级代谢产物生物合成的研究进展。中国抗生素杂志，2012, 37 (4): 241-253. DOI: 10.13461/j.cnki.cja.004981.  Epub 2012 Apr 25.

55. Ziming Chen, Zhihui Zheng, Hongbo Huang, Yongxiang Song, Xuelian Zhang, Junying Ma, Bo Wang, Changsheng Zhang, Jianhua Ju*. Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg Med Chem Lett. 2012 May 1; 22 (9): 3332-3335. doi: 10.1016/j.bmcl.2012.02.106. Epub 2012 Mar 11.

54. 李军, 朱清华, 张云, 马俊英, 田新朋, 李文均, 张长生, 鞠建华*。深海放线菌Marinactinospora thermotolerans SCSIO 00652遗传操作系统的建立。中国抗生素杂志，2012, 37 (2): 105-111. DOI: 10.13461/j.cnki.cja.004934. Epub 2012 Feb 25.

53. Junying Ma, Dianguang Zuo, Yongxiang Song, Bo Wang, Hongbo Huang, Yueliang Yao, Wenjun Li, Si Zhang, Changsheng Zhang, Jianhua Ju*. Characterization of a single gene cluster responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012 Mar 5; 13 (4): 547-552. DOI: 10.1002/cbic.201100700. Epub 2012 Feb 23.

52. 胡涛, 张光涛, 朱义广, 李苏梅, 张海波, 张改云, 杨晓红, 鞠建华, 张长生*。友菌素核苷转移酶amiE基因的克隆、表达和功能鉴定。微生物学报，2012, 52 (2): 214-220. Epub 2012 Feb 4.

51. Hongbo Huang, Tingting Yang, Xiangmei Ren, Jing Liu, Yongxiang Song, Aijun Sun, Junying Ma, Bo Wang, Yun Zhang, Caiguo Huang, Changsheng Zhang, Jianhua Ju*. Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. Journal of Natural Products, 2012 Feb 24;75 (2): 202-208. DOI: 10.1021/np2008335. Epub 2012 Feb 3.

50. Xuhua Mo, Junying Ma, Hongbo Huang, Bo Wang, Yongxiang Song, Si Zhang, Changsheng Zhang, Jianhua Ju*. Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. Journal of the American Chemical Society, 2012 Feb 15;134 (6): 2844-2847. DOI: 10.1021/ja206713a. Epub 2012 Feb 1.

49. Gaiyun Zhang, Haibo Zhang, Sumei Li, Ji Xiao, Guangtao Zhang, Yiguang Zhu, Siwen Niu, Jianhua Ju, and Changsheng Zhang*. Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation. Applied and Environmental Microbiology, 2012, 78 (7): 2393-2401. DOI: 10.1128/AEM.07185-11. Epub 2012 Jan 20.

48. Qinghua Zhu, Jun Li, Junying Ma, Minghe Luo, Bo Wang, Hongbo Huang, Xinpeng Tian, Wenjun Li, Si Zhang, Changsheng Zhang, Jianhua Ju*. Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from the deep-sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrobial Agents and Chemotherapy, 2012 Jan; 56 (1): 110-114. DOI: 10.1128/AAC.05278-11. Epub 2011 Nov 7.

47. Jie Li, Guang-Tao Zhang, Jian Yang, Xin-Peng Tian, Fa-Zuo Wang, Chang Sheng Zhang, Si Zhang*, Wen-Jun Li*. Marininema mesophilumgen. nov., sp. nov., a thermoactinomycete isolated from deep sea sediment, and emended description of the family Thermoactinomycetaceae. International Journal of Systematic and Evolutionary Microbiology, 2012, 62 (Pt 6): 1383-1388. DOI: 10.1099/ijs.0.035071-0. Epub 2011 Aug 5.

46. Xin-Peng Tian, Li-Juan Long, Fa-Zuo Wang, Ying Xu, Jie Li, Jing Zhang, Chang-Sheng Zhang, Si Zhang*, Wen-Jun Li*. Streptomyces nanhaiensis sp. nov., a marine streptomycete isolated from a deep-sea sediment. International Journal of Systematic and Evolutionary Microbiology, 2012, 62 (Pt 4): 864-868. doi: 10.1099/ijs.0.031591-0. Epub 2011 May 27.



