1、脑机接口检测调控芯片微系统

2、脑机接口智能算法

3、离体神经芯片与神经计算

   

0809Z1-生物电子学

脑机接口微电极阵列和芯片微系统

2005-09--2010-06   中国科学院电子学研究所   博士
2000-09--2004-06   北方工业大学   学士

研究生

博士

   

2022-11~现在, 中国科学院空天信息创新研究院, 特聘研究骨干
2016-07~现在, 中国科学院空天信息创新研究院, 副研究员
2010-07~2016-07,中国科学院电子学研究所, 助理研究员

2023-02-16-今,中国神经科学学会脑机接口分会会员,
2018-04-01-今,中国电子学会生物医学电子学分会会员,
2016-12-01-今,中国研究型医院学会移动医疗专业委员会青年委员会委员,

   

（1） 优秀职工, 研究所（学校）, 2021
（2） The 19th IEEE International Conference on Nanotechnology 唯一最佳会议论文奖, 其他, 2019
（3） 中国生物医学工程联合学术年会生物电子与传感器分论坛最佳论文奖, 其他, 2018

（ 1 ） 三维精准电刺激诱导休眠的神经信息检测双面微电极阵列, 发明专利, 2023, 第 3 作者, 专利号: 202310508489.2

（ 2 ） 一种用于临床脑功能定位的多位点钨丝微电极, 发明专利, 2023, 第 3 作者, 专利号: 202310394130.7

（ 3 ） 用于非人灵长类动物脑深部核团双模功能定位和精准电刺激的神经微探针, 发明专利, 2023, 第 3 作者, 专利号: 202310326745.6

（ 4 ） 一种双脑区神经元长期检测微电极阵列及多向驱动系统, 发明专利, 2022, 第 3 作者, 专利号: 201111455961.2

（ 5 ） 头戴式多脑区神经检测调控微系统及微纳电极阵列模块, 发明专利, 2021, 第 3 作者, 专利号: 202111601891.2

（ 6 ） 穴位电针装置及系统, 发明专利, 2021, 第 3 作者, 专利号: CN113648219A

（ 7 ） 多模式神经刺激调控与同步检测系统, 发明专利, 2021, 第 5 作者, 专利号: CN112842366A

（ 8 ） 单细胞水平脑功能定位的微纳电极阵列芯片及其制备方法, 发明专利, 2021, 第 8 作者, 专利号: CN112716497A

（ 9 ） 颅内皮层神经信息检测电极、电极阵列及其制备方法, 2021, 第 6 作者, 专利号: CN107485386B

（ 10 ） 神经调控检测集成系统及方法, 2020, 第 4 作者, 专利号: CN107468235B

（ 11 ） 电化学检测系统, 2020, 第 4 作者, 专利号: CN106419851B

（ 12 ） 微电极阵列植入式芯片及其制备方法, 2016, 第 8 作者, 专利号: CN103829938B

（ 13 ） 一种微纳阵列传感器及其制备方法, 2015, 第 8 作者, 专利号: CN103630571B

（ 14 ） 神经信号检测器, 2015, 第 3 作者, 专利号: CN103505197B

（ 15 ） 一种神经信息检测系统, 2015, 第 4 作者, 专利号: CN103417205B

（ 16 ） 超痕量疾病标志物快速检测仪, 2012, 第 1 作者, 专利号: CN101995481B

（ 17 ） 可佩戴式无创血糖快速检测仪, 发明专利, 2010, 第 1 作者, 专利号: CN101461712B

   

（1） Compendium of In-Vivo Monitoring in Real-time Molecular Neuroscience, World Scientific Publishing Co. Inc., 2019-11, 第 5 作者
（2） 智能传感器导论, 中国科学技术出版社, 2022-11, 第 其他 作者

