基本信息

王超群 男 博导 中国科学院上海药物研究所
电子邮件: cqwang@simm.ac.cn
通信地址: 上海市浦东张江祖冲之路555号
邮政编码:
电子邮件: cqwang@simm.ac.cn
通信地址: 上海市浦东张江祖冲之路555号
邮政编码:
招生信息
招生专业
100706-药理学
1007J6-再生医学
1007J6-再生医学
招生方向
慢阻肺
肺纤维化
肺干细胞与再生
肺纤维化
肺干细胞与再生
教育背景
2012-08--2015-12 香港中文大学 博士
工作经历
工作简历
2021-03~2023-06,加州大学旧金山分校 (UCSF), 研究专家 (Specialist)
2016-03~2021-02,加州大学旧金山分校 (UCSF), 博士后
2012-08~2015-12,香港中文大学, 博士
2016-03~2021-02,加州大学旧金山分校 (UCSF), 博士后
2012-08~2015-12,香港中文大学, 博士
出版信息
发表论文
(1) Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir, IMMUNITY, 2023, 第 1 作者
(2) Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5(+) basal cells, NATURE CELL BIOLOGY, 2022, 第 11 作者
(3) Sentinel p16(INK4a+) cells in the basement membrane form a reparative niche in the lung, SCIENCE, 2022, 第 9 作者
(4) CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia, MOLECULAR THERAPY - NUCLEIC ACIDS, 2021, 第 10 作者
(5) Gli1(+)mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung, NATURE CELL BIOLOGY, 2020, 第 2 作者
(6) The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance, JOURNAL OF DEVELOPMENTAL BIOLOGY, 2019, 第 1 作者
(7) Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches, IMMUNITY, 2019, 第 9 作者
(8) Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype, JOURNAL OF CLINICAL INVESTIGATION, 2018, 第 1 作者
(9) CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/beta-Catenin Complex in Human Endometriosis, AMERICAN JOURNAL OF PATHOLOGY, 2018, 第 1 作者
(10) CD147 regulates extrinsic apoptosis in spermatocytes by modulating NF��B signaling pathways, ONCOTARGET, 2016, 第 1 作者
(11) Generation of scFv specific to human VEGFR-3 from the neutralizing mAb BDD073, PROTEIN ENGINEERING DESIGN & SELECTION, 2015, 第 2 作者
(12) Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 第 1 作者
(13) Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells, FERTILITY AND STERILITY, 2014, 第 3 作者
(14) Protective effects of ETC complex III and cytochrome c against hydrogen peroxide-induced apoptosis in yeast, FREE RADICAL RESEARCH, 2014, 第 1 作者
(15) A chloroplast envelope membrane protein containing a putative LrgB domain related to the control of bacterial death and lysis is required for chloroplast development in Arabidopsis thaliana, NEW PHYTOLOGIST, 2012, 第 5 作者
(16) Regulating Cytoplasmic Calcium Homeostasis Can Reduce Aluminum Toxicity in Yeast, PLOS ONE, 2011, 第 3 作者
(2) Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5(+) basal cells, NATURE CELL BIOLOGY, 2022, 第 11 作者
(3) Sentinel p16(INK4a+) cells in the basement membrane form a reparative niche in the lung, SCIENCE, 2022, 第 9 作者
(4) CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia, MOLECULAR THERAPY - NUCLEIC ACIDS, 2021, 第 10 作者
(5) Gli1(+)mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung, NATURE CELL BIOLOGY, 2020, 第 2 作者
(6) The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance, JOURNAL OF DEVELOPMENTAL BIOLOGY, 2019, 第 1 作者
(7) Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches, IMMUNITY, 2019, 第 9 作者
(8) Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype, JOURNAL OF CLINICAL INVESTIGATION, 2018, 第 1 作者
(9) CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/beta-Catenin Complex in Human Endometriosis, AMERICAN JOURNAL OF PATHOLOGY, 2018, 第 1 作者
(10) CD147 regulates extrinsic apoptosis in spermatocytes by modulating NF��B signaling pathways, ONCOTARGET, 2016, 第 1 作者
(11) Generation of scFv specific to human VEGFR-3 from the neutralizing mAb BDD073, PROTEIN ENGINEERING DESIGN & SELECTION, 2015, 第 2 作者
(12) Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 第 1 作者
(13) Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells, FERTILITY AND STERILITY, 2014, 第 3 作者
(14) Protective effects of ETC complex III and cytochrome c against hydrogen peroxide-induced apoptosis in yeast, FREE RADICAL RESEARCH, 2014, 第 1 作者
(15) A chloroplast envelope membrane protein containing a putative LrgB domain related to the control of bacterial death and lysis is required for chloroplast development in Arabidopsis thaliana, NEW PHYTOLOGIST, 2012, 第 5 作者
(16) Regulating Cytoplasmic Calcium Homeostasis Can Reduce Aluminum Toxicity in Yeast, PLOS ONE, 2011, 第 3 作者
科研活动
科研项目
( 1 ) 肺纤维化中肺泡二型上皮细胞转分化机制研究, 负责人, 国家任务, 2024-01--2027-12
( 2 ) 中科院%%B类, 负责人, 中国科学院计划, 2023-01--2027-12
( 3 ) Hedgehog信号调控肺泡发育的机制研究, 负责人, 地方任务, 2022-10--2024-09
( 2 ) 中科院%%B类, 负责人, 中国科学院计划, 2023-01--2027-12
( 3 ) Hedgehog信号调控肺泡发育的机制研究, 负责人, 地方任务, 2022-10--2024-09