100701-药物化学
100706-药理学
100702-药剂学

药用植物分子生药学
中药系统生物学
中药体外肠代谢研究

2006-08--2008-08   美国华盛顿州立大学   访问学者
1997-09--2002-07   中国协和医科大学   博士研究生
1988-09--1992-07   山东中医学院   学士

   

2021-10~现在, 中国科学院杭州医学研究所, 教授
2017-02~2021-09,浙江大学医疗健康信息工程研究所, 教授、副所长
2007-12~2017-01,浙江大学生物医学工程与仪器科学学院, 教授、副院长
2006-08~2008-08,美国华盛顿州立大学, 访问学者
2004-06~2007-11,浙江大学药学院, 副教授
2002-08~2004-05,山东省立医院, 副主任药师
1997-09~2002-07,中国协和医科大学, 博士研究生
1992-08~1997-08,山东省立医院, 药师
1988-09~1992-07,山东中医学院, 学士

2022-01-31-2025-12-31,世界中医药学会联合会道地药材多维评价专业委员会, 常务理事
2014-12-31-2025-12-31,中国药学会中药与天然药物专业委员会, 委员
2014-12-31-2025-12-31,中国药学杂志, 编委

   

（1） 基于活性酶诱导技术提高中药有效成分含量的作用机制研究, 三等奖, 省级, 2018
（2） 中药六类新药辛萸贴片的临床前研究, 三等奖, 省级, 2010

（ 1 ） Chalcomoracin在制备治疗增生性玻璃体视网膜病变药物中的应用, 2022, 第 1 作者, 专利号: 202010456433.3

（ 2 ） 鉴别良性甲状腺结节与甲状腺癌的生物标志物及其应用, 2022, 第 3 作者, 专利号: 202210104430.2

（ 3 ） 用于诊断甲状腺功能异常的生物标志物、试剂盒及其应用, 2022, 第 3 作者, 专利号: 202210104430.2

（ 4 ） 一种圆锥铁线莲来源的香豆素合酶、基因、载体及其应用, 2022, 第 4 作者, 专利号: 202210312834.0

（ 5 ） LC-A在制备治疗和预防增生性玻璃体以及增殖性糖尿病性视网膜病变药物中的应用, 2022, 第 2 作者, 专利号: CN114191444A

（ 6 ） 一种从植物叶片中提取纯化内质网及其蛋白的有效方法, 2022, 第 3 作者, 专利号: CN111004766B

（ 7 ） 一种细梗香草皂苷A的制备方法, 2021, 第 1 作者, 专利号: CN113061156A

（ 8 ） 一种防治家蚕BmNPV病的诱导桑叶及其用途, 2020, 第 2 作者, 专利号: CN107114561B

（ 9 ） 基于紫外诱导的桑叶中生物活性单体成分chalcomoracin及其制备方法和用途, 2020, 第 8 作者, 专利号: CN108250167B

（ 10 ） Eurycomanone及其类似物在制备治疗高脂血症、脂肪肝药物或减肥产品的用途, 2020, 第 1 作者, 专利号: CN110974821A

（ 11 ） 一种抗结核药物及其制备方法和用途, 2017, 第 2 作者, 专利号: CN107115340A

（ 12 ） 从细梗香草中提取三个黄酮类成分混合体、制剂及其方法, 2015, 第 1 作者, 专利号: CN104817601A

（ 13 ） 运用活性酶诱导技术提高黄花蒿中青蒿素含量的方法, 2012, 第 2 作者, 专利号: CN101874823B

（ 14 ） 一种提高新鲜植物次生代谢产物含量的光酶诱导仪, 2011, 第 1 作者, 专利号: CN201861994U

（ 15 ） 从中药材圆锥铁线莲中分离纯化活性成分金色酰胺醇酯的方法, 2011, 第 1 作者, 专利号: CN102070485A

（ 16 ） 一种提高银杏叶药效成分含量的方法, 2011, 第 3 作者, 专利号: CN101703535B

（ 17 ） 利用大孔树脂制备细梗香草总皂苷提取物的方法及用途, 2009, 第 1 作者, 专利号: CN101507740A

（ 18 ） 一种治疗多动症的中药复方制剂及其制备方法和用途, 2008, 第 2 作者, 专利号: CN101129649A

   

