2001,4-2004,4  Ph.D, Division of Agriculture, Tokyo University of Agriculture and Technology, Japan.

1998,4-2001,3  M.Sc, Biosystem, University of Tsukuba, Japan.

1986,9-1990,7  B.Sc, Animal Science, China Agricultural University, Beijing, China

2009,6－present  Professor, Institute of Urban Environment, Chinese Academy of Sciences

2007,4－2009,5  Specific Researcher, International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women’s Medical University, Tokyo, Japan

2004,5-2007,3  Specific Researcher, Signaling Molecules Research Laboratory, National Institute of Advanced Science and Technology, Tsukuba, Ibaraki, Japan

1993,7-1998,3  Assistant animal expert，Beijing Wanli Company

1990,7-1993,6  Assistant animal expert，Beijing Huadu Breeding Company, animal breeding

​

100 Talents Program of Chinese Academy of Sciences, 2009

BHPB Scholarship, 2014

​

1.        Lin Y, Ding D, Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J, Dong*.  Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. Biochim Biophys Acta.- Molecular and Cell Biology of Lipids 2017 May;1862(9):869-882. （IF：5.5）

2.        Huang Q, Chen Y, Lin L, Liu Y, Chi Y, Lin Y, Ye G, Zhu H, Dong*. Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses. Sci Total Environ. 2017 Oct 1;595:752-758（IF：4.9）

3.        Yulang Chi, Huanteng Zhang, Qiansheng Huang, Yi Lin, Guozhu Ye, Huimin Zhu, Sijun Dong*. (2017) Environmental risk assessment of selected organic chemicals based on TOC test and QSAR estimation models. Journal of Environmental Sciences.（IF：2.9）

4.        Ye, G., Chen, Y., Wang, H. O., Ye, T., Lin, Y., Huang, Q. & Dong S*. (2016). Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol A and tetrachlorobisphenol A. Scientific Reports, 6: 35257.（IF：4.2）

5.        Huang, Q., Chen, Y., Chen, Q., Zhang, H., Lin, Y., Zhu, M., & Dong S*. (2016). Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine–inflammation interactions. Archives of Toxicology, 1-10. （IF：5.9）

6.        Zhang Y, Dong S, Wang H, Tao S, Kiyama R. (2016) Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors. Environ Pollut. 2016 Jun; 213:809-24. （IF：5.0）

7.        Lu, Y. Y., Lin, Y., Zhang, H., Ding, D., Sun, X., Huang, Q. & Dong S*. (2016). Evaluation of Volatile Organic Compounds and Carbonyl Compounds Present in the Cabins of Newly Produced, Medium-and Large-Size Coaches in China. International Journal of Environmental Research and Public Health, 13(6), 596.  （IF：2.0）

8.        Chi, Y., Huang, Q., Zhang, H., Chen, Y., & Dong S*. (2016). In situ combined chemical and biological assessment of estrogenic pollution in a water recycling system. Journal of Environmental Sciences, 43, 216-223.  （IF：2.9）

9.        Huang, Q., Zhang, H., Chen, Y. J., Chi, Y. L., & Dong S*. (2016). The Inflammation Response to DEHP through PPARγ in Endometrial Cells. International journal of environmental research and public health, 13(3), 318. （IF：2.1）

10.    Chi Y, Wu Z, Zhong Y, Dong S*. (2016). Enantiomeric resolution, stereochemical assignment and toxicity evaluation of TPA enantiomers. Biomed Chromatogr. 2016 Dec 26. doi: 10.1002/bmc.3924. （IF：1.7）

11.    Huang Q, Chen Y, Chi Y, Lin Y, Zhang H, Fang C, Dong S*. Immunotoxic effects of perfluorooctane sulfonate and di(2-ethylhexyl) phthalate on the marine fish Oryzias melastigma. Fish Shellfish Immunol. 2015; 44(1):302-6. （IF：3.1）

12.    Du M, Fang C, Qiu L, Dong S, Zhang X, Yan C. Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome P450s in zebrafish (Danio rerio). Chemosphere. 2015; 132:24-31. （IF：4.2）

13.    Sun X,Lin Y,Huang Q,Shi P,Qiu L,Kang M,Chen Y, Fang C, Ye T, Dong S* Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. J Cell Mol Med. 2015; 19(3):581-94. （IF：4.5）

14.    Chao Fang, Bo Ning, Ahmed Bilal Waqar, Manabu Niimi, Shen Lib,Kaneo Satohc, Masashi Shiomid, Ting Ye, Sijun Dong* and Jianglin Fan*. Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits. Journal of Applied Toxicology. 2015,35(9):1058-1070. （IF：3.1）

15.    Chen Y, Huang Q, Chen Q, Lin Y, Sun X, Zhang H, Zhu M, Dong S*. The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells. Toxicol In Vitro. 2014; 29(2):308-313. （IF：2.8）

