基本信息
章牡丹 女 硕导 中国科学院武汉病毒研究所
电子邮件： mudan@wh.iov.cn
通信地址： 湖北省武汉市
邮政编码：
电子邮件： mudan@wh.iov.cn
通信地址： 湖北省武汉市
邮政编码：
研究领域
以黏膜传播病毒HSV-2和HuNoV为研究对象，聚焦病毒免疫激活、逃逸、致病机制及疫苗开发等研究方向。
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
病毒的致病机理，天然免疫与免疫逃逸，疫苗开发
教育背景
2010-07--2015-07 中国科学院武汉病毒研究所 理学博士
2006-09--2010-07 安徽师范大学 理学学士
2006-09--2010-07 安徽师范大学 理学学士
工作经历
工作简历
2022-07~现在, 中国科学院武汉病毒研究所, 副研究员
2020-11~2022-06,广州医科大学附属广州市妇女儿童医疗中心, 研究主管
2015-07~2020-08,广州医科大学附属广州市妇女儿童医疗中心, 博士后
2020-11~2022-06,广州医科大学附属广州市妇女儿童医疗中心, 研究主管
2015-07~2020-08,广州医科大学附属广州市妇女儿童医疗中心, 博士后
专利与奖励
奖励信息
（1） 武汉市英才, 市地级, 2023
（2） 广州市青年后备人才, 市地级, 2021
（2） 广州市青年后备人才, 市地级, 2021
专利成果
[1] 胡勤学, 章牡丹. 一株HuNoV GII.4临床分离株序列及其感染性克隆的构建与应用. CN: CN110144331A, 2019-08-20.
出版信息
发表论文
[1] Huimin Hu, Ming Fu, Chuntian Li, Binman Zhang, Yuncheng Li, Qinxue Hu, Mudan Zhang. Herpes simplex virus type 2 inhibits TNF-α-induced NF-κB activation through viral protein ICP22-mediated interaction with p65. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 7 作者 通讯作者 13: https://doaj.org/article/98a216681f894592a2add9695eec47c5.
[2] Mudan Zhang, Binman Zhang, Rui Chen, Miaomiao Li, Zifeng Zheng, Wanfu Xu, Yifan Zhang, Sitang Gong, Qinxue Hu. Human Norovirus Induces Aquaporin 1 Production by Activating NF-κB Signaling Pathway. VIRUSES[J]. 2022, 第 1 作者14(842): https://doaj.org/article/b755ad5195cb4a6298def764d7413dd6.
[3] Zifeng Zheng, Yuncheng Li, Mudan Zhang, Yalan Liu, Ming Fu, Sitang Gong, Qinxue Hu. Human Norovirus NTPase Antagonizes Interferon-β Production by Interacting With IkB Kinase ε. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 3 作者12: https://doaj.org/article/fb66add6b411443fabc57ce0ebb6d815.
[4] Yan, Yan, Hu, Kai, Fu, Ming, Deng, Xu, Luo, Sukun, Tong, Lina, Guan, Xinmeng, He, Siyi, Li, Chang, Jin, Wei, Du, Tao, Zheng, Zifeng, Zhang, Mudan, Liu, Yalan, Hu, Qinxue. CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge. MSPHERE[J]. 2021, 第 13 作者6(2): http://dx.doi.org/10.1128/mSphere.00058-21..
[5] Zhang, Mudan, Fu, Ming, Hu, Qinxue. Advances in Human Norovirus Vaccine Research. VACCINES[J]. 2021, 第 1 作者9(7): http://dx.doi.org/10.3390/vaccines9070732.
[6] Li, Chuntian, Zhang, Mudan, Guan, Xinmeng, Hu, Huimin, Fu, Ming, Liu, Yalan, Hu, Qinxue. Herpes simplex virus type 2 glycoprotein D inhibits NF-κB activation by interacting with p65. JOURNAL OF IMMUNOLOGY[J]. 2021, 第 2 作者206(12): 2852-2861,
[7] Zhang, Mudan, Fu, Ming, Li, Miaomiao, Hu, Huimin, Gong, Sitang, Hu, Qinxue. Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 1 作者205(5): 1281-1292, https://www.webofscience.com/wos/woscc/full-record/WOS:000562763400010.
