基本信息

周彬 女 硕导 中国科学院上海药物研究所
电子邮件: zbbrush@simm.ac.cn
通信地址: 祖冲之路555号
邮政编码:
电子邮件: zbbrush@simm.ac.cn
通信地址: 祖冲之路555号
邮政编码:
招生信息
招生专业
100701-药物化学
100705-微生物与生化药学
100705-微生物与生化药学
招生方向
天然药物化学
教育背景
2011-09--2016-07 中国科学院上海药物研究所 博士
2007-09--2011-07 中国药科大学 学士
2007-09--2011-07 中国药科大学 学士
工作经历
工作简历
2020-10~2023-07,中国科学院上海药物研究所, 副研究员
2017-10~2019-12,美国伊利诺伊大学芝加哥分校, 博士后
2016-07~2020-10,中国科学院上海药物研究所, 助理研究员
2011-09~2016-07,中国科学院上海药物研究所, 博士
2007-09~2011-07,中国药科大学, 学士
2017-10~2019-12,美国伊利诺伊大学芝加哥分校, 博士后
2016-07~2020-10,中国科学院上海药物研究所, 助理研究员
2011-09~2016-07,中国科学院上海药物研究所, 博士
2007-09~2011-07,中国药科大学, 学士
专利与奖励
奖励信息
(1) 上海市浦江人才计划, 一等奖, 省级, 2021
专利成果
( 1 ) 一类麦角甾烷型甾体化合物、其制备方法及用途, 2019, 第 3 作者, 专利号: CN109134573A
( 2 ) 一类乌药烷型二聚倍半萜类化合物在制备抗疟药物中的用途, 2018, 第 2 作者, 专利号: CN107865865A
( 3 ) 一类乌药烷型二聚倍半萜类化合物、其制备方法及用途, 2018, 第 2 作者, 专利号: CN107868068A
( 2 ) 一类乌药烷型二聚倍半萜类化合物在制备抗疟药物中的用途, 2018, 第 2 作者, 专利号: CN107865865A
( 3 ) 一类乌药烷型二聚倍半萜类化合物、其制备方法及用途, 2018, 第 2 作者, 专利号: CN107868068A
出版信息
发表论文
(1) Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti- neuroinflammatory Activity from a Sarcandra Species, ORGANIC LETTERS, 2023, 第 1 作者
(2) Laeviganoids A-T, ent-Clerodane-Type Diterpenoids from Croton laevigatus, JOURNAL OF NATURAL PRODUCTS, 2023, 第 7 作者 通讯作者
(3) Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora, JOURNAL OF ORGANIC CHEMISTRY, 2023, 第 8 作者 通讯作者
(4) Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus, JOURNAL OF NATURAL PRODUCTS, 2023, 第 5 作者
(5) Modulatory role of terminal monomeric flavan-3-ol units in the viscoelasticity of dentin, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2023, 第 3 作者
(6) Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen-rich dentin, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2022, 第 2 作者
(7) New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships, ORGANIC LETTERS, 2022, 第 1 作者
(8) Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities, JOURNAL OF NATURAL PRODUCTS, 2022, 第 10 作者 通讯作者
(9) Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora, JOURNAL OF ORGANIC CHEMISTRY, 2022, 第 8 作者 通讯作者
(10) Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus, JOURNAL OF NATURAL PRODUCTS, 2022, 第 6 作者 通讯作者
(11) Seco B-Type Oligomers from Pinus massoniana Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity, JOURNAL OF NATURAL PRODUCTS, 2022, 第 1 作者
(12) Seco B-Type Oligomers from Pinus massoniana Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity, JOURNAL OF NATURAL PRODUCTS, 2022, 第 1 作者
(13) Picomolar antimalarial agent from a Chinese medicinal plant, Picomolar antimalarial agent from a Chinese medicinal plant, SCIENCE CHINA-CHEMISTRY, 2022, 第 1 作者
(14) Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities, JOURNAL OF NATURAL PRODUCTS, 2022, 第 1 作者
(15) Natural products are the treasure pool for antimalarial agents, Natural products are the treasure pool for antimalarial agents, NATIONAL SCIENCE REVIEW, 2022, 第 1 作者
(16) Sublyratins A-O, Labdane-Type Diterpenoids from Croton sublyratus, JOURNAL OF NATURAL PRODUCTS, 2021, 第 5 作者
(17) Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus, ORGANIC CHEMISTRY FRONTIERS, 2021, 第 6 作者 通讯作者
(18) Discovery of four modified classes of triterpenoids delineated a metabolic cascade: compound characterization and biomimetic synthesis, CHEMICAL SCIENCE, 2021, 第 1 作者
(19) Tri- and Tetrameric Proanthocyanidins with Dentin Bioactivities from Pinus massoniana, JOURNAL OF ORGANIC CHEMISTRY, 2020, 第 1 作者
(20) Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus, JOURNAL OF NATURAL PRODUCTS, 2020, 第 1 作者
(21) Proanthocyanidin Block Arrays (PACBAR) for Comprehensive Capture and Delineation of Proanthocyanidin Structures, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 第 4 作者
(22) Diverse Diterpenoids from Microdesmis casearifolia, CHINESEJOURNALOFORGANICCHEMISTRY, 2020, 第 5 作者
(23) Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502, JOURNAL OF NATURAL PRODUCTS, 2020, 第 1 作者
(24) Limonoids from Cipadessa baccifera, JOURNAL OF NATURAL PRODUCTS, 2020, 第 3 作者
