人类的适应性进化：基于基因组学、表型组学，利用生物信息学工具，解析人类适应不同环境的进化事件和遗传基础。比如人类群体正在发生的藏族人群的高原极端环境适应和人类物种相较于其他灵长类特有的表型进化。

欢迎每一个热爱科学，对人类进化具有好奇和探索之心的人。

071007-遗传学

人类适应性进化

2014-09--2019-06   中国科学院大学   博士研究生/理学博士
2010-09--2014-07   云南大学   本科/理学学士

   

[1] Wangshan Zheng, Yaoxi He, Yongbo Guo, Tian Yue, Hui Zhang, Jun Li, Bin Zhou, Xuerui Zeng, Liya Li, Bin Wang, Jingxin Cao, Li Chen, Chunxia Li, Hongyan Li, Chaoying Cui, Caijuan Bai, Baimakangzhuo, Xuebin Qi, Ouzhuluobu, Bing Su. Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans. GENOME BIOLOGY[J]. 2023, 24(1): 1-25, https://doaj.org/article/163b08b919484e2da7faba233901d414.
[2] Zhang, Xiaoming, Ji, Xueping, Li, Chunmei, Yang, Tingyu, Huang, Jiahui, Zhao, Yinhui, Wu, Yun, Ma, Shiwu, Pang, Yuhong, Huang, Yanyi, He, Yaoxi, Su, Bing. A Late Pleistocene human genome from Southwest China. CURRENT BIOLOGY[J]. 2022, 32(14): 3095-+, http://dx.doi.org/10.1016/j.cub.2022.06.016.
[3] Feng, Zhanying, Duren, Zhana, Xin, Jingxue, Yuan, Qiuyue, He, Yaoxi, Su, Bing, Wong, Wing Hung, Wang, Yong. Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification. ELIFE[J]. 2022, 11: http://dx.doi.org/10.7554/eLife.82535.
[4] Yang, Zhaohui, Bai, Caijuan, Pu, Youwei, Kong, Qinghong, Guo, Yongbo, Ouzhuluobu, Gengdeng, Liu, Xuyang, Zhao, Qi, Qiu, Zhichao, Zheng, Wangshan, He, Yaoxi, Lin, Yihan, Deng, Lian, Zhang, Chao, Xu, Shuhua, Peng, Yi, Xiang, Kun, Zhang, Xiaoming, Baimayangji, Cirenyangji, Cui, Chaoying, Baimakangzhuo, Gonggalanzi, Bianba, Pan, Yongyue, Xin, Jingxue, Wang, Yong, Liu, Shiming, Wang, Liangbang, Guo, Hengliang, Feng, Zhenzhen, Wang, Shaobo, Shi, Hong, Jiang, Binghua, Wu, Tianyi, Qi, Xuebin, Su, Bing. Genetic adaptation of skin pigmentation in highland Tibetans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(40): http://dx.doi.org/10.1073/pnas.2200421119.
[5] 和耀喜. Seasonality and Sex‑Biased Fluctuation of Birth Weight in Tibetan Populations. Phenomics[J]. 2021, [6] Jingxue Xin, Hui Zhang, Yaoxi He, Zhana Duren, Caijuan Bai, Lang Chen, Xin Luo, DongSheng Yan, Chaoyu Zhang, Xiang Zhu, Qiuyue Yuan, Zhanying Feng, Chaoying Cui, Xuebin Qi, Ouzhuluobu, Wing Hung Wong, Yong Wang, Bing Su. Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18638-8.
[7] 次旺拉姆, 和耀喜, 宿兵, 欧珠罗布. 基因组结构变异与藏族高原适应表型的遗传相关性初探. 高原科学研究[J]. 2020, 4(1): 70-78, http://lib.cqvip.com/Qikan/Article/Detail?id=7101570949.
[8] 和耀喜. 藏族人群高原低氧适应的表型与遗传机制研究. 2019, [9] He, Yaoxi, Luo, Xin, Zhou, Bin, Hu, Ting, Meng, Xiaoyu, Audano, Peter A, Kronenberg, Zev N, Eichler, Evan E, Jin, Jie, Guo, Yongbo, Yang, Yanan, Qi, Xuebin, Su, Bing. Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants. NATURE COMMUNICATIONS[J]. 2019, 10(1): http://gooa.las.ac.cn/external/index?type=-1&pid=1521503.
[10] Qi, Xuebin, Zhang, Qu, He, Yaoxi, Yang, Lixin, Zhang, Xiaoming, Shi, Peng, Yang, Linping, Liu, Zhengheng, Zhang, Fuheng, Liu, Fengyun, Liu, Shiming, Wu, Tianyi, Cui, Chaoying, Ouzhuluobu, Bai, Caijuan, Baimakangzhuo, Han, Jianlin, Zhao, Shengguo, Liang, Chunnian, Su, Bing. The Transcriptomic Landscape of Yaks Reveals Molecular Pathways for High Altitude Adaptation. GENOME BIOLOGY AND EVOLUTION[J]. 2019, 11(1): 72-85, https://www.webofscience.com/wos/woscc/full-record/WOS:000462712200007.
[11] Luo, Xin, He, Yaoxi, Zhang, Chao, He, Xiechao, Yan, Lanzhen, Li, Min, Hu, Ting, Hu, Yan, Jiang, Jin, Meng, Xiaoyu, Ji, Weizhi, Zhao, Xudong, Zheng, Ping, Xu, Shuhua, Su, Bing. Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys. NATURE COMMUNICATIONS[J]. 2019, 10(1): http://dx.doi.org/10.1038/s41467-019-13481-y.