[8] Hu, Kai, Fu, Ming, Wang, Jun, Luo, Sukun, Barreto, Mariana, Singh, Rubin, Chowdhury, Tasnim, Li, Mei, Zhang, Mudan, Guan, Xinmeng, Xiao, Juhua, Hu, Qinxue. HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway. FRONTIERS IN IMMUNOLOGY[J]. 2020, 第 9 作者11: https://doaj.org/article/61ecfe5de4274daea11a2c12e6b59e55.
[9] Li, Mei, Zhang, Di, Li, Chuntian, Zheng, Zifeng, Fu, Ming, Ni, Fengfeng, Liu, Yalan, Du, Tao, Wang, Hanzhong, Griffin, George E, Zhang, Mudan, Hu, Qinxue. Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells. FRONTIERS IN MICROBIOLOGY[J]. 2020, 第 11 作者 通讯作者 11: https://doaj.org/article/a0758ba1ab8c477eb31f0436febbec5a.
[10] Guan, Xinmeng, Zhang, Mudan, Fu, Ming, Luo, Sukun, Hu, Qinxue. Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-beta Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation. FRONTIERS IN IMMUNOLOGY[J]. 2019, 第 2 作者 通讯作者 10: http://www.corc.org.cn/handle/1471x/2373169.
[11] Liu, Yalan, Guan, Xinmeng, Li, Chuntian, Ni, Fengfeng, Luo, Sukun, Wang, Jun, Zhang, Di, Zhang, Mudan, Hu, Qinxue. HSV-2 glycoprotein J promotes viral protein expression and virus spread. VIROLOGY[J]. 2018, 第 8 作者525: 83-95, http://www.corc.org.cn/handle/1471x/2373205.
[12] Zheng, Zifeng, Yang, Jieyu, Jiang, Xuan, Liu, Yalan, Zhang, Xiaowei, Li, Mei, Zhang, Mudan, Fu, Ming, Hu, Kai, Wang, Hanzhong, Luo, MinHua, Gong, Peng, Hu, Qinxue. Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity. JOURNAL OF IMMUNOLOGY[J]. 2018, 第 7 作者201(1): 53-68, http://www.corc.org.cn/handle/1471x/2373246.
[13] Zhang, Mudan, Deng, Xu, Guan, Xinmeng, Geng, Lanlan, Fu, Ming, Zhang, Binman, Chen, Rui, Hu, Huimin, Hu, Kai, Zhang, Di, Li, Mei, Liu, Yalan, Gong, Sitang, Hu, Qinxue. Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4(+) T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4. FRONTIERS IN IMMUNOLOGY[J]. 2018, 第 1 作者9: http://202.127.146.157/handle/2RYDP1HH/6385.
[14] Hu, Kai, He, Siyi, Xiao, Juhua, Li, Mei, Luo, Sukun, Zhang, Mudan, Hu, Qinxue. Interaction between herpesvirus entry mediator and HSV-2 glycoproteins mediates HIV-1 entry of HSV-2-infected epithelial cells. JOURNAL OF GENERAL VIROLOGY[J]. 2017, 第 6 作者98(9): 2351-2361, http://www.corc.org.cn/handle/1471x/2373392.
[15] Li, Mei, Wang, Ping, Zheng, Zifeng, Hu, Kai, Zhang, Mudan, Guan, Xinmeng, Fu, Ming, Zhang, Di, Wang, Wei, Xiao, Gengfu, Hu, Qinxue, Liu, Yalan. Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E. VIROLOGY[J]. 2017, 第 5 作者510: 67-75, http://www.corc.org.cn/handle/1471x/2373378.
