Prof. Dr. Liang Cheng

CAS Key Laboratory of Molecular Recognition and Function

Institute of Chemistry, Chinese Academy of Sciences

P.O. Box 2709-24, No. 2 Zhongguancun North 1st Street

Beijing 100190, China

Tel: +86-10-6194-3102

Fax: +86-10-6255-4449


Research Areas

1) Recognition and modulation of RNA

2) Organic synthesis methodology development


2000-2004 B.Sc. Beijing Normal University

2004-2009 Ph.D Institute of Chemistry, Chinese Academy of Sciences

2011-2014 Postdoc Columbia University (with Prof. Ronald Breslow)


  1. Xie, L.-J.; Liu, L.; Cheng, L.* "Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases", Biochemistry2019, DOI: 10.1021/acs.biochem.9b00774 (Invited review).

  2. Xie, L.-J.; Liu, L.; Cheng, L.* "Modifying Methionine on Proteins", ChemBioChem2019, DOI: 10.1002/cbic.201900533 (Invited review).  

  3. Wang, R.-L.#; Jin, X.-Y.#; Kong, D.-L.; Chen, Z.-G.; Liu, J.; Liu, L.; Cheng, L.* "Visible-Light Facilitated Fluorescence "Switch-On" Labelling of 5-Formylpyrimidine RNA", Adv. Synth. Catal. 2019, DOI: 10.1002/adsc.201901032.  

  4. Wang, C.; Zou, P.; Yang, C.; Liu, L.; Cheng, L.; He, X.; Zhang, L.; Zhang, Y.; Jiang, H.*; Chen, P. R.* "Dynamic Modifications of Biomacromolecules: Mechanism and Chemical Interventions", Sci. China Life Sci. 2019, DOI: 10.1007/s11427-019-9823-1.

  5. Li, X.-D.#; Gao, Y.-T.#; Sun, Y.-J.; Jin, X.-Y.; Wang, D.; Liu, L.; Cheng, L.* "A NaI/H2O2 Mediated Sulfenylation and Selenylation of Unprotected Uracil and its Derivatives", Org. Lett. 201921, 6643-6647.  

  6. Jin, X.-Y.; Wang, R.-L.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "A chemical photo-oxidation of 5-methyl cytidines", Adv. Synth. Catal. 2019361, 4685-4690. (VIP Article) 

  7. Lan, L.; Wang, R. L.; Liu , L.; Cheng, L.* "A Label-free Colorimetric Detection of microRNA via G-Quadruplex-based Signal Quenching Strategy", Anal. Chim. Acta. 20191079, 207-211.

  8. 程靓,兰玲,刘利,“一种基于G-四链体探针结构解旋的可视化识别microRNA的检测方法”,中国专利,申请号:201910514343.2,申请日:2019年6月14日。

  9. Liu, T.; Zhu, J.; Sun, X.; Cheng, L.; Wu, L.* "I2/TBHP Mediated Divergent C(sp2)-P Cleavage of Allenylphosphine Oxides: Substituent-Controlled Regioselectivity", Adv. Synth. Catal. 2019361, 3532-3537. 

  10. Wang, R. -L.; Lan, L.; Liu, L.; Cheng, L.* "Asymmetric Polymerase Chain Reaction and Loop-mediated Isothermal Amplification (AP-LAMP) for ultrasensitive detection of microRNAs", Chin. Chem. Lett. 2019, DOI: 10.1016/j.cclet.2019.05.003. 

  11. 程靓,王瑞丽,刘利,“一种基于不对称PCR和LAMP循环扩增反应进行miRNA快速检测的方法”,中国专利,申请号:201910179354X,申请日:2019年3月11日。

  12. 程靓,李学东,刘利,“制备5-硫/硒修饰尿嘧啶衍生物的方法”,中国专利,申请号:2019100843077,申请日:2019年1月29日。

  13. Xie, L.-J.#; Yang, X.-T.#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 201958, 5028-5032. 

  14. Liu, J.-J.; Lan, L.; Gao, Y.-T.; Liu, Q.; Cheng, L.*; Wang, D.; Liu, L.* "Visible-Light-Mediated Stereoselective 1,2-Iodoalkylation of Alkynes", Adv. Synth. Catal. 2019361, 1283-1288.  

  15. Li, X.-D.; Liu, L.; Cheng, L.* "Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs", Org. Biomol. Chem. 201816, 9191-9196.  

