基本信息
李世武 男 硕导 中国科学院昆明动物研究所
电子邮件: lishiwu@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区茨坝街道龙欣路17号
邮政编码:
电子邮件: lishiwu@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区茨坝街道龙欣路17号
邮政编码:
招生信息
招生专业
071006-神经生物学
招生方向
精神疾病动物模型高原低氧与脑健康
教育背景
2017-09--2021-01 中国科学院昆明动物研究所 博士研究生2012-09--2015-06 昆明理工大学 硕士研究生2008-09--2012-06 湘南学院 本科
工作经历
工作简历
2021-04~现在, 中国科学院昆明动物研究所, 副研究员2021-01~2021-04,中国科学院昆明动物研究所, 助理研究员2017-09~2021-01,中国科学院昆明动物研究所, 博士研究生2015-09~2017-08,中国科学院昆明动物研究所, 研究实习员2012-09~2015-06,昆明理工大学, 硕士研究生2008-09~2012-06,湘南学院, 本科
专利与奖励
专利成果
( 1 ) 一种供显微镜观察使用的可拆卸的细胞培养盒, 2022, 第 1 作者, 专利号: CN 218115467 U
出版信息
发表论文
(1) The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, TRANSLATIONAL PSYCHIATRY, 2022, 第 1 作者(2) Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression, BRAIN, 2022, 第 1 作者(3) Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1, BRAIN, 2022, 第 2 作者(4) Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus, BRAIN, 2022, 第 3 作者(5) A functional population-specific variant rs77416373 in the CaV2.1 gene is associated with antidepressant treatment response in Han Chinese subjects with major depressive disorder, ASIAN JOURNAL OF PSYCHIATRY, 2022, 第 3 作者(6) Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants, BMC MEDICINE, 2022, 第 3 作者(7) Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression, ADVANCED SCIENCE, 2022, 第 3 作者(8) A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression, MOLECULAR PSYCHIATRY, 2021, 第 8 作者(9) Functional variants fine-mapping and gene function characterization provide insights into the role of ZNF323 in schizophrenia pathogenesis, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2021, 第 1 作者(10) Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia, BMC MEDICINE, 2021, 第 2 作者(11) Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene, JOURNAL OF MEDICAL GENETICS, 2021, 第 2 作者(12) The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia, MOLECULAR PSYCHIATRY, 2021, 第 2 作者(13) A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population, A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population, JOURNAL OF GENETICS AND GENOMICS, 2020, 第 6 作者(14) Regulatory mechanisms of major depressive disorder risk variants, MOLECULAR PSYCHIATRY, 2020, 第 1 作者(15) The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population, TRANSLATIONAL PSYCHIATRY, 2019, 第 8 作者(16) Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder, NEUROPSYCHOPHARMACOLOGY, 2019, 第 2 作者(17) Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk, NATURE COMMUNICATIONS, 2019, 第 2 作者
科研活动
科研项目
( 1 ) NEGR1基因影响抑郁症的发病机制研究, 负责人, 地方任务, 2023-06--2026-05( 2 ) 精神分裂症风险区域2q33.1在疾病中遗传机制及致病机理研究, 负责人, 国家任务, 2022-01--2025-12( 3 ) 基于精神分裂症临床队列的免疫组学异常特征及其生物标记物的研究, 参与, 国家任务, 2023-01--2026-12( 4 ) 精神分裂风险基因TYW5在疾病中潜在致病机制及药物靶点研究, 负责人, 中国科学院计划, 2022-01--2023-12