2011


45. 陈子明，汪中文，黄洪波，陈玉婵，章卫民，张长生，鞠建华*。海洋真菌Xylaria sp.SOF11中细胞松弛素类化合物的研究。天然产物研究与开发， 2011, 23 (5): 801-804. Epub 2011 Oct 15.

44.  Hongbo Huang, Yueliang Yao, Zhengxiang He, Tingting Yang, Junying Ma, Xinpeng Tian, Yayong Li, Caiguo Huang, Xiaoping Chen, Wenjun Li, Si Zhang, Changsheng Zhang, Jianhua Ju*. Antimalarial beta-carboline and indolactam alkaloids from Marinactinosporathermotolerans, a deep sea isolate. Journal of Natural Products, 2011, 74 (10): 2122-2127.DOI: 10.1021/np200399t. Epub 2011 Oct 6.

43. Siwen Niu, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Weimin Zhang, Xiaohong Yang, Si Zhang, Jianhua Ju & Changsheng Zhang*. Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127. The Journal of Antibiotics, 2011, 64 (11):711-716. DOI: 10.1038/ja.2011.78. Epub 2011 Sep 7.

42. Sumei Li, Xinpeng Tian, Siwen Niu, Wenjun Zhang, Yuchan Chen, Haibo Zhang, Xianwen Yang, Weimin Zhang, Wenjun Li, Si Zhang, Jianhua Ju and Changsheng Zhang*. Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299. Marine Drugs, 2011, 9 (8): 1428-1439. DOI: 10.3390/md9081428. Epub 2011 Aug 23.

41.  任香梅，黄洪波，刘 静，张 云，马俊英，王 博，张长生，鞠建华*。海洋链霉菌Streptomyces lusitanus SCSIO 32中芳酰胺类代谢产物的研究。天然产物研究与开发， 2011, 23 (4): 591-595. Epub 2011 Aug 15.

40. 林钦恒, 张光涛, 李苏梅, 张海波, 鞠建华, 朱伟明, 张长生*。浅蓝霉素产生菌海洋异壁放线菌WH1-2216-6 遗传操作体系的建立。微生物学报，2011, 51 (8): 1032-1041. Epub 2011 Aug 4.

39. Junying Ma, Zhongwen Wang, Hongbo Huang, Minghe Luo, Dianguang Zuo, Bo Wang, Aijun Sun, Yi-Qiang Cheng, Changsheng Zhang, Jianhua Ju*. Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. AngewandteChemie International Edition, 2011, 50 (34): 7797-7802. DOI: 10.1002/anie.201102305. Epub 2011 Jul 1.

38. 牛四文, 李苏梅, 田新朋, 胡涛, 鞠建华, 杨晓红, 张偲, 张长生*。海洋放线菌Streptomyces sp. SCSIO 1934中次生代谢产物的分离和鉴定。中国中药杂志，2011, 36 (13): 1763-1768.37. Epub 2011 Jul 1.

37.  周俊勇, 黄洪波, 汪中文, 杨民和, 田新朋, 张偲, 张长生, 鞠建华*。海洋链霉菌Streptomyces sp.SCSIO 1667中吲哚咔唑生物碱类成分的研究。天然产物研究与开发，2011, 23(3): 415-419. DOI:10.16333/j.1001-6880.2011.03.043. Epub 2011 Jun 15.

36.  Siwen Niu,# Tao Hu,# Sumei Li, Yi Xiao, Liang Ma, Guangtao Zhang, Haibo Zhang, Xiaohong Yang, Jianhua Ju, Changsheng Zhang*. Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity. ChemBioChem, 2011, 12(11): 1740-1748. DOI: 10.1002/cbic.201100129. Epub 2011 Jun 1.

35. Xuhua Mo, Hongbo Huang, Junying Ma, Zhongwen Wang, Bo Wang, Si Zhang, Changsheng Zhang, Jianhua Ju*. Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway. Organic Letters, 2011, 13 (9): 2212-2215. DOI: 10.1021/ol200447h. Epub 2011 Apr 1.

