100706-药理学
1007J6-再生医学

糖尿病、肥胖、非酒精性脂肪肝以及心血管疾病发病的分子机制研究及相关疾病创新药物的开发

2008-08--2011-07   北京协和医学院/清华大学医学部   博士研究生
2004-08--2007-07   石河子大学   硕士研究生
2000-08--2004-07   甘肃农业大学   学士

   

2017-06~2022-09,阿拉巴马大学伯明翰分校, 助理教授
2012-10~2017-05,奥古斯塔大学, 博士后
2011-09~2012-10,西北大学, 博士后
2008-08~2011-07,北京协和医学院/清华大学医学部, 博士研究生
2004-08~2007-07,石河子大学, 硕士研究生
2000-08~2004-07,甘肃农业大学, 学士

2023-02-03-今,美国心脏病协会 Career Development Award, 基金评审专家
2023-02-02-今,Biology (Guest Editor for Research Topic), 杂志编委
2022-01-01-今,Frontiers in Pharmacology (Guest Editor for Research Topic), 杂志编委
2022-01-01-今,JoVE (Guest Editor for Research Topic), 杂志编委
2021-02-02-今,Erwin Schroedinger F ellowship of Austrian Science Fund (FWF), 基金评审专家
2021-02-01-今,Frontiers in Physiology (Guest Editor for Research Topic), 杂志编委
2021-02-01-今,Pilot and Feasib ility grant proposal of Michigan Diabetes Research Center (MDRC), 基金评审专家
2020-02-01-今,Frontiers in Physiology-Specialty Section of Oxidant Physiology, 杂志编委
2020-01-01-今,Frontiers in Molecular Biosciences, 杂志编委
2020-01-01-今,Frontiers in Cell and Developmental Biology, 杂志编委
2020-01-01-今,PLOS ONE, 杂志编委
2019-01-02-今,美国心脏病协会 Postdoctoral Fellowship, 基金评审专家
2019-01-01-今,中国生物物理学, 学会会员
2017-01-01-今,美国糖尿病协会, 协会会员
2011-01-01-今,美国心脏病协会, 协会会员

YAP signaling in lung development
Deparment weekly Seminar
Quantitative Physiology-Liver Physiology and Metabolic Diseases

   

（1） 上海市白玉兰青年项目, 省级, 2023
（2） 中科院引才计划, , 院级, 2023
（3） Career Development Award, , 国家级, 2019
（4） 优秀博士学位论文, , 研究所（学校）, 2011
（5） 医学分子生物学国家重点实验室优秀博士研究生, 研究所（学校）, 2011
（6） 优秀硕士学位论文, , 省级, 2008
（7） 优秀硕士学位论文, , 研究所（学校）, 2007

（ 1 ） Compositions and methods for treatment of diabetes, obesity, hypercholesterolemia, and atherosclerosis by inhibition of Sam68, 2021, 第 1 作者, 专利号: US20220119511A1

   