（1） Integrative analysis of transcriptome and metabolome provide new insights into mechanisms of Capilliposide A against cisplatin-induced nephrotoxicity, Journal of Pharmaceutical and Biomedical Analysis, 2024, 第 6 作者
（2） Proteomic and metabolomic characterization of bone, liver, and lung metastases in breast cancer patient plasma, Proteomics-Clinical Applications, 2024, 第 7 作者
（3） Lysimachia capillipes Hemsl. saponins ameliorate colorectal cancer in mice via regulating gut microbiota and restoring metabolic profiles, Fitoterapia, 2024, 
（4） NF��B-Mediated Expression of Phosphoinositide 3-Kinase �� Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells, CELLS, 2023, 第 8 作者
（5） Integrative proteomic and phosphoproteomic analyses revealed the regulatory mechanism of the response to UV-B stress in Clematis terniflora DC., ACS Omega, 2023, 第 5 作者
（6） Comprehensive multi-omics analysis reveals the importance of CtCOSY in the energy metabolism and coumarin biosynthesis in Clematis terniflora DC, INDUSTRIAL CROPS AND PRODUCTS, 2023, 第 8 作者  通讯作者
（7） Molecular characterization of a feruloyl-CoA 6���-hydroxylase involved in coumarin biosynthesis in Clematis terniflora DC, PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2023, 第 5 作者
（8） Integrative omic analysis reveals the dynamic change in phenylpropanoid metabolism in Morus alba under different stress, Molecular Therapy: Nucleic Acids, 2023, 第 8 作者
（9） Capilliposide B inhibits the migration ability of prostate cancer by inducing autophagy through ROS/AMPK/mTOR pathway, Phytotherapy Research, 2023, 
（10） Integrating plasma metabolomics and proteomics reveals novel molecular insights and biomarker panels for cholelithiasis, Journal of Pharmaceutical and Biomedical Analysis, 2023, 第 7 作者
（11） Proteomic analysis of Morus leaf epidermis indicates the roles of photosystems and ROS in UV-B response, INDUSTRIAL CROPS AND PRODUCTS, 2022, 第 8 作者
（12） Proteomic and Metabolomic Revealed Differences in the Distribution and Synthesis Mechanism of Aroma Precursors in Yunyan 87 Tobacco Leaf, Stem, and Root at the Seedling Stage, ACS OMEGA, 2022, 第 5 作者
（13） Guangsangon E triggers mitochondria dysfunction and mitophagy in triple-negative breast cancer and leads to non-apoptotic cell death, MOLECULAR CARCINOGENESIS, 2022, 第 8 作者  通讯作者
（14） Mitochondrial proteomic analysis reveals the regulation of energy metabolism and reactive oxygen species production in Clematis terniflora DC. leaves under high-level UV-B radiation followed by dark treatment, JOURNAL OF PROTEOMICS, 2022, 第 8 作者  通讯作者
（15） De novo Transcriptome Analysis Revealed the Putative Pathway Genes Involved in Biosynthesis of Moracins in Morus alba L., ACS OMEGA, 2022, 第 4 作者
（16） Optimization of an Alkaline Hydrolysis Preparation of Capilliposide-A from Lysimachia capillipes Hemsl. Using Response Surface Methodology Coupled with HPLC-ELSD Analysis, CHROMATOGRAPHIA, 2022, 第 8 作者  通讯作者
（17） Tandem mass tag-based proteomic analysis of endoplasmic reticulum proteins in mulberry leaves under ultraviolet-B and dark stress, PHYSIOLOGIA PLANTARUM, 2022, 第 7 作者  通讯作者
（18） LC-MS/MS based metabolomics and proteomics reveal candidate biomarkers and molecular mechanism of early IgA nephropathy, CLINICAL PROTEOMICS, 2022, 第 5 作者
（19） Phosphoproteomics Reveals Regulation of Secondary Metabolites in Mahonia bealei Exposed to Ultraviolet-B Radiation, FRONTIERS IN PLANT SCIENCE, 2022, 第 8 作者  通讯作者
（20） Hypoglycemic and hypolipidemic effects of sugar beet (Beta vulgaris L.) extract on C57BL/KsJ db/db mice, RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI, 2022, 第 6 作者
（21） Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia, JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2022, 第 5 作者
（22） A Quassinoid Diterpenoid Eurycomanone from Eurycoma longifolia Jack Exerts Anti-Cancer Effect through Autophagy Inhibition, MOLECULES, 2022, 第 8 作者  通讯作者
（23） Comparative Proteomic and Metabolomic Analyses of Plasma Reveal the Novel Biomarker Panels for Thyroid Dysfunction, FRONTIERS IN BIOSCIENCE-LANDMARK, 2022, 第 8 作者
（24） SWATH-based quantitative proteomic analysis of Morus alba L. leaves after exposure to ultraviolet-B radiation and incubation in the dark, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2022, 第 7 作者  通讯作者
（25） Metabolomics and proteomics revealed the synthesis difference of aroma precursors in tobacco leaves at various growth stages, PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2022, 第 8 作者
（26） Idelalisib inhibits experimental proliferative vitroretinopathy, LABORATORY INVESTIGATION, 2022, 第 9 作者
（27） Investigation of phytochemical composition and metabolite profiling in vivo of Beta vulgaris L., RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2021, 第 8 作者  通讯作者