[16] Wang, Ping, Hu, Kai, Luo, Sukun, Zhang, Mudan, Deng, Xu, Li, Chang, Jin, Wei, Hu, Bodan, He, Siyi, Li, Mei, Du, Tao, Xiao, Gengfu, Zhang, Bo, Liu, Yalan, Hu, Qinxue. DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein. VIROLOGY[J]. 2016, 第 4 作者488: 108-119, http://dx.doi.org/10.1016/j.virol.2015.11.006.
[17] Liu, Yalan, Li, Mei, Zhang, Di, Zhang, Mudan, Hu, Qinxue. HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway. VIROLOGYJOURNAL[J]. 2016, 第 4 作者13(1): http://www.corc.org.cn/handle/1471x/2376301.
[18] Zhang, Mudan, Liu, Yalan, Wang, Ping, Guan, Xinmeng, He, Siyi, Luo, Sukun, Li, Chang, Hu, Kai, Jin, Wei, Du, Tao, Yan, Yan, Zhang, Zhenfeng, Zheng, Zhenhua, Wang, Hanzhong, Hu, Qinxue. HSV-2 Immediate-Early Protein US1 Inhibits IFN-beta Production by Suppressing Association of IRF-3 with IFN-beta Promoter. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 1 作者194(7): 3102-3115, http://dx.doi.org/10.4049/jimmunol.1401538.
[19] Yan, Yan, Hu, Kai, Deng, Xu, Guan, Xinmeng, Luo, Sukun, Tong, Lina, Du, Tao, Fu, Ming, Zhang, Mudan, Liu, Yalan, Hu, Qinxue. Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 9 作者195(1): 329-338, http://dx.doi.org/10.4049/jimmunol.1500198.
[20] Liu, Yalan, Luo, Sukun, He, Siyi, Zhang, Mudan, Wang, Ping, Li, Chang, Huang, Wenjie, Hu, Bodan, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins. VIROLOGY[J]. 2015, 第 4 作者475: 96-109, http://dx.doi.org/10.1016/j.virol.2014.11.005.
[21] Luo, Sukun, Hu, Kai, He, Siyi, Wang, Ping, Zhang, Mudan, Huang, Xin, Du, Tao, Zheng, Chunfu, Liu, Yalan, Hu, Qinxue. Contribution of N-linked glycans on HSV-2 gB to cell-cell fusion and viral entry. VIROLOGY[J]. 2015, 第 5 作者483: 72-82, http://dx.doi.org/10.1016/j.virol.2015.04.005.
[22] Huang, Wenjie, Hu, Kai, Luo, Sukun, Zhang, Mudan, Li, Chang, Jin, Wei, Liu, Yalan, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Herpes Simplex Virus Type 2 Infection of Human Epithelial Cells Induces CXCL9 Expression and CD4(+) T Cell Migration via Activation of p38-CCAAT/Enhancer-Binding Protein-beta Pathway. JOURNAL OF IMMUNOLOGY[J]. 2012, 第 4 作者188(12): 6247-6257, http://dx.doi.org/10.4049/jimmunol.1103706.
[2] Mudan Zhang, Binman Zhang, Rui Chen, Miaomiao Li, Zifeng Zheng, Wanfu Xu, Yifan Zhang, Sitang Gong, Qinxue Hu. Human Norovirus Induces Aquaporin 1 Production by Activating NF-κB Signaling Pathway. VIRUSES[J]. 2022, 第 1 作者14(842): https://doaj.org/article/b755ad5195cb4a6298def764d7413dd6.
[3] Zifeng Zheng, Yuncheng Li, Mudan Zhang, Yalan Liu, Ming Fu, Sitang Gong, Qinxue Hu. Human Norovirus NTPase Antagonizes Interferon-β Production by Interacting With IkB Kinase ε. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 3 作者12: https://doaj.org/article/fb66add6b411443fabc57ce0ebb6d815.
[4] Yan, Yan, Hu, Kai, Fu, Ming, Deng, Xu, Luo, Sukun, Tong, Lina, Guan, Xinmeng, He, Siyi, Li, Chang, Jin, Wei, Du, Tao, Zheng, Zifeng, Zhang, Mudan, Liu, Yalan, Hu, Qinxue. CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge. MSPHERE[J]. 2021, 第 13 作者6(2): http://dx.doi.org/10.1128/mSphere.00058-21..
