1、天然药物功能蛋白质组学

2、活性多肽与疾病（溃疡性结肠炎、阿尔兹海默症、细菌或病毒感染、卒中等）机理

   

071010-生物化学与分子生物学

天然药物功能蛋白质组学；活性多肽与疾病机理

2012-09--2017-06   中国科学院昆明动物研究所   博士
2008-09--2012-06   商丘师范学院   学士

   

2021-01~现在, 中国科学院昆明动物研究所, 副研究员
2017-07~2020-12,中国科学院昆明动物研究所, 助理研究员

   

（1） 全国科技系统抗击新冠肺炎先进集体, 部委级, 2021

   

（1） A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus, FRONTIERS IN MICROBIOLOGY, 2022, 通讯作者
（2） Human antimicrobial peptide LL-37 contributes to Alzheimer's disease progression, MOLECULAR PSYCHIATRY, 2022, 第 5 作者
（3） Shrew's venom quickly causes circulation disorder, analgesia and hypokinesia, CELLULAR AND MOLECULAR LIFE SCIENCES, 2022, 第 8 作者
（4） Role of LL-37 in thrombotic complications in patients with COVID-19, CELLULAR AND MOLECULAR LIFE SCIENCES, 2022, 第 1 作者
（5） SARS-CoV-2 M-pro inhibitors with antiviral activity in a transgenic mouse model, SCIENCE, 2021, 第 18 作者
（6） SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, CELL RESEARCH, 2021, 第 10 作者
（7） Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice, Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice, ZOOLOGICAL RESEARCH, 2021, 第 4 作者
（8） Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study, ZOOLOGICAL RESEARCH, 2021, 第 6 作者
（9） Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, NATIONAL SCIENCE REVIEW, 2021, 第 4 作者
（10） High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main protease, High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main protease, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 3 作者
（11） Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models, Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models, CELL RESEARCH, 2021, 第 3 作者
（12） The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation, BLOOD, 2020, 第 10 作者
（13） Isolation and Characterization of Poecistasin, an Anti-Thrombotic Antistasin-Type Serine Protease Inhibitor from Leech Poecilobdella manillensis, TOXINS, 2018, 第 3 作者
（14） Antimicrobial peptide LL-37 forms complex with bacterial DNA to facilitate blood translocation of bacterial DNA and aggravate ulcerative colitis, SCIENCEBULLETIN, 2018, 第 1 作者
（15） An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis, INTERNATIONAL IMMUNOPHARMACOLOGY, 2017, 第 6 作者
（16） Joannsin, a novel Kunitz-type FXa inhibitor from the venom of Prospirobolus joannsi, THROMBOSIS AND HAEMOSTASIS, 2017, 通讯作者
（17） A short peptide from frog skin accelerates diabetic wound healing, FEBS JOURNAL, 2014, 第 2 作者
（18） A novel 26RFa peptide containing both analgesic and anti-inflammatory functions from Chinese tree shrew, BIOCHIMIE, 2014, 第 2 作者
（19） A Small Peptide with Therapeutic Potential for Inflammatory Acne Vulgaris, PLOS ONE, 2013, 第 4 作者

   

（ 1 ） 抗菌蛋白/肽高效表达与生 产, 负责人, 国家任务, 2022-11--2026-10