基本信息
孙兵  男  博导  中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)
电子邮件: bsun@sibs.ac.cn
通信地址: 岳阳路320号
邮政编码: 200031
部门/实验室:生物化学与细胞生物学研究所

研究领域

分子免疫学

招生信息

   
招生专业
071009-细胞生物学
071005-微生物学
招生方向
分子免疫学
分子病毒学

简历

1988-03--1991-01   上海第二医科大学   博士研究生
教育背景

1988.03-1991.01 

免疫学博士研究生,免疫学基础,上海第二医科大学

1983.07-1986.09 

硕士研究生,新疆医学院药理学专业

1978.10-1983.07 

本科,新疆医学院医疗系


工作经历

2005.12- 2016.12       

中科院上海巴斯德所中方所长、研究员、研究组长。主要研究呼吸道流感病毒和SARS病毒感染的致病机制和抗HCV丙肝感染的免疫保护的机制研究。

1998.05-至今 

中科院上海生科院生化与细胞所研究员、研究组长

重点研究树突状细胞成熟与分化和T辅助细胞亚群(Th1Th2细胞)分化。 

1994.01-1999.01 

美国国立卫生研究院博士后和高级访问学者

1991.01-1994.01 

上海第一医科大学药学院讲师、副教授

1986.09-1988.03 

    新疆医学院药学系助教


教授课程

实验生物学
高级免疫学与病毒学系列讲座
抗体工程
分子病毒学

专利与奖励

   
奖励信息
(1) 国家自然科学二等奖, 二等奖, 国家级, 2013
(2) 2012年度上海市自然科学二等奖, 二等奖, 省级, 2012
(3) “优秀研究生导师”奖, , 部委级, 2008
(4) 上海市优秀学科带头人, , 省级, 2007
(5) 千百万人才工程奖, , 国家级, 2004
(6) 上海市科技系统先进工作者, , 省级, 2004
专利成果
( 1 ) SARS早期诊断的多肽及试剂盒, 发明, 2008, 第 1 作者, 专利号: 3128832.4
( 2 ) SARS冠状病毒相关多肽及其应用, 发明, 2005, 第 1 作者, 专利号: ZL03129289.5
( 3 ) 一种SARS冠状病毒药物靶点及其应用, 发明, 2011, 第 1 作者, 专利号: ZL200610027476X
( 4 ) 检测乙型肝炎病毒e抗原的试剂盒和用途, 发明, 2011, 第 1 作者, 专利号: ZL200610143423.4
( 5 ) SARS冠状病毒的干扰RNA及其应用, 发明, 2007, 第 1 作者, 专利号: ZL2006 1 0027475.5
( 6 ) 抗-HBeAg单克隆抗体及其细胞株、制备方法和用途, 发明, 2008, 第 1 作者, 专利号: ZL2005 1 0030849.4
( 7 ) 抗-HBeAg单克隆抗体及其细胞株、制备方法和抗HBeAg单抗, 发明, 2008, 第 1 作者, 专利号: ZL200510030851.1
( 8 ) 针对禽流感病毒的重组联合DNA疫苗, 发明, 2008, 第 1 作者, 专利号: 200810037040.8
( 9 ) 一种青藤碱衍生物、合成方法及其用途, 发明, 2010, 第 1 作者, 专利号: 201010108675.X
( 10 ) 抗H5N1来源的血凝素蛋白的单克隆抗体及其应用, 发明, 2008, 第 1 作者, 专利号: 200810037362.2
( 11 ) 一种抗甲型H1N1流感病毒血凝素蛋白的抗体, 发明, 2010, 第 1 作者, 专利号: 201010174886.3
( 12 ) H5N1亚型禽流感假病毒的制备方法及其用途, 发明, 2010, 第 1 作者, 专利号: 201010118101.0
( 13 ) 甲型流感病毒疫苗哺乳动物细胞适应株的获得方法和适应位点, 发明, 2013, 第 1 作者, 专利号: 201310098172.2
( 14 ) 一种中和丙型肝炎病毒的全人单克隆抗体及其用途, 发明, 2014, 第 1 作者, 专利号: 201410128238.2
( 15 ) 甲型流感病毒疫苗Vero细胞适应株的获得方法和适应位点, 发明, 2014, 第 1 作者, 专利号: 201510091993.2
( 16 ) 针对胱抑素C的单克隆抗体、杂交瘤细胞株制备及其用途, 发明, 2013, 第 1 作者, 专利号: 201310153514.6
( 17 ) 细胞外基质蛋白1及其调节剂在制备过敏性疾病诊断或治疗药物中的应用, 发明, 2014, 第 1 作者, 专利号: ZL201010620105.9
( 18 ) protein and use thereof in treating multiple sclerosis, 发明, 2016, 第 1 作者, 专利号: US15/105930
( 19 ) protein and use thereof in treating multiple sclerosis, 发明, 2016, 第 1 作者, 专利号: 14872967.6