  16. Gao, Y.-T.; Jin, X.-Y.; Liu, Q.; Liu, A.-D.; Cheng, L.*; Wang, D.; Liu, L.* "Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles", Molecules201823, 2265. 

  17. Liu, Q.; Liu, J.-J.; Cheng, L.*, Wang, D.; Liu, L.* "TEMPO Promoted Direct Multi-functionalization of Terminal Alkynes with 2-Oxindoles/Benzofuran-2(3H)-one", Org. Biomol. Chem. 201816, 5228-5231.

  18. Zhong, N.-J.; Wang, Y.-Z.; Cheng, L.*; Wang, D.; Liu, L.* "Recent advances in the annulation of Morita-Baylis-Hillman adducts", Org. Biomol. Chem. 201816, 5214-5227.

  19. Li, X.-D.; Chen, B.; Lan, L.; Wang, R.-L.; Luo, D.-Q.; Liu, L.; Cheng, L.* "Selective Recognition of HIV RNA by Dinuclear Metallic Ligands", Chin. Chem. Lett. 201829, 1637-1640.

  20. Jin, X.-Y.; Xie, L.-J.; Cheng, H.-P.; Liu, A.-D.; Li, X.-D.; Wang, D.; Cheng, L.*; Liu, L.* "Ruthenium-Catalyzed Decarboxylative C-H Alkenylation in Aqueous Media: A Synthesis of Tetrahydropyridoindoles", J. Org. Chem. 201883, 7514-7522. 

  21. Liu, J.-J.#; Huang, H.-Y.#Cheng, L.*; Liu, Q.; Wang, D.; Liu, L.* "Catalyst-Free Intermolecular trans-Iodoalkylation of Alkynes", Org. Biomol. Chem. 201816, 899-903.

  22. Gu, C.-L.*; Li, Y.-X.; Xiao, L.; Fu, H.-B.; Wang, D.; Cheng, L.; Liu, L.* "Tunable Heck-Mizoroki Reaction of Dibromo Naphthalene Diimide with Aryl ethylenes: Design, Synthesis and Characterization of Coplanar NDI-based Conjugated Molecules", J. Org. Chem. 201782, 12806-12812.

  23. Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.; Cheng, L.* "Visible-Light-Mediated Oxidative Demethylation of N6-Methyl Adenines", Chem. Commun. 201753, 10734-10737.

  24. 程靓,谢丽君,刘利,"N6‑甲基腺嘌呤的光化学脱甲基方法",中国专利,授权公告号:CN 106967068 B,申请日:2017年5月9日(授权日:2019年1月11日)。

  25. Liu, J.-J.; Cheng, L.*; Huang, H.-Y.; Wei, F.; Wang, D.; Liu, L.* "Unprecedented Formation of 3-(Tetrahydrofuran-2-yl)-4H-chromen-4-one in the Reaction between 3,3a-Dihydro-9H-furo[3,4-b]chromen-9-one with Malononitrile", Org. Biomol. Chem. 201715, 5078-5088.

  26. Huang, H.-Y.; Cheng, L.*; Liu, J.-J.; Wang, D.; Liu, L.*; Li, C.-J.* "Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling", J. Org. Chem. 201782, 2656-2663.

  27. Wei, F.; Cheng, L.*; Huang, H.-Y.; Liu, J.-J.; Wang, D.; Liu, L.* "Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2 for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines", Sci. China Chem. 201659, 1311-1316.

  28. Kong, D.-L.; Cheng, L.*; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L.* "Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides", J. Org. Chem. 201681, 5337-5344.

  29. Wu, H.-R.; Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.*; Wang, D.; Li, C.-J.* "FeCl3-Mediated Radical Tandem Reactions of 3-Benzyl-2-oxindoles with Styrene Derivatives for the Stereoselective Synthesis of Spirocyclohexene Oxindoles", Org. Lett. 201618, 1382-1385.

  30. Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "Metal-free Allylation of Electron-rich Heteroaryl Boronic Acids with Allylic Alcohols", Tetrahedron 201672, 1873-1880.

  31. Kong, D.-L.; Cheng, L.; Wu, H.; Li, Y.; Wang, D.; Liu, L.* "Metal-free Yne-addition/1,4-aryl migration/decarboxylation Cascade Reaction of Alkynoates with Csp3-H Centers", Org. Biomol. Chem. 201614, 2210-2217.

