1.中子生物成像方法方法学研究

2.基于硼中子俘获的肿瘤治疗（BNCT）

3.基于结构的药物设计和筛选

4.大分子机器组装机制

5.细胞内信号传导

招收生物、药学、化学和物理方向硕士和博士研究生

071010-生物化学与分子生物学
071011-生物物理学
0710Z2-计算生物学

中子成像技术研究，结构生物学方法学研究，肿瘤药物递送，生物大分子结构与功能

1999-09--2004-07   中国科学技术大学   博士
1995-09--1999-06   中国科学技术大学   学士

   

2023-02~现在, 中国科学院高能物理研究所, 研究员
2013-11~2023-01,南方科技大学, 副教授/研究员
2008-11~2013-10,香港大学, 研究助理教授
2004-09~2008-11,哈佛医学院, 博士后

普通生物学

   

（ 1 ） 铋(III)化合物及其方法, 发明专利, 2019, 第 5 作者, 专利号: CN110121349A

（ 2 ） Bismuth(III) compounds and methods thereof, 发明专利, 2019, 第 5 作者, 专利号: US10201518(B2)

（ 3 ） BISMUTH (III) COMPOUNDS AND METHODS THEREOF, 发明专利, 2018, 第 5 作者, 专利号: WO2018059263-A1

   

（1） Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2, ANTIVIRAL RESEARCH, 2023, 通讯作者
（2） Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 第 10 作者
（3） The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle, CELL DEATH AND DIFFERENTIATION, 2022, 通讯作者
（4） Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria, JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 通讯作者
（5） A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1, NATURE COMMUNICATIONS, 2022, 通讯作者
（6） Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate, ELIFE, 2021, 通讯作者
（7） Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 通讯作者
（8） Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors, ELIFE, 2021, 第 6 作者
（9） Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle, JOURNAL OF VIROLOGY, 2021, 第11作者
（10） Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ, ONCOGENE, 2021, 第 14 作者
（11） N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 4 作者
（12） Functional Identification and Structural Analysis of a New Lipoate Protein Ligase in Mycoplasma hyopneumoniae, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 通讯作者
（13） Mass production of active recombinantChryseobacterium proteolyticumprotein glutaminase inEscherichia coliusing a sequential dual expression system and one-step purification, IUBMB LIFE, 2020, 通讯作者
（14） Bacterial Lipoprotein Biosynthetic Pathway as a Potential Target for Structure-based Design of Antibacterial Agents, CURRENT MEDICINAL CHEMISTRY, 2020, 第 6 作者
（15） Pose Filter-Based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists, JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2020, 通讯作者
（16） Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma., BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2019, 通讯作者
（17） Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts, INFECTION AND IMMUNITY, 2019, 第 5 作者
（18） Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2019, 通讯作者
（19） The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis, LABORATORYINVESTIGATION, 2018, 通讯作者
（20） Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors, NATURECOMMUNICATIONS, 2018, 第 4 作者
（21） A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018, 第 6 作者
（22） Identifying GAPDH as a Cyclic Adenosine Diphosphoribose (cADPR) Binding Protein by Pho-toaffinity Protein-Ligand Labeling Approach, J Am Chem Soc, 2017, 第 1 作者
（23） Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, CELL CHEMICAL BIOLOGY, 2017, 第 3 作者
（24） High resolution crystal structure of the catalytic domain of MCR-1., SCIENTIFIC REPORTS, 2016, 通讯作者
（25） Immuno-targeting the multifunctional CD38 using nanobody, SCIENTIFIC REPORTS, 2016, 通讯作者
（26） Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion, SCIENTIFIC REPORTS, 2016, 第 2 作者
（27） Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS NEGLECTED TROPICAL DISEASES, 2016, 第 7 作者
（28） Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, SCIENTIFIC REPORTS, 2016, 通讯作者
（29） "Anion clamp'' allows flexible protein to impose coordination geometry on metal ions, CHEMICAL COMMUNICATIONS, 2015, 第 4 作者
（30） Protein-complex structure completion using IPCAS (Iterative Protein Crystal structure Automatic Solution), ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2015, 第 2 作者
（31） Cyclic Adenosine 5′-DiphosphateRibose Analogswithout a "Southern" Ribose Inhibit ADP-ribosyl Cyclase–HydrolaseCD38, JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 3 作者
（32） Crystallographic phasing with NMR models: an envelope approach, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2014, 第 3 作者
（33） Crystal Structures of Human CD38 in Complex with NAADP and ADPRP, Messenger, 2013, 第 1 作者
（34） Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein, JOURNAL OF VIROLOGY, 2012, 第 3 作者
（35） Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe, SCIENTIFIC REPORTS, 2012, 第 2 作者
（36） Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38, BIOCHEMISTRY, 2012, 
（37） Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal, JOURNAL OF MOLECULAR BIOLOGY, 2011, 第 1 作者
（38） A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: implications for pre-TCR dimerization, FRONTIERS IN IMMUNOLOGY, 2011, 
（39） Crystal structure of NDM-1 reveals a common beta-lactam hydrolysis mechanism, FASEB JOURNAL, 2011, 通讯作者
（40） Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 第 2 作者
（41） Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems, FASEB JOURNAL, 2009, 第 1 作者
（42） Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 第 1 作者
（43） An unusual allosteric mobility of the C-terminal helix of a high-affinity alpha(L) integrin I domain variant bound to ICAM-5, MOLECULAR CELL, 2008, 第 1 作者
（44） Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design, FASEB JOURNAL, 2008, 第 2 作者
（45） Developmental expression of FXPRLamide neuropeptides in peptidergic neurosecretory cells of diapause- and nondiapause-destined individuals of the cotton bollworm, Helicoverpa armigera, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2005, 
（46） Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2004, 
（47） Hydrogen peroxide produced by two amino acid oxidases mediates antibacterial actions, JOURNAL OF MICROBIOLOGY, 2004, 
（48） The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5) *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 2 作者