本人的研究以纳米生物界面为主线、纳米材料的安全应用为目标，主要围绕纳米材料介导的炎症反应、细胞焦亡及毒性机理、纳米材料的构效关系、功能性纳米材料的生物合成及潜在应用展开研究。针对炎症反应这一共性问题，以肺纤维化等炎症相关疾病为研究对象，通过交叉科学研究手段发展一系列新型纳米药物，在治疗方式、给药途径、作用机理等方面有所创新，旨在为重大疾病提供安全高效的治疗方案。近年来，在 Adv. Mater., Matter, Nano Today, ACS Nano, Small等学术期刊上发表 SCI 论文 20 余篇，申请国家发明专利4项，现已授权3 项。研究成果被Nat. Nanotechnol.，Nat. Comm., Advance Material等知名期刊或媒体广泛报道。

   

0710J1-纳米科学与技术
0703J1-纳米科学与技术
071011-生物物理学

纳米生物学，纳米医学，纳米毒理学

2014-09--2019-06   浙江大学   博士研究生
2010-09--2014-06   石河子大学   本科学士

   

2019-07~2021-10,美国加州大学洛杉矶分校, 博士后研究员
2018-10~2019-07,美国东北大学, 访问学者

   

（1） 浙江省优秀毕业生, , 省级, 2019
（2） 浙江大学毕业研究生奖学金, 研究所（学校）, 2019
（3） 第七届全国核农学青年学术论坛二等奖, 二等奖, 其他, 2017
（4） 国家奖学金, 部委级, 2011

（ 1 ） 一种纳米金的制备方法、纳米金及应用, 发明专利, 2018, 第 2 作者, 专利号: CN107916277A

（ 2 ） 一种纳米金的制备方法、纳米金及应用, 专利授权, 2018, 第 2 作者, 专利号: CN107916277A

（ 3 ） 一种基于细菌提取物制备纳米银的方法, 专利授权, 2018, 第 2 作者, 专利号: CN107904262A

   

