长期从事天然质谱、原位分析与多模态质谱成像研究，聚焦蛋白质相互作用与构象动态表征、代谢与肿瘤空间异质性解析等方向的方法学创新与平台建设。曾任英国物理实验室高级科学家，主持并作为骨干参与多项英国国家计量体系（NMS）项目及与阿斯利康、葛兰素史克等国际制药企业合作的产业课题，累计竞争性科研及产业合作经费超过180万英镑，具备较强的技术攻关、平台建设与成果转化能力。主导及合作研究成果发表于 Chemical Science、Analyst、Journal of the American Society for Mass Spectrometry、Nature Metabolism、Cancer Discovery 等国际知名期刊，在质谱、组学及肿瘤研究等领域重要国际学术会议作口头报告十余次，其中受邀报告2次，并担任 Chemical Science、Analyst、Analytical and Bioanalytical Chemistry、RSC Advances 等主流化学、分析化学期刊审稿人。曾获英国国家实验室2024年度科学奖和2025年度探索基金独立研究资助。
研究领域
- 原位天然（非变性）质谱与蛋白质–配体相互作用表征
- 空间多组学与质谱成像技术
- 前沿质谱方法开发及其在肿瘤等生命科学中的应用
招生信息
空间组学与质谱成像
原位天然质谱与蛋白质相互作用
质谱技术开发及肿瘤生命科学应用
教育背景
工作经历
工作简历
专利与奖励
奖励信息
出版信息
代表论文
1. Bin Yan* and Josephine Bunch*, A straightforward method for measuring binding affinities of ligands to proteins of unknown concentration in biological tissues, Chemical Science, 2025, 16, 8673-8681. (cover article)
2. Bin Yan* et al., Differentiation of lactose sample batches from surface impurities by OrbiSIMS, The Analyst, 2025, 150, 3712-3719.
3. Bin Yan* et al., Exploring the catalytic mechanism of ATPase at the molecular level by tandem mass spectrometry, International Journal of Mass Spectrometry, 2025, 508, 117393.
4. Johan Vande Voorde, ..., Bin Yan et al., Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target, Nature Metabolism, 2023, 5, 1303-1318.
5. Bin Yan and Josephine Bunch, Probing Folded Proteins and Intact Protein Complexes by Desorption Electrospray Ionization Mass Spectrometry, Journal of the American Society for Mass Spectrometry, 2021, 32, 690-699.
6. Bin Yan et al., Direct Tissue Mass Spectrometry Imaging by Atmospheric Pressure UV-Laser Desorption Plasma Postionization, Journal of the American Society for Mass Spectrometry, 2021, 32, 429-435
科研活动
会议报告
• “Analysis and comparison of matched FFPE and fresh frozen tissues by multimodal MSI”, British Mass Spectrometry Society Annual Meeting, Edinburgh, UK, 9 Sep 2025
• “A straightforward mass spectrometry method to measure protein-ligand binding affinities”, NextGen Omics 2024, London, UK, 24 Oct 2024 - Invited Talk
• “Comparative multimodal mass spectrometry imaging of FFPE and fresh frozen tissue samples”, 2nd International Mass Spectrometry Imaging Conference, Münster, Germany, 12 Sep 2024
• “Uncovering metabolic signatures associated with the invasiveness of metastatic melanoma by DESI MSI”, 1st International Mass Spectrometry Imaging Conference, Montreal, Canada, 24 Oct 2023
• “Development of ambient mass spectrometry for in-situ protein analysis and its implications in cancer research”, Cancer Grand Challenges Future Leaders Conference, Barcelona, Spain, 3 Nov 2022
• “Multimodal mass spectrometry imaging in cancer research”, 7th EU Pharmaceutical Flow Cytometry and Imaging Meeting, Manchester, UK, 30 Nov 2021 - Invited Talk