My research area is focused on developing microbiological detection methodology and control methodology.

July 2007 ~ July 2010, Postdoctoral research associate in Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198 USA
Sep 2004 ~ July 2007, Ph.D. in Physical Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China.
Sep 2001 ~ July 2004, M.S. Degree in Analytical Chemistry, Wuhan University, Wuhan, Hubei 430072, P. R. China
Sep 1997 ~ July 2001, Bachelor of Engineering Degree in Industrial Analysis, China University of Geosciences, Wuhan, Hubei 430074, P. R. China

Aug 2011~ Current, Associate Professor in Microbiology in Wuhan Institute of Viorology, Chinese Academy of Sciences
Oct 2010~Aug 2011, Assistant Professor in Microbiology in Wuhan Institute of Viorology, Chinese Academy of Sciences

1. Yun Zhang, Hang Yang, Junping Yu*, Hongping Wei*. Rapid and sensitive detection of HIV-1 p24 antigen by immunomagnetic separation coupled with catalytic fluorescent immunoassay. Anal Bioanal Chem (2016) 408:6115–6121.

2. Junping Yu, Yun Zhang, Yun Zhang, Heng Li, Hang Yang, Hongping Wei*. Sensitive and rapid detection of Staphylococcus aureus in milk via cell binding domain of lysin. Biosensor and Bioelectronics. 2016, 77, 366-371. (SCI, IF=6.4)

3. Jianli Liu,  Xuejie Zhang, Hang Yang, Jinghe Yuan, Hongping Wei, Junping Yu* and Xiaohong Fang*. Study of the interactions between endolysin and bacterial peptidoglycan on S. aureus by dynamic force spectroscopy. Nanoscale. 2015, 7, 15245-15250. (SCI, IF=7.39)

4. Tao Jia, Jing Wang, Peng Guo and Junping Yu*. Characterizations of cationic γ-carbolines binding with double-stranded DNA by spectroscopic methods and AFM imaging. Org. Biomol. Chem., 2015, 13,1234-1242. (SCI, IF=3.562)

5. Tao Jia, Jin Xiang, Jing Wang, Peng Guo and Junping Yu*. Interactions of newly designed dicationic carbazole derivatives with double-stranded DNA: syntheses, binding studies and AFM imaging. Org. Biomol. Chem., vol.11, 2013, pp. 5512-5520. (SCI, IF=3.562)

6. Junping Yu, Mirong Guan, Fengyun Li, Zhiping Zhang, Chunru Wang, Chunying Shu*, Hongping Wei* and Xian-En Zhang*. Effects of fullerene derivatives on bioluminescence and application for protease detection. Chem Comm, vol.48, 2012, pp.11011–11013. (SCI, IF=6.834)

7. Junping Yu, Julia Warnke, Yuri L. Lyubchenko. Nanoprobing of α-synuclein misfolding and aggregation with AFM. Nanomedicine: Nanotechnology, Biology and Medicine, 2011, 7, 146-152. (SCI, IF=6.155)

8. Tieshan Teng, Junping Yu, Hang Yang, Hongping Wei*. Isolation and Complete Genome Sequence of a Novel Virulent Mycobacteriophage, Casbig. Virol Sin 2015, 30, 76. (SCI)

9. Wei Hu, Yun Zhang, Hang Yang, Junping Yu, Hongping Wei^*. Simple and rapid preparation of red fluorescence and red color S. aureus derived nanobioparticles for pathogen detection. Journal of microbiological methods, 2015, 115, 47-53. (SCI)

10. Yanling Huang, Hang Yang, Junping Yu, Hongping Wei^*. Molecular Dissection of Phage Lysin Plyss2: Integrity of the Catalytic and Cell Wall Binding Domains Is Essential for Its Broad Lytic Activity. Virol Sin 2015, 30, 45. (SCI)

11. Yang, H., Wang, M., Yu, J., Wei, H., 2015. Aspartate inhibits Staphylococcus aureus biofilm formation. FEMS microbiology letters 362(7). doi: 10.1093/femsle/fnv025. (SCI, IF=2.121)

12. Qiuhua Dong, Jing Wang, Hang Yang, Cuihua Wei, Junping Yu, Yun Zhang, Yanling Huang, Xian-En Zhang^*, Hongping Wei^*. Construction of a chimeric lysin Ply187N-V12C with extended lytic activity against staphylococci and streptococci. Microb Biotechnol, 2015, 8(2), 210-220. (SCI, IF=3.081)

