神经退行性疾病分子机理研究，早期诊断和药物研发

   

071006-神经生物学
071010-生物化学与分子生物学
071009-细胞生物学

神经退行性疾病发病机制及早期诊断
小分子神经退行性疾病新药物的开发与研究
药物的筛选，化学合成，改造及药物设计

1993-09--1998-07   美国埃默里大学   博士

1993-9–1998-4，美国埃默里大学，生物化学和细胞生物学，博士。
1990-8–1993-7，北京大学，化学系，硕士；

1986-8–1990-7，吉林大学，化学系，学士；

   

2021-09~现在, 深圳先进技术研究院, 教授
2010-09~2021-08,埃默里大学 医学院病理系, 教授
2007-09~2010-08,埃默里大学 医学院病理系, 副教授
2001-11~2007-08,埃默里大学 医学院病理系, 助理教授
1998-09~2001-07,约翰霍普金斯大学 医学院神经生物学系, 博士后

   

（1） 教育部“长江学者”讲座教授, 部委级, 2011
（2） 美国癌症学会研究学者奖, 其他, 2004
（3） 杰出青年科学家奖（美国）, 国家级, 2003

[1] YE, KEQIANG. ASPARAGINE ENDOPEPTIDASE (AEP) INHIBITORS, COMPOSITIONS, AND USES RELATED THERETO. US: CA3141720(A1), 2020-12-03.

[2] YE, KEQIANG. TrkB agonists and methods of use. US: US09504674B2, 2016-11-29.

[3] Ye Keqiang. TREATING VARIOUS DISORDERS USING TRKB AGONISTS. US: US2012277222A1, 2012-11-01.

   

