1. 开发世界上首个面向疾病机理及全新药物设计途径的iHuman（数字人体动态模拟）系统。

    注：iHuman是一个全新的面向疾病机理及全新药物设计的人体数字动态模拟系统。可以直接模拟基因敲入、敲除、过表达等用以研究疾病机理和发现治疗靶点，同时可以模拟不同药物浓度对个体或特定细胞的影响以进行新型药物设计与筛选。

 

2. 利用多组学数据研究衰老及衰老相关复杂疾病分子机理。

 

3. 整合生物信息学和化学信息学针对复杂疾病进行药物设计。

   

071007-遗传学

生物信息学，系统生物学，代谢网络，虚拟人体

2003-09--2009-07   中国科学院昆明动物研究所   博士
1999-09--2003-07   武汉轻工业大学   学士

研究生

博士学位

   

2015-07~现在, 中国科学院昆明动物研究所, 副研究员
2014-06~2015-07,美国哈佛医学院麻省总医院, 访问学者
2009-07~2014-07,中国科学院昆明动物研究所, 助理研究员

   

[1] 赵旭东, 李文兴, 李功华, 黄京飞, 代绍兴. 基于多基因表达特征谱胶质母细胞瘤个性化预后评估方法. CN: CN108733980B, 2022-01-18.
[2] 李文兴, 李功华, 黄京飞, 赵旭东, 代绍兴. 一种肾透明细胞癌个性化预后评估方法. CN: CN108647493B, 2022-01-18.
[3] 孔庆鹏, 葛明侠, 李功华. 健康衰老诊断circRNA标志物及应用. CN: CN111424079A, 2020-07-17.
[4] 李功华, 黄京飞, 孔庆鹏, 郑俊娟. 阿兹海默病标志物及应用. CN: CN111413424A, 2020-07-14.
[5] 孔庆鹏, 李功华, 杨利琴. 指征健康老龄关键通路的内源性代谢小分子标志物及应用. CN: CN111398456A, 2020-07-10.
[6] 孔庆鹏, 李功华, 杨利琴. 健康老龄诊断标志物及应用. CN: CN111380979A, 2020-07-07.
[7] 孔庆鹏, 尹藩乾, 李功华. 指征健康衰老关键通路的血清蛋白质标志物及应用. CN: CN111366736A, 2020-07-03.
[8] 李功华, 黄京飞, 孔庆鹏. 神经退行性疾病内源性小分子早期预测标志物及应用. CN: CN111366650A, 2020-07-03.
[9] 李功华, 黄京飞, 孔庆鹏. 帕金森病特异血清内源小分子标志物及应用. CN: CN111366651A, 2020-07-03.
[10] 孔庆鹏, 葛明侠, 李功华. 指示健康衰老关键通路的circRNA小分子标志物及应用. CN: CN111363802A, 2020-07-03.
[11] 孔庆鹏, 尹藩乾, 李功华. 健康衰老血清蛋白标志物及应用. CN: CN111337688A, 2020-06-26.
[12] 赵旭东, 李文兴, 李功华, 黄京飞, 代绍兴. 一种基于多基因表达特征谱的胶质母细胞瘤个性化预后评估方法. CN: CN108733980A, 2018-11-02.
[13] 李文兴, 李功华, 黄京飞, 赵旭东, 代绍兴. 一种基于多基因表达特征谱的肾透明细胞癌个性化预后评估方法. CN: CN108647493A, 2018-10-12.
[14] 李功华, 李文兴, 黄京飞, 赵旭东, 代绍兴. 一种基于多基因表达特征谱的胰腺癌个性化预后评估方法. CN: CN108648826A, 2018-10-12.
[15] 李文兴, 李功华, 黄京飞, 赵旭东, 代绍兴. 一种基于多基因表达特征谱的肝癌个性化预后评估方法. CN: CN108630317A, 2018-10-09.
[16] 李文兴, 李功华, 黄京飞, 赵旭东, 代绍兴. 一种基于多基因表达特征谱的宫颈癌个性化预后评估方法. CN: CN108611416A, 2018-10-02.
[17] 李功华, 黄京飞, 李文兴, 代绍兴, 唐承薇, 童欢. 肝硬化早期小分子标志物及其应用. CN: CN108572251A, 2018-09-25.
[18] 黄京飞, 李文兴, 李功华, 赵旭东, 代绍兴. 一种基于多基因表达特征谱的胃癌个性化预后评估方法. CN: CN108470111A, 2018-08-31.
[19] 李文兴, 李功华, 黄京飞, 赵旭东, 代绍兴. 一种基于多基因表达特征谱的肺腺癌个性化预后评估方法. CN: CN108363907A, 2018-08-03.
[20] 李文兴, 李功华, 黄京飞, 赵旭东, 代绍兴. 一种基于多基因表达特征谱的结肠癌个性化预后评估方法. CN: CN108320806A, 2018-07-24.
[21] 代绍兴, 黄京飞, 陈欢, 郑永唐, 李功华, 李文兴. 蒽环类化合物在制备治疗艾滋病的药物中的应用. CN: CN107041891A, 2017-08-15.
[22] 代绍兴, 黄京飞, 陈欢, 郑永唐, 李功华, 李文兴. 西曲瑞克在制备治疗艾滋病的药物中的应用. CN: CN107007814A, 2017-08-04.
[23] 代绍兴, 黄京飞, 陈欢, 郑永唐, 李功华, 李文兴. 达巴万星在制备治疗艾滋病的药物中的应用. CN: CN106668833A, 2017-05-17.
[24] 徐林, 黄京飞, 周启心, 李功华, 谭继伟, 熊贵静, 韩会丽. 一种阻断突触长时程增强（LTP）的短肽及其应用. CN: CN106632601A, 2017-05-10.

