基本信息

罗应刚 男 博导 中国科学院成都生物研究所
电子邮件: yinggluo@cib.ac.cn
通信地址: 成都市人民南路4段9号
邮政编码: 610041
电子邮件: yinggluo@cib.ac.cn
通信地址: 成都市人民南路4段9号
邮政编码: 610041
研究领域
天然药物生物合成,天然药物合成生物学,天然药物发现
招生信息
招生专业
100701-药物化学
招生方向
天然药物发现与生物合成
教育背景
2000-09--2003-07 中国科学院成都有机化学研究所 博士1997-09--2000-07 中国科学院成都生物研究所 硕士1993-09--1997-07 西南师范大学 学士
出版信息
发表论文
(1) The versatile O-methyltransferase LrOMT catalyzes multiple O-methylation reactions in Amaryllidaceae alkaloid biosynthesis, International Journal of Biological Macromolecules, 2019-12, 通讯作者(2) Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis, ACS Chemical Biology, 2019-06, 通讯作者(3) Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris, Phytochemistry, 2018, 通讯作者(4) Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encodiing genes from Lycoris radiata, a galanthamine-producing plant, International Journal of Biological Macromolecules, 2018, 通讯作者(5) Enhanced production of camptothecin and biological preparation of N1-acetylkynuramine in Camptotheca acuminata cell suspension cultures, Applied Microbiology and Biotechnology, 2017, 通讯作者(6) A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial application in geraniol production in Escherichia coli, Journal of Industrial Microbiology & Biotechnology, 2017, 通讯作者(7) Iridoid glucosides and diteropenoids from Caryopteris glutinosa, Journal of Natural Products, 2016, 通讯作者(8) Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in the production of geraniol in Escherichia coli, Journal of Industrial Microbiology & Biotechnology, 2016, 通讯作者(9) Molecular cloning and functional characterization of a cinnamate 4-hydroxylase-encoding gene from Camptotheca acuminata, Acta Physiol Plant, 2016, 通讯作者(10) Molecular cloning, heterologous expression, and functional characterization of an NADPH-cytochrome P450 reductase gene from Camptotheca acuminata, a camptothecin-producing plant, PLoS ONE, 2015, 通讯作者(11) Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata, Journal of Industrial Microbiology & Biotechnology, 2015, 通讯作者(12) Phenolic derivatives from Hypericum japonicum, Natural Product Communications, 2015, 通讯作者(13) Nitrogen-containing Dihydro-?-agarofuran Derivatives from Tripterygium wilfordii, Journal of Natural Product, 2014, 第 1 作者(14) Dimeric 2-Arylbenzofurans and Polyisoprenylated Flavanones from Sophora tonkinensis, Fitoterapia, 2014, 通讯作者(15) 3-Formyl-2-arylbenzofurans from the aerial parts of Itea ilicifolia, Phytochemistry Letters, 2014, 通讯作者(16) Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087, Journal of Agricultural and Food Chemistry, 2013, 通讯作者(17) Camptothecin-producing Endophytic Fungus Trichoderma atroviride LY357: Isolation, Identification, and Fermentation Conditions Optimization for Camptothecin Production, Applied Microbiology and Biotechnology, 2013, 通讯作者(18) Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii, Journal of Natural Products, 2012, 第 1 作者(19) A new cyclododecap[d]oxazole derivative from Streptomyces spp. CIBYL1, Natural Products Research, 2012, 通讯作者(20) SHP2 is a Target of the Immunosuppressant Tautomycetin, Chemistry and Biology, 2011, 第 4 作者(21) Chromones and coumarins from the dried fructus of Cnidium monnieri, Fitoterapia, 2011, 通讯作者(22) Discovery and identification of 2-phenylethyl 2,6-dihydroxybenzoate as a natural lipid-lowering lead, Planta Medica, 2011, 通讯作者(23) Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis, Journal of the American Chemical Society , 2010, 第 1 作者(24) Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring a C-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate, Journal of the American Chemical Society, 2010, 第 4 作者
科研活动
科研项目
( 1 ) 喜树碱的生物合成研究, 主持, 国家级, 2012-01--2015-12( 2 ) 微生物发酵生产反式-4-羟基-L-脯氨酸, 主持, 省级, 2015-01--2017-12( 3 ) 中药化学对照品, 主持, 研究所(学校), 2014-10--2017-10( 4 ) 药物前期研发, 主持, 研究所(学校), 2015-06--2019-12( 5 ) 针对阿尔茨海默症多靶点的先导化合物研究, 主持, 部委级, 2016-11--2018-06( 6 ) 酶催化合成卤代色胺, 主持, 市地级, 2017-08--2020-08( 7 ) 苷类化合物生物活性与生物利用度改进, 参与, 部委级, 2018-11--2019-11( 8 ) 基于天然产物的老年性疾病候选药物研究, 参与, 国家级, 2019-01--2021-12
指导学生
已指导学生
张翔 硕士研究生 077901-药物化学
屈细兴 硕士研究生 077901-药物化学
陈菲 硕士研究生 085235-制药工程
杨利霞 硕士研究生 078001-药物化学
现指导学生
庞静 硕士研究生 085238-生物工程
胡佳伟 硕士研究生 078001-药物化学
刘梦洁 硕士研究生 085238-生物工程
李艺 硕士研究生 078001-药物化学