分子影像与分子探针

生物成像

肿瘤诊疗

   

086000-生物与医药

分子影像探针
生物成像
肿瘤诊疗

2015-08--2018-11   澳门大学   博士
2008-09--2011-06   华中农业大学   硕士
2004-09--2008-06   华中农业大学   学士

   

2011-07~2015-08,中科院深圳先进技术研究院, 研究助理/助理研究员

   

[1] Gao, Duyang, Luo, Zichao, He, Yang, Yang, Lixiang, Hu, Dehong, Liang, Yongye, Zheng, Hairong, Liu, Xiaogang, Sheng, Zonghai. Low-Dose NIR-II Preclinical Bioimaging Using Liposome-Encapsulated Cyanine Dyes. SMALL[J]. 2023, 19(17): http://dx.doi.org/10.1002/smll.202206544.
[2] Liu, Jing, Gao, Duyang, Hu, Dehong, Lan, Siyi, Liu, Yu, Zheng, Hairong, Yuan, Zhen, Sheng, Zonghai. Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson's Disease. RESEARCH[J]. 2023, 2023: [3] Gao, Duyang, Li, Yaxi, Wu, Yayun, Liu, Yu, Hu, Dehong, Liang, Simin, Liao, Jiuling, Pan, Min, Zhang, Pengfei, Li, Kai, Liu, Xin, Zheng, Hairong, Sheng, Zonghai. Albumin-Consolidated AIEgens for Boosting Glioma and Cerebrovascular NIR-II Fluorescence Imaging. ACS APPLIED MATERIALS & INTERFACES. 2022, http://dx.doi.org/10.1021/acsami.1c22700.
[4] Miao, Zhaohua, Hu, Dehong, Gao, Duyang, Fan, Linxin, Ma, Yan, Ma, Teng, Liu, Xin, Zheng, Hairong, Zha, Zhengbao, Sheng, Zonghai, Xu, ChengYan. Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics. SCIENCE BULLETIN[J]. 2021, 66(2): 147-157, http://dx.doi.org/10.1016/j.scib.2020.09.027.
[5] Zhou, HuiChao, Ren, Jie, Lin, Yuejun, Gao, Duyang, Hu, Dehong, Yin, Tinghui, Qiu, Chen, Miao, Xiaoyan, Liu, Chengbo, Liu, Xin, Zheng, Hairong, Zheng, Rongqin, Sheng, Zonghai. Intravital NIR-II three-dimensional photoacoustic imaging of biomineralized copper sulfide nanoprobes. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2021, 9(13): 3005-3014, https://www.webofscience.com/wos/woscc/full-record/WOS:000637929100014.
[6] Gao, Duyang, Hu, Dehong, Liu, Xin, Zhang, Xuanjun, Yuan, Zhen, Sheng, Zonghai, Zheng, Hairong. Recent Advances in Conjugated Polymer Nanoparticles for NIR-II Imaging and Therapy. ACS APPLIED POLYMER MATERIALSnull. 2020, 2(10): 4241-4257, http://dx.doi.org/10.1021/acsapm.0c00679.
[7] Sheng, Zonghai, Li, Yaxi, Hu, Dehong, Min, Tianliang, Gao, Duyang, Ni, JenShyang, Zhang, Pengfei, Wang, Yuenan, Liu, Xin, Li, Kai, Zheng, Hairong, Tang, Ben Zhong. Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates. RESEARCH[J]. 2020, 2020: http://dx.doi.org/10.34133/2020/4074593.
[8] 盛宗海, 李三清, 胡德红, 高笃阳, 郑海荣. 功能化纳米探针用于脑胶质瘤精准诊疗研究进展. 集成技术[J]. 2020, 9(1): 1-11, http://lib.cqvip.com/Qikan/Article/Detail?id=7101013266.
[9] Geng, Xiaorui, Gao, Duyang, Hu, Dehong, Liu, Quanhong, Liu, Chengbo, Yuan, Zhen, Zhang, Xuanjun, Liu, Xin, Sheng, Zonghai, Wang, Xiaobing, Zheng, Hairong. Active-Targeting NIR-II Phototheranostics in Multiple Tumor Models Using Platelet-Camouflaged Nanoprobes. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(50): 55624-55637, http://dx.doi.org/10.1021/acsami.0c16872.
