研究组致力于开发和整合组学技术和生物信息手段提升精准医学。即基于多种组学技术刻画人的衰老和癌症样本，通过建立新的人工智能算法和模型解析生物学过程，鉴定关键信号和分子靶点。主要研究方向：
（1）开发组学技术和组学计算方法，尤其是单细胞多组学技术及其分析方法；
（2）多组学数据整合，构建全息细胞图谱解析细胞解析细胞对外界刺激的应答；
（3）利用单细胞技术解析肿瘤微环境和肿瘤微进化，发展精准免疫治疗。

0710Z1-基因组学，基因组研究方法

0710Z2-计算生物学，生物信息

1001Z1-精准医学，肿瘤免疫

2006-09--2012-01   中国科学院上海生命科学研究院   博士
2001-09--2006-07   郑州大学   学士

2023-10~现在, 中国科学院上海营养和健康研究所, 研究员
2017-03~2024-02,南方科技大学, 副教授,研究员
2013-01~2017-03,美国国立卫生研究院（NIH）, 博士后
2012-01~2012-12,中国科学院上海生命科学研究院, 助理研究员

2023-11-01-今,中国遗传学会, 三维基因组学专委会委员
2023-05-31-今,中国生物信息学学会（筹）, 表观遗传信息学专委会委员
2023-05-01-今,广东省生物信息学会, 常务理事
2023-04-01-今,中国生物信息学学会（筹）, 非编码RNA与RNA信息学专业委员会委员
2021-03-01-今,中国生物工程学会, 系统生物医学专业委员会委员

   

（1） 南方科技大学优秀研究生导师, , 研究所（学校）, 2022
（2） 南方科技大学“良师益友”优秀研究生导师, 研究所（学校）, 2022
（3） 广东省珠江人才计划青年拔尖, , 省级, 2019

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[2] 袁昕, 余胜, 洪旎, 靳文菲. 一种单细胞文库的构建方法. CN: CN113584598A, 2021-11-02.

   

[1] 靳文菲. Single cell analyses of cancer cells identified two regulatorily and functionally distinct categories in differentially expressed genes among tumor subclones. Heliyon[J]. 2024, 10(6): e28071-, https://www.sciencedirect.com/science/article/pii/S2405844024041021?via%3Dihub.
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[3] Zhou, Jie, Chen, Guanming, Wang, Jiuling, Zhou, Bo, Sun, Xuemin, Wang, Jinsong, Tang, Shu, Xing, Xiangju, Hu, Xiaofei, Zhao, Yang, Peng, Yu, Shi, Wenjiong, Zhao, Tingting, Wu, Yuzhang, Zhong, Hanbing, Hong, Ni, Ruan, Zhihua, Zhang, Yi, Jin, Wenfei. Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer. ONCOGENESIS[J]. 2023, 12(1): http://dx.doi.org/10.1038/s41389-023-00468-0.
[4] Hui Li, Hongyi Liu, Yifei Liu, Xuefei Wang, Shiya Yu, Hongwen Huang, Xiangru Shen, Qi Zhang, Ni Hong, Wenfei Jin. Exploring the dynamics and influencing factors of CD4 Tcell activation using single-cell RNA-seq. ISCIENCE. 2023, 26(9): http://dx.doi.org/10.1016/j.isci.2023.107588.
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（1） 混合人群的混合动态、自然选择与疾病, Admixture Dynamics, Natural Selection and Diseases in Admixed Populations, 施普林格, 2015-10, 第 1 作者

   

（ 1 ） 整合多种单细胞技术解析肿瘤浸润免疫细胞的耗竭机制, 负责人, 国家任务, 2019-01--2022-12
（ 2 ） 发展单细胞多组学技术在单细胞水平研究基因调控, 负责人, 国家任务, 2022-01--2025-12
（ 3 ） 开发多模态单细胞数据整合方法在单细胞水平解析基因调控和发育, 负责人, 国家任务, 2024-01--2027-12
（ 4 ） 单细胞测序数据计算方法开发和数据挖掘, 负责人, 国家任务, 2018-01--2018-12
（ 5 ） 新型可遗传获得性性状和表观载体的筛选, 负责人, 国家任务, 2018-12--2021-11
（ 6 ） 细胞多重分子特征多维度分析、建模及癌变预警应用, 负责人, 国家任务, 2021-12--2024-11
（ 7 ） 基于单细胞测序和染色质开放位点分析的肿瘤浸润淋巴细胞耗竭过程研究, 负责人, 地方任务, 2018-05--2021-05
（ 8 ） 基于个体化肿瘤数字模型的结直肠癌精准诊疗研发团队, 参与, 地方任务, 2019-11--2024-10
（ 9 ） 肿瘤免疫微环境三维高精度分析算法研究, 负责人, 地方任务, 2022-10--2025-10
（ 10 ） 真核生物人工染色体的设计建造与功能研究, 参与, 国家任务, 2021-12--2026-12
（ 11 ） 整合Stereo-seq和单细胞转录组构建单细胞分辨率的三维肿瘤微环境, 负责人, 境内委托项目, 2023-01--2024-12
（ 12 ） 单细胞多组学技术在辅助生殖中的应用, 参与, 地方任务, 2023-05--2026-05