[1] Jiulong Li, Chunying Chen, Tian Xia. Understanding Nanomaterial–Liver Interactions to Facilitate the Development of Safer Nanoapplications (Adv. Mater. 11/2022). Advanced Materials[J]. 2022, [2] Jiulong Li, Graciel Diamante, In Sook Ahn, Darren Wijaya, Xiang Wang, Chong Hyun Chang, Sungmin Ha, Kavya Immadisetty, Huan Meng, Andr Nel, Xia Yang, Tian Xia. Determination of the nanoparticle- and cell-specific toxicological mechanisms in 3D liver spheroids using scRNAseq analysis. Nano Today. 2022, 47: http://dx.doi.org/10.1016/j.nantod.2022.101652.
[3] Cao, Wei, Wang, Xiang, Li, Jiulong, Yan, Ming, Chang, Chong Hyun, Kim, Joshua, Jiang, Jinhong, Liao, YuPei, Tseng, Shannon, Kusumoputro, Sydney, Lau, Candice, Huang, Marissa, Han, Pengli, Lu, Pengju, Xia, Tian. NLRP3 inflammasome activation determines the fibrogenic potential of PM2.5 air pollution particles in the lung. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2022, 111(1): 429-441, http://dx.doi.org/10.1016/j.jes.2021.04.021.
[4] Xie, Xiaodong, Jiang, Jinhong, Liu, Xiangsheng, Cao, Yuhong, Li, Jiulong, Xia, Tian, Meng, Huan. Interleukin-10 plasmid delivery by polymeric nanocarrier shows efficient and safe tissue repair in acute muscle damage models in mice. NANO TODAY[J]. 2022, 46: http://dx.doi.org/10.1016/j.nantod.2022.101544.
[5] Wang, Wenbin, Sun, Hui, Gong, Yan, Liu, Xiangsheng, Liu, Xiao, Wang, Mengru, Li, Silu, Li, Jiulong, Zhu, Lin, Meng, Huan. Ratiometric co-delivery of hydroxychloroquine and calculated low-dose paclitaxel efficiently suppresses tumor growth in hepatocellular carcinoma mouse models in vivo. NANO TODAY[J]. 2022, 44: http://dx.doi.org/10.1016/j.nantod.2022.101446.
[6] Li, Jiulong, Gao, Xingfa, Wang, Yuguang, Xia, Tian, Zhao, Yuliang, Meng, Huan. Precision design of engineered nanomaterials to guide immune systems for disease treatment. MATTERnull. 2022, 5(4): 1162-1191, http://dx.doi.org/10.1016/j.matt.2022.03.005.
[7] Liu, Qi, Wang, Xiang, Liao, YuPei, Chang, Chong Hyun, Li, Jiulong, Xia, Tian, Nel, Andre E. Use of a liver-targeting nanoparticle platform to intervene in peanut-induced anaphylaxis through delivery of an Ara h2 T-cell epitope. NANO TODAY[J]. 2022, 42: http://dx.doi.org/10.1016/j.nantod.2021.101370.
[8] Jiulong Li, et al.. Dissolution of 2D Molybdenum Disulfide Generates Differential Toxicity among Liver Cell Types Compared to Non‐Toxic 2D Boron Nitride Effects. Small[J]. 2021, [9] Jiulong Li, Xiang Wang, KuoChing Mei, Chong Hyun Chang, Jinhong Jiang, Xiangsheng Liu, Qi Liu, Linda M Guiney, Mark C Hersam, YuPei Liao, Huan Meng, Tian Xia. Lateral size of graphene oxide determines differential cellular uptake and cell death pathways in Kupffer cells, LSECs, and hepatocytes. Nano today. 2021, 37: [10] Li, Jiulong, Wang, Xiang, Chang, Chong Hyun, Jiang, Jinhong, Liu, Qi, Liu, Xiangsheng, Liao, YuPei, Ma, Tiancong, Meng, Huan, Xia, Tian. Nanocellulose Length Determines the Differential Cytotoxic Effects and Inflammatory Responses in Macrophages and Hepatocytes. SMALL[J]. 2021, 17(38): http://dx.doi.org/10.1002/smll.202102545.
[11] Jiang, Meng, Dai, Shang, Wang, Binqiang, Xie, Zhenming, Li, Jiulong, Wang, Liangyan, Li, Shan, Tan, Yuanyuan, Tian, Bing, Shu, Qingyao, Huang, Jianzhong. Gold nanoparticles synthesized using melatonin suppress cadmium uptake and alleviate its toxicity in rice. ENVIRONMENTAL SCIENCE-NANO[J]. 2021, 8(4): 1042-1056, http://dx.doi.org/10.1039/d0en01172j.
[12] Wang, Xiang, Chang, Chong Hyun, Jiang, Jinhong, Liu, Xiangsheng, Li, Jiulong, Liu, Qi, Liao, YuPei, Li, Linjiang, Nel, Andre E, Xia, Tian. Mechanistic Differences in Cell Death Responses to Metal-Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes. SMALL[J]. 2020, 16(21): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263057/.
[13] Weng Y, Li, Jiulong, Ding X, Wang B, Dai S, Zhou Y, Pang R, Zhao Y, Xu H, Tian B, Hua Y. Functionalized Gold and Silver Bimetallic Nanoparticles Using Deinococcus radiodurans Protein Extract Mediate Degradation of Toxic Dye Malachite Green. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2020, 15: 1823-1835, https://doaj.org/article/436c813828ea49c5baf40ace58a70c8d.
[14] Li, Jiulong, Webster, Thomas, Tian, Bing. Functionalized Nanomaterial Assembling and Biosynthesis Using the Extremophile Deinococcus radiodurans for Multifunctional Applications. SMALLnull. 2019, 15(20): [15] Tian, Bing, Li, Jiulong, Pang, Renjiang, Dai, Shang, Li, Tao, Weng, Yulan, Jin, Ye, Hua, Yuejin. Gold Nanoparticles Biosynthesized and Functionalized Using a Hydroxylated Tetraterpenoid Trigger Gene Expression Changes and Apoptosis in Cancer Cells. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(43): 37353-37363, http://dx.doi.org/10.1021/acsami.8b09206.
[16] Jiulong Li, et al. Biosynthesis of Au, Ag, and Au–Ag bimetallic nanoparticles using protein extracts of Deinococcus radiodurans and evaluation of their cytotoxicity2. International Journal of Nanomedicine[J]. 2018, [17] Li J, Li Q, Ma X, Tian B, Li T, Yu J, Dai S, Weng Y, Hua Y. Biosynthesis of gold nanoparticles by the extreme bacterium Deinococcus radiodurans and an evaluation of their antibacterial properties. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2016, 11: 5931-5944, https://doaj.org/article/88fdbe23760e425588c49bb5f40505cc.
[18] 李九龙, 张丽沙, 唐慧东, 吕新民, 李婷, 刘慧英. 发酵菌剂对玉米芯与菇渣混合物堆肥发酵的影响. 新疆农业科学[J]. 2014, 51(7): 1263-1268, http://lib.cqvip.com/Qikan/Article/Detail?id=662302517.
[19] 孙志红, 李九龙, 衡思金, 王刚. 不同授粉品种对香梨坐果和果实脱萼的影响. 新疆农垦科技[J]. 2014, 37(12): 16-17, http://lib.cqvip.com/Qikan/Article/Detail?id=663442513.

   

（ 1 ） 基于稀土纳米材料诱导的肿瘤细胞焦亡抑制三阴性乳腺癌的机理和初步应用研究, 负责人, 国家任务, 2023-01--2025-12
（ 2 ） 治疗溃疡性结肠炎创新口服纳米治疗体系的构建, 参与, 国家任务, 2022-05--2024-05

（1）Intrinsic properties of 2D nanomaterials determine differential cellular uptake and cell death pathways in various liver cells types.   2021-11-12
（2）Biosynthesis of Functionalized Green Gold Nanoparticles Using a Hydroxylated Tetraterpenoid for Anti-Cancer Applications.   2019-04-22
（3）Biomanufacturing functionalized green gold nanoparticles using a hydroxylated tetraterpenoid for anti-cancer applications.   2018-12-11