• • [1] Zhaojie Xu, Fan Mo, Gucheng Yang, Penghui Fan, Yiding Wang, Botao Lu, Jingyu Xie, Yuchuan Dai, Yilin Song, Enhui He, Shihong Xu, Juntao Liu, Mixia Wang*, Xinxia Cai*. Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for medial entorhinal cortex. Microsystems & Nanoengineering, 2022, 8:104;
  • [2] Mixia Wang, Yilin Song, Song Zhang, Shengwei Xu, Yu Zhang, Guihua Xiao, Ziyue Li, Fei Gao, Feng Yue, Ping Zhuang, Piu Chan, Xinxia Cai*, Functional localization in the brain of a cynomolgus monkey based on spike pattern recognition with machine learning, Journal of Ambient Intelligence and Humanized Computing, (2019), 1-8. DOI: 10.1007/s12652-019-01576-9; 
  • [3] Yun Wang, Mixia Wang, Yuchuan Dai, Yilin Song, Yiding Wang, Botao Lu, Yinghui Li*, Xinxia Cai*. PtNPs/short MWCNT-PEDOT: PSS-modified microelectrode array to detect neuronal firing patterns in the dorsal raphe nucleus and hippocampus of insomnia rats. Micromachines, 2022,13:488;
  • [4] Mixia Wang^#, Shengwei Xu^#, Yu Zhang, Enhui He, Yilin Song, Fei Gao, Guihua Xiao, Xinxia Cai*, Multi-level neural stimulation and dual-mode neural signal detection system based on implantable microelectrode array (MEA), July 20-24, 2020, The 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2020), Canada, 2178;
  • [5] Mixia Wang, Yilin Song, Song Zhang, Shengwei Xu, Guihua Xiao, Ziyue Li, Fei Gao, Yu Zhang, Feng Yue, Piu Chan, Xinxia Cai*, Abnormal spontaneous neuronal discharge and local field potential both in cortex and striatum of a non-human primate of Parkinson’s disease using implantable microelectrode arrays, July 17-21, 2018, The 40th International Conference of the IEEE Engineering in Medicine and Biology Society(IEEE EMBC’18), Honolulu, USA, p3438-3441;
  • [6] Mixia Wang, ShengweiXu, Yilin Song, Song Zhang, Xinxia Cai*, Research on neural information detecting system measuring neuroelectricity in hippocampus in vivo and dopamine in vitro based on microelectrode array, August 17-20, 2016, The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’16), America, p4837-4840; 
  • [7] Song Zhang,Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, Feng Yue*, Piu Chan*, Xinxia Cai*, Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays. Microsystems & Nanoengineering, 4(2018), 17070; doi:10.1038/micronano.2017.70;
  • [8] Song Zhang, Yilin Song, Mixia Wang, Zhiming Zhang, Xinyi Fan, Xianteng Song, Ping Zhuang, Feng Yue, Piu Chan*, Xinxia Cai*, A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain, Biosensors and Bioelectronics, 85(2016), 53-61; 
  • [9] Yun Wang, Zhiqi Fan, Mixia Wang, Juntao Liu, Shengwei Xu, Zeying Lu, Hao Wang, Yilin Song, Yiding Wang, Lina Qu, Yinghui Li*, Xinxia Cai*. Research on the specificity of electrophysiological signals of human acupoints based on the 90-day simulated weightlessness experiment on the ground. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2021,29:2164-2172.
  • [10] Enhui He^#, You Zhou^#, Jinping Luo, Shihong Xu, Kui Zhang, Yilin Song, Mixia Wang, Shengwei Xu, Yuchuan Dai, Gucheng Yang, Jingyu Xie, Zhaojie Xu, Wanwan Zhu, Yu Deng, Qi Xu*, Xinxia Cai*. Sensitive detection of electrophysiology and dopamine vesicular exocytosis of hESC-derived dopaminergic neurons using multifunctional microelectrode array. Biosensors & Bioelectronics, 2022, 209: 114263;
  • [11] Fan Mo, Zhaojie Xu, Gucheng Yang, Penghui Fan, Yiding Wang, Botao Lu, Juntao Liu, Mixia Wang, Luyi Jing, Wei Xu, Ming Li, Jin Shan ,Yilin Song* , Xinxia Cai*. Single-neuron detection of place cells remapping in short-term memory using motion microelectrode arrays. Biosensors & Bioelectronics, 2022, 217:114726;
  • [12] Fei Gao, Guihua Xiao, Yilin Song, Mixia Wang, Ziyue Li, Yu Zhang, Shengwei Xu, Jingyu Xie, Xinxia Cai*. Recording of neural activity under modulation of caged compounds photolysis in seizures rat using microelectrode arrays. IEEE Transactions on Biomedical Engineering, 66(11)(2019), 3080-3087; 
  • [13] Guihua Xiao, Yilin Song, Yu Zhang, Yu Xing, Shengwei Xu, Mixia Wang, Junbo Wang, Deyong Chen, Jian Chen, Xinxia Cai*, Dopamine and striatal neuron firing respond to frequency-dependent DBS detected by microelectrode arrays in the rat model of Parkinson’s Disease, Biosensors, 10(10)(2020), 136;
  • [14] Yu Zhang, Shengwei Xu, Guihua Xiao, Yilin Song, Fei Gao, Mixia Wang, Hongyan Zhao, Guogang Xing, Xinxia Cai*, High frequency stimulation of subthalamic nucleus synchronously modulates primary motor cortex and caudate putamen based on electrophysiology activities and dopamine concentration using microelectrode arrays in Parkinson’s disease rats, Sensors and Actuators B-Chemical, 301(9)(2019),127126;
  • [15] Enhui He^#, Shengwei Xu^#, Yuchuan Dai, Yiding Wang, Guihua Xiao, Jingyu Xie, Shihong Xu, Penghui Fan, Fan Mo, Mixia Wang, Yilin Song, Huabing Yin, Yinghui Li, Ying Wang*, Xinxia Cai*. SWCNTs/PEDOT:PSS-modified microelectrode arrays for dual-mode detection of electrophysiological signals and dopamine concentration in the striatum under isoflurane anesthesia. ACS Sensors, 2021, 6(9):3377-3386;
  • [16] Guihua Xiao, Yilin Song, Yu Zhang, Yu Xing, Hongyan Zhao, Jingyu Xie, Shengwei Xu, Fei Gao, Mixia Wang, Guogang Xing, Xinxia Cai*, Microelectrode arrays modified with nanocomposites for monitoring dopamine and spike firings under deep brain stimulation in rat models of Parkinson’s disease, ACS Sensors, 8(40)( 2019), 1992-2000;
  • [17] Penghui Fan, Yilin Song*, Botao Lu, Yiding Wang, Yuchuan Dai, Jingyu Xie, Enhui He, Zhaojie Xu, Gucheng Yang, Fan Mo, Juntao Liu, Mixia Wang, Xinxia Cai*. PtNPs/PEDOT:PSS-modifified microelectrode arrays reveal electrophysiological activities of different neurons in medial amygdala of mice under innate fear. Frontiers in Neuroscience, 2022,16:1-11;
  • [18] Xinrong Li,Yilin Song,Guihua Xiao,Enhui He,Jingyu Xie,Yuchuan Dai,Yu Xing,Yun Wang,Yiding Wang,Shengwei Xu, Mixia Wang,Tiger H. Tao*,Xinxia Cai*. PDMS−parylene hybrid, flexible micro-ECoG electrode array for spatiotemporal mapping of epileptic electrophysiological activity from multicortical brain regions. ACS Applied Bio Materials, 2021, 4:8013-8022;
  • [19] Guihua Xiao, Yilin Song, Yu Zhang, Yiding Wang, Yu Xing, Shengwei Xu, Jingyu Xie, Yuchuan Dai, Mixia Wang, Jian Chen, Deyong Chen, Junbo Wang, Xinxia Cai*, Synchronous beta oscillation of epileptiform activities detected by microelectrode arrays in the awake and anesthetized mice, Sensors and Actuators A: Physical, 318 (2021), 112529;
  • [20] Guihua Xiao, Yilin Song, Yu Zhang, Yu Xing, Shengwei Xu, Zeying Lu, Mixia Wang, Xinxia Cai*, Cellular-scale microelectrode arrays to monitor movement-related neuron activities in the epileptic hippocampus of awake mice, IEEE Transactions on Biomedical Engineering, (2020), https://doi.org/10.1109/TBME.2020.2990356;