   

[1] Shen, Qiu, Yang, Hua, Kong, QingPeng, Li, GongHua, Li, Li. Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis. METABOLITES[J]. 2023, 13(2): http://dx.doi.org/10.3390/metabo13020172.
[2] WenXing Li, Xin Tong, PengPeng Yang, Yang Zheng, JiHao Liang, GongHua Li, Dahai Liu, DaoGang Guan, ShaoXing Dai. Screening of antibacterial compounds with novel structure from the FDA approved drugs using machine learning methods. AGING (ALBANY NY). 2022, 14(3): 1448-1472, [3] Ge, Mingxia, Jiang, Jianjun, Yang, Liqin, Yang, Xingli, He, Yonghan, Li, Gonghua, Kong, Qingpeng. Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity. GENES[J]. 2022, 13(5): 749-, [4] Li, GongHua, Han, Feifei, Xiao, FuHui, Gu, KangSuYun, Shen, Qiu, Xu, Weihong, Li, WenXing, Wang, YanLi, Liang, Bin, Huang, JingFei, Xiao, Wenzhong, Kong, QingPeng. System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity. AGING CELL[J]. 2022, 21(4): http://dx.doi.org/10.1111/acel.13595.
[5] Ge, MingXia, Yu, Qin, Li, GongHua, Yang, LiQin, He, Yonghan, Li, Ji, Kong, QingPeng. Multiple time-series expression trajectories imply dynamic functional changes during cellular senescence. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2022, 20: 4131-4137, http://dx.doi.org/10.1016/j.csbj.2022.08.005.
[6] Wang, YanYing, Chang, Le, Zhu, GaoHong, Li, GongHua, Kong, QingPeng, Lv, LongBao, Wang, Qiang, Tian, Chuan, Li, Ye, Zhu, XiangQing, Pan, XingHua. Mechanism of Thymus Rejuvenation in Elderly Macaques. REJUVENATION RESEARCH[J]. 2022, 25(5): 223-232, http://dx.doi.org/10.1089/rej.2022.0013.
[7] Li, WenXing, Li, GongHua, Tong, Xin, Yang, PengPeng, Huang, JingFei, Xu, Lin, Dai, ShaoXing. Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases. AGING-US[J]. 2020, 12(10): 9882-9914, https://www.webofscience.com/wos/woscc/full-record/WOS:000537718700067.
[8] Shen, Qiu, Lu, Chao, Yang, Hua, Ge, MingXia, Xia, WangXiao, Kong, QingPeng, Li, GongHua, Gu, YanHong. Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma. PEERJ[J]. 2020, 8: https://doaj.org/article/dce9123300d347b9be4d5b6603081eb7.
[9] Wang, Hao-Tian, Xiao, Fu-Hui, Li, Gong-Hua, Kong, Qing-Peng. Identification of DNA N-6-methyladenine sites by integration of sequence features. EPIGENETICS & CHROMATIN[J]. 2020, 13(1): http://dx.doi.org/10.1186/s13072-020-00330-2.
[10] Li, GongHua, Dai, Shaoxing, Han, Feifei, Li, Wenxin, Huang, Jingfei, Xiao, Wenzhong. FastMM: an efficient toolbox for personalized constraint-based metabolic modeling. BMC BIOINFORMATICS[J]. 2020, 21(1): http://dx.doi.org/10.1186/s12859-020-3410-4.
