071008-发育生物学
071009-细胞生物学
071010-生物化学与分子生物学

干细胞、心肺血管及代谢性疾病、细胞治疗和基因治疗技术

1996-09--1999-07   哈尔滨医科大学   博士
1993-09--1996-07   福建中医药大学   硕士
1988-09--1993-07   福建中医药大学   学士

   

2023-02~2029-02,中国科学院深圳理工大学, 教授、研究员
2019-11~2020-07,英国爱丁堡国家输血中心细胞治疗先进制造, 高级访问研究员
2019-11~2023-01,香港大学李嘉诚医学院, 细胞制造中心科学主任、国家重点实验室副主任、首席研究员
2019-01~2019-10,英国阿伯丁大学国王学院, Reader、终身准教授
2011-01~2018-12,香港大学李嘉诚医学院内科学系, 助理教授、首席研究员
2008-09~2010-12,香港大学李嘉诚医学院内科学系, 研究助理教授、研究员
2007-02~2008-08,新加坡国立大学医学院研究所, 研究员
2001-10~2007-01,新加坡国立大学医学院、新加坡基因组研究院, 博士后
1999-08~2001-09,福建省医科大学附属泉州第一医院心脏中心, 心血管主治医师

2021-05-15-今,香港科技园Incubio科创基金会, 科学评审专家
2020-02-01-今,国际学术期刊《移植》,JCR/Q1(in Surgery,Transplantation,2022 IF 5.4), 副主编，Associate Editor
2018-11-01-今,以色列科学基金会(ISF), 科学评审专家
2018-04-01-今,法国国家科研署(ANR), 科学评审专家

细胞和基因治疗产品的良好生产规范的基本概念
先进治疗药物（ATMP）基础
干细胞和发育生物

   

（ 1 ） 包含芳基硫酸酯酶A的重组载体及其在用于治疗异染性脑白质营养不良的干细胞治疗中的用途, 发明专利, 2021, 第 1 作者, 专利号: CN113544279A

（ 2 ） MSC-TNF α-AB干细胞及其制备方法和应用, 2021, 第 1 作者, 专利号: CN106167791B

   

