主要从事糖类分子在微生物致病性、耐药性、环境感知、细胞发育等方面功能研究。先后在《Journal of Biological Chemistry》、《Development》、《Genome Research》等学术杂志上发表文章20余篇。参与撰写冷泉港出版社真菌科研专著《Human Fungal Pathogens》。

   

081703-生物化工

糖生物学与糖生物工程

2004-08--University of Oklahoma   博士

   

2010-10~2014-07,Washington University in St.Louis, 博士后

2019-05-01-今,中国生物工程学会糖生物工程专业委员会委员,

   

[1] 杜昱光, 赵雪, 葛少林, 王倬, 王瀚博, 陈燕旌, 冯翠, 张毓宸. 一种用于扩增SARS-CoV-2的CAMP引物组及试剂盒. CN: CN113862398A, 2021-12-31.

[2] 陆俊, 杜昱光, 王倬, 张琛, 赵雪, 李国强, 谭广文, 竺晓山, 丁玮. 锁相检测装置及相应的核酸检测设备. CN: CN113583832A, 2021-11-02.

[3] 陆俊, 杜昱光, 王倬, 张琛, 赵雪, 李国强, 谭广文, 竺晓山, 丁玮. 一种自助式核酸检测一体机及微流控芯片. CN: CN214088513U, 2021-08-31.

[4] 陆俊, 李晶, 陈科, 杜昱光, 王倬, 张琛, 李国强, 赵雪, 谭广文, 竺晓山, 丁玮. 一种可持续工作的核酸检测设备. CN: CN112708532A, 2021-04-27.

[5] 马光辉, 王冰, 杨建国, 杜昱光, 张明程, 黄永东, 王琪, 夏宇飞, 朱玉山, 齐建成, 刘冬冬, 李恩成, 李颖, 王倬, 王双, 于龙河, 吴楠, 朱凯, 未金花, 闫雅璐, 周炜清. 一种COVID-19病毒抗体检测微球及其制备方法和含该微球的试剂盒. CN: CN111551713A, 2020-08-18.

[6] 杜昱光, 毛瑞, 梁祖源, 王倬, 冯翠, 张毓宸. 一种用于扩增ASFV的CAMP引物组及试剂盒和应用. CN: CN110551851A, 2019-12-10.

[7] 杜昱光, 王倬, 李瑞莲, 焦思明, 冯翠, 张毓宸. 一种杀菌药物组合物及其在制备抗真菌生物膜药物中的应用. CN: CN110478486A, 2019-11-22.

[8] 杜昱光, 张琛, 焦建会, 韩业君, 彭小伟, 王倬, 焦思明, 冯翠, 张毓宸. 一种基于有机质快速形成的改良荒漠化土壤的方法. CN: CN110419288A, 2019-11-08.

[9] 杜昱光, 荆柏林, 李建军, 王倬. 一种微流控芯片和基于该芯片的肿瘤转移模型及模型构建方法和应用. CN: CN109517737A, 2019-03-26.

[10] 杜昱光, 王倬, 张贵强, 刘静, 焦思明, 冯翠, 张毓宸. 一种菊粉-壳聚糖偶联物、药物组合物、其应用和其制备方法. CN: CN108484793A, 2018-09-04.

[11] 杜昱光, 王倬, 李瑞莲, 张贵强, 单俊伟, 王海华. 浒苔多糖、浒苔寡糖、药物组合物及其用途. CN: CN108409877A, 2018-08-17.

[12] 杜昱光, 齐立斐, 毛瑞, 王倬. 一种用于扩增甲型流感病毒的LAMP引物组及试剂盒. CN: CN107586885A, 2018-01-16.

[13] 杜昱光, 王倬, 未金花, 李瑞莲, 焦思明, 程功. 一种抗菌膜活性的壳寡糖与抗生素及其应用. CN: CN107441494A, 2017-12-08.

[14] 杜昱光, 毛瑞, 王倬. 一种用于扩增MERS‑CoV的LAMP引物组及试剂盒. CN: CN106868220A, 2017-06-20.

[15] 杜昱光, 毛瑞, 刘洪涛, 王倬. 一种恒温条件下合成核酸的方法. CN: CN106636071A, 2017-05-10.