34. Xuhua Mo, Zhongwen Wang, Bo Wang, Junying Ma, Hongbo Huang, Xinpeng Tian, Si Zhang, Changsheng Zhang, Jianhua Ju*. Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666. Biochemical and Biophysical Research Communications, 2011, 406 (3): 341-347. DOI: 10.1016/j.bbrc.2011.02.040. Epub 2011 Feb 15.

33. 李苏梅, 田新朋, 牛四文, 张偲, 鞠建华, 张长生*. 南海链霉菌SCSIO 1635中抗霉素类化合物的分离鉴定 (in English). 天然产物研究与开发, 2011, 23 (1): 10-14. Epub 2011 Feb 15.

32. Yi Xiao, Sumei Li, Siwen Niu, Liang Ma, Guangtao Zhang, Haibo Zhang, Gaiyun Zhang, Jianhua Ju, and Changsheng Zhang*. Characterization of Tiacumicin B Biosynthetic Gene Cluster Affording Diversified Tiacumicin Analogues and Revealing a Tailoring Dihalogenase. Journal of the American Chemical Society, 2011, 133 (4): 1092–1105. DOI: 10.1021/ja109445q. Epub 2010 Dec 27. ("Hot off the press" in Natural Product Reports, 2011, 28: 659-662. DOI: 10.1039/C1NP90009A.)

31. Liping Gong, Yi Xiao, Qiang Liu, Sumei Li, Changsheng Zhang,* Jinsong Liu*.  Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2011, 67(1): 136-139. DOI: 10.1107/S1744309110048268. Epub 2010 Dec 23.

30. Gavin J Williams, Jie Yang, Changsheng Zhang, Jon S Thorson*. Recombinant E. coli Prototype Strains for in Vivo Glycorandomization. ACS Chemical Biology, 2011, 6(1): 94-100. DOI: 10.1021/cb100267k. Epub 2010 Oct 22.


2010

29. 张偲*，张长生，田新朋，王发左，李洁。中国海洋微生物多样性研究。中国科学院院刊，2010, 25(6)：651-658。Epub 2010 Nov 15.

28. 段传人, 姚月良, 汪中文, 田新朋, 张偲, 张长生, 鞠建华*。海洋链霉菌Streptomyces sp. SCSIO 1666活性代谢产物替达霉素A和B的发酵优化及分离鉴定。中国海洋药物，2010年，29: (6): 12-20. DOI :10.13400/j.cnki.cjmd.2010.06.010. Epub 2010 Dec 28.

27. 罗明和, 汪中文, 黄洪波, 朱清华, 田新朋, 白志川, 张偲, 张长生, 鞠建华* 。海洋链霉菌Streptomyces sp. SCSIO 1672及其代谢产物水杨酸的分离鉴定。 微生物学杂志，2010，30 (6): 22-26. Epub 2010 Nov 15.

26.  肖毅, 李苏梅, 马亮, 张改云, 鞠建华, 张长生*。台勾霉素生产菌指孢囊菌NRRL 18085遗传操作体系的建立。微生物学报, 2010, 50 (8): 1014-1022. DOI: 10.13343/j.cnki.wsxb.2010.08.005. Epub 2010 Aug 4.

25. 张长生*，鞠建华，龙丽娟，张偲。海洋微生物资源的开发和工业应用。2010工业生物技术发展报告，科学出版社，2010: 77-89。Epub 2010 Jul 1.


2009

24. Su-Mei Li , Xian-Wen Yang, Yong-Li Li, Yun-Heng Shen, Lin Feng, Yue-Hu Wang, Hua-Wu Zeng, Xiao-Hua Liu, Chang-Sheng Zhang, Chun-Lin Long, Wei-Dong Zhang.* Chemical constituents of Dracocephalum forresti. Planta Medica, 2009, 75 (15):1591-6. DOI: 10.1055/s-0029-1185868. Epub 2009 Dec.

Postdoctoral and Graduate (2002-2008)

23. Changsheng Zhang, Rocco Moretti, Jiqing Jiang, Jon S Thorson*. The In Vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI. ChemBioChem, 2008, 9(15): 2506-2514. DOI: 10.1002/cbic.200800349. Epub 2008 Oct 6.

