基本信息
陈铎之  男  博导  中国科学院昆明植物研究所
电子邮件: chenduozhi@mail.kib.ac.cn
通信地址: 昆明市蓝黑路132号中国科学院昆明植物研究所
邮政编码:

个人简介

陈铎之,中国科学院昆明植物研究所研究员,主要研究方向为天然产物化学生物学与天然药物化学。已取得以1个候选药物 (新型抗白癜风候选药物)2类先导化合物 (靶向N蛋白的抗新冠活性化合物、新型抗PEDV活性化合物)3条新作用机制 (抗白癜风新型作用机制、靶向N蛋白的抗新冠病毒作用机制、抗PEDV新型作用机制)为代表的科研成果体系,在包括Nat. Chem. Biol.、Euro. J. Med. Chem.、J. Org. Chem.、Organ. Lett.等权威期刊发表论文45 (第一或通讯作者20篇,中科院14篇,28),获国家发明专利十余项、美国专利1项。主持国家自然科学基金项目3项,省部级及其他科研项目10项;先后入选中科院青年创新促进会、云南省万人计划-青年拔尖人才和中组部-中科院西部青年学者等人才计划。


招生信息

已指导博、硕士研究生十余人次,先后获得国家奖学金1人次,省部级三好学生2人次,校级奖学金8人次,欢迎药学、有机化学、药理学相关专业背景同学报考。

招生专业
100701-药物化学
070303-有机化学
招生方向
天然产物化学生物学
新型生物活性小分子研究与开发
天然药物化学

教育背景

2010-09--2013-07   中国科学院昆明植物研究所   博士研究生/理学博士
2007-09--2009-12   昆明理工大学   硕士研究生/医学硕士
2003-09--2007-07   昆明理工大学   本科/工学学士

工作经历

   
工作简历
2022-01~现在, 中国科学院昆明植物研究所, 研究员
2016-01~2021-12,中国科学院昆明植物研究所, 副研究员
2013-12~2015-12,中国科学院昆明植物研究所, 助理研究员

专利与奖励

   
专利成果
( 1 ) Phenanthridine derivatives preparation methods and uses thereof, 发明专利, 2017, 第 2 作者, 专利号: US9682954B2

