基本信息
王昱凯  男  硕导  中国科学院动物研究所
电子邮件: wangyukai@ioz.ac.cn
通信地址: 北京市朝阳区大屯路甲3号
邮政编码:

招生信息

   
招生专业
0710J6-再生医学
招生方向
神经生物学,神经疾病,干细胞治疗

教育背景

2008-09--2011-07   山东大学   博士
2005-09--2008-07   山东大学   硕士
2001-09--2005-07   南京工业大学   学士

工作经历

   
工作简历
2019-08~现在, 中国科学院动物研究所, 副研究员
2015-06~2019-08,中国科学院动物研究所, 助理研究员
2011-07~2015-06,中国科学院动物研究所, 博士后
2008-09~2011-07,山东大学, 博士
2005-09~2008-07,山东大学, 硕士
2001-09~2005-07,南京工业大学, 学士

专利与奖励

   
专利成果
( 1 ) 一种通过血样检测判断动物体内存在移植物的方法, 2023, 第 4 作者, 专利号: CN116042848A

( 2 ) 一种视网膜色素上皮细胞的扩增培养基及培养方法, 2023, 第 7 作者, 专利号: CN115873797A

( 3 ) 一种神经细胞组合和其应用, 2023, 第 4 作者, 专利号: CN 115873796 A

( 4 ) 一种神经细胞组合和其应用, 2023, 第 4 作者, 专利号: CN115873796A

( 5 ) 用于指示中脑多巴胺神经前体细胞或神经元的报告系统, 2023, 第 5 作者, 专利号: CN 115558645 A

( 6 ) 一种中脑多巴胺细胞群、其制造方法以及用途, 2022, 第 4 作者, 专利号: CN 115354028 A

( 7 ) 一种中脑多巴胺细胞群、其制造方法以及用途, 2022, 第 4 作者, 专利号: CN115354028A

( 8 ) 神经类器官及其制备方法, 2021, 第 5 作者, 专利号: CN113493768B

( 9 ) 蛋白激酶抑制剂在抑制单倍体细胞二倍化中的用途, 2020, 第 4 作者, 专利号: CN108998410B

出版信息

   
发表论文
(1) One-step cell biomanufacturing platform:porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo, One-step cell biomanufacturing platform:porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo, 中国神经再生研究:英文版, 2024, 通讯作者
(2) A scalable culture system incorporating microcarrier for specialised mesenchymal stem cells from human embryonic stem cells, MATERIALS TODAY BIO, 2023, 第 14 作者
(3) Human midbrain dopaminergic progenitors, Cell Prolif, 2023, 
(4) High-Strength Cell Sheets and Vigorous Hydrogels from Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells, ACS Appl Mater Interfaces, 2023, 
(5) Human neural stem cells, Cell Prolif, 2023, 
(6) Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig, STEM CELL REPORTS, 2023, 第 9 作者
(7) Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction, CELL & BIOSCIENCE, 2023, 通讯作者
(8) Gene editing monkeys: Retrospect and outlook, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 通讯作者
(9) Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs, STEM CELL RESEARCH & THERAPY, 2022, 通讯作者
(10) Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion, CELL PROLIFERATION, 2022, 通讯作者
(11) NEURONAL CELL-BASED MEDICINES FROM PLURIPOTENT STEM CELLS: DEVELOPMENT, PRODUCTION, AND PRECLINICAL ASSESSMENT, STEM CELLS TRANSLATIONAL MEDICINE, 2021, 通讯作者
(12) Autologous Transplantation for Parkinson's Disease Patients:Feasibility and Challenge, AUTOLOGOUS TRANSPLANTATION FOR PARKINSON'S DISEASE PATIENTS: FEASIBILITY AND CHALLENGE, NEUROSCIENCE BULLETIN, 2021, 第 3 作者
(13) INFUSION OF HESC DERIVED IMMUNITY-AND-MATRIX REGULATORY CELLS IMPROVES COGNITIVE ABILITY IN EARLY-STAGE AD MICE, CELL PROLIFERATION, 2021, 通讯作者
(14) Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis, Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis, CELL RESEARCH, 2020, 第 17 作者
(15) Hyaluronate supports hESC-cardiomyocyte cell therapy for cardiac regeneration after acute myocardial infarction, CELL PROLIFERATION, 2020, 第 6 作者
(16) Stem cell therapy for COVID-19, ARDS and pulmonary fibrosis, CELL PROLIFERATION, 2020, 第 6 作者
(17) Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, CELLDEATHDISEASE, 2019, 第 7 作者
(18) Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, CELL, 2018, 第 4 作者
(19) 人胚胎干细胞的临床转化研究进展, 中国细胞生物学学报, 2018, 第 2 作者
(20) A fully defined static suspension culture system for large-scale human embryonic stem cell production, CELL DEATH & DISEASE, 2018, 其他(合作组作者)
(21) Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic NeuronsRecover Locomotive Defects of Nonhuman Primate Models ofParkinson's Disease, STEM CELL REPORTS, 2018, 第 1 作者
(22) Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis, CELL RESEARCH, 2018, 其他(合作组作者)
(23) Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-Wide Genetic Screening, CELL REPORTS, 2017, 第 3 作者
(24) Variations in Mesenchymal-Epithelial Transition-Related Transcription Factors During Reprogramming of Somatic Cells from Different Germ Layers into iPSCs, JOURNAL OF GENETICS AND GENOMICS, 2016, 第 2 作者
(25) 人胚胎干细胞来源多巴胺前体细胞治疗帕金森病猴, 生命科学, 2016, 第 1 作者
(26) Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells, CELL, 2016, 第 4 作者
(27) Durable Pluripotency and Haploidy in Epiblast Stem Cells Derived from Haploid Embryonic Stem Cells In Vitro, JOURNAL OF MOLECULAR CELL BIOLOGY, 2015, 第 2 作者
(28) Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, JOURNAL OF GENETICS AND GENOMICS, 2015, 第 3 作者
(29) Immunogenicity and Functional Evaluation of iPSC-Derived Organs for Transplantation, CELL DISCOVERY, 2015, 第 3 作者
(30) 细胞重编程改写细胞命运:细胞的返老还童——2012年诺贝尔生理学或医学奖简介, Cell Fate Changed by Reprogramming: the Rejuve- nation of Cells A Brief Introduction to the Nobel Prize in Physiology or Medicine 2012, 自然杂志, 2012, 第 1 作者

科研活动

   
科研项目
( 1 ) 人中脑多巴胺神经细胞分化的阶段性命运调控研究, 负责人, 国家任务, 2020-01--2023-12
( 2 ) 单基因遗传病的基因治疗研究, 参与, 国家任务, 2019-10--2023-12
( 3 ) 类生命机器人智能, 参与, 中国科学院计划, 2022-07--2027-07
( 4 ) 神经和肝脏疾病的细胞治疗, 负责人, 地方任务, 2023-10--2027-12