[1] Geng, Leiluo, Liao, Boya, Jin, Leigang, Yu, Jiasui, Zhao, Xiaoyu, Zhao, Yuntao, Zhong, Ling, Wang, Baile, Li, Jiufeng, Liu, Jie, Yang, JinKui, Jia, Wei, Lian, Qizhou, Xu, Aimin. beta-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130. NATURE METABOLISM[J]. 2022, 4(5): 608-+, http://dx.doi.org/10.1038/s42255-022-00572-2.
[2] Lian, Qizhou, Zhang, Kui, Zhang, Zhao, Duan, Fuyu, Guo, Liyan, Luo, Weiren, Mok, Bobo WingYee, Thakur, Abhimanyu, Ke, Xiaoshan, Motallebnejad, Pedram, Nicolaescu, Vlad, Chen, Jonathan, Ma, Chui Yan, Zhou, Xiaoya, Han, Shuo, Han, Teng, Zhang, Wei, Tan, Adrian Y, Zhang, Tuo, Wang, Xing, Xu, Dong, Xiang, Jenny, Xu, Aimin, Liao, Can, Huang, FangPing, Chen, YaWen, Na, Jie, Randall, Glenn, Tse, Hungfat, Chen, Zhiwei, Chen, Yin, Chen, Huanhuan Joyce. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. NATURE COMMUNICATIONS[J]. 2022, 13(1): https://doaj.org/article/9938f59e696a4a09b36d23579730178b.
[3] Leigang Jin, Leiluo Geng, Qizhou Lian, Lei Ying, Lingling Shu, Kevin Ye, Ranyao Yang, Yan Liu, Yao Wang, Yin Cai, Xue Jiang, Qin Wang, Xingqun Yan, Boya Liao, Jie Liu, Fuyu Duan, Gary Sweeney, Connie Wai Hong Woo, Yu Wang, Zhengyuan Xia, Aimin Xu. FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity.. CIRCULATION[J]. 2022, 146(20): 1537-1557, https://pubmed.ncbi.nlm.nih.gov/36134579/.
[4] Zhang, Zhao, Guo, Liyan, Huang, Li, Zhang, Che, Luo, Ruibang, Zeng, Liang, Liang, Huiying, Li, Qiuhui, Lu, Xiaoxia, Wang, Xianfeng, Ma, Chui Yan, Shao, Jianbo, Luo, Weiren, Li, Le, Liu, Li, Li, Ziyue, Zhou, Xiaoya, Zhang, Xiaoxian, Liu, Jie, Yang, Jinjuan, Kwan, Ka Yi, Liu, Wei, Xu, Yi, Jiang, Hua, Liu, Hongsheng, Du, Hui, Wu, Yanheng, Yu, Guangyin, Chen, Junhui, Wu, Jieying, Zhang, Jinqiu, Liao, Can, Chen, Huanhuan Joyce, Chen, Zhiwei, Tse, HungFat, Xia, Huimin, Lian, Qizhou. Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells. CLINICAL INFECTIOUS DISEASES[J]. 2021, 73(11): E4154-E4165, http://dx.doi.org/10.1093/cid/ciaa1911.
[5] Zhang, Zhao, Yan, Bin, Gao, Fei, Li, Qing, Meng, Xiaohong, Chen, Peikai, Zhou, Lei, Deng, Wen, Li, Cheng, Xu, Weiyi, Han, Shuo, Feng, Hong, Li, Yaping, Chen, Junhui, Yin, Zhengqin, Liao, Can, Tse, HungFat, Xu, Aimin, Lian, Qizhou. PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy. MOLECULAR THERAPY[J]. 2020, 28(12): 2642-2661, http://dx.doi.org/10.1016/j.ymthe.2020.07.024.
[6] Zhang, Yuelin, Zhang, Zhao, Chen, Peikai, Ma, Chui Yan, Li, Cheng, Au, Tiffany Y K, Tam, Vivian, Peng, Yan, Wu, Ron, Cheung, Kenneth Man Chee, Sham, Pak C, Tse, Hungfat, Chan, Danny, Leung, Victor Y, Cheah, Kathryn S E, Lian, Qizhou. Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells. CELL REPORTS[J]. 2020, 30(8): 2791-+, https://doaj.org/article/b6e01329e7e54253844de4c14a97fa7b.
[7] Li, Xiang, Michaeloudes, Charalambos, Zhang, Yuelin, Wiegman, Coen H, Adcock, Ian M, Lian, Qizhou, Mak, Judith C W, Bhavsar, Pankaj K, Chung, Kian Fan. Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY[J]. 2018, 141(5): 1634-+, http://dx.doi.org/10.1016/j.jaci.2017.08.017.
[8] Fu, Q L, Chow, Y Y, Sun, S J, Zeng, Q X, Li, H B, Shi, J B, Sun, Y Q, Wen, W, Tse, H F, Lian, Q, Xu, G. Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis. ALLERGY[J]. 2012, 67(10): 1215-1222, https://www.webofscience.com/wos/woscc/full-record/WOS:000308710700003.
[9] Zhang, Jinqiu, Lian, Qizhou, Zhu, Guili, Zhou, Fan, Sui, Lin, Tan, Cindy, Mutalif, Rafidah Abdul, Navasankari, Raju, Zhang, Yuelin, Tse, HungFat, Stewart, Colin L, Colman, Alan. A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects. CELL STEM CELL[J]. 2011, 8(1): 31-45, http://dx.doi.org/10.1016/j.stem.2010.12.002.
[10] Lian, Qizhou, Zhang, Yuelin, Zhang, Jinqiu, Zhang, Hua Kun, Wu, Xingang, Zhang, Yang, Lam, Francis FuYuen, Kang, Sarang, Xia, Jian Chuan, Lai, WingHong, Au, KaWing, Chow, Yen Yen, Siu, ChungWah, Lee, ChuenNeng, Tse, HungFat. Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice. CIRCULATION[J]. 2010, 121(9): 1113-U91, https://www.webofscience.com/wos/woscc/full-record/WOS:000275331600008.

（1） 心脏修复和再生的最佳细胞, Optimal cells for cardiac repair and regeneration, Mesenchymal Stem Cells, 2013-01, 第 2 作者
（2） 人诱导多能干细胞向间充质干细胞的定向分化, Directed Differentiation of Human-Induced Pluripotent Stem Cells to Mesenchymal Stem Cells, Methods Mol Biol, 2016-01, 第 1 作者

   

（ 1 ） Fighting Disease Recurrence and Promoting Tissue Repair after Liver Transplantation: Translating Basic Discoveries to Clinical Excellence, 负责人, 其他, 2019-12--2024-12
（ 2 ） Therapeutic application of induced pluripotent stem cells derived mesenchymal stromal cells for treatment of heart failure（The Research Impact Fund (RIF), 负责人, 其他, 2021-12--2024-12
（ 3 ） A novel Role of Stanniocalcin-2 in the Regulation of Insulin Secretion from Pancreatic β cells, 负责人, 其他, 2022-12--2025-12
（ 4 ） “干细胞研究与器官修复”专项, 负责人, 国家任务, 2022-12--2027-11