   

[1] Li, Ruilian, Zhu, Limeng, Liu, Dongdong, Wang, Wenjing, Zhang, Chen, Jiao, Siming, Wei, Jinhua, Ren, Lishi, Zhang, Yuchen, Gou, Xun, Yuan, Xianghua, Du, Yuguang, Wang, Zhuo A. High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases. CARBOHYDRATE POLYMERS[J]. 2022, 285: http://dx.doi.org/10.1016/j.carbpol.2022.119253.
[2] Bolin Jing, Kun Xia, Chen Zhang, Siming Jiao, Limeng Zhu, Jinhua Wei, Zhuo A Wang, Nannan Chen, Pengfei Tu, Jianjun Li, Yuguang Du. Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2022, 10: [3] Cao, Ruiqi, Yu, Haomiao, Long, Huibin, Zhang, Hongrui, Hao, Chao, Shi, Lin, Du, Yuguang, Jiao, Siming, Guo, Ai, Ma, Lifeng, Wang, Zhuo. Low deacetylation degree chitosan oligosaccharide protects against IL-1 beta induced inflammation and enhances autophagy activity in human chondrocytes. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION[J]. 2022, 33(4): 517-531, http://dx.doi.org/10.1080/09205063.2021.1996962.
[4] 周欣欣, 吴声敢, 王倬, 焦思明, 蓝帅, 袁善奎. 植物免疫诱导剂酰氨寡糖素对环境非靶标生物的毒性研究. 现代农药[J]. 2022, 21(3): 50-53, http://lib.cqvip.com/Qikan/Article/Detail?id=7107315336.
[5] Wang, Yujie, Wen, Rong, Liu, Dongdong, Zhang, Chen, Wang, Zhuo A, Du, Yuguang. Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo. MOLECULES[J]. 2021, 26(8): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070450/.
[6] Cao, Ruiqi, Yu, Haomiao, Long, Huibin, Zhang, Hongrui, Hao, Chao, Shi, Lin, Du, Yuguang, Jiao, Siming, Guo, Ai, Ma, Lifeng, Wang, Zhuo. Low deacetylation degree chitosan oligosaccharide protects against IL-1 beta induced inflammation and enhances autophagy activity in human chondrocytes. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION[J]. 2021, [7] Li, Xiaoguang, Li, Jing, Ge, Qinggang, Du, Yuguang, Li, Guoqiang, Li, Wei, Zhang, Tong, Tan, Lei, Zhang, Runqiang, Yuan, Xiaoning, Zhang, He, Zhang, Chen, Liu, Wenjun, Ding, Wei, Sun, Liang, Chen, Ke, Wang, Zhuo, Shen, Ning, Lu, Jun. Detecting SARS-CoV-2 in the Breath of COVID-19 Patients. FRONTIERS IN MEDICINE[J]. 2021, 8: https://doaj.org/article/0a94036fb325407189dfe27328e76c0d.
[8] Wang, Yining, Ge, Ge, Mao, Rui, Wang, Zhuo, Sun, YuZhe, Du, YuGuang, Gao, XingHua, Qi, RuiQun, Chen, HongDuo. Genotyping of 30 kinds of cutaneous human papillomaviruses by a multiplex microfluidic loop-mediated isothermal amplification and visual detection method. VIROLOGY JOURNAL[J]. 2020, 17(1): http://dx.doi.org/10.1186/s12985-020-01373-3.
[9] Yuan, Xianghua, Liu, Jing, Li, Ruilian, Zhou, Junlin, Wei, Jinhua, Jiao, Siming, Wang, Zhuo A, Du, Yuguang. Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol. MOLECULES[J]. 2020, 25(24): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767115/.
[10] 张琛, 焦建会, 王倬, 冯翠, 张毓宸, 杜昱光. 珊瑚岛屿表层土壤的主要化学性质和微生物群落结构研究. 环境生态学[J]. 2020, 2(6): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=7102092334.