16.    Fang C，Ning B, Waqar AB, Niimi M, Li S,  Sato Kane, Shiomi M, Ye T, Sun X, Lin Y, Huang Q, Dong S*, Jianglin Fan. Bisphenol A exposure enhances atherosclerosis in WHHL rabbits. PLOS ONE. 2014; 9(10):e110977. （IF：2.8）

17.    Yu Q, Liu Z, Waqar AB, Ning B, Yang X, Shiomi M, Rosanne M. Crooke, Liu E, Dong S, and Fan J.Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits,“ Mediators of Inflammation. 2014. Article ID 979132. （IF：3.2）

18.    Dong S*, Kang M, Wu X, Ye T. Development of a Promising Fish Model (Oryzias melastigma) for Assessing Multiple Responses to Stresses in the Marine Environment. Biomed Res Int. 2014; 2014:563131. （IF：2.4）

19.    Ye T, Kang M, Huang Q, Dong S*. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma).Aquat Toxicol. 2014 Jan;146:115-26 （IF：4.1）

20.    Ye T, Kang M, Huang Q, Fang C, Chen Y, Liu L, Dong S*. Accumulation of di(2-ethylhexyl) phthalate causes endocrine-disruptive effects in marine medaka (Oryzias melastigma) embryos. Environ Toxicol. 2016 Jan;31(1):116-27.（IF：2.9）

21.    Lin Y, Sun X, Qiu L, Wei J, Huang Q, Fang C, Ye T, Kang M, Dong S*. Exposure to Bisphenol A Induces Dysfunction of Insulin Secretion and Apoptosis through the Damage of Mitochondria in Rat Insulinoma (INS-1) Cells. CELL DEATH & DISEASE 2013, 4, e460. （IF：5.9）

22.    Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R. Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agric Food Chem. 2013 61, 128-136 （IF：3.1）

23.    Liao Y, Dong S*. Cai P, Huang QS, Fang C, Kiyama R, Shen H. Flos Lonicerae extracts and chlorogenic acid protect human umbilical vein endothelial cells from the toxic damage of perfluorooctane sulphonate. Inflammation 2013;36(3):767-79 （IF：2.9）

24.    Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. Embryonic exposure to PFOS induced immunosuppression in the fish larvae of marine medaka. Ecotoxicology and Environmental Safety 2013 Jun;92:104-11. （IF：3.1）

25.    Lin Y，Huang Q, Fang C, Wu X, Fan J, Dong S*. The combined effects of DEHP and PCBs on the phospholipase in mice model. Environmental Toxicology 2015, 30(2):197-204.（IF：2.9）

26.    Shen H, Xu W, Zhang J, Chen M, Martin FL, Xia Y, Liu L, Dong S, Zhu YG. Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a han chinese population. Environ Sci Technol. 2013; 47(15): 8843-51. （IF：6.1）

27.    Zhang J, Liu F, Chen R, Feng T, Dong S, Shen H. Levels of polychlorinated biphenyls and organochlorine pesticides in edible shellfish from Xiamen (China) and estimation of human dietary intake. Food Chem Toxicol. 2012, 50(12):4285-91. （IF：3.7）

28.    Xu W, Bao H, Liu F, Liu L, Zhu YG, She J, Dong S, Cai M, Li L, Li C, Shen H. Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study .Environ Health. 2012, 9;11:46. （IF：3.4）

29.    Liu L, Xia T, Guo L, Cao L, Zhao B, Zhang J, Dong S, Shen H. Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example. J Expo Sci Environ Epidemiol. 2012, 22(6):625-31. （IF：3.1）

30.    Huang Q, Dong S*, Fang C, Wu X, Ye T, Lin Y. Deep sequencing-based transcriptome profiling analysis of Oryzias melastigma exposed to PFOS. Aquat Toxicol. 2012, 120-121:54-8. （IF：4.1）

31.    Wang J, Liao Y, Fan J, Ye T, Sun X, Dong S*. Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo. Inflammation. 2012, 35(4):1466-76. （IF：2.9）

32.    Zhang J, Yan L, Tian M, Huang Q, Peng S, Dong S, Shen H. The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice. J Pharm Biomed Anal. 2012, 66:287-97. （IF：3.2）

33.    Tian M, Peng S, Martin FL, Zhang J, Liu L, Wang Z, Dong S, Shen H. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology. 2012, 296(1-3):48-55. （IF：3.8）

34.    Wu X, Huang Q, Fang C, Ye T, Qiu L, Dong S*. PFOS induced precocious hatching of Oryzias melastigma--from molecular level to individual level. Chemosphere. 2012, 87(7):703-8. （IF：4.2）

35.    Liao Y, Wang J, Huang QS, Fang C, Kiyama R, Shen H, Dong S*. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol In Vitro. 2012, 26(3):421-8. （IF：3.3）

36.    Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquat Toxicol. 2012, 106-107:9-19. （IF：4.1）

37.    Dong S, et al. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract. Microbiol Res. 2012, 167(4):231-7. （IF：3.0）

38.    Wang J, Dong S*. ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells. Inflammation. 2012, 35(3):859-70. （IF：2.9）