[5] Zhang, Mudan, Fu, Ming, Hu, Qinxue. Advances in Human Norovirus Vaccine Research. VACCINES[J]. 2021, 第 1 作者9(7): http://dx.doi.org/10.3390/vaccines9070732.
[6] Li, Chuntian, Zhang, Mudan, Guan, Xinmeng, Hu, Huimin, Fu, Ming, Liu, Yalan, Hu, Qinxue. Herpes simplex virus type 2 glycoprotein D inhibits NF-κB activation by interacting with p65. JOURNAL OF IMMUNOLOGY[J]. 2021, 第 2 作者206(12): 2852-2861,
[7] Zhang, Mudan, Fu, Ming, Li, Miaomiao, Hu, Huimin, Gong, Sitang, Hu, Qinxue. Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 1 作者205(5): 1281-1292, https://www.webofscience.com/wos/woscc/full-record/WOS:000562763400010.
[8] Hu, Kai, Fu, Ming, Wang, Jun, Luo, Sukun, Barreto, Mariana, Singh, Rubin, Chowdhury, Tasnim, Li, Mei, Zhang, Mudan, Guan, Xinmeng, Xiao, Juhua, Hu, Qinxue. HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway. FRONTIERS IN IMMUNOLOGY[J]. 2020, 第 9 作者11: https://doaj.org/article/61ecfe5de4274daea11a2c12e6b59e55.
[9] Li, Mei, Zhang, Di, Li, Chuntian, Zheng, Zifeng, Fu, Ming, Ni, Fengfeng, Liu, Yalan, Du, Tao, Wang, Hanzhong, Griffin, George E, Zhang, Mudan, Hu, Qinxue. Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells. FRONTIERS IN MICROBIOLOGY[J]. 2020, 第 11 作者 通讯作者 11: https://doaj.org/article/a0758ba1ab8c477eb31f0436febbec5a.
[10] Guan, Xinmeng, Zhang, Mudan, Fu, Ming, Luo, Sukun, Hu, Qinxue. Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-beta Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation. FRONTIERS IN IMMUNOLOGY[J]. 2019, 第 2 作者 通讯作者 10: http://www.corc.org.cn/handle/1471x/2373169.
[11] Liu, Yalan, Guan, Xinmeng, Li, Chuntian, Ni, Fengfeng, Luo, Sukun, Wang, Jun, Zhang, Di, Zhang, Mudan, Hu, Qinxue. HSV-2 glycoprotein J promotes viral protein expression and virus spread. VIROLOGY[J]. 2018, 第 8 作者525: 83-95, http://www.corc.org.cn/handle/1471x/2373205.
[12] Zheng, Zifeng, Yang, Jieyu, Jiang, Xuan, Liu, Yalan, Zhang, Xiaowei, Li, Mei, Zhang, Mudan, Fu, Ming, Hu, Kai, Wang, Hanzhong, Luo, MinHua, Gong, Peng, Hu, Qinxue. Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity. JOURNAL OF IMMUNOLOGY[J]. 2018, 第 7 作者201(1): 53-68, http://www.corc.org.cn/handle/1471x/2373246.
[13] Zhang, Mudan, Deng, Xu, Guan, Xinmeng, Geng, Lanlan, Fu, Ming, Zhang, Binman, Chen, Rui, Hu, Huimin, Hu, Kai, Zhang, Di, Li, Mei, Liu, Yalan, Gong, Sitang, Hu, Qinxue. Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4(+) T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4. FRONTIERS IN IMMUNOLOGY[J]. 2018, 第 1 作者9: http://202.127.146.157/handle/2RYDP1HH/6385.
[14] Hu, Kai, He, Siyi, Xiao, Juhua, Li, Mei, Luo, Sukun, Zhang, Mudan, Hu, Qinxue. Interaction between herpesvirus entry mediator and HSV-2 glycoproteins mediates HIV-1 entry of HSV-2-infected epithelial cells. JOURNAL OF GENERAL VIROLOGY[J]. 2017, 第 6 作者98(9): 2351-2361, http://www.corc.org.cn/handle/1471x/2373392.
