• 光活性有机共轭材料的诊疗应用
• 基于苯硼酸-葡萄糖识别的持续血糖监测研究
• 有机-生物杂化体系的构建和应用

   

070303-有机化学
083100-生物医学工程

生物医用光活性有机共轭材料
持续血糖监测

2009-09--2015-07   中国科学院化学研究所   博士
2005-09--2009-07   中国科学技术大学   学士

   

2020-11~现在, 中国科学院宁波材料技术与工程研究所, 项目研究员
2015-09~2020-11,加州大学圣塔芭芭拉分校, 博士后

   

[1] Ke Nan, Yu-Na Jiang, Meng Li, Bing Wang. Recent Progress in Diboronic-Acid-Based Glucose Sensors. Biosensors[J]. 2023, 13(6): 618-, https://www.mdpi.com/2079-6374/13/6/618.
[2] Li, Meng, Li, Zheng, Yu, Danni, Wang, Ming, Wang, Dong, Wang, Bing. Quinoid Conjugated Polymer Nanoparticles with NIR-II Absorption Peak Toward Efficient Photothermal Therapy. CHEMISTRY-A EUROPEAN JOURNAL. 2023, http://dx.doi.org/10.1002/chem.202202930.
[3] Du, Changsheng, Gao, Dong, Gao, Mengshi, Yuan, Hongbo, Liu, Xiaoning, Wang, Bing, Xing, Chengfen. Property Regulation of Conjugated Oligoelectrolytes with Polyisocyanide to Achieve Efficient Photodynamic Antibacterial Biomimetic Hydrogels. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(24): 27955-27962, http://dx.doi.org/10.1021/acsami.1c06659.
[4] Abrams, Austin S, Eden, Alexander, Zhou, Lingyun, Wang, Bing, Huber, David E, Pennathur, Sumita. Real-Time Zeta Potential Analysis of Microchannel Surfaces during Aminosilane Deposition and Exposure Using Current Monitoring. ANALYTICAL CHEMISTRY[J]. 2021, 93(49): 16512-16519, http://dx.doi.org/10.1021/acs.analchem.1c03628.
[5] Kim, Hyunjin, Cohen, Dan, Wang, Bing, Queenan, B N, Bazan, Guillermo C, Pennathur, Sumita. Integration of buried dual-junction photodetection with ratiometric FRET-based biosensing: Results and design considerations. SENSORS AND ACTUATORS A-PHYSICAL[J]. 2020, 315: http://dx.doi.org/10.1016/j.sna.2020.112364.
[6] Wang, Bing, Queenan, Bridget N, Wang, Shu, Nilsson, K Peter R, Bazan, Guillermo C. Precisely Defined Conjugated Oligoelectrolytes for Biosensing and Therapeutics. ADVANCED MATERIALSnull. 2019, 31(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000475696300005.
[7] Wang, Bing, Chou, KuangHua, Queenan, Bridget N, Pennathur, Sumita, Bazan, Guillermo C. Molecular Design of a New Diboronic Acid for the Electrohydrodynamic Monitoring of Glucose. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(31): 10612-10615, https://www.webofscience.com/wos/woscc/full-record/WOS:000474084700001.
[8] Wang, Bing, Fronk, Stephanie L, Rengert, Zachary D, Limwongyut, Jakkarin, Bazan, Guillermo C. Conjugated Oligoelectrolytes: Materials for Acceleration of Whole Cell Biocatalysis. CHEMISTRY OF MATERIALS[J]. 2018, 30(17): 5836-5840, https://www.webofscience.com/wos/woscc/full-record/WOS:000444792800006.
[9] Jia, Bing, Zhang, Xin, Wang, Bing, Chen, Muhua, Lv, Fengting, Wang, Shu, Wang, Fan. Dual-Modal Probe Based on Polythiophene Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Imaging. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(7): 6646-6651, [10] Wang, Bing, Wang, Ming, Mikhailovsky, Alexander, Wang, Shu, Bazan, Guillermo C. A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(18): 5031-5034, http://dx.doi.org/10.1002/anie.201701146.