[11] Xia, Wang-Xiao, Yu, Qin, Li, Gong-Hua, Liu, Yao-Wen, Xiao, FuHui, Yang, Li-Qin, Rahman, Zia Ur, Wang, Hao-Tian, Kong, Qing-Peng. Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA. PEERJ[J]. 2019, 7: https://doaj.org/article/76f0ef2fac0d45c789e4382ebe731230.
[12] Zheng, JunJuan, Li, WenXing, Liu, JiaQian, Guo, YiCheng, Wang, Qian, Li, GongHua, Dai, ShaoXing, Huang, JingFei. Low expression of aging-related NRXN3 is associated with Alzheimer disease A systematic review and meta-analysis. MEDICINEnull. 2018, 97(28): https://www.webofscience.com/wos/woscc/full-record/WOS:000439577500021.
[13] Zhang, YuJuan, Zhu, Chengxu, Ding, Yiran, Yan, ZhengWen, Li, GongHua, Lan, Yang, Wen, JianFan, Chen, Bin. Subcellular stoichiogenomics reveal cell evolution and electrostatic interaction mechanisms in cytoskeleton. BMC GENOMICS[J]. 2018, 19(1): http://159.226.149.26:8080/handle/152453/12392.
[14] Chen, BiWen, Li, WenXing, Wang, GuangHui, Li, GongHua, Liu, JiaQian, Zheng, JunJuan, Wang, Qian, Li, HuiJuan, Dai, ShaoXing, Huang, JingFei. A strategy to find novel candidate anti-Alzheimer's disease drugs by constructing interaction networks between drug targets and natural compounds in medical plants. PEERJ[J]. 2018, 6: https://doaj.org/article/d9a1ae3c8ce347ba8e051cab18c89918.
[15] Li, HuiJuan, Li, WenXing, Dai, ShaoXing, Guo, YiCheng, Zheng, JunJuan, Liu, JiaQian, Wang, Qian, Chen, BiWen, Li, GongHua, Huang, JingFei. Identification of metabolism-associated genes and pathways involved in different stages of clear cell renal cell carcinoma. ONCOLOGY LETTERS[J]. 2018, 15(2): 2316-2322, https://www.webofscience.com/wos/woscc/full-record/WOS:000426145100038.
[16] Zhou, Xia, Li, Gonghua, An, Sanqi, Li, WenXing, Yang, Huihui, Guo, Yicheng, Dai, Zhi, Dai, Shaoxing, Zheng, Junjuan, Huang, Jingfei, Iavarone, Antonio, Zhao, Xudong. A new method of identifying glioblastoma subtypes and creation of corresponding animal models. ONCOGENE[J]. 2018, 37(35): 4781-4791, http://159.226.149.26:8080/handle/152453/12399.
[17] Li, WenXing, He, Kan, Tang, Ling, Dai, ShaoXing, Li, GongHua, Lv, WenWen, Guo, YiCheng, An, SanQi, Wu, GuoYing, Liu, Dahai, Huang, JingFei. Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets. ONCOTARGET[J]. 2017, 8(4): 6775-6786, http://www.corc.org.cn/handle/1471x/2157938.
[18] Liu, JiaQian, Dai, ShaoXing, Zheng, JunJuan, Guo, YiCheng, Li, WenXing, Li, GongHua, Huang, JingFei. The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds. SCIENTIFIC REPORTS[J]. 2017, 7: http://www.corc.org.cn/handle/1471x/2158091.
[19] Li, WenXing, Cheng, Fei, Zhang, AJie, Dai, ShaoXing, Li, GongHua, Lv, WenWen, Zhou, Tao, Zhang, Qiang, Zhang, Hong, Zhang, Tao, Liu, Fang, Liu, Dahai, Huang, JingFei. Folate Deficiency and Gene Polymorphisms of MTHFR,MTR and MTRR Elevate the Hyperhomocysteinemia Risk. CLINICAL LABORATORY[J]. 2017, 63(3): 523-533, http://www.corc.org.cn/handle/1471x/2156542.