（28） A Prognostic Signature Constructed by CTHRC1 and LRFN4 in Stomach Adenocarcinoma, FRONTIERS IN GENETICS, 2021, 第 14 作者  通讯作者
（29） A two-step strategy for quality control of Xin-Yu-Tie-Pian, an ointment patch, BIOMEDICAL CHROMATOGRAPHY, 2021, 第 6 作者  通讯作者
（30） DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 8 作者
（31） New Determination Method of Two Bioactive Saponins in Lysimachia capillipes Hemsl. by Quantitative Analysis of Multi-Components by Single-Marker, JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2021, 
（32） Combined ultraviolet and darkness regulation of medicinal metabolites in Mahonia bealei revealed by proteomics and metabolomics, JOURNAL OF PROTEOMICS, 2021, 第 9 作者  通讯作者
（33） Morphophysiological and Proteomic Responses on Plants of Irradiation with Electromagnetic Waves, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 第 4 作者
（34） A novel Diels–Alder adduct of mulberry leaves exerts anticancer effect through autophagy-mediated cell death, A novel Diels-Alder adduct of mulberry leaves exerts anticancer effect through autophagy-mediated cell death, ACTA PHARMACOLOGICA SINICA, 2021, 第 12 作者  通讯作者
（35） Chalcomoracin prevents vitreous-induced activation of AKT and migration of retinal pigment epithelial cells, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 第 4 作者
（36） Capilliposide B blocks VEGF-induced angiogenesis in vitro in primary human retinal microvascular endothelial cells, BIOMEDICINE & PHARMACOTHERAPY, 2021, 第 7 作者  通讯作者
（37） Comparative proteomics of Mesembryanthemum crystallinum guard cells and mesophyll cells in transition from C3 to CAM, JOURNAL OF PROTEOMICS, 2021, 第 6 作者  通讯作者
（38） Integrative omic analysis reveals the improvement of alkaloid accumulation by ultraviolet-B radiation and its upstream regulation in Catharanthus roseus, INDUSTRIAL CROPS AND PRODUCTS, 2021, 第 11 作者  通讯作者
（39） Transcriptome profiling analysis reveals that ATP6V0E2 is involved in the lysosomal activation by anlotinib, Cell Death and Disease, 2020, 第 8 作者
（40） Physiological Changes in Mesembryanthemum crystallinum During the C 3 to CAM Transition Induced by Salt Stress, FRONTIERS IN PLANT SCIENCE, 2020, 第 4 作者  通讯作者
（41） Analgesic and antiinflammatory activities of the capilliposide derived from Lysimachia capillipes Hemsl., a traditional Chinese medicinal herb, ARCHIVES OF BIOLOGICAL SCIENCES, 2020, 第 9 作者  通讯作者
（42） A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer, FRONTIERS IN PHARMACOLOGY, 2020, 第 12 作者  通讯作者
（43） Plant-derived smoke enhances plant growth through ornithine-synthesis pathway and ubiquitin-proteasome pathway in soybean, JOURNAL OF PROTEOMICS, 2020, 第 9 作者  通讯作者
（44） Proteomic Analysis of Irradiation with Millimeter Waves on Soybean Growth under Flooding Conditions, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 第 8 作者
（45） Transcriptome profiling analysis reveals that ATP6V0E2 is involved in the lysosomal activation by anlotinib, CELL DEATH AND DISEASE, 2020, 第 8 作者
（46） Phosphoinositide 3-kinase �� inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 第 5 作者
（47） Phosphoproteomics Reveals the Biosynthesis of Secondary Metabolites in Catharanthus roseus under Ultraviolet-B Radiation, JOURNAL OF PROTEOME RESEARCH, 2019, 第 8 作者  通讯作者
（48） A metabolomic strategy revealed the role of JA and SA balance in Clematis terniflora DC. Response to UVB radiation and dark, Physiologia Plantarum, 2019, 第 10 作者  通讯作者
（49） Integrative omics of Lonicera japonica Thunb. Flower development unravels molecular changes regulating secondary metabolites, JOURNAL OF PROTEOMICS, 2019, 第 5 作者
（50） Organ-Specific Analysis of Morus alba Using a Gel-Free/Label-Free Proteomic Technique, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 第 7 作者  通讯作者
（51） Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors, BMC PLANT BIOLOGY, 2019, 第 8 作者  通讯作者
（52） Hydrolysis product of Nigella A obtained from Nigella glandulifera Freyn seeds promotes apoptosis and AMPK-mediated autophagy in human colon cancer SW620 cells, ARCHIVES OF BIOLOGICAL SCIENCES, 2018, 
（53） SWATH定量蛋白质组学揭示光酶诱导桑叶及桑辛素N对家蚕中肠组织的影响, Proteomic analysis of midgut in silkworm reared on UV-B induced mulberry leaves and moracin N by SWATH-MS, 中国科学. 生命科学, 2018, 第 7 作者
（54） Molecular Characterization of a Geranyl Diphosphate-Specific Prenyltransferase Catalyzing Stilbenoid Prenylation from Morus alba, PLANT AND CELL PHYSIOLOGY, 2018, 第 9 作者  通讯作者
（55） Chalcomoracin is a potent anticancer agent acting through triggering Oxidative stress via a mitophagy- and paraptosis-dependent mechanism, SCIENTIFIC REPORTS, 2018, 第 9 作者  通讯作者
（56） Comparative Proteomic Analysis Reveals Elevated Capacity for Photosynthesis in Polyphenol Oxidase Expression-Silenced Clematis terniflora DC. Leaves, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 9 作者  通讯作者