[1] Jie Xiang, Youqi Tao, yiyuan xia, luo shilin, Qinyue Zhao, Bowei Li, Xiaoqian Zhang, Yunpeng Sun, Wencheng Xia, Mingming Zhang, Seong Su Kang, Eun-Hee Ahn, Xia Liu, Fang Xie, Yihui Guan, Jenny J Yang, Lihong Bu, Shengxi Wu, Xiaochuan Wang, Xuebing Cao, Cong Liu, Zhentao Zhang, Dan Li, Keqiang Ye. Development of an α-Synuclein Positron Emission Tomography (PET) Tracer for Imaging Synucleinopathies. Cell[J]. 2023, https://www.sciencedirect.com/science/article/pii/S009286742300644X?via%3Dihub.
[2] English, Arthur W, Carrasco, Dario, Hoffman, Dustin, Isaacson, Robin, Kang, Seong Su, Khan, Samia, Liu, Xia, Ye, Keqiang. Oral Treatments With the TrkB Ligand Prodrug, R13, Promote Enhanced Axon Regeneration Following Peripheral Nerve Injury. FRONTIERS IN CELLULAR NEUROSCIENCE[J]. 2022, 16: http://dx.doi.org/10.3389/fncel.2022.857664.
[3] Chen, Guiqin, Ahn, Eun Hee, Kang, Seong Su, Xia, Yiyuan, Liu, Xia, Zhang, Zhaohui, Ye, Keqiang. UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. ADVANCED SCIENCE[J]. 2022, 9(7): http://dx.doi.org/10.1002/advs.202103396.
[4] Kang, Seong Su, Meng, Lanxia, Zhang, Xingyu, Wu, Zhiping, Mancieri, Ariana, Xie, Boer, Liu, Xia, Weinshenker, David, Peng, Junmin, Zhang, Zhentao, Ye, Keqiang. Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2022, 29(4): 292-+, http://dx.doi.org/10.1038/s41594-022-00745-3.
[5] Xiong, Jing, Kang, Seong Su, Wang, Zhihao, Liu, Xia, Kuo, TanChun, Korkmaz, Funda, Padilla, Ashley, Miyashita, Sari, Chan, Pokman, Zhang, Zhaohui, Katsel, Pavel, Burgess, Jocoll, Gumerova, Anisa, Ievleva, Kseniia, Sant, Damini, Yu, ShanPing, Muradova, Valeriia, Frolinger, Tal, Lizneva, Daria, Iqbal, Jameel, Goosens, Ki A, Gera, Sakshi, Rosen, Clifford J, Haroutunian, Vahram, Ryu, Vitaly, Yuen, Tony, Zaidi, Mone, Ye, Keqiang. FSH blockade improves cognition in mice with Alzheimer's disease. NATURE[J]. 2022, 603(7901): 470-+, http://dx.doi.org/10.1038/s41586-022-04463-0.
[6] ZhiHao Wang, Yiyuan Xia, Zhourui Wu, Seong Su Kang, Jichun Zhang, Pai Liu, Xia Liu, Weihong Song, Vincent Huin, ClaireMarie Dhaenens, Shan Ping Yu, XiaoChuan Wang, Keqiang Ye. Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer’s disease pathology in a mouse model. PROGRESS IN NEUROBIOLOGY[J]. 2022, 209: [7] Xia, Yiyuan, Wang, ZhiHao, Liu, Pai, EdgingtonMitchell, Laura, Liu, Xia, Wang, XiaoChuan, Ye, Keqiang. TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies. MOLECULAR PSYCHIATRY[J]. 2021, 26(7): 2943-2963, http://dx.doi.org/10.1038/s41380-020-00863-8.
[8] Jasmin, Melissa, Ahn, Eun Hee, Voutilainen, Merja H, Fombonne, Joanna, Guix, Catherine, Viljakainen, Tuulikki, Kang, Seong Su, Yu, Liying, Saarma, Mart, Mehlen, Patrick, Ye, Keqiang. Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. EMBO JOURNAL[J]. 2021, 40(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849168/.
[9] Zhenlei Zhao, Fan Xue, Yanpei Gu, Jianxin Han, Yingxian Jia, Keqiang Ye, Ying Zhang. Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice. MOLECULAR METABOLISM[J]. 2021, 45: 101149-, http://dx.doi.org/10.1016/j.molmet.2020.101149.
[10] Ahn, Eun Hee, Kang, Seong Su, Liu, Xia, Cao, Xuebing, Choi, Soo Young, Musazzi, Laura, Mehlen, Patrick, Ye, Keqiang. BDNF and Netrin-1 repression by C/EBP beta in the gut triggers Parkinson's disease pathologies, associated with constipation and motor dysfunctions. PROGRESS IN NEUROBIOLOGYnull. 2021, 198: http://dx.doi.org/10.1016/j.pneurobio.2020.101905.
[11] Blennow, Kaj, Chen, Chun, Cicognola, Claudia, Wildsmith, Kristin R, Manser, Paul T, Bohorquez, Sandra M Sanabria, Zhang, Zhentao, Xie, Boer, Peng, Junmin, Hansson, Oskar, Kvartsberg, Hlin, Portelius, Erik, Zetterberg, Henrik, Lashley, Tammaryn, Brinkmalm, Gunnar, Kerchner, Geoffrey A, Weimer, Robby M, Ye, Keqiang, Hoglund, Kina. Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology. BRAIN[J]. 2020, 143(2): 650-660, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009597/.
[12] Chen, Chun, Ahn, Eun Hee, Kang, Seong Su, Liu, Xia, Alam, Ashfaqul, Ye, Keqiang. Gut dysbiosis contributes to amyloid pathology, associated with C/EBP beta/AEP signaling activation in Alzheimer's disease mouse model. SCIENCE ADVANCES[J]. 2020, 6(31): https://www.webofscience.com/wos/woscc/full-record/WOS:000556543100010.
[13] Wu, Zhourui, Liu, Xia, Cheng, Liming, Ye, Keqiang. Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice. CELL DEATH & DISEASE[J]. 2020, 11(12): https://doaj.org/article/2d3601e1d3e5450a9f09f05c02dd6232.
[14] Lei, Kecheng, Gu, Xiaoxia, Alvarado, Alvaro G, Du, Yuhong, Luo, Shilin, Ahn, Eun Hee, Kang, Seong Su, Ji, Bing, Liu, Xia, Mao, Hui, Fu, Haian, Kornblum, Harley I, Jin, Lingjing, Li, Hua, Ye, Keqiang. Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma. JOURNAL OF HEMATOLOGY & ONCOLOGY[J]. 2020, 13(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000583358800001.
[15] Seong Su Kang, Eun Hee Ahn, Keqiang Ye. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. EXPERIMENTAL AND MOLECULAR MEDICINE[J]. 2020, 52(8): 1275-1287, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080617/.
[16] Xia, Yiyuan, Wang, Zhihao, Zhang, Jichun, Liu, Xia, Yu, Shan Ping, Ye, Karen X, Wang, JianZhi, Ye, Keqiang, Wang, XiaoChuan. C/EBP beta is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. MOLECULAR PSYCHIATRY. 2020, http://dx.doi.org/10.1038/s41380-020-00956-4.
[17] Zhentao Zhang, Ye Tian, Keqiang Ye. δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities. TRANSLATIONAL NEURODEGENERATION[J]. 2020, 9(1): 1-9, http://dx.doi.org/10.1186/s40035-019-0179-3.
[18] Lei, Kecheng, Xia, Yiyuan, Wang, XiaoChuan, Ahn, Eun Hee, Jin, Lingjing, Ye, Keqiang. C/EBP beta mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation. REDOX BIOLOGY[J]. 2020, 34: https://www.webofscience.com/wos/woscc/full-record/WOS:000545325700001.
[19] Wu, Zhourui, Wang, ZhiHao, Liu, Xia, Zhang, Zhentao, Gu, Xiaohuan, Yu, Shan Ping, Keene, C Dirk, Cheng, Liming, Ye, Keqiang. Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology. PROGRESS IN NEUROBIOLOGYnull. 2020, 185: http://dx.doi.org/10.1016/j.pneurobio.2019.101730.
[20] Kang, Seong Su, Liu, Xia, Ahn, Eun Hee, Xiang, Jie, Manfredsson, Fredric P, Yang, Xifei, Luo, Hongbo R, Liles, L Cameron, Weinshenker, David, Ye, Keqiang. Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus. THE JOURNAL OF CLINICAL INVESTIGATION[J]. 2020, 130(1): 422-437, https://www.webofscience.com/wos/woscc/full-record/WOS:000505205000042.
[21] Ahn, Eun Hee, Kang, Seong Su, Qi, Qi, Liu, Xia, Ye, Keqiang. Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(39): 24503-24513, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533679/.
[22] Eun Hee Ahn, Seong Su Kang, Xia Liu, Guiqin Chen, Zhentao Zhang, Bindu Chandrasekharan, Ashfaqul M Alam, Andrew S Neish, Xuebing Cao, Keqiang Ye. Initiation of Parkinson’s disease from gut to brain by δ-secretase. CELL RESEARCH[J]. 2019, 30(1): 70-87, http://lib.cqvip.com/Qikan/Article/Detail?id=7101214655.