22. Changsheng Zhang, Eduard Bitto, Randal D Goff, Shanteri Singh, Craig A Bingman, Byron R Griffith, Christoph Albermann, George N Phillips Jr,* Jon S Thorson*. Biochemical and Structural Insights of the Early Glycosylation Steps in Calicheamicin Biosynthesis. Chemistry and Biology, 2008, 15(8): 842-853. DOI: 10.1016/j.chembiol.2008.06.011.Epub 2008 Aug 22.

21. Shanteri Singh  1 , Jason G McCoy, Changsheng Zhang, Craig A Bingman, George N Phillips Jr,* Jon S Thorson RebM*. Structure and Mechanism of the Rebeccamycin Sugar 4-O-Methyltransferase RebM. Journal of Biological Chemistry, 2008, 283(33): 22628-22636. DOI: 10.1074/jbc.M800503200. Epub 2008 May 23.

20. Gavin J Williams, Randal D Goff, Changsheng Zhang, Jon S Thorson*. Optimizing glycosyltransferase specificity via ‘hot spot’ saturation mutagenesis presents a new catalyst for novobiocin glycorandomization. Chemistry and Biology, 2008, 15(4): 393-401.DOI: 10.1016/j.chembiol.2008.02.017. Epub 2008 Apr 18.

19. Gavin J Williams , Changsheng Zhang, Jon S Thorson*. Expanding the Promiscuity of A Natural Product Glycosyltransferase by Directed Evolution. Nature Chemical Biology, 2007, 3(10): 657-662. DOI: 10.1038/nchembio.2007.28. Epub 2007 Sep 7. (Featured in Nature Chemical Biology, 2007, 3: 604; and Chemical & Engineering News, 2007, 85: 9; and reported in various press including: United Press International, Chemistry World, UW news, and Wisconsin State Journal, etc.)

18. Changsheng Zhang, Qiang Fu, Christoph Albermann, Lingjun Li, Jon S Thorson*. The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification. ChemBioChem, 2007, 8(4): 385-390. DOI: 10.1002/cbic.200600509. Epub 2007 Feb 19.

17. Changsheng Zhang, Christoph Albermann, Xun Fu, Jon S Thorson*. The In Vitro Characterization of the Iterative Avermectin Glycosyltransferase AveBI Reveals Reaction Reversibility and Sugar Nucleotide Flexibility. Journal of the American Chemical Society, 2006, 128(51): 16420-16421. DOI: 10.1021/ja065950k. Epub 2006 Dec 5.

16. Shanteri Singh, Martin H Hager, Changsheng Zhang, Byron R Griffith, Min S Lee, Klaas Hallenga, John L Markley, Jon S Thorson*. Structural insight into self-sacrifice mechanism of enediyne resistance. ACS Chemical Biology, 2006, 1(7): 451-460. DOI: 10.1021/cb6002898. Epub 2006 Aug 18.

15.Changsheng Zhang, Byron R Griffith, Qiang Fu, Christoph Albermann, Xun Fu, In-Kyoung Lee, Lingjun Li, Jon S Thorson*. Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions. Science, 2006, 313(5791): 1291-1294. DOI: 10.1126/science.1130028. Epub 2006 Sep 1. (Featured in Nature,  ACS Chemical Biology,  Angewandte Chemie International Edition; highlighted in Nature, Nature Chemical Biology,  Nature Methods,  and Chemical & Engineering News, 2006, 84:13; and reported in various press including United Press International, Wisconsin State Journal, Wisconsin Technology Network, UW news, The Daily Cardinal, Milwaukee Journal Sentinel, etc.)

14. Qunjie Gao, Changsheng Zhang, Sophie Blanchard, Jon S Thorson*. Deciphering indolocarbazole and enediyne aminopentose biosynthesis through comparative genomics: New insights and tools from the Actinomadura melliaura AT2433 biosynthetic locus. Chemistry and Biology, 2006, 13(7):733-743. DOI: 10.1016/j.chembiol.2006.05.009. Epub 2006 Jul 28.