13. Hang Yang, Junping Yu, Hongping Wei*. Engineered bacteriophage lysins as novel anti-infectives. Front Microbiol. vol. 5, 2014, pp. 542. (SCI, IF=3.989)

14. Jinjuan Qiao, Junping Yu, Hang Yang , Hongping Wei*. PCR-based in vitro synthesis of HCV NS3 protease for rapid phenotypic resistance testing of protease inhibitors. Journal of Clinical Microbiology, vol.52, 2014, pp. 1139-1145. (SCI, IF=3.993)

15. Heng Li, Jun Chen, Man Zhou, Xuelei Geng, Junping Yu, Weihua Wang, Xian-En Zhang, Hongping Wei*. Rapid detection of Mycobacterium tuberculosis and pyrazinamide susceptibility related to pncA mutations in sputum specimens through an integrated gene-to-protein function approach. Journal of Clinical Microbiology, vol.52, 2014, pp.260-267. (SCI, IF=3.993)

16. Li Huang, Xiumei Hu, Man Zhou, Yinmei Yang, Jinjuan Qiao, Dianbing Wang, Junping Yu, Zongqiang Cui, Zhiping Zhang, Xian-En Zhang, Hongping Wei^*. Rapid Detection of New Delhi Metallo-β-Lactamase Gene and Variants coding Carbapenemase with Different Activity by a PCR-based in vitro protein expression method. Journal of Clinical Microbiology, 2014, 52, 1947-1953. (SCI, IF=3.993)

17. Hang Yang, Yun Zhang, Junping Yu, Yanling Huang, Xian-En Zhang, Hongping Wei*. Novel Chimeric Lysin with High-Level Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo. Antimicrobial Agents and Chemotherapy, vol.58, 2014, pp.536-542. (SCI, IF=4.476)

18. Fengyun Li, Junping Yu, Zhiping Zhang, Zongqiang Cui, Dianbing Wang, Hongping Wei* and Xian-En Zhang*. Use of hGluc/tdTomato pair for sensitive BRET sensing of protease with high solution media tolerance. Talanta, vol.109, 2013, pp.141-146. (SCI, IF=3.545)

19. Hang Yang, Dian-Bing Wang, Qiuhua Dong, Zhiping Zhang,Zongqiang Cui, Jiaoyu Deng, Junping Yu, Xian-en Zhang* and Hongping Wei*. Existence of Separate Domains in Lysin PlyG for Recognizing Bacillus anthracis Spores and Vegetative Cells. Antimicrob. Agents Chemother. 2012, 56(10):5031-5039. (SCI, IF=4.476)

20. Fengyun Li, Junping Yu, Zhiping Zhang, Zongqiang Cui, Dianbing Wang, Hongping Wei*, Xian-en Zhang*. Buffer Enhanced Bioluminescence Resonance Energy Transfer Sensor Based on Gaussia Luciferase for in-vitro Detection of Protease. Analytica Chimica Acta, vol.724, 2012, pp.104-110. (SCI, IF=4.513)

21. Yue Wang, Fang Wang, Junping Yu, Feng-Chao Jiang, Xin-Lei Guan, Can-Ming Wang, Lei Li, Hui Cao, Ming-Xing Lia, Jian-Guo Chen*. Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca²⁺ overload. Bioorganic & Medicinal Chemistry, 2012, 20, 6513-22. (SCI, IF=2.793)

22. Qingye Liu, Xiaojuan Xu, Lina Zhang, Junping Yu. Interaction between polydeoxyadenylic acid and beta-glucan from Lentinus edodes. European Polymer Journal, 2012, 48, 1329–1338. (SCI, IF=3.005)

23. Zhiguo Wu, Tian Tian, Junping Yu, Xiaocheng Weng, Yi Liu, Xiang Zhou*. Formation of Sequence-Independent Z-DNA Induced by a Ruthenium Complex at Low Salt Concentrations. Angew Chem Int Edit. 2011, 50, 11962-11967. (SCI, IF=11.261)

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My research interests are focused on detecting pathogens rapidly and sensitively by using some advanced techniques or nanomaterials, controlling pathogens by combining nanomaterials and bacteriophage or related lysins.

已指导学生

王孟月  02  63228  

现指导学生

严城辉  02  19178