[10] Zhu, Lipeng, Gao, Duyang, Xie, Lisi, Dai, Yunlu, Zhao, Qi. NIR II-Excited and pH-Responsive Ultrasmall Nanoplatform for Deep Optical Tissue and Drug Delivery Penetration and Effective Cancer Chemophototherapy. MOLECULAR PHARMACEUTICS[J]. 2020, 17(10): 3720-3729, https://www.webofscience.com/wos/woscc/full-record/WOS:000580389300006.
[11] Dan, Qing, Hu, Dehong, Ge, Yongshuai, Zhang, Shiyu, Li, Sanqing, Gao, Duyang, Luo, Wanxian, Ma, Teng, Liu, Xin, Zheng, Hairong, Li, Yingjia, Sheng, Zonghai. Ultrasmall theranostic nanozymes to modulate tumor hypoxia for augmenting photodynamic therapy and radiotherapy. BIOMATERIALS SCIENCE[J]. 2020, 8(3): 973-987, http://dx.doi.org/10.1039/c9bm01742a.
[12] Mei, Zihan, Gao, Duyang, Hu, Dehong, Zhou, Huichao, Ma, Teng, Huang, Liang, Liu, Xin, Zheng, Rongqin, Zheng, Hairong, Zhao, Ping, Zhou, Jianqiao, Sheng, Zonghai. Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods. BIOMATERIALS[J]. 2020, 251: http://dx.doi.org/10.1016/j.biomaterials.2020.120092.
[13] Gao, Duyang, Hu, Dehong, Liu, Xin, Sheng, Zonghai, Zheng, Hairong. Recent advances in functional nanomaterials for photoacoustic imaging of glioma. NANOSCALE HORIZONSnull. 2019, 4(5): 1037-1045, https://www.webofscience.com/wos/woscc/full-record/WOS:000481910600003.
[14] Zhu, Lipeng, Li, Ping, Gao, Duyang, Liu, Jie, Liu, Yubin, Sun, Chen, Xu, Mengze, Chen, Xin, Sheng, Zonghai, Wang, Ruibing, Yuan, Zhen, Cai, Lintao, Ma, Yifan, Zhao, Qi. pH-sensitive loaded retinal/indocyanine green micelles as an "all-in-one" theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy. CHEMICAL COMMUNICATIONS[J]. 2019, 55(44): 6209-6212, https://www.webofscience.com/wos/woscc/full-record/WOS:000469258900009.
[15] Gao Duyang. Molecular engineering of near-infrared light-responsive BODIPY-based nanoparticles with enhanced photothermal and photoacoustic efficiencies for cancer theranostics. Theranostics. 2019, [16] Gao, D Y, Ji, X, Wang, J L, Wang, Y T, Li, D L, Liu, Y B, Chang, K W, Qu, J L, Zheng, J, Yuan, Z. Engineering a protein-based nanoplatform as an antibacterial agent for light activated dual-modal photothermal and photodynamic therapy of infection in both the NIR I and II windows. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(5): 732-739, http://dx.doi.org/10.1039/c7tb02990j.
[17] Gao, Duyang, Zhang, Pengfei, Liu, Yubin, Sheng, Zonghai, Chen, Huajie, Yuan, Zhen. Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging. NANOSCALE[J]. 2018, 10(42): 19742-19748, http://ir.siat.ac.cn:8080/handle/172644/14617.
[18] Liu, Shuhui, Zhang, Pengfei, Pan, Hong, Gao, Duyang, Chen, Chi, Zheng, Mingbin, Sheng, Zonghai, Gong, Ping, Gao, Guanhui, Wang, Hanzhong, Ma, Yifan, Cai, Lintao. QDs-virus bioconjugate as potential gene-drug co-delivery system for synergistic tumor therapy. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINEnull. 2016, 12(2): 544-544, http://dx.doi.org/10.1016/j.nano.2015.12.273.