（ 1 ） 天然药物化学, Natural Medicinal Chemistry, 化学工业出版社, 2018-10, 第 2 作者

   

（ 1 ） 桑蚕科技创新相关技术研发及健康产品开发, 负责人, 境内委托项目, 2024-05--2028-12
（ 2 ） 抗肿瘤辅助用中药院内制剂的开发, 负责人, 地方任务, 2023-01--2025-12
（ 3 ） 杭州市中医院中药制剂, 负责人, 境内委托项目, 2023-01--2025-12
（ 4 ） 浙江省卫生高层次人才领军人才, 负责人, 地方任务, 2023-01--2027-12
（ 5 ） 分子医学与制剂重点实验室, 负责人, 地方任务, 2023-01--2025-12
（ 6 ） 基于活性导向抗癌中药新药的研究, 负责人, 地方任务, 2022-01--2024-12
（ 7 ） 引进人才科研与启动经费, 负责人, 其他, 2021-10--2026-09
（ 8 ） 基于脐融透皮给药关键技术的中药新药—辛萸贴片研究, 负责人, 国家任务, 2019-01--2021-10
（ 9 ） 紫外诱导桑叶Diels-Alderase合酶的分离纯化及其结构研究, 负责人, 国家任务, 2019-01--2022-12
（ 10 ） 浙江-马来西亚传统药物联合研究中心, 负责人, 地方任务, 2016-01--2020-12

（1）Proteomics contribution in the field of secondary metabolism   第四届亚太地区农业蛋白质组学会议   2017-05-10
（2）Gel-free quantitative proteomic analysis of Catharanthus roseus seedlings with induction of indole alkaloids   第三届亚太地区农业蛋白质组学会议   2016-07-08