  1. Cheng, L.; Charles, D.*; Breslow, R.* "Evidence for Tunneling in Base-catalyzed Isomerization of Glyceraldehyde to Dihydroxyacetone by Hydride Shift under Formose Conditions", Proc. Natl. Acad. Sci. USA 2015112, 4218-4220.
  2. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* "Deoxypolypeptides Bind and Cleave RNA", Proc. Natl. Acad. Sci. USA 2014111, 7920-7924.

  3. Cheng, L.; Abhilash, K. G.; Breslow, R.* "Binding and Biomimetic Cleavage of the RNA Poly(U) by Synthetic Polyimidazoles", Proc. Natl. Acad. Sci. USA 2012109, 12884-12887.

  4. Cheng, L.; Liu, L.*; Li, C.; Jia, H.; Wang, D.; Chen, Y. J.* "Nucleophilic Addition of Regioselectively Lithiated Indoline with Aldimines for the Syntheses of 2- and 7-Indolinyl Methanamine Derivatives", Tetrahedron Lett. 201253, 4004-4007.

  5. Zhang, T.; Cheng, L.; Hameed, S.; Liu, L.*; Wang, D.; Chen, Y. J.* "Highly Enantioselective Michael Addition of 2-Oxindoles to Vinyl Selenone in RTILs Catalyzed by a Cinchona Alkaloid-based Thiourea", Chem. Commun. 201147, 6644-6646.

  6. Zhang, T.; Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* "Asymmetric Organocatalytic N-Nitroso-aldol Reaction of Oxindoles", Tetrahedron: Asymmetry 201021, 2800-2806.

  7. Cheng, L.; Liu, L.*; Wang, D.; Chen, Y. J.* "Highly Enantioselective and Organocatalytic alpha-Amination of 2-Oxindoles", Org. Lett. 200911, 3874-3877.

  8. Cheng, L.; Liu, L.*; Jia, H.; Wang, D.; Chen, Y. J.* "Enantioselective Organocatalytic anti-Mannich-type Reaction of N-Unprotected 3-Substituted 2-Oxindoles with Aromatic N-Ts-Aldimines", J. Org. Chem. 200974, 4650-4653.

  9. Cheng, L.; Liu, L.*; Sui, Y.; Wang, D.; Chen, Y. J.* "Highly Diastereoselective Reactions of 2-Lithiated Indoles with Chiral N-Tert-butanesulfinyl Aldimines for the Synthesis of Chiral (2-Indolyl) Methanamine Derivatives", Tetrahedron: Asymmetry 200718, 1833-1843.

  10. 校登明,程靓,刘希杰,胡远东,许新合,刘志华,张立鹏,吴伟,王树龙,沈宇,李根,王银,赵胜,李舂龙,唐佳,于洪灏,"作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物",中国专利,授权公告号­:CN103476776B,授权公告日:2016年9月28日。

  11. Xiao, D. M.; Cheng, L.; Liu, X. J.; Hu, Y. D.; Xu, X. H.; Liu, Z. H.; Zhang, L. P.; Wu, W.; Wang, S. L.; Shen, Y.; Li, G.; Wang, Y.; Zhao, S.; Li, C. L.; Tang, J.; Yu, H. H. "2,4-Diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine Derivatives as FAK/Pyk2 Inhibitors", US Patent 9428508 B2, Date of Patent: 08/30/2016.

  12. 校登明,程靓,刘希杰,胡远东,许新合,刘志华,张立鹏,吴伟,王树龙,沈宇,李根,王银,赵胜,李舂龙,唐佳,于洪灏,"作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物",中国专利,授权公告号:CN102093364A,授权公告日:2015年1月28日。

Honors & Distinctions

  • 2020  Thieme Chemistry Journals Award

  • 2016  CIFAR (Canadian Institute for Advanced Research) Azrieli Global Scholars Program, Finalist

  • 2015  Young Elite Scientist Sponsorship Program by China Association for Science and Technology

  • 2011  Centaurus BioPharma's Annual Outstanding Staff Award

  • 2009  Best Report Award in the 2nd "CCME-IOC & ICCAS-LMRF" Alfa Aesar® Symposium

  • 2009  Excellent Student of the Chinese Academy of Sciences

  • 2008  Excellent Student of the Chinese Academy of Sciences

  • 2008  Outstanding Young Scientist Award of the Chinese Academy of Sciences

  • 2007  Excellent Student of the Chinese Academy of Sciences