   

（ 1 ） 微电极阵列及其记录系统研究, 负责人, 国家任务, 2022-11--2025-10
（ 2 ） 微纳传感器智能精准功能定位帕金森靶点的关键技术与装置, 负责人, 国家任务, 2020-01--2023-12
（ 3 ） 基于微纳电极与嵌入式系统的脑-机交互接口技术研究, 负责人, 国家任务, 2022-08--2025-12
（ 4 ） 睡眠-觉醒脑神经电活动高分辨感测与电刺激方法研究, 参与, 国家任务, 2023-01--2027-12
（ 5 ） 神经再生功能信息原位探测纳米生物传感技术, 参与, 国家任务, 2020-01--2024-12
（ 6 ） 神经芯片, 负责人, 国家任务, 2023-07--2025-10
（ 7 ） 脑机接口新器件与系统前沿交叉研判项目, 参与, 国家任务, 2023-01--2023-12

（1）细胞水平智能脑功能定位系统研究   第五届细胞生物信息学研讨会   2023-02-23
（2）Multi-level neural stimulation and dual-mode neural signal detection system based on implantable microelectrode array (MEA)    2020-07-20
（3）Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non-human Primate of Parkinson’s Disease using Implantable Microelectrode Arrays   2018-07-17
（4）Research on neural information detecting system measuring neuroelectricity in hippocampus in vivo and dopamine in vitro based on microelectrode array   2016-08-17