[19] Zhang, Pengfei, Pan, Hong, Gao, Duyang, Chen, Chi, Li, Wenjun, Wu, Yayun, Hu, Dehong, Li, Chuansheng, Gong, Ping, Sheng, Zonghai, Gao, Guanhui, Ma, Yifan, Cai, Lintao. Bioorthogonal multifunctional nanoprobes for biomedicine and theranostic applications. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINEnull. 2016, 12(2): 486-486, http://dx.doi.org/10.1016/j.nano.2015.12.114.
[20] Wu, Yayun, Gao, Duyang, Zhang, Pengfei, Chen, Chi, Sheng, Zonghai, Hu, Dehong, Zheng, Mingbin, Gong, Ping, Li, Chuansheng, Gao, Guanhui, Cai, Lintao. Theranostic iron oxide nanoparticles protected by NIR-emitting multidentate-ligands for multimodal imaging-guided photothermal therapy. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINEnull. 2016, 12(2): 567-567, http://dx.doi.org/10.1016/j.nano.2015.12.336.
[21] Xie, Xiaobin, Gao, Guanhui, Kang, Shendong, Shibayama, Tamaki, Lei, Yanhua, Gao, Duyang, Cai, Lintao. Site-Selective Trimetallic Heterogeneous Nanostructures for Enhanced Electrocatalytic Performance. ADVANCED MATERIALS[J]. 2015, 27(37): 5573-5577, https://www.webofscience.com/wos/woscc/full-record/WOS:000362727900017.
[22] 张利, 陈驰, 孟晓青, 吕亚琳, 周理华, 张鹏飞, 高笃阳, 盛宗海, 胡德红, 高冠慧, 易虎强, 刘朋, 龚萍, 蔡林涛. 量子点的近红外调控研究进展概述. 集成技术[J]. 2015, 17-27, http://lib.cqvip.com/Qikan/Article/Detail?id=665556345.
[23] Chen, Chi, Zhang, Pengfei, Zhang, Li, Gao, Duyang, Gao, Guanhui, Yang, Yong, Li, Wenjun, Gong, Ping, Cai, Lintao. Long-decay near-infrared-emitting doped quantum dots for lifetime-based in vivo pH imaging. CHEMICAL COMMUNICATIONS[J]. 2015, 51(56): 11162-11165, https://www.webofscience.com/wos/woscc/full-record/WOS:000357173100002.
[24] Gao, Duyang, Zhang, Pengfei, Liu, Chengbo, Chen, Chi, Gao, Guanhui, Wu, Yayun, Sheng, Zonghai, Song, Liang, Cai, Lintao. Compact chelator-free Ni-integrated CuS nanoparticles with tunable near-infrared absorption and enhanced relaxivity for in vivo dual-modal photoacoustic/MR imaging. NANOSCALE[J]. 2015, 7(42): 17631-17636, https://www.webofscience.com/wos/woscc/full-record/WOS:000363650700005.
[25] Sun, Zhengbo, Zhang, Wenlu, Zhang, Pengfei, Gao, Duyang, Gong, Ping, Yu, XueFeng, Wu, Yingliang, Cao, Zhijian, Li, Wenxin, Cai, Lintao. Neurotoxin-directed synthesis and in vitro evaluation of Au nanoclusters. RSC ADVANCES[J]. 2015, 5(38): 29647-29652, https://www.webofscience.com/wos/woscc/full-record/WOS:000352789500006.
[26] Ao, Lijiao, Wang, Bi, Liu, Peng, Huang, Liang, Yue, Caixia, Gao, Duyang, Wu, Chunlei, Su, Wu. A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery. NANOSCALE[J]. 2014, 6(18): 10710-10716, https://www.webofscience.com/wos/woscc/full-record/WOS:000341020700038.
