基本信息
吴振芳 男 杭州高等研究院
电子邮件： zhenfwu@ucas.ac.cn
通信地址： 浙江省杭州市西湖区象山支弄1号
邮政编码：
电子邮件： zhenfwu@ucas.ac.cn
通信地址： 浙江省杭州市西湖区象山支弄1号
邮政编码：
教育背景
2009-09--2014-07 中国科学院大学微生物研究所 博士研究生
2006-09--2009-06 四川农业大学 硕士研究生
2002-09--2006-06 重庆邮电大学 学士
2006-09--2009-06 四川农业大学 硕士研究生
2002-09--2006-06 重庆邮电大学 学士
工作经历
工作简历
2023-11~现在, 国科大杭州高等研究院, 副研究员
2019-01~2023-09,上海交通大学医学院附属第九人民医院, 副研究员
2018-06~2018-12,上海交通大学医学院附属第九人民医院, 助理研究员
2014-08~2018-05,中国科学院分子细胞科学卓越创新中心, 博士后
2019-01~2023-09,上海交通大学医学院附属第九人民医院, 副研究员
2018-06~2018-12,上海交通大学医学院附属第九人民医院, 助理研究员
2014-08~2018-05,中国科学院分子细胞科学卓越创新中心, 博士后
出版信息
发表论文
[1] Structure. 2024, 通讯作者
[2] Sun, Hong, Wu, Zhenfang, Zhou, Yuanze, Lu, Yanjia, Lu, Huaisheng, Chen, Hongwen, Shi, Shaohua, Zeng, Zhixiong, Wu, Jian, Lei, Ming. Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex. PLOS GENETICS[J]. 2022, 第 2 作者 通讯作者 18(7): http://dx.doi.org/10.1371/journal.pgen.1010308.
[3] 鲁彦伽, 孙虹, 吴振芳, 雷鸣. 裂殖酵母Shelterin五元复合物的电镜结构研究. 上海交通大学学报:医学版[J]. 2022, 第 3 作者42(3): 290-297, http://lib.cqvip.com/Qikan/Article/Detail?id=7107084394.
[4] Futang Wan, Yongbo Ding, Yuebin Zhang, Zhenfang Wu, Shaobai Li, Lin Yang, Xiangyu Yan, Pengfei Lan, Guohui Li, Jian Wu, Ming Lei. Zipper head mechanism of telomere synthesis by human telomerase. 细胞研究:英文版[J]. 2021, 第 4 作者31(12): 1275-1290, http://lib.cqvip.com/Qikan/Article/Detail?id=7106384930.
[5] Shi, Shaohua, Zhou, Yuanze, Lu, Yanjia, Sun, Hong, Xue, Jing, Wu, Zhenfang, Lei, Ming. Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres. LIFE SCIENCE ALLIANCE[J]. 2021, 第 6 作者 通讯作者 4(11): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701914400014.
[6] Chen, Cong, Tan, Ming, Wu, Zhenfang, Zhang, Yuebin, He, Fanyang, Lu, Yanjia, Li, Shaobai, Cao, Mi, Li, Guohui, Wu, Jian, Cheng, Hong, Lei, Ming. Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. SCIENCE BULLETIN[J]. 2021, 第 3 作者66(23): 2347-2352, http://dx.doi.org/10.1016/j.scib.2021.08.004.
[7] Wang, Qianmin, Li, Shaobai, Wan, Futang, Xu, Youwei, Wu, Zhenfang, Cao, Mi, Lan, Pengfei, Lei, Ming, Wu, Jian. Structural insights into transcriptional regulation of human RNA polymerase III. NATURESTRUCTURALMOLECULARBIOLOGY[J]. 2021, 第 5 作者28(2): 220-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000616068500005.
[8] Ge, Yunhui, Wu, Zhenfang, Chen, Hongwen, Zhong, Qinglu, Shi, Shaohua, Li, Guohui, Wu, Jian, Lei, Ming. Structural insights into telomere protection and homeostasis regulation by yeast CST complex. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2020, 第 2 作者 通讯作者 27(8): 752-+, http://dx.doi.org/10.1038/s41594-020-0459-8.
[9] Zhang, Chunli, Shuai, Jin, Ran, Zhaoxing, Zhao, Jiaohong, Wu, Zhenfang, Liao, Rijing, Wu, Jian, Ma, Weimin, Lei, Ming. Structural insights into NDH-1 mediated cyclic electron transfer. NATURE COMMUNICATIONS[J]. 2020, 第 5 作者11(1): http://dx.doi.org/10.1038/s41467-020-14732-z.