出版信息

   
发表论文
(1) Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation, Cell Research, 2017, 通讯作者
(2) Interferon alpha (IFNalpha)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A, Cellular & molecular immunology, 2016, 通讯作者
(3) Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 2016, 通讯作者
(4) Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses, NATURE COMMUNICATIONS, 2016, 通讯作者
(5) TRIM35 negatively regulates TLR7-and TLR9-mediated type I interferon production by targeting IRF7, Febs Letters, 2015, 通讯作者
(6) A single NS2 mutation of K86R promotes PR8 vaccine donor virus growth in Vero cells, Virology, 2015, 通讯作者
(7) The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis, Journal of Virology, 2015, 通讯作者
(8) A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages, Vaccine, 2015, 通讯作者
(9) beta-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes, Journal of Immunology, 2015, 通讯作者
(10) TRIM30 alpha Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING, Plos Pathogens, 2015, 通讯作者
(11) 2. Zhou HY, Wang YM, Lian QS, Yang B, Ma YL, Wu XD, Sun SH, Liu YJ, Sun B. Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction. , European Journal of Immunology, 2014, 通讯作者
(12) 3. Zhang RH, Wang K, Lv W, Yu WJ, Xie SQ, Xu K, Schwarz W, Xiong SD, Sun B. The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production. Biochimica Et , Biophysica Acta-Biomembranes, 2014, 通讯作者
(13) Human NLRP3 inflammasome senses multiple types of bacterial RNAs. ,  Proceedings of the National Academy of Sciences of the United States of America, 2014, 通讯作者
(14) Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Growth. , Journal of Virology , 2014, 通讯作者
(15) The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus, Journal of General Virology , 2014, 通讯作者
(16) Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock., Cell Res., 2013, 通讯作者
(17) Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient., Virology. , 2013, 通讯作者
(18)  Cellular localization of NLRP3 inflammasome., Protein Cell., 2013, 通讯作者
(19) Unusual architecture of the p7 channel from hepatitis C virus., Nature, 2013, 通讯作者
(20) The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production., Biochim Biophys Acta, 2013, 通讯作者
(21) Novel function of Trim44 promotes an antiviral response by stabilizing VISA., J Immunol, 2013, 通讯作者
(22)  Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7.,  J Immunol, 2013, 通讯作者
(23)  Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells.,  J Gen Virol., 2012, 通讯作者
(24) PEDV ORF3 encodes an ion channel protein and regulates virus production. , FEBS Letters. 17 February 2012, Volume 586, Issue 4, 384–391, 2012, 通讯作者
(25)  Amino acids 473V and 598P of PB1 from an avian origin influenza A virus contribute to polymerase activity especially in mammalian cells.,  J Gen Virol. 2011; 93(Pt 3):531-40., 2011, 通讯作者
(26) DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71. , Cell Research, 2011, 1-5., 2011, 通讯作者
(27) SUMO1 modification of the non-structural protein 1 of influenza A virus., Journal of Virology, 2011, 通讯作者
(28) Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1, Nature Immunology, 2011, 通讯作者
(29) Influenza A virus replication Induces Cell Cycle Arrest in G0/G1 Phase., Journal of Virology, 2010, 通讯作者
(30) Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production., Journal of Immunology , 2010, 通讯作者
(31) Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment., Nature Immunology, 2009, 通讯作者
(32) Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling, Journal of Immunology , 2009, 通讯作者
(33) TRIM30a?negatively regulates TLR-mediated NF-kB activation by targeting TAB2 and TAB3 for degradation., Nature Immunology, 2008, 通讯作者
发表著作
(1) T辅助细胞的分化及其功能, T Helper Cell Differentiation and Their Function, springer, 2014-12, 第 1 作者

项目承担情况

Execution period

Source

Name

Amount(RMB)

2009-2012

MOST

The pathogenicity of RNA polymerase and NS1 suppression   on IFN-α/ß production in different strains of avian flu viruses

2,600,000

2011-2015

MOHC

Detection technology of major infectious disease   emergency

1,910,000

2011-2015

MOHC

Prediction of hepatitis research

2,430,000

2011-2014

NSFC

ECM1 regulation of helper T cell subsets and   pathogenicity of migration

2,000,000

  2012-2015

MOST863

Development of high-throughput immune cell chip   technology with single cell surface specific protein markers detection   instrument

720,000

2012-2015

MOST863

Mumps reduced key technology of attenuated vaccine and   product development

393,000

2013-2015

NSFC

New research NLRP3 inflammasome activation and   regulation mechanisms

2,810,000

2013-2014

CAS

Scientific research on human infection with avian   influenza H7N9 virus

700,000

2014-2015

CAS

Ebola virus disease emergency technology research

500,000

2014-2016

NSFC

Molecular mechanisms of T helper cell differentiation   and migration regulated by transcription factors of T-bet and GATA3 in immune   related diseases

1,800,000

2015-2016

NN-CAS

Treatment of EAE with Extracellular matrix protein 1(ECM1)   by inhibiting Th17 cell differentiation

500,000

2013-2017

MOST973

Study of functional T cell subsets and their associated   mechanisms of immune regulation

5,540,000

2015-2019

MOST973

Study on immune escape and immune pathology in Chronic   hepatitis C

820,000

2016-2021

MOST

Functional mechanism of protein machine during specific   immune response

2,000,000

2016-2021

MOST

Functional mechanism of protein machine during specific   immune response

1,419,500

2016

CAS

Establishment of screening platform for therapeutic   antibody targets and functional research of antibody

1,500,000

2017

CAS

Maturation of dendritic cells and differentiation mechanism   of Th2 cells in immune diseases

565,000

2017

CAS

Maturation of dendritic cells and differentiation   mechanism of Th2 cells in immune diseases

576,000

2017-2021

NSFC

The protective mechanism study for ECM1 to regulate the   function of macrophage in inflammatory bowel disease

3,442,000

2017-2021

NSFC

Novel long intergenic non-coding RNAs and transcription   factors inregulating the functions ofTh2 cells and type 2 innate lymphoid   cells in mouse models of asthma

1,700,000

2016-2019

SMSTC

Screeningculture and characterization research of   broad-spectrum human anti-influenza antibody

1,000,000


项目协作单位
   

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