基本信息
周燕  女  博导  中国科学院成都生物研究所
电子邮件: zhouyan@cib.ac.cn
通信地址: 四川省成都市416信箱
邮政编码: 610041

招生信息

   
招生专业
100701-药物化学
招生方向
药物分析
质谱分析

教育背景

2004-11--2005-11   香港中文大学   博士后
2001-09--2004-07   中国科学院成都有机化学研究所   理学博士

工作经历

   
工作简历
2011-01~现在, 中国科学院成都生物研究所, 高级工程师(正高)
2007-11~2010-11,香港应用科技研究院辖属赛马会中药研究院, 科学主任
2001-11~2002-11,日本东丽药物研究所, 访问学者
社会兼职
2020-01-01-2023-12-31,四川省分析测试协会有机质谱委员会, 主任委员
2019-01-01-2022-12-31,中国化学会有机分析专委会, 委员

教授课程

液质联用分析
有机质谱分析

专利与奖励

   
专利成果
( 1 ) 耐盐液相色谱电喷雾质谱联用接口装置及其使用方法, 发明, 2017, 第 2 作者, 专利号: ZL201510790496.1
( 2 ) 一种基于导电纳米材料的电喷雾质谱装置及其实现电喷雾质谱分析的方法, 发明, 2018, 第 1 作者, 专利号: ZL201610125529.5
( 3 ) 一种基于微球的电喷雾装置及方法, 发明, 2017, 第 2 作者, 专利号: ZL2016010181400.6

出版信息

   
发表论文
(1) Antifungal Halogenated Cyclopentenones from the Endophytic Fungus Saccharicola bicolor of Bergenia purpurascens by the One Strain-Many Compounds Strategy, J. Agric. Food Chem., 2020, 通讯作者
(2) High-sensitivity detection of therapeutic drugs in complex biofluids using a packed ballpoint-electrospray ionization technique, Analytical and Bioanalytical Chemistry, 2020, 通讯作者
(3) homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum, Fitoterapia, 2019, 通讯作者
(4) Flow controllable three-dimensional paper-based microfluidic analytical devices fabricated by 3D printing technology, Analytica Chimica Acta, 2019, 通讯作者
(5) Analysis of Compounds Dissolved in Nonpolar Solvents, Journal of The American Society for, 2018, 通讯作者
(6) Low-cost and convenient ballpoint tip-protected liquid-phase microextraction for sensitive analysis of organic molecules in water samples, Analytica Chimica Acta, 2018, 通讯作者
(7) Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica, Phytochemistry, 2018, 通讯作者
(8) Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons, Journal of Natural Products, 2018, 通讯作者
(9) Determination of Sulfonamides in Chicken Muscle by Pulsed Direct Current Electrospray Ionization Tandem Mass Spectrometry, Journal of Agriculture and Food Chemistry, 2017, 通讯作者
(10) 天然产物的质谱智能解析研究, Intelligent interpretation of mass spectra of natural products, 中国科学: 化学, 2017, 通讯作者
(11) Generating Electrospray Ionization on Ballpoint Tips, Analytical Chemistry, 2016, 通讯作者
(12) Polycyclic Spiro Lignans and Biphenyl Tetrahydrofuranone Lignans from Gymnotheca involucrata, Planta Medica, 2016, 通讯作者
(13) Application of fractionized sampling and stacking for construction of an interface for online heart-cutting two-dimensional liquid chromatography, Journal of Chromatography A, 2016, 通讯作者
(14) Development and characterization of a nanodendritic silver-based solid-phase extraction sorbent for selective enrichment of endocrine-disrupting chemicals in water and milk samples, Analytica Chimica Acta, 2015, 通讯作者
(15) Determination of kepone and its metabolite in water and soil by liquid chromatography coupled with mass spectrometry, Analytical Letters, 2015, 通讯作者
(16) Strategy to rapidly discriminate trace isomeric lignan compounds from Gymnotheca chinensis by probe electrospray ionization tandem mass spectrometry, Eur. J. Mass Spectrom., 2015, 通讯作者
(17) Reversible tuning of the wettability on a silver mesodendritic surfaceby the formation and disruption of lipid-like bilayers, Applied Surface Science, 2015, 通讯作者
(18) Advanced ultra-performance liquid chromatography–photodiode array–quadrupole time-of-flight mass spectrometric methods forsimultaneous screening and quantification of triterpenoids in Poria cocos, Food Chemistry, 2014, 通讯作者
(19)  A rapid and highly specific method to evaluate the presence of 2-(2-phenylethyl) chromones in agarwood by supercritical fluid chromatography-mass spectrometry, European Journal of Mass Spectrometry, 2014, 通讯作者
(20) Investigation of the Chemical Compositions in Tobacco of Different Origins and Maturities at Harvest by GC?MS and HPLC?PDA-QTOFMS, Journal of Agricultural and Food Chemistry, 2014, 通讯作者
(21) Two novel norlignans from Gymnotheca chinensis, Tetrahedron Letters, 2014, 通讯作者
(22) Two novel polycyclic spiro lignans from Gymnotheca involucrate, Tetrahedron Letters, 2014, 通讯作者
(23) Efficient optimization of ultra-highperformance supercritical fluid chromatographic separation of Rosa sericea by response surface methodology, Journal of Separation Sciences, 2013, 通讯作者
(24) Fast analysis of triterpenoids in Ganoderma lucidum spores by ultra performance liquid chromatography coupled with triple quadrupole mass spectrometry, Biomedical Chromatography, 2013, 通讯作者
(25) Tandem mass spectrometry fragmentation of the protonated 2-(2-phenylethyl)chromones from Agarwood: radical ions versus non-radical ions, Journal of Mass Spectrometry, 2013, 通讯作者
(26) Rapid separation and characterization of triacylglycerols in ostrich oil by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, Food Chemistry, 2013, 第 1 作者
(27) Non-target screening of veterinary drugs using tandem mass spectrometry on SmarMass, Journal of American Society for Mass Spectrometry, 2013, 通讯作者
(28) Gymnothelignans A-O: conformation and absolute configuration analyses of lignans bearing tetrahydrofuran from Gymnotheca chinensis, the Journal of Organic Chemistry, 2012, 通讯作者
(29) Terpenoids from Loxocalyx urticifolius, Helvetica Chimica Acta, 2012, 通讯作者
(30) A high sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos, Biomedical Chromatography, 2011, 第 1 作者
(31) MyMolDB: a micro-molecular database solution with open source and free components, Journal of Computational Chemistry, 2011, 通讯作者
(32) A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential PAs-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry, Analytica Chimica Acta, 2010, 第 1 作者
(33) Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flighttandem mass spectrometry, Analytica Chimica Acta, 2010, 第 1 作者
(34) Optimisation of UPLC conditions using response surface methodology for rapid separation and quantitative determination of phenolic compounds in Artemisia minor, Journal of Separation Sciences, 2010, 第 1 作者
(35) Analysis of Saussurea species from tibet using HPLC-DAD-ESI-MSn, Acata Chromatographica, 2010, 通讯作者
(36) Screening and Identification of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Q-TOF Electrospray Ionization Tandem Mass Spectrometry, Journal of American Society for Mass Spectrometry , 2009, 第 1 作者
(37)  Using SAS statistic strategy to obtain optimal gradient LC and ESI-QTOF-MS conditions to determine the alkaloids from Meconopsis species, Journal of Chromatography A, 2009, 第 1 作者
(38) Qualitative and quantitative analysis of diterpenoids in Salvia species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Chromatography A, 2009, 第 1 作者
(39) Electrospray ionization tandem mass spectrometric analysis of ent-6,7-seco-kaurane diterpenoids from the Isodon species, Rapid Communications in Mass Spectrometry, 2009, 第 1 作者