(25) Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata, Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata, CHINESE JOURNAL OF CHEMISTRY, 2020, 第 1 作者
(26) Rare A-Type, Spiro-Type, and Highly Oligomeric Proanthocyanidins from Pinus massoniana, ORGANIC LETTERS, 2020, 第 1 作者
(27) Proanthocyanidin Dimers and Trimers from Vitis vinifera Provide Diverse Structural Motifs for the Evaluation of Dentin Biomodification, JOURNAL OF NATURAL PRODUCTS, 2019, 第 5 作者
(28) Cytotoxic Tigliane Diterpenoids from Croton damayeshu, JOURNAL OF NATURAL PRODUCTS, 2019, 第 4 作者
(29) MUTATIONS IN PLASMODIUM FALCIPARUM PRO-DRUG ACTIVATION AND RESISTANCE ESTERASE MEDIATES RESISTANCE TO A SUB-CLASS OF SESQUITERPENE DIMER ANTIMALARIAL NATURAL PRODUCTS, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2019, 第 10 作者
(30) Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, 中国化学:英文版, 2018, 第 2 作者
(31) Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale, ORGANIC LETTERS, 2018, 第 3 作者
(32) A new class of HIV-1 inhibitors and the target identification via proteomic profiling, A new class of HIV-1 inhibitors and the target identification via proteomic profiling, 中国科学:化学英文版, 2018, 第 2 作者
(33) Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, CHINESE JOURNAL OF CHEMISTRY, 2018, 第 2 作者
(34) A new class of HIV-1 inhibitors and the target identification via proteomic profiling, A new class of HIV-1 inhibitors and the target identification via proteomic profiling, SCIENCE CHINA-CHEMISTRY, 2018, 第 2 作者
(35) Fortunoids A-C, Three Sesquiterpenoid Dimers with Different Carbon Skeletons from Chloranthus fortunei, ORGANIC LETTERS, 2017, 第 1 作者
(36) Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships, JOURNAL OF NATURAL PRODUCTS, 2017, 第 1 作者
(37) 六种药用植物中萜类化合物的研究, 2016, 第 1 作者
(38) Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula, JOURNAL OF NATURAL PRODUCTS, 2016, 第 1 作者
(39) Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 第 6 作者
(40) Cytotoxic tigliane-type diterpenoids from Croton tiglium, TETRAHEDRON, 2015, 第 2 作者
(41) Limonoids with 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum, JOURNAL OF NATURAL PRODUCTS, 2015, 第 1 作者
(42) Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity, PHYTOCHEMISTRY, 第 8 作者
(2) Laeviganoids A-T, ent-Clerodane-Type Diterpenoids from Croton laevigatus, JOURNAL OF NATURAL PRODUCTS, 2023, 第 7 作者 通讯作者
(3) Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora, JOURNAL OF ORGANIC CHEMISTRY, 2023, 第 8 作者 通讯作者
(4) Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus, JOURNAL OF NATURAL PRODUCTS, 2023, 第 5 作者
(5) Modulatory role of terminal monomeric flavan-3-ol units in the viscoelasticity of dentin, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2023, 第 3 作者
(6) Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen-rich dentin, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2022, 第 2 作者
(7) New Rufomycins from Streptomyces atratus MJM3502 Expand Anti- Mycobacterium tuberculosis Structure-Activity Relationships, ORGANIC LETTERS, 2022, 第 1 作者
(8) Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities, JOURNAL OF NATURAL PRODUCTS, 2022, 第 10 作者 通讯作者
(9) Baccaramiones A-D, Four Highly Oxygenated and Rearranged Trinorditerpenoids from Baccaurea ramiflora, JOURNAL OF ORGANIC CHEMISTRY, 2022, 第 8 作者 通讯作者
(10) Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus, JOURNAL OF NATURAL PRODUCTS, 2022, 第 6 作者 通讯作者
(11) Seco B-Type Oligomers from Pinus massoniana Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity, JOURNAL OF NATURAL PRODUCTS, 2022, 第 1 作者
(12) Seco B-Type Oligomers from Pinus massoniana Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity, JOURNAL OF NATURAL PRODUCTS, 2022, 第 1 作者
(13) Picomolar antimalarial agent from a Chinese medicinal plant, Picomolar antimalarial agent from a Chinese medicinal plant, SCIENCE CHINA-CHEMISTRY, 2022, 第 1 作者
(14) Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities, JOURNAL OF NATURAL PRODUCTS, 2022, 第 1 作者
