基本信息
方燕姗 女 其它
中国科学院上海有机化学研究所 研究员

中科院上海生物与化学交叉研究中心 
上海市零陵路345号
邮政编码:200032
电子邮件:fangys (at) sioc.ac.cn

研究领域

方燕姗课题组隶属于中国科学院上海有机化学研究所和上海药物研究所共同建立的中科院生物与化学交叉研究中心。课题组主要研究方向为神经损伤和神经退行性疾病中的神经轴突退化变性坏死(axon degeneration)。

神经轴突退化变性坏死是急性神经损伤如脊髓损伤和脑创伤以及很多与衰老相关的慢性神经退行性疾病如老年痴呆症(AD)、帕金森氏症(PD)、亨廷顿氏症(HD)、多发性硬化症(MS)、肌萎缩性脊髓侧索硬化症(ALS)等疾病中的常见病变。此外,糖尿病、青光眼和化疗引起的神经毒性也会导致继发性的神经轴突的退化变性坏死。由于人类的中枢神经在受损或变性坏死后再生能力极其有限,如何保护受损或患病的神经,预防、延缓、阻止乃至逆转神经轴突退化变性坏死是神经生物学领域的一个重要前沿课题。

方燕姗课题组课题组运用全新的果蝇神经损伤活体动物模型结合分子遗传学、细胞生物学、生物化学、药物化学、高分辨率荧光成像、新一代测序技术、现代蛋白质组学和代谢组学等技术研究调控神经轴突退化变性坏死和促进神经再生的分子机制,并以此作为基础开发用于疾病诊断治疗的生物标志物和新型药物。
 


(Fang et al., Curreng Biology, 2012)

教育背景

2002-09--2007-12 美国宾夕法尼亚大学(University of Pennsylvania) 神经科学博士学位
1997-09--2002-07 北京大学医学部 医学学士学位

工作经历

2013-09 ~ 今 中国科学院上海有机化学研究所 中科院上海生物与化学交叉研究中心 研究员、课题组长
2008-06 ~ 2013-08 美国霍华德休斯医学研究院(Howard Hughes Medical Institute) 研究助理 
2008-01 ~ 2008-05 美国宾夕法尼亚大学(University of Pennsylvania) 博士后

获奖情况

入选国家青年千人计划,2014
入选国家863计划青年科学家项目,2014


第七届世界神经科学大会ACS青年科学家旅行资助奖,Australasian Chronobiology Society, 2007


北京市优秀毕业生,中华人民共和国教育部, 2002

光华特等奖学金,2001 
联邦制药特等奖学金,1999 
北京大学一等奖学金,1998, 2000

代表论著

Liu, C., and FANG, Y. (2019) New insights of poly(ADP-ribosylation) in neurodegenerative diseases: a focus on protein phase separation and pathologic aggregation. Biochemical Pharmacology, pii: S0006-2952(19)30163-7. [Epub ahead of print]

 

Duan, Y., Du, A., Gu, J., Duan, G., Wang, C., Gui, X., Ma, Z., Qian, B., Deng, X., Zhang, K., Sun, L., Tian, K., Zhang, Y., Jiang, H., Liu, C., and FANG, Y. (2019) “PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins.” Cell Research, 29(3):233-247. 

 

Wang, H., Wang, X., Zhang, K., Wang, Q., Cao, X., Wang, Z., Zhang, S., Li, A., Liu, K., and FANG, Y. (2019) “Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration.” Science Advances, 5(2):eaav4971. 

 

Sun, X., Duan, Y., Qin, C., Li, J.C., Duan, G., Deng, X., Ni, J., Cao, X., Xiang, K., Tian, K., Chen, C.H., Li, A., and FANG, Y. (2018) “Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy.” Cell Death & Disease, 9(10):953.

 

Cao, X., Wang, H., Wang, Z., Wang, Q., Zhang. S., Deng, Y., and FANG, Y. (2017) “In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging.” Aging Cell, 16(5):1180-1190. 

 

Cao, X., and FANG, Y. (2015) “Transducing oxidative stress to death signals in neurons”. Journal of Cell Biology, 211(4):741-743. 

 

FANG, Y., and Boinini, N.M. (2015) “Hope on the Fruit Fly - The Drosophila Wing Paradigm of Axon Injury”. Neural Regeneration Research, 10(2):173-175.

 

Garbe, D.S., FANG, Y., Zheng, X., Sowcik, M., Anjum, R., Gygi, S.P., and Sehgal, A. (2013) Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.” PLoS Genetics, 9(9): e1003749.

 

FANG, Y., Soares, L., and Bonini, N.M. (2013) Design and Implementation of In Vivo Imaging of Neural Injury Responses in the Adult Drosophila Wing. Nature Protocols, 8(4): 810-819. 

FANG, Y., and Boinini, N.M. (2012) “Axon Degeneration and Regeneration: Insights from Drosophila Models of Nerve Injury.” Annual Review of Cell and Developmental Biology, 28:575-597.

 

FANG, Y., Soares, L., Teng, X., Geary, M., and Bonini, N.M. (2012) “A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity.” Current Biology, 22(7):590-595.

 

FANG, Y., and Sehgal, A. (2010) “Protein Phosphatases and Circadian Clocks.” in Handbook of Cell Signaling, 2nd Edition, eds. Bradshaw, R. A. & Dennis, E. A. Oxford:Academic Press, pp. 877-882.

 

Wu, Y., Bolduc, F.V., Bell, K., Tully, T., FANG, Y., Sehgal, A., and Fischer, J.A. (2008) “A Drosophila Model for Angelman Syndrome.” Proc Natl Acad Sci U S A, 105(34):12399-12404.

 

FANG, Y., Sathyanarayanan, S., and Sehgal, A. (2007) “Post-translational Regulation of the Drosophila Circadian Clock Requires Protein Phosphatase 1 (PP1).” Genes and Development, 21(12):1506-1518.

 

Sehgal, A., Joiner, W., Crocker, A., Koh, K, Sathyanarayanan, S., FANG, Y., Wu, M., Williams, J., and Zheng, X. (2007) “Molecular Analysis of Sleep:Wake Cycles in Drosophila.” Cold Spring Harb Symp Quant Biol, 72:557-564.

 

Stein, J.M., Bergman, W., FANG, Y., Davison, L., Brensinger, C., Robinson, M.B., Hecht, N.B., and Abel, T. (2006) “Behavioral and Neurochemical Alterations in Mice Lacking the RNA-binding Protein Translin.” Journal of Neuroscience, 26(8):2184-2196.

合作情况

   
项目协作单位
上海交通大学附属第一人民医院神经外科

招生信息

   
招生专业
071009-细胞生物学
071006-神经生物学
071007-遗传学
招生方向
神经损伤和再生
神经轴突退化变性坏死
衰老和人类神经退行性疾病