科研活动

   
科研项目
( 1 ) 探针电喷雾离子化的机理和应用研究, 主持, 国家级, 2016-01--2019-12
( 2 ) 基于自由微液滴萃取解吸电喷雾的质谱成像装置的研制, 主持, 部委级, 2018-01--2020-12
( 3 ) 开放式电分离的机理研究, 主持, 国家级, 2017-01--2021-12
( 4 ) 基于质谱碎裂特征的食品化学危害因子非定向筛查技术研究, 主持, 国家级, 2018-12--2021-12
( 5 ) 活性天然化合物发现、评价与转化, 参与, 部委级, 2019-01--2020-12

指导学生

已指导学生

李金蓉  硕士研究生  077901-药物化学  

颜朦朦  硕士研究生  077901-药物化学  

何达海  博士研究生  100701-药物化学  

刘洁  硕士研究生  085235-制药工程  

郭大乐  博士研究生  100701-药物化学  

高元吉  博士研究生  100701-药物化学  

马风伟  博士研究生  100701-药物化学  

陈雷  硕士研究生  078001-药物化学  

季宝成  博士研究生  100701-药物化学  

雷珊  硕士研究生  078001-药物化学  

叶烨  博士研究生  100701-药物化学  

现指导学生

刘光辉  硕士研究生  085235-制药工程  

傅弦  博士研究生  100701-药物化学  

王鑫梦  硕士研究生  078001-药物化学  

石培育  博士研究生  100701-药物化学  

陈璐  硕士研究生  078001-药物化学  

王宇  博士研究生  100701-药物化学