[11] Wang, Bing, Feng, Guangxue, Seifrid, Martin, Wang, Ming, Liu, Bin, Bazan, Guillermo C. Antibacterial Narrow-Band-Gap Conjugated Oligoelectrolytes with High Photothermal Conversion Efficiency. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(50): 16063-16066, http://dx.doi.org/10.1002/anie.201709887.
[12] Bing Wang, Chenyao Nie, Libing Liu, Fengting Lv, Shu Wang. Selective biocompatibility and responsive imaging property of cationic conjugated polyelectrolyte to cancer cells. 中国化学快报：英文版[J]. 2017, 28(10): 1975-1978, http://lib.cqvip.com/Qikan/Article/Detail?id=673829529.
[13] Nie, Chenyao, Li, Shengliang, Wang, Bing, Liu, Libing, Hu, Rong, Chen, Hui, Lv, Fengting, Dai, Zhihui, Wang, Shu. Preparation of Reactive Oligo(p-Phenylene Vinylene) Materials for Spatial Profiling of the Chemical Reactivity of Intracellular Compartments. ADVANCEDMATERIALS[J]. 2016, 28(19): 3749-3754, https://www.webofscience.com/wos/woscc/full-record/WOS:000376480500016.
[14] Wang, Fengyan, Li, Meng, Wang, Bing, Zhang, Jiangyan, Cheng, Yongqiang, Liu, Libing, Lv, Fengting, Wang, Shu. Synthesis and Characterization of Water-Soluble Polythiophene Derivatives for Cell Imaging. SCIENTIFIC REPORTS[J]. 2015, 5: 7617-, https://www.webofscience.com/wos/woscc/full-record/WOS:000347794900004.
[15] Chen, Hui, Wang, Bing, Zhang, Jiangyan, Nie, Chenyao, Lv, Fengting, Liu, Libing, Wang, Shu. Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability. CHEMICAL COMMUNICATIONS[J]. 2015, 51(19): 4036-4039, http://ir.iccas.ac.cn/handle/121111/28290.
[16] Nie, Chenyao, Wang, Bing, Zhang, Jiangyan, Cheng, Yongqiang, Liu, Libing, Lv, Fengting, Wang, Shu. Multifunctional Assembly of Micrometer-Sized Colloids for Cell Sorting. SMALL[J]. 2015, 11(21): 2555-2563, http://ir.iccas.ac.cn/handle/121111/28172.
[17] Bai, Haotian, Yuan, Huanxiang, Nie, Chenyao, Wang, Bing, Lv, Fengting, Liu, Libing, Wang, Shu. A Supramolecular Antibiotic Switch for Antibacterial Regulation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(45): 13208-13213, http://ir.iccas.ac.cn/handle/121111/29188.
[18] Yuan, Hongbo, Qi, Junjie, Xing, Chengfen, An, Hailong, Niu, Ruimin, Zhan, Yong, Fan, Yibing, Yan, Wenmin, Li, Ruihua, Wang, Bing, Wang, Shu. Graphene-Oxide-Conjugated Polymer Hybrid Materials for Calmodulin Sensing by Using FRET Strategy. ADVANCED FUNCTIONAL MATERIALS[J]. 2015, 25(28): 4412-4418, http://ir.iccas.ac.cn/handle/121111/27772.
[19] Hu, Rong, Yuan, Huanxiang, Wang, Bing, Liu, Libing, Lv, Fengting, Wang, Shu. DNA Hydrogel by Multicomponent Assembly for Encapsulation and Killing of Cells. ACS APPLIED MATERIALS & INTERFACES[J]. 2014, 6(15): 11823-11828, https://www.webofscience.com/wos/woscc/full-record/WOS:000340446300003.
[20] Yuan, Huanxiang, Wang, Bing, Lv, Fengting, Liu, Libing, Wang, Shu. Conjugated-Polymer-Based Energy-Transfer Systems for Antimicrobial and Anticancer Applications. ADVANCED MATERIALS[J]. 2014, 26(40): 6978-6982, http://dx.doi.org/10.1002/adma.201400379.
[21] Wang, Bing, Song, Jinzhao, Yuan, Huanxiang, Nie, Chenyao, Lv, Fengting, Liu, Libing, Wang, Shu. Multicellular Assembly and Light-Regulation of Cell-Cell Communication by Conjugated Polymer Materials. ADVANCED MATERIALS[J]. 2014, 26(15): 2371-2375, https://www.webofscience.com/wos/woscc/full-record/WOS:000334181400011.