(15) Natural products are the treasure pool for antimalarial agents, Natural products are the treasure pool for antimalarial agents, NATIONAL SCIENCE REVIEW, 2022, 第 1 作者
(16) Sublyratins A-O, Labdane-Type Diterpenoids from Croton sublyratus, JOURNAL OF NATURAL PRODUCTS, 2021, 第 5 作者
(17) Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus, ORGANIC CHEMISTRY FRONTIERS, 2021, 第 6 作者 通讯作者
(18) Discovery of four modified classes of triterpenoids delineated a metabolic cascade: compound characterization and biomimetic synthesis, CHEMICAL SCIENCE, 2021, 第 1 作者
(19) Tri- and Tetrameric Proanthocyanidins with Dentin Bioactivities from Pinus massoniana, JOURNAL OF ORGANIC CHEMISTRY, 2020, 第 1 作者
(20) Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus, JOURNAL OF NATURAL PRODUCTS, 2020, 第 1 作者
(21) Proanthocyanidin Block Arrays (PACBAR) for Comprehensive Capture and Delineation of Proanthocyanidin Structures, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 第 4 作者
(22) Diverse Diterpenoids from Microdesmis casearifolia, CHINESEJOURNALOFORGANICCHEMISTRY, 2020, 第 5 作者
(23) Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502, JOURNAL OF NATURAL PRODUCTS, 2020, 第 1 作者
(24) Limonoids from Cipadessa baccifera, JOURNAL OF NATURAL PRODUCTS, 2020, 第 3 作者
(25) Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata, Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata, CHINESE JOURNAL OF CHEMISTRY, 2020, 第 1 作者
(26) Rare A-Type, Spiro-Type, and Highly Oligomeric Proanthocyanidins from Pinus massoniana, ORGANIC LETTERS, 2020, 第 1 作者
(27) Proanthocyanidin Dimers and Trimers from Vitis vinifera Provide Diverse Structural Motifs for the Evaluation of Dentin Biomodification, JOURNAL OF NATURAL PRODUCTS, 2019, 第 5 作者
(28) Cytotoxic Tigliane Diterpenoids from Croton damayeshu, JOURNAL OF NATURAL PRODUCTS, 2019, 第 4 作者
(29) MUTATIONS IN PLASMODIUM FALCIPARUM PRO-DRUG ACTIVATION AND RESISTANCE ESTERASE MEDIATES RESISTANCE TO A SUB-CLASS OF SESQUITERPENE DIMER ANTIMALARIAL NATURAL PRODUCTS, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2019, 第 10 作者
(30) Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, 中国化学:英文版, 2018, 第 2 作者
(31) Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale, ORGANIC LETTERS, 2018, 第 3 作者
(32) A new class of HIV-1 inhibitors and the target identification via proteomic profiling, A new class of HIV-1 inhibitors and the target identification via proteomic profiling, 中国科学:化学英文版, 2018, 第 2 作者
(33) Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, CHINESE JOURNAL OF CHEMISTRY, 2018, 第 2 作者
(34) A new class of HIV-1 inhibitors and the target identification via proteomic profiling, A new class of HIV-1 inhibitors and the target identification via proteomic profiling, SCIENCE CHINA-CHEMISTRY, 2018, 第 2 作者
(35) Fortunoids A-C, Three Sesquiterpenoid Dimers with Different Carbon Skeletons from Chloranthus fortunei, ORGANIC LETTERS, 2017, 第 1 作者
(36) Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure-Activity Relationships, JOURNAL OF NATURAL PRODUCTS, 2017, 第 1 作者
(37) 六种药用植物中萜类化合物的研究, 2016, 第 1 作者
(38) Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula, JOURNAL OF NATURAL PRODUCTS, 2016, 第 1 作者
(39) Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 第 6 作者
(40) Cytotoxic tigliane-type diterpenoids from Croton tiglium, TETRAHEDRON, 2015, 第 2 作者
(41) Limonoids with 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum, JOURNAL OF NATURAL PRODUCTS, 2015, 第 1 作者
(42) Monoterpenoid indole alkaloids from Alstonia scholaris and their Toxoplasma gondii inhibitory activity, PHYTOCHEMISTRY, 第 8 作者
科研活动
科研项目
( 1 ) 天然药物化学, 负责人, 国家任务, 2024-01--2026-12
( 2 ) 微量特色功效分子的成药性研究, 参与, 国家任务, 2023-01--2027-12
( 3 ) 抗病毒芳构化二萜的发现和研究, 负责人, 国家任务, 2022-01--2025-12
( 4 ) 抗疟疾乌药烷二聚倍半萜的发现与研究, 负责人, 国家任务, 2018-01--2021-12
( 2 ) 微量特色功效分子的成药性研究, 参与, 国家任务, 2023-01--2027-12
( 3 ) 抗病毒芳构化二萜的发现和研究, 负责人, 国家任务, 2022-01--2025-12
( 4 ) 抗疟疾乌药烷二聚倍半萜的发现与研究, 负责人, 国家任务, 2018-01--2021-12