[10] He, MingHong, Liu, JiaCheng, Lu, YiSi, Wu, ZhiJing, Liu, YingYing, Wu, Zhenfang, Peng, Jing, Zhou, JinQiu. KEOPS complex promotes homologous recombination via DNA resection. NUCLEIC ACIDS RESEARCH[J]. 2019, 第 6 作者47(11): 5684-5697, http://dx.doi.org/10.1093/nar/gkz228.
[11] Shao, Yangyang, Lu, Ning, Wu, Zhenfang, Cai, Chen, Wang, Shanshan, Zhang, LingLi, Zhou, Fan, Xiao, Shijun, Liu, Lin, Zeng, Xiaofei, Zheng, Huajun, Yang, Chen, Zhao, Zhihu, Zhao, Guoping, Zhou, JinQiu, Xue, Xiaoli, Qin, Zhongjun. Creating a functional single-chromosome yeast. NATURE[J]. 2018, 第 3 作者560(7718): 331-+, http://202.127.25.143/handle/331003/3385.
[12] Wu, Zhenfang, He, MingHong, Zhang, LingLi, Liu, Jun, Zhang, QiongDi, Zhou, JinQiu. Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae. DNA REPAIR[J]. 2018, 第 1 作者 通讯作者 72: 64-76, http://dx.doi.org/10.1016/j.dnarep.2018.09.007.
[13] Zhang, LingLi, Wu, Zhenfang, Zhou, JinQiu. Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae. JOURNAL OF GENETICS AND GENOMICS[J]. 2018, 第 2 作者 通讯作者 45(9): 467-476, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6353422&detailType=1.
[14] Wu, Zhenfang, Liu, Jun, Zhang, QiongDi, Lv, DeKang, Wu, NianFeng, Zhou, JinQiu. Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 1 作者45(6): 3308-3322, http://dx.doi.org/10.1093/nar/gkx101.
[15] Liu, Jun, He, MingHong, Peng, Jing, Duan, YiMin, Lu, YiSi, Wu, Zhenfang, Gong, Ting, Li, HongTao, Zhou, JinQiu. Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast. AGING-US[J]. 2016, 第 6 作者8(11): 2827-2847, http://dx.doi.org/10.18632/aging.101095.
[16] Yang, Haibo, Wu, Zhenfang, Liu, Jingfang, Liu, Xiaoqing, Wang, Lei, Cai, Shuangfeng, Xiang, Hua. Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins. NATURE COMMUNICATIONS[J]. 2015, 第 2 作者6: https://www.webofscience.com/wos/woscc/full-record/WOS:000363020800005.
[17] Wu, Zhenfang, Liu, Jingfang, Yang, Haibo, Liu, Hailong, Xiang, Hua. Multiple replication origins with diverse control mechanisms in Haloarcula hispanica. NUCLEIC ACIDS RESEARCH[J]. 2014, 第 1 作者42(4): 2282-2294, https://www.webofscience.com/wos/woscc/full-record/WOS:000332381000024.
[18] Wu, Zhenfang, Liu, Jingfang, Yang, Haibo, Xiang, Hua. DNA replication origins in archaea. FRONTIERS IN MICROBIOLOGY[J]. 2014, 第 1 作者5: https://doaj.org/article/895384f218cd42a298627b5d98b1584e.
[19] Wu, Zhenfang, Yang, Haibo, Liu, Jingfang, Wang, Lei, Xiang, Hua. Association between the Dynamics of Multiple Replication Origins and the Evolution of Multireplicon Genome Architecture in Haloarchaea. GENOME BIOLOGY AND EVOLUTION[J]. 2014, 第 1 作者6(10): 2799-2810, https://www.webofscience.com/wos/woscc/full-record/WOS:000346775800018.
[20] Liu, Hailong, Luo, Yuanming, Han, Jing, Wu, Jinhua, Wu, Zhenfang, Feng, Deqin, Cai, Shuangfeng, Li, Ming, Liu, Jingfang, Zhou, Jian, Xiang, Hua. Proteome Reference Map of Haloarcula hispanica and Comparative Proteomic and Transcriptomic Analysis of Polyhydroxyalkanoate Biosynthesis under Genetic and Environmental Perturbations. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 第 5 作者12(3): 1300-1315, https://www.webofscience.com/wos/woscc/full-record/WOS:000315708000022.
[21] Liu, Xiaoqing, Miao, Di, Zhang, Fan, Wu, Zhenfang, Liu, Jingfang, Xiang, Hua. Characterization of the minimal replicon of pHM300 and independent copy number control of major and minor chromosomes of Haloferax mediterranei. FEMS MICROBIOLOGY LETTERS[J]. 2013, 第 4 作者339(1): 66-74, https://www.webofscience.com/wos/woscc/full-record/WOS:000313721100009.