[22] Wang, Fengyan, Liu, Zhang, Wang, Bing, Feng, Liheng, Liu, Libing, Lv, Fengting, Wang, Yilin, Wang, Shu. Multi-Colored Fibers by Self-Assembly of DNA, Histone Proteins, and Cationic Conjugated Polymers. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2014, 53(2): 424-428, https://www.webofscience.com/wos/woscc/full-record/WOS:000329152600009.
[23] Wang, Bing, Yuan, Huanxiang, Liu, Zhang, Nie, Chenyao, Liu, Libing, Lv, Fengting, Wang, Yilin, Wang, Shu. Cationic Oligo(p-phenylene vinylene) Materials for Combating Drug Resistance of Cancer Cells by Light Manipulation. ADVANCED MATERIALS[J]. 2014, 26(34): 5986-5990, https://www.webofscience.com/wos/woscc/full-record/WOS:000342147400011.
[24] Wang, Bing, Zhu, Chunlei, Liu, Libing, Lv, Fengting, Yang, Qiong, Wang, Shu. Synthesis of a new conjugated polymer for cell membrane imaging by using an intracellular targeting strategy. POLYMER CHEMISTRY[J]. 2013, 4(20): 5212-5215, https://www.webofscience.com/wos/woscc/full-record/WOS:000325404800007.
[25] Song, Jinzhao, Zhang, Jiangyan, Lv, Fengting, Cheng, Yongqiang, Wang, Bing, Feng, Liheng, Liu, Libing, Wang, Shu. Multiplex Detection of DNA Mutations by the Fluorescence Fingerprint Spectrum Technique. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(49): 13020-13023, https://www.webofscience.com/wos/woscc/full-record/WOS:000327410300048.
[26] Yang, Gaomai, Lv, Fengting, Wang, Bing, Liu, Libing, Yang, Qiong, Wang, Shu. Multifunctional Non-Viral Delivery Systems Based on Conjugated Polymers. MACROMOLECULAR BIOSCIENCE[J]. 2012, 12(12): 1600-1614, https://www.webofscience.com/wos/woscc/full-record/WOS:000312242600002.
[27] Yuan, Huanxiang, Chong, Hui, Wang, Bing, Zhu, Chunlei, Liu, Libing, Yang, Qiong, Lv, Fengting, Wang, Shu. Chemical Molecule-Induced Light-Activated System for Anticancer and Antifungal Activities. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(32): 13184-13187, https://www.webofscience.com/wos/woscc/full-record/WOS:000307487200011.
[28] Wang, Bing, Yuan, Huanxiang, Zhu, Chunlei, Yang, Qiong, Lv, Fengting, Liu, Libing, Wang, Shu. Polymer-drug conjugates for intracellar molecule-targeted photoinduced inactivation of protein and growth inhibition of cancer cells. SCIENTIFIC REPORTS[J]. 2012, 2: 766-, http://dx.doi.org/10.1038/srep00766.
[29] Wang, Bing, Yang, Qiong, Liu, Libing, Wang, Shu. Direct energy transfer from conjugated polymer to DNA intercalated dye: Label-free fluorescent DNA detection. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2011, 85(1): 8-11, http://dx.doi.org/10.1016/j.colsurfb.2010.10.026.

   

（ 1 ） 有机光学诊疗材料与技术, 负责人, 中国科学院计划, 2021-01--2023-12
（ 2 ） 基于共轭寡聚电解质/细胞膜组装的双模式协同拮抗肿瘤耐药性研究, 负责人, 国家任务, 2022-01--2024-12
（ 3 ） 有机光功能诊疗材料, 负责人, 国家任务, 2022-01--2024-12
（ 4 ） 具有自我校准能力的无痛持续血糖监测技术的研究, 负责人, 地方任务, 2022-01--2026-12

（1）光活性嵌膜共轭寡聚电解质的功能调控及其抗菌应用研究   中国化学会第十七届全国光化学学术讨论会   2021-10-09
（2）稳定的持续血糖监测的技术与策略   中国生物物理学会材料生物学与智能诊疗技术分会   2020-12-26
（3）光活性嵌膜共轭寡聚电解质的抗菌应用研究   中国化学会第二届全国光功能材料青年学者研讨会   2020-10-09