[27] Zheng, Mingbin, Zhao, Pengfei, Luo, Zhenyu, Gong, Ping, Zheng, Cuifang, Zhang, Pengfei, Yue, Caixia, Gao, Duyang, Ma, Yifan, Cai, Lintao. Robust ICG Theranostic Nanoparticles for Folate Targeted Cancer Imaging and Highly Effective Photothermal Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2014, 6(9): 6709-6716, https://www.webofscience.com/wos/woscc/full-record/WOS:000336075300085.
[28] Hu, Dehong, Sheng, Zonghai, Fang, Shengtao, Wang, Yanan, Gao, Duyang, Zhang, Pengfei, Gong, Ping, Ma, Yifan, Cai, Lintao. Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis. THERANOSTICS[J]. 2014, 4(2): 142-153, https://www.webofscience.com/wos/woscc/full-record/WOS:000334663600003.
[29] Sheng, Zonghai, Hu, Dehong, Zheng, Mingbin, Zhao, Pengfei, Liu, Huilong, Gao, Duyang, Gong, Ping, Gao, Guanhui, Zhang, Pengfei, Ma, Yifan, Cai, Lintao. Smart Human Serum Albumin-Indocyanine Green Nanoparticles Generated by Programmed Assembly for Dual-Modal Imaging-Guided Cancer Synergistic Phototherapy. ACS NANO[J]. 2014, 8(12): 12310-12322, https://www.webofscience.com/wos/woscc/full-record/WOS:000347138000044.
[30] Gao, Duyang, Zhang, Pengfei, Sheng, Zonghai, Hu, Dehong, Gong, Ping, Chen, Chi, Wan, Qian, Gao, Guanhui, Cai, Lintao. Highly Bright and Compact Alloyed Quantum Rods with Near Infrared Emitting: a Potential Multifunctional Nanoplatform for Multimodal Imaging In Vivo. ADVANCED FUNCTIONAL MATERIALS[J]. 2014, 24(25): 3897-3905, https://www.webofscience.com/wos/woscc/full-record/WOS:000338011200006.
[31] Pan, Hong, Zhang, Pengfei, Gao, Duyang, Zhang, Yijuan, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Ma, Yifan, Cai, Lintao. Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal Conjugated Near-Infrared-Emitting Quantum Dots. ACS NANO[J]. 2014, 8(6): 5468-5477, https://www.webofscience.com/wos/woscc/full-record/WOS:000338089200012.
[32] Gong, Ping, Yang, Yueting, Yi, Huqiang, Fang, Shengtao, Zhang, Pengfei, Sheng, Zonghai, Gao, Guanhui, Gao, Duyang, Cai, Lintao. Polypeptide micelles with dual pH activatable dyes for sensing cells and cancer imaging. NANOSCALE[J]. 2014, 6(10): 5416-5424, https://www.webofscience.com/wos/woscc/full-record/WOS:000335148800054.
[33] Wang, Yuhui, Gao, Duyang, Zhang, Pengfei, Gong, Ping, Chen, Chi, Gao, Guanhui, Cai, Lintao. A near infrared fluorescence resonance energy transfer based aptamer biosensor for insulin detection in human plasma. CHEMICAL COMMUNICATIONS[J]. 2014, 50(7): 811-813, https://www.webofscience.com/wos/woscc/full-record/WOS:000328884500013.
[34] Chen, Chi, Zhang, Pengfei, Gao, Guanhui, Gao, Duyang, Yang, Yong, Liu, Hong, Wang, Yuhui, Gong, Ping, Cai, Lintao. Near-Infrared-Emitting Two-Dimensional Codes Based on Lattice-Strained Core/(Doped) Shell Quantum Dots with Long Fluorescence Lifetime. ADVANCED MATERIALS[J]. 2014, 26(36): 6313-6317, https://www.webofscience.com/wos/woscc/full-record/WOS:000342622700014.
[35] 龚萍, 杨月婷, 石碧华, 张鹏飞, 郑明彬, 胡德红, 高笃阳, 盛宗海, 郑翠芳, 刘朋, 王碧, 蔡林涛. 纳米探针在分子影像领域的研究进展. 科学通报[J]. 2013, 58(9): 762-776, https://www.sciengine.com/doi/10.1360/972012-1727.