[20] Li, WenXing, Qi, Fei, Liu, JiaQian, Li, GongHua, Dai, ShaoXing, Zhang, Tao, Cheng, Fei, Liu, Dahai, Zheng, Song Guo. Different impairment of immune and inflammation functions in short and long-term after ischemic stroke. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH[J]. 2017, 9(2): 736-745, http://www.corc.org.cn/handle/1471x/2157812.
[21] Wang, Qian, Li, WenXing, Dai, ShaoXing, Guo, YiCheng, Han, FeiFei, Zheng, JunJuan, Li, GongHua, Huang, JingFei. Meta-Analysis of Parkinson's Disease and Alzheimer's Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes. JOURNAL OF ALZHEIMERS DISEASE[J]. 2017, 56(4): 1525-1539, https://www.webofscience.com/wos/woscc/full-record/WOS:000395757100026.
[22] Li, WenXing, Cheng, Fei, Zhang, AJie, Dai, ShaoXing, Li, GongHua, Lv, WenWen, Zhou, Tao, Zhang, Qiang, Zhang, Hong, Zhang, Tao, Liu, Fang, Liu, Dahai, Huang, JingFei. Folate Deficiency and Gene Polymorphisms of MTHFR,MTR and MTRR Elevate the Hyperhomocysteinemia Risk. CLINICAL LABORATORY[J]. 2017, 63(3): 523-533, http://www.corc.org.cn/handle/1471x/2156542.
[23] Li, WenXing, Qi, Fei, Liu, JiaQian, Li, GongHua, Dai, ShaoXing, Zhang, Tao, Cheng, Fei, Liu, Dahai, Zheng, Song Guo. Different impairment of immune and inflammation functions in short and long-term after ischemic stroke. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH[J]. 2017, 9(2): 736-745, http://www.corc.org.cn/handle/1471x/2157812.
[24] Dai, ShaoXing, Li, GongHua, Gao, YueDong, Huang, JingFei. Pharmacophore-Map-Pick: A Method to Generate Pharmacophore Models for All Human GPCRs. MOLECULAR INFORMATICS[J]. 2016, 35(2): 81-91, http://www.irgrid.ac.cn/handle/1471x/1149322.
[25] Guo, YiCheng, Zhang, Lin, Dai, ShaoXing, Li, WenXing, Zheng, JunJuan, Li, GongHua, Huang, JingFei. Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts. PLOS ONE[J]. 2016, 11(5): http://dx.doi.org/10.1371/journal.pone.0155140.
[26] Li, WenXing, Dai, ShaoXing, Wang, Qian, Guo, YiCheng, Hong, Yi, Zheng, JunJuan, Liu, JiaQian, Liu, Dahai, Li, GongHua, Huang, JingFei. Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets. PEERJ[J]. 2016, 4(X): http://159.226.149.26:8080/handle/152453/10952.
[27] Li, WenXing, Dai, ShaoXing, Liu, JiaQian, Wang, Qian, Li, GongHua, Huang, JingFei. Integrated Analysis of Alzheimer's Disease and Schizophrenia Dataset Revealed Different Expression Pattern in Learning and Memory. JOURNAL OF ALZHEIMERS DISEASE[J]. 2016, 51(2): 417-425, http://www.irgrid.ac.cn/handle/1471x/1152025.