[11] Jing, Bolin, Wang, Zhuo A, Zhang, Chen, Deng, Quanfeng, Wei, Jinhua, Luo, Yong, Zhang, Xiuli, Li, Jianjun, Du, Yuguang. Establishment and Application of Peristaltic Human Gut-Vessel Microsystem for Studying Host-Microbial Interaction. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2020, 8: https://doaj.org/article/821504332f9241b190608e8bee849f66.
[12] Limeng Zhu, Ruilian Li, Siming Jiao, Jinhua Wei, Yalu Yan, Zhuo A Wang, Jianjun Li, Yuguang Du. Blood-Brain Barrier Permeable Chitosan Oligosaccharides Interfere with β-Amyloid Aggregation and Alleviate β-Amyloid Protein Mediated Neurotoxicity and Neuroinflammation in a Dose- and Degree of Polymerization-Dependent Manner. MARINE DRUGS[J]. 2020, 18(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650801/.
[13] Huang, ChingCheng, Lin, YungFang, Wu, YuYi, Lee, TzuPei, Lu, YuHung, Liu, Dongdong, Mao, Rui, Wang, Zhuo, Du, Yuguang. Biological and pre-clinical evaluation of novel designed CAMP IVD devices by using a microfluidic chip with dendritic channels/reaction wells for pet care managements in pathogen detections. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGYnull. 2019, 125: 22-23, https://www.webofscience.com/wos/woscc/full-record/WOS:000496794300028.
[14] 王倬, 刘洪涛, 尹恒, 杜昱光. 糖工程发展态势分析. 中国生物工程杂志[J]. 2019, 39(1): 1-12, https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20190101.
[15] 刘静, 贾培媛, 焦思明, 程功, 李瑞莲, 王倬, 裴志超, 杜昱光. 3种常见壳寡糖盐的生物活性比较. 西北农林科技大学学报:自然科学版[J]. 2019, 47(6): 139-144, http://lib.cqvip.com/Qikan/Article/Detail?id=7002195416.
[16] 王倬. ynthesis and evaluation of a Chitosan oligosaccharide-streptomycin conjugate against Pseudomonas aeruginosa biofilms. Marine Drugs. 2019, [17] Huang, ChingCheng, Lin, YungFang, Wu, YuYi, Liu, Dongdong, Mao, Rui, Wang, Zhuo, Du, Yuguang. Biological and pre-clinical evaluation of a novel rapid competitive annealing mediated isothermal amplification method combined with a designed microfluidic chip for rabies virus detection. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGYnull. 2019, 125: 19-20, [18] Wei, Jinhua, Wang, Zhuo A, Wang, Bing, Jahan, Marefa, Wang, Zhongfu, Wynn, Peter C, Du, Yuguang. Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://doaj.org/article/8db96c2e7a5042028d287e8517e73d0f.
[19] 刘洪涛, 原旭冰, 王倬, 杜昱光. 功能糖在生命健康领域的研究进展及产业发展现状. 生物产业技术[J]. 2018, 15-22, http://lib.cqvip.com/Qikan/Article/Detail?id=7000969980.
[20] Wang, Zhuo A, Li, Lucy X, Doering, Tamara L. Unraveling synthesis of the cryptococcal cell wall and capsule. GLYCOBIOLOGY[J]. 2018, 28(10): 719-730, http://dx.doi.org/10.1093/glycob/cwy030.
[21] Zhang, Guiqiang, Liu, Jing, Li, Ruilian, Jiao, Siming, Feng, Cui, Wang, Zhuo A, Du, Yuguang. Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan. MARINE DRUGS[J]. 2018, 16(5): http://www.irgrid.ac.cn/handle/1471x/1764401.
