基本信息

李守信 男 杭州医学研究所
电子邮件: lishouxin@him.cas.cn
通信地址: 杭州市钱塘区和达药谷四期1幢803
邮政编码:
电子邮件: lishouxin@him.cas.cn
通信地址: 杭州市钱塘区和达药谷四期1幢803
邮政编码:
教育背景
2002-09--2005-07 华东理工大学 硕士
1988-09--1992-07 山东中医学院 本科
1988-09--1992-07 山东中医学院 本科
工作经历
工作简历
2021-02~现在, 中国科学院杭州医学研究所, 研究员
2018-08~2021-01,浙江大学, 研究员
2007-10~2018-07,鲁南制药集团, 高级工程师
2002-09~2005-07,华东理工大学, 硕士
1998-10~2007-09,鲁南制药集团, 工程师
1992-08~1998-09,鲁南制药集团, 助理工程师
1988-09~1992-07,山东中医学院, 本科
2018-08~2021-01,浙江大学, 研究员
2007-10~2018-07,鲁南制药集团, 高级工程师
2002-09~2005-07,华东理工大学, 硕士
1998-10~2007-09,鲁南制药集团, 工程师
1992-08~1998-09,鲁南制药集团, 助理工程师
1988-09~1992-07,山东中医学院, 本科
出版信息
发表论文
(1) Lysimachia capillipes Hemsl. saponins ameliorate colorectal cancer in mice via regulating gut microbiota and restoring metabolic profiles, Fitoterapia, 2024,
(2) Identification of hypoxia-immune-related signatures for predicting immune efficacy in triple-negative breast cancer, Oncologie, 2024,
(3) Mitochondrial proteomic analysis reveals the regulation of energy metabolism and reactive oxygen species production in Clematis terniflora DC. leaves under high-level UV-B radiation followed by dark treatment, Journal of Proteomics, 2022, 第 6 作者
(4) Optimization of an alkaline hydrolysis preparation of capilliposide-A from Lysimachia capillipes Hemsl. using response surface methodology coupled with HPLC-ELSD analysis, Chromatographia, 2022, 第 6 作者
(5) Hypoglycemic and hypolipidemic efects of sugar beet (Beta vulgaris L.) extract on C57BL/KsJ db/db mice, Rendiconti Lincei. Scienze Fisiche e Naturali, 2022,
(6) Guangsangon E mitochondria dysfunction and mitophagy in triple-negative breast cancer and leads to non-apoptotic cell death, Molecular Carcinogenesis, 2022, 第 7 作者
(7) DHOK exerts anti-cancer effect through autophagy inhibition in colorectal caner, Frontiers in Cell and Developmental Biology, 2021, 第 7 作者
(8) A two-step strategy for quality control of Xin-Yu-Tie-Pian, an ointment patch, Biomedical Chromatography, 2021, 第 4 作者
(9) New determination method of two bioactive saponins in Lysimachia capillipes Hemsl. by quantitative analysis of multi-components by single-marker,, Journal of Chromatographic Science, 2021, 第 6 作者
(10) Investigation of phytochemical composition and metabolite profiling in vivo of Beta vulgaris L., Rapid Communications in Mass Spectrometry, 2021,
(11) Analgesic and antiinflammatory activities of the capilliposide derived from Lysimachia capillipes Hemsl, a traditional Chinese medicine herb, Archives Biological Sciences, 2020, 第 7 作者
(2) Identification of hypoxia-immune-related signatures for predicting immune efficacy in triple-negative breast cancer, Oncologie, 2024,
(3) Mitochondrial proteomic analysis reveals the regulation of energy metabolism and reactive oxygen species production in Clematis terniflora DC. leaves under high-level UV-B radiation followed by dark treatment, Journal of Proteomics, 2022, 第 6 作者
(4) Optimization of an alkaline hydrolysis preparation of capilliposide-A from Lysimachia capillipes Hemsl. using response surface methodology coupled with HPLC-ELSD analysis, Chromatographia, 2022, 第 6 作者
(5) Hypoglycemic and hypolipidemic efects of sugar beet (Beta vulgaris L.) extract on C57BL/KsJ db/db mice, Rendiconti Lincei. Scienze Fisiche e Naturali, 2022,
(6) Guangsangon E mitochondria dysfunction and mitophagy in triple-negative breast cancer and leads to non-apoptotic cell death, Molecular Carcinogenesis, 2022, 第 7 作者
(7) DHOK exerts anti-cancer effect through autophagy inhibition in colorectal caner, Frontiers in Cell and Developmental Biology, 2021, 第 7 作者
(8) A two-step strategy for quality control of Xin-Yu-Tie-Pian, an ointment patch, Biomedical Chromatography, 2021, 第 4 作者
(9) New determination method of two bioactive saponins in Lysimachia capillipes Hemsl. by quantitative analysis of multi-components by single-marker,, Journal of Chromatographic Science, 2021, 第 6 作者
(10) Investigation of phytochemical composition and metabolite profiling in vivo of Beta vulgaris L., Rapid Communications in Mass Spectrometry, 2021,
(11) Analgesic and antiinflammatory activities of the capilliposide derived from Lysimachia capillipes Hemsl, a traditional Chinese medicine herb, Archives Biological Sciences, 2020, 第 7 作者
科研活动
科研项目
( 1 ) 满山香片药理学研究, 负责人, 境内委托项目, 2023-11--2024-11
( 2 ) 具有缓解视疲劳功能的杞芍明目颗粒的研制, 负责人, 地方任务, 2023-01--2025-12
( 3 ) 乌饭树叶防腐保鲜总黄酮提取精制及应用示范研究, 负责人, 地方任务, 2022-01--2024-12
( 4 ) 中药新药开发研究-基于活性导向抗前列腺癌中药新药LC-B的研究, 参与, 地方任务, 2022-01--2024-12
( 2 ) 具有缓解视疲劳功能的杞芍明目颗粒的研制, 负责人, 地方任务, 2023-01--2025-12
( 3 ) 乌饭树叶防腐保鲜总黄酮提取精制及应用示范研究, 负责人, 地方任务, 2022-01--2024-12
( 4 ) 中药新药开发研究-基于活性导向抗前列腺癌中药新药LC-B的研究, 参与, 地方任务, 2022-01--2024-12