[12] He, Yaoxi, Qi, Xuebin, Ouzhuluobu, Liu, Shiming, Li, Jun, Zhang, Hui, Baimakangzhuo, Bai, Caijuan, Zheng, Wangshan, Guo, Yongbo, Duojizhuoma, Baimayangji, Dejiquzong, Bianba, Gonggalanzi, Pan, Yongyue, Qula, Kangmin, Cirenyangji, Guo, Wei, Yangla, Peng, Yi, Zhang, Xiaoming, Xiang, Kun, Yang, Zhaohui, Wang, Liangbang, Gengdeng, Zhang, Yanfeng, Wu, Tianyi, Su, Bing, Cui, Chaoying. Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia. NATIONAL SCIENCE REVIEW[J]. 2018, 5(4): 516-529, http://lib.cqvip.com/Qikan/Article/Detail?id=6100230367.
[13] Zheng, WangShan, He, YaoXi, Cui, ChaoYing, Ouzhuluobu, Dejiquzong, Peng, Yi, Bai, CaiJuan, Duojizhuoma, Gonggalanzi, Bianba, Baimakangzhuo, Pan, YongYue, Qula, Kangmin, Cirenyangji, Baimayangji, Guo, Wei, Yangla, Zhang, Hui, Zhang, XiaoMing, Guo, YongBo, Xu, ShuHua, Chen, Hua, Zhao, ShengGuo, Cai, Yuan, Liu, ShiMing, Wu, TianYi, Qi, XueBin, Su, Bing. EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production. ZOOLOGICAL RESEARCH[J]. 2017, 38(3): 163-170, http://159.226.149.26:8080/handle/152453/11737.
[14] Guo, YongBo, He, YaoXi, Cui, ChaoYing, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Peng, Yi, Bai, Caijuan, Gonggalanzi, Pan, YongYue, Qula, Kangmin, Cirenyangji, Baimayangji, Guo, Wei, Yangla, Zhang, Hui, Zhang, XiaoMing, Zheng, WangShan, Xu, ShuHua, Chen, Hua, Zhao, ShengGuo, Gai, Yuan, Liu, ShiMing, Wu, TiariYi, Qi, XueBin, Su, Bing. GCH1 plays a role in the high-altitude adaptation of Tibetans. ZOOLOGICAL RESEARCH[J]. 2017, 38(3): 155-162, http://159.226.149.26:8080/handle/152453/11736.
[15] Peng Yi, Cui Chaoying, He Yaoxi, Ouzhuluobu, Zhang Hui, Yang Deying, Zhang Qu, Bianbazhuoma, Yang Lixin, He Yibo, Xiang Kun, Zhang Xiaoming, Bhandari Sushil, Shi Peng, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan Yongyue, Cirenyangji, Baimayangji, Gonggalanzi, Bai Caijuan, Bianba, Basang, Ciwangsangbu, Xu Shuhua, Chen Hua, Liu Shiming, Wu Tianyi, Qi Xuebin, Su Bing, 陈华. Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(4): 818-830, http://www.irgrid.ac.cn/handle/1471x/1149185.
[16] Zhang, Hui, He, Yaoxi, Cui, Chaoying, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Gonggalanzi, Pan, Yongyue, Qula, Kangmin, Cirenyangji, Baimayangji, Bai, Caijuan, Guo, Wei, Yangla, Peng, Yi, Zhang, Xiaoming, Xiang, Kun, Yang, Zhaohui, Liu, Shiming, Tao, Xiang, Gengdeng, Zheng, Wangshan, Guo, Yongbo, Wu, Tianyi, Qi, Xuebin, Su, Bing. Cross-altitude analysis suggests a turning point at the elevation of 4,500 m for polycythemia prevalence in Tibetans. AMERICAN JOURNAL OF HEMATOLOGY. 2017, 92(9): E552-E554, http://159.226.149.26:8080/handle/152453/11744.
[17] Yang, Deying, Peng, Yi, Ouzhuluobu, Bianbazhuoma, Cui, Chaoying, Bianba, Wang, Liangbang, Xiang, Kun, He, Yaoxi, Zhang, Hui, Zhang, Xiaoming, Liu, Jiewei, Shi, Hong, Pan, Yongyue, Duojizhuoma, Dejiquzong, Cirenyangji, Baimakangzhuo, Gonggalanzi, Liu, Shimin, Gengdeng, Wu, Tianyi, Chen, Hua, Qi, Xuebin, Su, Bing. HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans. HUMAN MUTATION[J]. 2016, 37(2): 216-223, http://www.irgrid.ac.cn/handle/1471x/1149141.

   

（ 1 ） 藏族人群高原适应关键生理表型的变化模式及其分子调控机制的研究, 主持, 国家级, 2021-01--2023-12
（ 2 ） 藏族人群新生儿适合度的评估和遗传分析, 主持, 研究所（学校）, 2020-01--2022-12
（ 3 ） 中国科学院青年创新促进会项目, 主持, 研究所（学校）, 2020-01--2023-12