[36] Hu, DeHong, Sheng, ZongHai, Zhang, PengFei, Yang, DaZhi, Liu, ShuHui, Gong, Ping, Gao, DuYang, Fang, ShengTao, Ma, YiFan, Cai, LinTao. Hybrid gold-gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo. NANOSCALE[J]. 2013, 5(4): 1624-1628, https://www.webofscience.com/wos/woscc/full-record/WOS:000314477300048.
[37] Gao, Duyang, Zhang, Pengfei, Jia, Jing, Li, Mingxing, Sheng, Zonghai, Hu, Dehong, Gong, Ping, Wan, Qian, Cai, Lintao. Ultrasmall paramagnetic near infrared quantum dots as dual modal nanoprobes. RSC ADVANCES[J]. 2013, 3(44): 21247-21250, https://www.webofscience.com/wos/woscc/full-record/WOS:000326056600010.
[38] Jia, Jing, Zhang, Pengfei, Gao, Duyang, Sheng, Zonghai, Hu, Dehong, Gong, Ping, Wu, Chunlei, Chen, Jianhai, Cai, Lintao. One-step synthesis of peptide-programmed QDs as ready-to-use nanoprobes. CHEMICAL COMMUNICATIONS[J]. 2013, 49(40): 4492-4494, https://www.webofscience.com/wos/woscc/full-record/WOS:000317934700016.
[39] Gong, Ping, Shi, Bihua, Zheng, Mingbin, Wang, Bi, Zhang, Pengfei, Hu, Dehong, Gao, Duyang, Sheng, Zonghai, Zheng, Cuifang, Ma, Yifan, Cai, Lintao. PEI protected aptamer molecular probes for contrast-enhanced in vivo cancer imaging. BIOMATERIALS[J]. 2012, 33(31): 7810-7817, http://dx.doi.org/10.1016/j.biomaterials.2012.07.011.
[40] Sheng, Zonghai, Hu, Dehong, Zhang, Pengfei, Gong, Ping, Gao, Duyang, Liu, Shuhui, Cai, Lintao. Cation exchange in aptamer-conjugated CdSe nanoclusters: a novel fluorescence signal amplification for cancer cell detection. CHEMICAL COMMUNICATIONS[J]. 2012, 48(35): 4202-4204, https://www.webofscience.com/wos/woscc/full-record/WOS:000302309100015.
[41] Gong, Ping, Shi, Bihua, Zhang, Pengfei, Hu, Dehong, Zheng, Mingbin, Zheng, Cuifang, Gao, Duyang, Cai, Lintao. DNase-activatable fluorescence probes visualizing the degradation of exogenous DNA in living cells. NANOSCALE[J]. 2012, 4(7): 2454-2462, https://www.webofscience.com/wos/woscc/full-record/WOS:000301591300037.
[42] Zhang, Pengfei, Liu, Shuhui, Gao, Duyang, Hu, Dehong, Gong, Ping, Sheng, Zonghai, Deng, Jizhe, Ma, Yien, Cai, Lintao. Click-Functionalized Compact Quantum Dots Protected by Multidentate-Imidazole Ligands: Conjugation-Ready Nanotags for Living-Virus Labeling and Imaging. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(20): 8388-8391, https://www.webofscience.com/wos/woscc/full-record/WOS:000304285700026.
[43] Hu, Dehong, Zhang, Pengfei, Gong, Ping, Lian, Shuhong, Lu, Yangyang, Gao, Duyang, Cai, Lintao. A fast synthesis of near-infrared emitting CdTe/CdSe quantum dots with small hydrodynamic diameter for in vivo imaging probes. NANOSCALE[J]. 2011, 3(11): 4724-4732, https://www.webofscience.com/wos/woscc/full-record/WOS:000296659000035.

   

（ 1 ） IGF1R靶向的白蛋白磁光纳米自组装体的构建及其用于胰腺癌的多模态分子成像研究, 主持, 国家级, 2020-01--2022-12