Entomology; Microbiology; Genomics; Biological Engineering;

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10/2015-5/2016 Joint Ph.D. Infectious Diseases, Yale School of Medicine, Yale University, New Haven, United States. 

9/2011-9/2015 Ph.D. Zoology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. 

9/2007-8/2011 B.S. Plant Protection, College of Plant Protection, Henan Agricultural University, Zhengzhou, China.

2/2021 – Present Chinese Academy of Sciences, Beijing, China Principal Investigator in Institute of Zoology 

10/2019 – 1/2021 University of California, San Diego, United States Postdoctoral Fellow in Division of Biological Sciences, laboratory of Dr. Omar S. Akbari. Project: Genetic basis of mosquito olfaction and behavior using genome engineering technologies. 

8/2016 – 10/2019 Harvard University, Cambridge, United States Postdoctoral Fellow in Rowland Institute, laboratory of Dr. Robert M. Brucker. Project: Experimental testing microbe function: pesticides metabolism and speciation. 

9/2015 – 5/2016 Yale University, New Haven, United States Joint Ph.D. student in Infection of Disease, laboratory of Dr. Erol Fikrig. Project: Exploring proteins that facilitate Plasmodium transmission from mosquito to mammal. 

6/2011 – 9/2015 Chinese Academy of Sciences, Beijing, China Ph.D. student in Institute of Zoology, laboratory of Dr. Da-Wei Huang. Project: Functions of phage to endosymbiont and insect host.

21. Zhengyu Zhu, Runbiao Wu, Guan-Hong Wang. 2023. Genome Sequence of Staphylococcus nepalensis ZZ-2023a, Isolated from Nasonia vitripennis. (submitted to Microbiology Resource Announcements).

20. Runbiao Wu, Zhengyu Zhu, Guan-Hong Wang. 2023. Genome Sequence of Providencia stuartii, Isolated from the wasp Nasonia vitripennis. (submitted to Microbiology Resource Announcements).

19. Tao Wang; Xin-Rui Ren; Jin Geng; Yun-Ru Gao; Luo-Nan Wu; Guan-Hong Wang; Da-Wei Huang; Jinhua Xiao. 2023. Adaptation of intestinal microbiota and metabolome to divergent mitochondrial DNA in larvae of black soldier fly (Hermetia illucens). (submitted to Science Advances).

18. Jianqiu Cheng, Yizhen Xu, Zi Wang, Pengcheng Liu, Guan-Hong Wang, Gen Zhang, Haoyuan Hu. 2023. The monandry of female Nasonia vitripennis is induced by male’s oral pheromones and mediated by the dopamine signaling pathway. (Under review @ Molecular Ecology).

17. Zhengyu Zhu, Dandan Wang, Yanjun Liu, Guan-Hong Wang. 2023. Rearing method of germ-free Nasonia wasp. (accepted and in press @ JoVE).

16. Ronger Zheng, Qiqi Wang, Runbiao Wu, Prasad N Paradkar, Ary A Hoffmann, Guan-Hong Wang. 2023. Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens. The ISME Journal.

15. Jiahui Wu, Qiqi Wang, Dandan Wang, Adam CN Wong, Guan-Hong Wang. 2023. Axenic and gnotobiotic insect technologies in host-microbiota interaction research. Trends in Microbiology.

14. Zhengyu Zhu, Yanjun Liu, Haoyuan Hu, Guan-Hong Wang. 2023. Nasonia-microbiome associations: a model for evolutionary hologenomics research. Trends in Parasitology 39:4-17.

13. Guan-Hong Wang, Jie Du, Chen Yi Chu, MukundMadhav, Grant L. Hughes, Jackson Champer. 2022. Symbionts and gene drive: two strategies to combat vector-borne disease. Trends in Genetics 38:708-23.

12. Wang, G.-H., R. M. Brucker. 2022. An optimized method for Nasonia germ-free rearing. Scientific Reports 12:219.

11. Wang, G.-H., Stephanie Gamez, Robyn Raban, John Marshall, Luke Alphey, Ming Li, Jason Rasgon, Omar S. Akbari. 2021. Combating mosquito-borne pathogens using genetic control technologies. Nature Communications12, 4388.

10. Wang G-H, Dittmer J, Douglas B, Huang L, Brucker RM. 2021. Coadaptation between host genome and microbiome under long-term xenobiotic-induced selection. Science Advances 7, eabd4473.