13. Changsheng Zhang, Christoph Albermann, Xun Fu, Noel R Peters, John D Chisholm, Guisheng Zhang, Eric J Gilbert, Peng George Wang, David L Van Vranken, Jon S Thorson*. RebG- and RebM-catalyzed Indolocarbazole Diversification. ChemBioChem, 2006, 7(5): 795-804. DOI: 10.1002/cbic.200500504. Epub 2007 Apr 26.

12. Svetlana A Borisova, Changsheng Zhang, Haruko Takahashi, Hua Zhang, Alexander W Wong, Jon S Thorson, Hung-wen Liu*. Substrate Specificity of the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII: Opportunities, Limitations and Mechanistic Hypotheses. Angewandte Chemie International Edition, 2006, 45(17): 2748-2753. DOI: 10.1002/anie.200503195. Epub 2006 Apr 11.

11. Changsheng Zhang, Rachel L Weller, Jon S Thorson, Scott R Rajski*. Natural Product Diversification Using Non-natural Cofactor Analogues of S-adenosyl-L-methionine.  Journal of the American Chemical Society, 2006, 128(9): 2760-2761. DOI: 10.1021/ja056231t. Epub 2006 Feb 10.

10.  Xun Fu, Christoph Albermann, Changsheng Zhang, Jon S Thorson*. Diversifying Vancomycin via Chemoenzymatic Strategies.Organic Letters, 2005, 7(8): 1513-1515. DOI: 10.1021/ol0501626. Epub 2005 Mar 18.

9.  Xun Fu, Christoph Albermann, Jiqing Jiang, Jianchun Liao, Changsheng Zhang, Jon S Thorson*. Antibiotic optimization via in vitro glycorandomization. Nature Biotechnology, 2003, 21(12): 1467-1469. DOI: 10.1038/nbt909. Epub 2003 Nov 9.

8.  Chang-Sheng Zhang, Michael Podeschwa, Oliver Block, Hans-Josef Altenbach, Wolfgang Piepersberg, Udo F Wehmeier*. Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanessp. SE50/110. FEBS Letters, 2003, 540(1-3): 53-57. DOI: 10.1016/s0014-5793(03)00222-9. Epub 2003 Mar 20.

7.  Chang-Sheng Zhang, Michael Podeschwa, Hans-Josef Altenbach, Wolfgang Piepersberg, Udo F Wehmeier*. The acarbose-biosynthetic enzyme AcbO from Actinoplanessp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase. FEBS Letters, 2003, 540(1-3): 47-52. DOI: 10.1016/s0014-5793(03)00221-7. Epub 2003 Mar 20.

6.  Piepersberg W*, Diaz-Guardamino UM, Stratmann A, Thomas H, Wehmeier UF, Zhang C. Recent Developments in the Biosynthesis and Regulation of Aminoglycosides. In: Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation, Research Signpost, Keral, India. 2002, pp. 1-26

5.  Chang-Sheng Zhang, Ansgar Stratmann, Oliver Block, Ralph Brückner, Michael Podeschwa, Hans-Josef Altenbach, Udo F Wehmeier, Wolfgang Piepersberg*. Biosynthesis of the C7-cyclitol Moiety of Acarbose in Actinoplanes Species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway. Journal of Biological Chemistry, 2002, 277(25): 22853-22862. DOI: 10.1074/jbc.M202375200. Epub 2002 Apr 5.

4.  张长生, 张惠展*, 姚峰，丁建忠。林可霉素生物合成基因lmbH的回转化。中国抗生素杂志, 1999，24(2): 90-92, 129. (in Chinese). Epub 1999 Apr 28.

3.  张长生, 张惠展*, 丁建忠。林可链霉菌噬菌体ΦSL60中具有启动子活性的DNA片段的克隆和鉴定。华东理工大学学报，1998, 24(4): 415-421。Epub 1998 Aug 30.

2.  张惠展*, 张长生, 周军。林可霉素生物合成研究进展。国外医药抗生素分册, 1998, 19(4): 246-253. (in Chinese). Epub 1998 Aug 15.

1.  张长生, 张惠展*。 链霉菌ＲＮＡ聚合酶的异质性和启动子的多样性。国外医药抗生素分册, 1997, 18(4): 248-250. (in chinese). Epub 1997 Aug 15.