（1） Autophagy: Playing an important role in diabetes and its complications, Medicine in Drug Discovery, 2024, 
（2） Editorial: Advances in novel drugs and targets for hepatic and gastrointestinal diseases, Front Pharmacol, 2024, 
（3） LncRNA-Snhg3 Aggravates Hepatic Steatosis by Regulating PPAR�� via SND1/H3K27me3, eLife, 2024, 
（4） Potential clinical biomarkers and perspectives in diabetic cardiomyopathy, DIABETOLOGY & METABOLIC SYNDROME, 2023, 第 4 作者  通讯作者
（5） Cardiac muscle patches containing four types of cardiac cells derived from human pluripotent stem cells improve recovery from cardiac injury in mice, CARDIOVASCULAR RESEARCH, 2023, 第 9 作者
（6） Transgenic RFP-RPS-30(UbL) strain of the nematode Caenorhabditis elegans as a biomonitor for environmental pollutants, ENVIRONMENTAL TOXICOLOGY, 2023, 第 3 作者
（7） Exosomes: New Insights into the Pathogenesis of Metabolic Syndrome, Biology, 2023, 
（8） Upregulated galectin-1 in Angiostrongylus cantonensis L5 reduces body fat and increases oxidative stress tolerance, PARASITES & VECTORS, 2022, 第 3 作者
（9） Editorial: Hepatic glucose and lipid metabolism, FRONTIERS IN PHYSIOLOGY, 2022, 第 3 作者  通讯作者
（10） Metabolic labeling of cardiomyocyte-derived small extracellular-vesicle (sEV) miRNAs identifies miR-208a in cardiac regulation of lung gene expression, JOURNAL OF EXTRACELLULAR VESICLES, 2022, 第 5 作者
（11） A three-dimensional culture system for generating cardiac spheroids composed of cardiomyocytes, endothelial cells, smooth-muscle cells, and cardiac fibroblasts derived from human induced-pluripotent stem cells, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 第 7 作者
（12） Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 第 1 作者  通讯作者
（13） Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure, FASEB JOURNAL, 2021, 第 1 作者  通讯作者
（14） Sam68 promotes hepatic gluconeogenesis via CRTC2, NATURE COMMUNICATIONS, 2021, 第 1 作者
（15） Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure, THERANOSTICS, 2021, 第 4 作者
（16） Analysis of mesenchymal stem cell proteomes in situ in the ischemic heart, THERANOSTICS, 2020, 第 6 作者
（17） Sam68 impedes the recovery of arterial injury by augmenting inflammatory response, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2019, 第 4 作者
（18） Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance, MOLECULAR AND CELLULAR BIOLOGY, 2018, 第 2 作者
（19） The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis, JOURNAL OF CELL BIOLOGY, 2017, 第 1 作者
（20） The hepatic FOXQ1 transcription factor regulates glucose metabolism in mice, DIABETOLOGIA, 2016, 第 2 作者
（21） MicroRNA���210 Decreases heme Levels by Targeting Ferrochelatase in Cardiomyocytes, JOURNAL OF THE AMERICAN HEART ASSOCIATION: CARDIOVASCULAR AND CEREBROVASCULAR DISEASE, 2013, 第 1 作者
（22） MicroRNA-29a-c decrease fasting blood glucose levels by negatively regulating hepatic gluconeogenesis, JOURNAL OF HEPATOLOGY, 2013, 第 3 作者
（23） MicroRNA-210 Decreases heme Levels by Targeting Ferrochelatase in Cardiomyocytes, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2013, 第 1 作者
（24） Mouse Patatin-Like Phospholipase Domain-Containing 3 Influences Systemic Lipid and Glucose Homeostasis, HEPATOLOGY, 2011, 第 1 作者
（25） PGC-1 beta-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha, MITOCHONDRION, 2010, 第 7 作者
（26） FoxO1 represses LXR��-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells, FEBS LETTERS, 2010, 第 2 作者
（27） PPAR�� co-activator-1�� co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone, PORTLAND PRESS LIMITED, 第 1 作者

（ 1 ） 心内科新医师手册（第三版）, 化学工业出版社, 2017-05, 第 1 作者

   

（ 1 ） %%%%, 负责人, 中国科学院计划, 2024-01--2026-12
（ 2 ） 肝脏Sam68调控胆固醇代谢的分子机理研究, 负责人, 国家任务, 2023-01--2026-12
（ 3 ） Sam68调控血糖稳态的机理研究及siRNA-Sam68/LNP递送体系治疗糖尿病的效果评价, 负责人, 研究所自主部署, 2023-01--2026-12
（ 4 ） 调控糖脂代谢新靶点的筛选与鉴定, 负责人, 地方任务, 2022-09--2027-09

（1）The Role of Hepatocyte Sam68 in Gluconeogenesis and Diabetes   第五届中国生物物理学会代谢生物学分会研讨会   2022-12-16