[15] Li, Mei, Wang, Ping, Zheng, Zifeng, Hu, Kai, Zhang, Mudan, Guan, Xinmeng, Fu, Ming, Zhang, Di, Wang, Wei, Xiao, Gengfu, Hu, Qinxue, Liu, Yalan. Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E. VIROLOGY[J]. 2017, 第 5 作者510: 67-75, http://www.corc.org.cn/handle/1471x/2373378.
[16] Wang, Ping, Hu, Kai, Luo, Sukun, Zhang, Mudan, Deng, Xu, Li, Chang, Jin, Wei, Hu, Bodan, He, Siyi, Li, Mei, Du, Tao, Xiao, Gengfu, Zhang, Bo, Liu, Yalan, Hu, Qinxue. DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein. VIROLOGY[J]. 2016, 第 4 作者488: 108-119, http://dx.doi.org/10.1016/j.virol.2015.11.006.
[17] Liu, Yalan, Li, Mei, Zhang, Di, Zhang, Mudan, Hu, Qinxue. HSV-2 glycoprotein gD targets the CC domain of tetherin and promotes tetherin degradation via lysosomal pathway. VIROLOGYJOURNAL[J]. 2016, 第 4 作者13(1): http://www.corc.org.cn/handle/1471x/2376301.
[18] Zhang, Mudan, Liu, Yalan, Wang, Ping, Guan, Xinmeng, He, Siyi, Luo, Sukun, Li, Chang, Hu, Kai, Jin, Wei, Du, Tao, Yan, Yan, Zhang, Zhenfeng, Zheng, Zhenhua, Wang, Hanzhong, Hu, Qinxue. HSV-2 Immediate-Early Protein US1 Inhibits IFN-beta Production by Suppressing Association of IRF-3 with IFN-beta Promoter. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 1 作者194(7): 3102-3115, http://dx.doi.org/10.4049/jimmunol.1401538.
[19] Yan, Yan, Hu, Kai, Deng, Xu, Guan, Xinmeng, Luo, Sukun, Tong, Lina, Du, Tao, Fu, Ming, Zhang, Mudan, Liu, Yalan, Hu, Qinxue. Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 9 作者195(1): 329-338, http://dx.doi.org/10.4049/jimmunol.1500198.
[20] Liu, Yalan, Luo, Sukun, He, Siyi, Zhang, Mudan, Wang, Ping, Li, Chang, Huang, Wenjie, Hu, Bodan, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins. VIROLOGY[J]. 2015, 第 4 作者475: 96-109, http://dx.doi.org/10.1016/j.virol.2014.11.005.
[21] Luo, Sukun, Hu, Kai, He, Siyi, Wang, Ping, Zhang, Mudan, Huang, Xin, Du, Tao, Zheng, Chunfu, Liu, Yalan, Hu, Qinxue. Contribution of N-linked glycans on HSV-2 gB to cell-cell fusion and viral entry. VIROLOGY[J]. 2015, 第 5 作者483: 72-82, http://dx.doi.org/10.1016/j.virol.2015.04.005.
[22] Huang, Wenjie, Hu, Kai, Luo, Sukun, Zhang, Mudan, Li, Chang, Jin, Wei, Liu, Yalan, Griffin, George E, Shattock, Robin J, Hu, Qinxue. Herpes Simplex Virus Type 2 Infection of Human Epithelial Cells Induces CXCL9 Expression and CD4(+) T Cell Migration via Activation of p38-CCAAT/Enhancer-Binding Protein-beta Pathway. JOURNAL OF IMMUNOLOGY[J]. 2012, 第 4 作者188(12): 6247-6257, http://dx.doi.org/10.4049/jimmunol.1103706.
科研活动
科研项目
（ 1 ） 诺如病毒免疫原性及抗体研发, 负责人, 企业委托, 2022-05--2025-05