人体生长发育、疾病发生发展的表观遗传组学机制，以及相关表观药物的研发，特别对包括但不限于如下的生命历程或疾病发生感兴趣：

1. T细胞耗竭、癌症免疫疗法背后表观遗传机制，以及创新性表观药物研发；

2. 从衰老、神经退行性疾病的表观遗传组机制，相关表观药物研发，到益寿延年美好愿景；

3. 环境因子、遗传多样性、和单亲本DNA甲基化互作致病机理，以及探索“局域性常染色体失活”新假说在发育、疾病中贡献；

4. 疾病的多代、跨代表观遗传机制。

2000-2006 美国俄亥俄州立大学, 园艺与作物学（分子遗传与生物技术）, 博士

1995-1998 中国农业科学院研究生院及生物技术所，分子生物学，硕士

1988-1992 青岛农业大学，作物学，学士

2022-至今，中国科学院深圳理工大学药学院，正教授
                    中国科学院深圳先进技术研究院生物医药与技术研究所，癌症免疫研究中心，研究员
​2017-2022，美国约翰霍普金斯大学彭博公共卫生学院，环境健康与工程系，副教授
                     美国约翰霍普金斯大学医学院，癌症学系、Kimmel综合癌症中心、表观遗传学中心，副教授
2010-2017，美国约翰霍普金斯大学彭博公共卫生学院，环境健康与工程系，助理教授
                     美国约翰霍普金斯大学医学院，癌症学系、Kimmel综合癌症中心、表观遗传学中心，助理教授
2006-2010，美国国立卫生研究院，心、肺、血液研究所，分子免疫学室，博士后
1998-2000，中国农业科学院生物技术研究所，分子生物学室，助理研究员

2020-至今 Cell Insights编委

2017-至今 Frontiers in Genetics和Frontiers in Cell & Developmental Biology在“Epigenetics & Epigenomics”领域审稿编辑

2016-至今 美国NIH Roadmap Epigenomics指导委员会

所获奖励与荣誉

1999 中国农业科学院第5届优秀青年科学家遴选及优秀论文评选，一等奖（第一名）
2009 美国Lenfant Schola
2011 美国约翰霍普金斯大学Faculty Innovation Award

2012 美国Kimmel Scholar

2016 美国约翰霍普金斯大学Catalyst Award

1. Huang M, Lou D, Charli A, Kong D, Jin H, Anantharam V, Kanthasamy A, Wang Z†, and Kanthasamy AG†. Mitochondrial dysfunction induces epigenetic dysregulation by H3K27 hyperacetylation to perturb active enhancers in Parkinson’s disease models. JCI insight 2021 Sep 8; 6(17):e138088. doi: 10.1172/jci.insight.138088. PMID: 34494552. PMCID: PMC8492320 († co-correspondence author).

2. Freeman DM, Lou D, Li Y, Martos, SN, and Wang Z. The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure. Epigenetics and Chromatin 2020 Mar 16; 13(1):17. doi: 10.1186/s13072-020-00338-8 PMID: 32178731. PMC7076959.

3. Freeman DM, O’Neal R, Zhang Q, Bouwer E, and Wang Z. Manganese-induced Parkinsonism in mice is reduced using a novel contaminated water sediment exposure model. Environmental Toxicology and Pharmacology 2020 Aug;78:103399. doi: 10.1016/j.etap.2020.103399. PMID: 32380377.

4. Wu S, Lei L, Liu M, Song Y, Lu S, Lou D, Shi Y, Wang Z† , and He D† . Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism. Experimental Neurology 2018 Nov;309:67-78. doi: 10.1016/j.expneurol.2018.07.018. PMID:30076829. PMCID: PMC6579610 († co-correspondence author).

5. TaRGET II Consortium, Bartolomei MS, Walker CL, Tyson FL. The NIEHS TaRGET II Consortium and environmental epigenomes. Nature Biotechnology 2018, 36, 225-227. doi: 10.1038/nbt.4099. PMID: 29509741. PMCID: PMC5991835.

6. Zhu Y, Li Y , Lou D, Gao Y, Yu J, Kong D, Zhang Q, Jia Y, Zhang H, and Wang Z. Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells. Toxicology and Applied Pharmacology 2018 Oct 15; 357:70-79. doi: 10.1016/j.taap.2018.08.011 PMID: 30130555. PMCID: PMC6526104.

7. Martos SN, Li T, Bossardi R, Lou D, Dai H, Xu J, Gao G, Wang Q, An C, Zhang X, Jia Y, Dawson V, Dawson TM, Ji HK, and Wang Z. Two approaches revealed a new paradigm of ‘switchable or genetics-influenced allele-specific DNA methylation (ASM)’ with potential in human disease. Cell Discovery 2017 Nov 14; 3:17038. doi: 10.1038/celldisc.2017.38. PMID: 29387450. PMCID: PMC5787696.