[28] Dai, ShaoXing, Li, WenXing, Han, FeiFei, Guo, YiCheng, Zheng, JunJuan, Liu, JiaQian, Wang, Qian, Gao, YueDong, Li, GongHua, Huang, JingFei. In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database. SCIENTIFIC REPORTS[J]. 2016, 6: http://www.corc.org.cn/handle/1471x/2159491.
[29] ShaoXing Dai, WenXing Li, FeiFei Han, YiCheng Guo, JunJuan Zheng, JiaQian Liu, Qian Wang, YueDong Gao, GongHua Li, JingFei Huang. Corrigendum: In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database. SCIENTIFIC REPORTS. 2016, 6: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056451/.
[30] Li Gonghua. ntegrated analysis of Alzheimer’s disease and schizophrenia dataset revealed different expression pattern in learning and memory. Journal of Alzheimer's Disease. 2016, [31] Dai, ShaoXing, Li, WenXing, Li, GongHua, Huang, JingFei. Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin. PEERJ[J]. 2016, 4(X): http://www.corc.org.cn/handle/1471x/2159478.
[32] Zhao, Yuqi, Wang, Yanjie, Gao, Yuedong, Li, Gonghua, Huang, Jingfei. Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins. PLOS ONE[J]. 2015, 10(2): http://dx.doi.org/10.1371/journal.pone.0117506.
[33] Liu, Zhen, Wang, Wei, Zhang, TongZuo, Li, GongHua, He, Kai, Huang, JingFei, Jiang, XueLong, Murphy, Robert W, Shi, Peng. Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES[J]. 2014, 281(1776): http://www.irgrid.ac.cn/handle/1471x/1150842.
[34] Li, GongHua, Huang, JingFei. Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer. BIOINFORMATICS[J]. 2014, 30(6): 748-752, http://www.irgrid.ac.cn/handle/1471x/1151996.
[35] Li, GongHua, Huang, JingFei. CDRUG: a web server for predicting anticancer activity of chemical compounds. BIOINFORMATICS[J]. 2012, 28(24): 3334-3335, http://dx.doi.org/10.1093/bioinformatics/bts625.
[36] Liu, Zhen, Li, GongHua, Huang, JingFei, Murphy, Robert W, Shi, Peng. Hearing Aid for Vertebrates via Multiple Episodic Adaptive Events on Prestin Genes. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2012, 29(9): 2187-2198, http://dx.doi.org/10.1093/molbev/mss087.
[37] Yu, Qi, Li, GongHua, Huang, JingFei. MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY[J]. 2012, 2012(X): https://doaj.org/article/c63edd44e9c04e23bd3320633e8d96a2.
[38] Li, GongHua, Huang, JingFei. CMASA: an accurate algorithm for detecting local protein structural similarity and its application to enzyme catalytic site annotation. BMC BIOINFORMATICS[J]. 2010, 11(1): 439-439, http://159.226.149.42:8080/handle/152453/6343.

   

（ 1 ） 中国长寿家系人群多组学数据整合分析及关键调控因子鉴定, 主持, 国家级, 2019-08--2022-12
（ 2 ） 中国健康长寿大人群多队列的系统研究, 参与, 国家级, 2018-12--2022-12
（ 3 ） 猕猴“相对定量”代谢网络图谱的建立与验证, 主持, 省级, 2021-04--2024-03