[22] Wu, Zhenfang, Liu, Hailong, Liu, Jingfang, Liu, Xiaoqing, Xiang, Hua. Diversity and evolution of multiple orc/cdc6-adjacent replication origins in haloarchaea. BMC GENOMICS[J]. 2012, 第 1 作者13: https://www.webofscience.com/wos/woscc/full-record/WOS:000312736600001.
[2] Sun, Hong, Wu, Zhenfang, Zhou, Yuanze, Lu, Yanjia, Lu, Huaisheng, Chen, Hongwen, Shi, Shaohua, Zeng, Zhixiong, Wu, Jian, Lei, Ming. Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex. PLOS GENETICS[J]. 2022, 第 2 作者 通讯作者 18(7): http://dx.doi.org/10.1371/journal.pgen.1010308.
[3] 鲁彦伽, 孙虹, 吴振芳, 雷鸣. 裂殖酵母Shelterin五元复合物的电镜结构研究. 上海交通大学学报:医学版[J]. 2022, 第 3 作者42(3): 290-297, http://lib.cqvip.com/Qikan/Article/Detail?id=7107084394.
[4] Futang Wan, Yongbo Ding, Yuebin Zhang, Zhenfang Wu, Shaobai Li, Lin Yang, Xiangyu Yan, Pengfei Lan, Guohui Li, Jian Wu, Ming Lei. Zipper head mechanism of telomere synthesis by human telomerase. 细胞研究:英文版[J]. 2021, 第 4 作者31(12): 1275-1290, http://lib.cqvip.com/Qikan/Article/Detail?id=7106384930.
[5] Shi, Shaohua, Zhou, Yuanze, Lu, Yanjia, Sun, Hong, Xue, Jing, Wu, Zhenfang, Lei, Ming. Ccq1-Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres. LIFE SCIENCE ALLIANCE[J]. 2021, 第 6 作者 通讯作者 4(11): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701914400014.
[6] Chen, Cong, Tan, Ming, Wu, Zhenfang, Zhang, Yuebin, He, Fanyang, Lu, Yanjia, Li, Shaobai, Cao, Mi, Li, Guohui, Wu, Jian, Cheng, Hong, Lei, Ming. Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. SCIENCE BULLETIN[J]. 2021, 第 3 作者66(23): 2347-2352, http://dx.doi.org/10.1016/j.scib.2021.08.004.
[7] Wang, Qianmin, Li, Shaobai, Wan, Futang, Xu, Youwei, Wu, Zhenfang, Cao, Mi, Lan, Pengfei, Lei, Ming, Wu, Jian. Structural insights into transcriptional regulation of human RNA polymerase III. NATURESTRUCTURALMOLECULARBIOLOGY[J]. 2021, 第 5 作者28(2): 220-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000616068500005.
[8] Ge, Yunhui, Wu, Zhenfang, Chen, Hongwen, Zhong, Qinglu, Shi, Shaohua, Li, Guohui, Wu, Jian, Lei, Ming. Structural insights into telomere protection and homeostasis regulation by yeast CST complex. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2020, 第 2 作者 通讯作者 27(8): 752-+, http://dx.doi.org/10.1038/s41594-020-0459-8.
[9] Zhang, Chunli, Shuai, Jin, Ran, Zhaoxing, Zhao, Jiaohong, Wu, Zhenfang, Liao, Rijing, Wu, Jian, Ma, Weimin, Lei, Ming. Structural insights into NDH-1 mediated cyclic electron transfer. NATURE COMMUNICATIONS[J]. 2020, 第 5 作者11(1): http://dx.doi.org/10.1038/s41467-020-14732-z.
[10] He, MingHong, Liu, JiaCheng, Lu, YiSi, Wu, ZhiJing, Liu, YingYing, Wu, Zhenfang, Peng, Jing, Zhou, JinQiu. KEOPS complex promotes homologous recombination via DNA resection. NUCLEIC ACIDS RESEARCH[J]. 2019, 第 6 作者47(11): 5684-5697, http://dx.doi.org/10.1093/nar/gkz228.
[11] Shao, Yangyang, Lu, Ning, Wu, Zhenfang, Cai, Chen, Wang, Shanshan, Zhang, LingLi, Zhou, Fan, Xiao, Shijun, Liu, Lin, Zeng, Xiaofei, Zheng, Huajun, Yang, Chen, Zhao, Zhihu, Zhao, Guoping, Zhou, JinQiu, Xue, Xiaoli, Qin, Zhongjun. Creating a functional single-chromosome yeast. NATURE[J]. 2018, 第 3 作者560(7718): 331-+, http://202.127.25.143/handle/331003/3385.