8. Dhar S, Lee SH, Chen K, Zhu G, Oh WK, Alton K, Gafni O, Kim YZ, Barton M, Hanna JH, Wang Z† , Li W† , Lee MG† . An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Research. 2016 May 5; 44(8):3659-74. doi: 10.1093/nar/gkv1516. ( †co-correspondence author) PMCID: PMC4856969.

9. Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen T-Y, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG. ZMYND8 reads the dual histone mark H3K4me1-H3K14ac to antagonize the expression of metastasis-linked genes. Molecular Cell 2016 Aug 4; 63(3):470-84. doi: 10.1016/j.molcel.2016.06.035. PMID: 27477906.

10. Li Z, Dai H, Martos SN, Xu B, Gao Y, Zhu G, Li T, Schones DE, and Wang Z. Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells. Genome Biology 2015 Jun 2; 16(1):115. doi: 10.1186/s13059-015-0685-2. PMID: 26032981. PMCID: PMC4474455.

11. Wu H, D'Alessio ACD, Ito S, Xia K, Wang Z, Cui K, Zhao K, Sun YE, and Zhang Y. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 2011 May 19; 473(7347):389-93. doi: 10.1038/nature09934.

12. Wu H, D'Alessio ACD, Ito S, Wang Z, Cui K, Zhao K, Sun YE, and Zhang Y. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes & Development 2011 Apr 1; 25(7):679-84. doi: 10.1101/gad.2036011.

13. Qi HH, Sarkissian M, *Hu G-q, *Wang Z, Bhattacharjee A, Gordon DB, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, and Shi Y. Histone H3K9/H4K20 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature 2010 Jul 22; 466(7305):503-7. doi: 10.1038/nature09261 ( ^# These authors contribute equally; * These authors contribute equally to ChIP-seq analyses) PMC3072215.

14. Daniel JA, *Santos MA, *Wang Z, *Zang C, Jankovic M, Gazumyan A, Kristopher R, Schwab KR, Yamane A, Filsuf D, Cho Y-W, Ge K, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, and Nussenzweig A. PTIP promotes chromatin changes critical for immunoglobulin switch recombination. Science 2010 Aug 20;329(5994):917-23. doi: 10.1126/science.1187942. (*Co-second author) PMC3008398.

15. Zhou J, Wang C, Wang Z, Dampier W, Wu K, Casimiro MC, Yu Z, Wang M, Liang B, Chepelev L, Popov VM, Sune C, Quong A, Lisanti MP, Tozeren A, Zhao K, and Pestell RG. Attenuation of forkhead signaling by the retinal determination factor DACH1. Proceedings of the National Academy of Sciences USA 2010 Apr 13;107(15):6864-9. doi: 10.1073/pnas.1002746107.

16. Wang Z, Zang C, Cui K, Schones DE, Barski A, Peng W, and Zhao K. Genome-wide mapping of HATs and HDACs reveals distinct 5unctions in active and inactive genes. Cell 2009 Sep 4;138(5):1019-31. doi: 10.1016/j.cell.2009.06.049. PMID:19698979. PMC2750862.

17. *Araki Y, *Wang Z, Zang C, Wood W III, Schones DE, Lhotsky B, Westo R, Peng W, Becker K, Zhao K, and Weng N-p. (2009) Genome-wide analysis of histone methylation reveals chromatin state-based complex regulation of gene transcription and function of memory CD8 + T cells. Immunity 2009 Jun 19;30(6):912-25. doi: 10.1016/j.immuni.2009.05.006 (* co-first author) PMID:19523850.

18. Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, Cuddapah S, Cui K, Roh T-y, Peng W, Zhang M, Zhao K. (2008). Combinatorial patterns of histone acetylations and methylations in the human genome. Nature Genetics 2008 Jul;40(7):897-903. doi: 10.1038/ng.154 PMID:18552846.

19. Schones DE, Cui K, Cuddapah S, Roh T-y, Barski A, Wang Z, Wei G, Zhao K. Dynamic regulation of nucleosome positioning in the human genome. Cell 2008 Mar 7;132(5):887-98. doi: 10.1016/j.cell.2008.02.022.

20. *Barski A, *Cuddapah S, *Cui K, *Roh T-y, *Schones DE, *Wang Z, *Wei G, Chepelev I, Zhao K. High-resolution profiling of histone methylations in the human genome. Cell 2007 May 18;129(4):823-37. doi: 10.1016/j.cell.2007.05.009. PMID:17512414 ( *Contribute equally and are listed alphabetically).

现指导学生

张雨  硕士研究生  086000-生物与医药