[22] Zhang, Chen, Jiao, Siming, Wang, Zhuo A, Du, Yuguang. Exploring Effects of Chitosan Oligosaccharides on Mice Gut Microbiota in in vitro Fermentation and Animal Model. FRONTIERS IN MICROBIOLOGY[J]. 2018, 9: http://ir.ipe.ac.cn/handle/122111/26289.
[23] Mao, Rui, Qi, Lifei, Wang, Zhuo, Liu, Hongtao, Du, Yuguang. Helix loop-mediated isothermal amplification of nucleic acids. RSC ADVANCES[J]. 2018, 8(34): 19098-19102, https://www.webofscience.com/wos/woscc/full-record/WOS:000433391600038.
[24] Mao, Rui, Qi, Lifei, Li, Jianjun, Sun, Ming, Wang, Zhuo, Du, Yuguang. Competitive annealing mediated isothermal amplification of nucleic acids. ANALYST[J]. 2018, 143(3): 639-642, https://www.webofscience.com/wos/woscc/full-record/WOS:000423680700006.
[25] 齐立斐, 毛瑞, 吴萍, 王倬, 叶元土, 杜昱光. 鲤疱疹病毒Ⅱ型的核酸恒温扩增微流控快速检测芯片的建立. 沈阳农业大学学报[J]. 2018, 49(2): 220-226, http://lib.cqvip.com/Qikan/Article/Detail?id=7000616400.
[26] 王倬, 曾粮斌, 袁善奎, 李建军, 杜昱光. 几丁类寡糖构效关系及植物免疫诱导活性研究进展. 农药科学与管理[J]. 2018, 39(4): 45-50, http://lib.cqvip.com/Qikan/Article/Detail?id=675802207.
[27] Mao, Rui, Ge, Ge, Wang, Zhuo, Hao, Rongzhang, Zhang, Guohao, Yang, Zhenzhou, Lin, Bincheng, Ma, Yajun, Liu, Hongtao, Du, Yuguang. A multiplex microfluidic loop-mediated isothermal amplification array for detection of malaria-related parasites and vectors. ACTA TROPICA[J]. 2018, 178: 86-92, http://dx.doi.org/10.1016/j.actatropica.2017.10.025.
[28] Meng XianPu, Jiao SiMing, Qin ShengQi, Yang XianBei, Li JianShe, Wei JinHua, Wang Zhuo, Du YuGuang. Comparative Study on Milk Oligosaccharides in Buffalo and Cow Colostrum Milk. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2017, 44(10): 942-948, https://www.webofscience.com/wos/woscc/full-record/WOS:000413991500013.
[29] 李瑞莲, 王倬, 杜昱光. 白色念珠菌生物被膜研究进展. 微生物学报[J]. 2017, 57(8): 1206-1218, [30] Meng XianPu, Jiao SiMing, Qin ShengQi, Yang XianBei, Li JianShe, Wei JinHua, Wang Zhuo, Du YuGuang. Comparative Study on Milk Oligosaccharides in Buffalo and Cow Colostrum Milk. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2017, 44(10): 942-948, https://www.webofscience.com/wos/woscc/full-record/WOS:000413991500013.
[31] 任立世, 焦思明, 刘洪涛, 王倬, 冯翠, 贾培媛, 程功, 李建军, 未金花, 杜昱光. 岩藻寡糖的制备及抗氧化活性测定. 2015中国酶工程与糖生物工程学术研讨会论文摘要集null. 2015, http://ir.ipe.ac.cn/handle/122111/20431.
[32] 未金花, 王倬, 刘洪涛, 许青松, 杜昱光. 猪乳功能寡糖与哺乳期仔猪生长发育水平的相关性研究. 2015中国酶工程与糖生物工程学术研讨会论文摘要集null. 2015, http://ir.ipe.ac.cn/handle/122111/20439.
[33] 程功, 任立世, 焦思明, 未金花, 王倬, 贾培媛, 李建军, 刘洪涛, 冯翠, 杜昱光. 化学酶法生产可控聚合度及脱乙酰度壳寡糖方法初探. 2015中国酶工程与糖生物工程学术研讨会论文摘要集null. 2015, http://ir.ipe.ac.cn/handle/122111/20393.
[34] 王倬, 未金花, 刘洪涛, 杜昱光. 抗生素糖修饰与病原细菌菌膜耐药性关系. 2015中国酶工程与糖生物工程学术研讨会论文摘要集null. 2015, http://ir.ipe.ac.cn/handle/122111/20405.
[35] 焦思明, 任立世, 刘洪涛, 郑军平, 冯翠, 程功, 未金花, 王倬, 杜昱光. 牛樟芝寡糖的制备分离及其生物活性的研究. 2015中国酶工程与糖生物工程学术研讨会论文摘要集null. 2015, http://ir.ipe.ac.cn/handle/122111/20420.

   

（ 1 ） 壳寡糖对菌膜多糖结构破坏作用的机制研究, 主持, 国家级, 2017-01--2020-12
（ 2 ） 烈性外来动物疫病防控技术研发-ASFV亚单位疫苗寡糖疫苗佐剂, 主持, 国家级, 2017-07--2020-12