( 2 ) 菲啶类衍生物及 其药物组合物和 其制备方法与应 用, 发明专利, 2016, 第 2 作者, 专利号: ZL201310080161.1

出版信息

   
发表论文
[1] 陈铎之, 郝小江. 治疗丙型肝炎药物的研究进展. 云南民族大学学报:自然科学版[J]. 2021, 30(5): 419-435, http://lib.cqvip.com/Qikan/Article/Detail?id=7105623727.
[2] Chen, DuoZhi, Fan, ShiRui, Yang, BiJuan, Yao, HuoChun, Wang, YiTing, Cai, JieYun, Jing, ChenXu, Pan, ZiHao, Luo, Miao, Yuze, YanQiu, Liu, GuangJin, Hao, XiaoJiang. Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus Inhibitors. JOURNAL OF NATURAL PRODUCTS[J]. 2021, 84(4): 1175-1184, http://dx.doi.org/10.1021/acs.jnatprod.0c01252.
[3] Yuan, WenJuan, Gao, WenFen, Zhao, JiangYu, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L. FITOTERAPIA[J]. 2020, 144(7): http://ir.kib.ac.cn/handle/151853/72049, http://www.irgrid.ac.cn/handle/1471x/6927915, http://ir.kib.ac.cn/handle/151853/72050, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537596000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[4] Yang, BiJuan, Fan, ShiRui, Cai, JieYun, Wang, YiTing, Jing, Chenxu, Guo, JingJing, Chen, DuoZhi, Hao, XiaoJiang. Aphananoid A is an Anti-Inflammatory Limonoid with a New 5/6/5 Fused Ring Featuring a C-24 Carbon Skeleton from Aphanamixis polystachya. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(13): 8597-8602, https://www.webofscience.com/wos/woscc/full-record/WOS:000547450900029.
[5] Fan, Shirui, Guo, Jingjing, Wang, Yiting, Yang, Bijuan, Chen, Duozhi, Hao, Xiaojiang. Two new bioactive lignans from leaves and twigs of Cleistanthus concinnus Croizat. NATURAL PRODUCT RESEARCH[J]. 2020, 34(23): 3328-3334, https://www.webofscience.com/wos/woscc/full-record/WOS:000594432300004.
[6] Jing, Chenxu, Guo, Jingjing, Yang, Bijuan, Fan, Shirui, Wang, Yiting, Chen, Duozhi, Hao, Xiaojiang. Stelleraguaianone B and C, two new sesquiterpenoids from Stellera chamaejasme L.. FITOTERAPIA[J]. 2019, 134: 443-446, http://dx.doi.org/10.1016/j.fitote.2019.03.024.
[7] Chen, Duozhi, Yang, Bijuan, He, Xiaoli, Fan, Shirui, Cai, Jieyun, Jing, Chenxu, Zhang, Heng, Zhang, Yu, Li, Lin, Hao, Xiaojiang. Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists. BIOORGANIC CHEMISTRY[J]. 2019, 84: 285-294, http://ir.kib.ac.cn/handle/151853/64207.
[8] Yi, Wenfang, Chen, Duozhi, Ding, Xiao, Li, Xiaonian, Li, Shunlin, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus. FITOTERAPIA[J]. 2018, 128: 162-168, http://dx.doi.org/10.1016/j.fitote.2018.05.015.
[9] Chen, Duozhi, Zhang, Heng, Jing, Chenxu, He, Xiaoli, Yang, Bijuan, Cai, Jieyun, Zhou, Yunfu, Song, Xiaoming, Li, Lin, Hao, Xiaojiang. Efficient synthesis of new phenanthridine Wnt/beta-catenin signaling pathway agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 157: 1491-1499, http://202.127.25.143/handle/331003/3398.
[10] Guo, Jingjing, Yang, Bijuan, Jing, Chenxu, Chen, Duozhi, Hao, Xiaojiang. Rapid synthesis of ismine, a bioactive amaryllidaceae alkaloid. JOURNAL OF CHEMICAL RESEARCH[J]. 2017, 41(4): 202-204, http://dx.doi.org/10.3184/174751917X14894997017496.
[11] Yuan, WenJuan, Gao, WenFen, Zhang, JiaHui, Cao, Pei, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. (+/-)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata. NATURAL PRODUCT COMMUNICATIONS[J]. 2017, 12(1): 63-65, http://ir.kib.ac.cn/handle/151853/41892.
[12] Yuan, WenJuan, Ding, Xiao, Wang, Zhe, Yang, BiJuan, Li, XiaoNian, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Chen, Quan, Di, YingTong, Aisa, Haji Akber, Hao, XiaoJiang. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. SCIENTIFICREPORTS[J]. 2017, 7(1): https://doaj.org/article/e37a28dc25a9453b84cb871969fa2f32.
[13] Chen, DuoZhi, Jing, ChenXu, Cai, JieYun, Wu, JiBo, Wang, Sheng, Yin, Jun Lin, Li, XiaoNian, Li, Lin, Hao, XiaoJiang. Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(1): 180-188, http://ir.kib.ac.cn/handle/151853/25949.
[14] Yuan, WenJuan, Yang, GuoPing, Zhang, JiaHui, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata. PHYTOCHEMISTRY LETTERS[J]. 2016, 18(1): 176-179, http://dx.doi.org/10.1016/j.phytol.2016.10.008.
[15] Zhang, JiaHui, JingGuo, Jing, Yuan, Yu Xi, Fu, YanHui, Gu, YuCheng, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum. FITOTERAPIA[J]. 2016, 112: 217-221, http://dx.doi.org/10.1016/j.fitote.2016.06.006.
[16] Yan, Chen, Huang, Li, Liu, HongChun, Chen, DuoZhi, Liu, HaiYang, Li, XiaoHui, Zhang, Yu, Geng, MeiYu, Chen, Quan, Hao, XiaoJiang. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2014, 24(8): 1884-1888, http://dx.doi.org/10.1016/j.bmcl.2014.03.019.
[17] Cao, MingMing, Zhang, Yu, Li, XiaoHui, Peng, ZongGen, Jiang, JianDong, Gu, YuCheng, Di, YingTong, Li, XiaoNian, Chen, DuoZhi, Xia, ChengFeng, He, HongPing, Li, ShunLin, Hao, XiaoJiang. Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus. JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 79(17): 7945-7950, http://dx.doi.org/10.1021/jo501076x.
[18] Huang ShengDian, Zhang Yu, He HongPing, Li ShiFei, Tang GuiHua, Chen DuoZhi, Cao MingMing, Di YingTong, Hao XiaoJiang. A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2013, 11(4): 406-410, http://dx.doi.org/10.1016/S1875-5364(13)60060-6.
[19] 黄升殿, 张于, 何红平, 李石飞, 唐贵华, 陈铎之, 曹明明, 邸迎彤, 郝小江. 红花石蒜中的一个新石蒜生物碱(英文). 中国天然药物[J]. 2013, 406-410, http://www.irgrid.ac.cn/handle/1471x/832399.
[20] Cai, JieYun, Zhang, Yu, Luo, ShiHong, Chen, DuoZhi, Tang, GuiHua, Yuan, ChunMao, Di, YingTong, Li, ShengHong, Hao, XiaoJiang, He, HongPing. Aphanamixoid A, a Potent Defensive Limonoid, with a New Carbon Skeleton from Aphanamixis polystachya. ORGANIC LETTERS[J]. 2012, 14(10): 2524-2527, http://dx.doi.org/10.1021/ol3008149.
[21] Cao, Mingming, Zhang, Yu, He, Hongping, Li, Shifei, Huang, Shendian, Chen, Duozhi, Tang, Guihua, Li, Shunlin, Di, Yingtong, Hao, Xiaojiang. Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 75(6): 1076-1082, http://www.irgrid.ac.cn/handle/1471x/522636.

科研活动

   
科研项目
( 1 ) 菲啶类Wnt/β-catenin信号通路激动剂抗白癜风活性及其作用机制研究, 负责人, 国家任务, 2018-01--2021-12
( 2 ) 中国“科学院青年创新促进会”人才计划, 负责人, 中国科学院计划, 2018-01--2021-12
( 3 ) 新型菲啶类抗PEDV药物先导化合物的发现及其作用机制研究, 负责人, 国家任务, 2020-01--2023-12
( 4 ) 云南省“万人计划,青年拔尖人才”人才计划, 负责人, 地方任务, 2020-01--2024-12
( 5 ) 西部青年学者人才计划, 负责人, 中国科学院计划, 2022-01--2024-12

指导学生

现指导学生

阮婷  硕士研究生  078001-药物化学