[12] Wu, Zhenfang, He, MingHong, Zhang, LingLi, Liu, Jun, Zhang, QiongDi, Zhou, JinQiu. Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae. DNA REPAIR[J]. 2018, 第 1 作者 通讯作者 72: 64-76, http://dx.doi.org/10.1016/j.dnarep.2018.09.007.
[13] Zhang, LingLi, Wu, Zhenfang, Zhou, JinQiu. Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae. JOURNAL OF GENETICS AND GENOMICS[J]. 2018, 第 2 作者 通讯作者 45(9): 467-476, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6353422&detailType=1.
[14] Wu, Zhenfang, Liu, Jun, Zhang, QiongDi, Lv, DeKang, Wu, NianFeng, Zhou, JinQiu. Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 1 作者45(6): 3308-3322, http://dx.doi.org/10.1093/nar/gkx101.
[15] Liu, Jun, He, MingHong, Peng, Jing, Duan, YiMin, Lu, YiSi, Wu, Zhenfang, Gong, Ting, Li, HongTao, Zhou, JinQiu. Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast. AGING-US[J]. 2016, 第 6 作者8(11): 2827-2847, http://dx.doi.org/10.18632/aging.101095.
[16] Yang, Haibo, Wu, Zhenfang, Liu, Jingfang, Liu, Xiaoqing, Wang, Lei, Cai, Shuangfeng, Xiang, Hua. Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins. NATURE COMMUNICATIONS[J]. 2015, 第 2 作者6: https://www.webofscience.com/wos/woscc/full-record/WOS:000363020800005.
[17] Wu, Zhenfang, Liu, Jingfang, Yang, Haibo, Liu, Hailong, Xiang, Hua. Multiple replication origins with diverse control mechanisms in Haloarcula hispanica. NUCLEIC ACIDS RESEARCH[J]. 2014, 第 1 作者42(4): 2282-2294, https://www.webofscience.com/wos/woscc/full-record/WOS:000332381000024.
[18] Wu, Zhenfang, Liu, Jingfang, Yang, Haibo, Xiang, Hua. DNA replication origins in archaea. FRONTIERS IN MICROBIOLOGY[J]. 2014, 第 1 作者5: https://doaj.org/article/895384f218cd42a298627b5d98b1584e.
[19] Wu, Zhenfang, Yang, Haibo, Liu, Jingfang, Wang, Lei, Xiang, Hua. Association between the Dynamics of Multiple Replication Origins and the Evolution of Multireplicon Genome Architecture in Haloarchaea. GENOME BIOLOGY AND EVOLUTION[J]. 2014, 第 1 作者6(10): 2799-2810, https://www.webofscience.com/wos/woscc/full-record/WOS:000346775800018.
[20] Liu, Hailong, Luo, Yuanming, Han, Jing, Wu, Jinhua, Wu, Zhenfang, Feng, Deqin, Cai, Shuangfeng, Li, Ming, Liu, Jingfang, Zhou, Jian, Xiang, Hua. Proteome Reference Map of Haloarcula hispanica and Comparative Proteomic and Transcriptomic Analysis of Polyhydroxyalkanoate Biosynthesis under Genetic and Environmental Perturbations. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 第 5 作者12(3): 1300-1315, https://www.webofscience.com/wos/woscc/full-record/WOS:000315708000022.
[21] Liu, Xiaoqing, Miao, Di, Zhang, Fan, Wu, Zhenfang, Liu, Jingfang, Xiang, Hua. Characterization of the minimal replicon of pHM300 and independent copy number control of major and minor chromosomes of Haloferax mediterranei. FEMS MICROBIOLOGY LETTERS[J]. 2013, 第 4 作者339(1): 66-74, https://www.webofscience.com/wos/woscc/full-record/WOS:000313721100009.
[22] Wu, Zhenfang, Liu, Hailong, Liu, Jingfang, Liu, Xiaoqing, Xiang, Hua. Diversity and evolution of multiple orc/cdc6-adjacent replication origins in haloarchaea. BMC GENOMICS[J]. 2012, 第 1 作者13: https://www.webofscience.com/wos/woscc/full-record/WOS:000312736600001.
科研活动
科研项目
（ 1 ） 肿瘤-睾丸抗原SAGE1调控ALT肿瘤细胞中端粒重组的机制研究, 负责人, 国家任务, 2023-01--2026-12
（ 2 ） 端粒酶RNA组分TERC调控基因转录的非典型功能及其机制研究, 负责人, 研究所自主部署, 2023-12--2026-11
（ 2 ） 端粒酶RNA组分TERC调控基因转录的非典型功能及其机制研究, 负责人, 研究所自主部署, 2023-12--2026-11