39.    Huang Q, Fang C, Chen Y, Wu X, Ye T, Lin Y, Dong S*. Embryonic exposure to low concentration of bisphenol A affects the development of Oryzias melastigma larvae. Environ Sci Pollut Res Int. 2011, 19(7): 2506-14. （IF：2.8）

40.    Dong S, Terasaka S, Kiyama R. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut. 2011, 159(1):212-8. （IF：5.0）

41.    Huang Q, Fang C, Wu X, Fan J, Dong S*. Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma). Aquat Toxicol. 2011, 105(1-2):71-7. （IF：4.1）

42.    Zhu Y, Ogaeri T, Suzuki J, Dong S, Aoyagi T, Mizuki K, Takasugi M, Isobe S, Kiyama R. Application of Fluolid-Orange-labeled probes for DNA microarray and immunological assays. Biotechnol Lett. 2011, 33(9):1759-66. （IF：1.7）

43.    Dong S, Kiyama R. Characterization of Estrogenic Activity of Ginsenosides in MCF-7 Cells using a Customized DNA Microarray. Food Chem. 2009. 113: 672-678. （IF：4.5）

44.    Ying S, Dong S, Kawada A, Kojima T, Chavanas S, Mechin MC, Adoue V, Serre G, Simon M, Takahara H. Transcriptional Regulation of Peptidylargine Deiminase Expression in Human Keratinocytes. J Dermatol Sci. 2009. 53(1):2-9. （IF：3.7）

45.    Zhou Y, Kogiso M, Asakawa M, Dong S, Kiyama R, Shimizu T. Antimicrobial Nanotubes as Delivery Vehicles Consisting of Ag-Embedded Peptidic Lipid-Bilayer Membranes. Adv. Mater. 2009. 21, 1-4. （IF：19.7）

46.    Chavanas S, Adoue V, Méchin MC, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte. PLoS ONE.  2008. 3(10):e3408. （IF：2.8）

47.    Adoue V, Chavanas S, Coudane F, Méchin MC, Caubet C, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. Long-Range Enhancer Differentially Regulated by c-Jun and JunD Controls Peptidylarginine Deiminase-3 Gene in Keratinocytes. J Mol Biol.  2008. 384(5):1048-1057. （IF：4.6）

48.    Dong S, Ying S, Kojima T, Shiraiwa M, Mechin MC, et. al.  Crucial Role of MZF1 and Sp1 for the transcriptional regulation of the Peptidylarginine Deiminase Type I Gene (PADI1) in Human Keratinocytes. Journal of Investigative Dermatology 2008.128(3): 549-557.    （IF：6.3）

49.    Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of glycyrrhiza glabra root. Food and Chemical Toxicology 2007. 45: 2470–2478. （IF：3.7）

50.    Dong S, Zhang Z, Takahara H. Estrogen-enhanced PADI4 expression in MCF-7 cells mediated by ER-promoted transfactors AP-1, NF-Y and SP1. Molecular Endocrinology 2007. 21: 1617-1629 （IF：4.0）

51.    Dong S, Kanno T, Yamaki A, Kojima T, Shirawa M, et. al. NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Biochemical Journal  2006.397(3):449-459 （IF：3.7）

52.    Dong S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Kawada A, and Takahara H. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. Journal of Investigative Dermatology 2005. 124(5):1026-1033. （IF：6.3）

1.       MATSUOKA RUMIKO; KIYAMA RYOICHI; DONG SIJUN; Extract useful as health supplement, and for treating diseases associated with estrogen deficiency e.g. arteriosclerosis and hyperlipidemia, obtained by extracting Agaricusblazei mycelium and/or its processed material with solvent专利号: WO2010125891-A1 JP2010275294-A JP2015143236-A JP5768230-B2专利权人: UNIV TOKYO WOMEN'S MEDICAL; NAT INST ADVANCED IND SCI & TECHNOLOGY; UNIV TOKYO JOSHI IKA; et. al

2.       DONG SIJUN; KIYAMA R. Evaluating activity of Chinese drug or its active ingredient, by administering Chinese drug or its active ingredient to subject, comparing expression profile of gene e.g. mitochondrial phosphoenolpyruvate carboxykinase 2 in subject. 专利号: JP2007319051-A JP5126644-B2,专利权人: DOKURITSU GYOSEI HOJIN SANGYO GIJUTSU SO

Marine Ecological Enviroment

已指导学生

伍辛泷  硕士研究生  083001-环境科学  

王佳  博士研究生  083001-环境科学  

康美  硕士研究生  085229-环境工程  

孙霞  博士研究生  083001-环境科学  

方超  博士研究生  083001-环境科学  

陈亚檞  硕士研究生  085229-环境工程  

叶婷  博士研究生  083001-环境科学  

现指导学生

卢艳阳  博士研究生  083001-环境科学  

王泓鸥  博士研究生  083001-环境科学  

池毓烺  博士研究生  083001-环境科学  

高菡  博士研究生  083001-环境科学