9. Wang, G.-H., B. M. Berdy, O. Velasquez, N. Jovanovic, S. Alkhalifa, K. P. C. Minbiole, and R. M. Brucker. 2020. Changes in Microbiome Confer Multigenerational Host Resistance after Sub-toxic Pesticide Exposure. Cell Host & Microbe 27:213-224.e217.

8. Wang, G.-H., and R. M. Brucker. 2019a. Genome sequence of Enterococcus faecalis NVIT04, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01156-01118.

7. Wang, G.-H., and R. M. Brucker. 2019b. Genome sequence of Providencia rettgeri NVIT03, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01157-01118.

6. Huan Li, Tongtong Li, Xiangzhen Li, Guanhong Wang, Qiang Lin and Jiapeng Qu. 2018. Gut microbiota in Tibetan herdsmen reflects the degree of urbanization. Frontiers in Microbiology 9:1745.

5. Guan-Hong Wang, Bao-Fa Sun, Tuan-Lin Xiong, Yan-Kun Wang, Jin-Hua Xiao, Da-Wei Huang. 2016. Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes. Frontiers in Microbiology 7:1867.

4. Guan-Hong Wang, Ling-Yi Jia, Jin-Hua Xiao, Da-Wei Huang. 2016. Discovery of a novel Wolbachia supergroup in cave spider species and the lateral transfer of phage WO among distant hosts. Infection, Genetics and Evolution 41 (2016) 1–7.

3. Guan-Hong Wang, Jin-Hua Xiao, Li-Ming Niu, Guang-Chang Ma, and Da-Wei Huang. 2014. Large proportion of genes in a cryptic WO prophage genome are actively transcribing in an insect species with sex-specific patterns: involvement in Wolbachia biology and reproductive manipulation? BMC Genomics 15:893.

2. G.-H. Wang, J.-H. Xiao, T.-L. Xiong, Z. Li, R. W. Murphy, and D.-W. Huang. 2013. High-Efficiency Thermal Asymmetric Interlaced PCR (hiTAIL-PCR) for determination of a highly degenerated prophage WO genome in a Wolbachia strain infecting a fig wasp species. Applied and Environmental Microbiology 79:7476-7481.

1. Xiao, Jin-Hua; Yue, Zhen; Jia, Ling-Yi; Yang, Xin-Hua; Niu, Li-Hua; Wang, Zhuo; Zhang, Peng; Sun, Bao-Fa; He, Shun-Min; …; Wang, Guan-Hong; Yu, Hui; Wu, Wen-Shan; Cook, James M.; Wang, Jun; Huang, Da-Wei. 2013. Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology 14:R141.

In Chinese

3. Ronger Zheng He Jiang, Guan-Hong Wang. 2023. The research progress of Wolbachia-based mosquito control. accepted and in press @ Chinese Bulletin of Entomology.

2. Na Zhang, Man Zhao, Guan-Hong Wang. 2022. Research progress on microorganism against pest and disease. Journal of Plant Protection.49(1):220-230.

1. Wei-Hua Li, He Jiang, Guan-Hong Wang. 2022. The progress in prevention and control of mosquito based on microorganism and gene editing. Journal of Plant Protection. 49(1):231-239.

Mosquitoes are vectors of many human pathogens including dengue virus, Zika virus, chikungunya virus, yellow fever virus, West Nile virus, Mayaro virus, and malaria. Roughly half of the world’s population is at risk of these diseases, with the highest burden falling on socially and economically disadvantaged populations. Dengue incidence has increased over 30-fold in the past 50 years, currently resulting in over 400 million new infections per year. The group uses genomics as the main method, based on genomics, gene editing, microbial isolation and screening, aseptic system, and other approaches to explore the interactions between host and microbiota, and develop new technologies using microbiome and genome editing for mosquito control.

1. New mosquito control technologies based on microbiome and gene editing/drive

Developing new economic, sustainable, and environment-friendly mosquito control technologies based on microbiome and gene editing.

2. Microbial function mining

Using parasitic wasps and mosquitoes as model systems, we will deeply explore the role of microorganisms in the evolution of host adaptability and drug resistance, develop probiotics or engineered functional bacteria.

3. Microbial structure regulation mechanisms

Using metagenomics, metabolomics, gene editing, and aseptic system, we will focus on the molecular and physiological mechanisms how host regulates microbiota structure, paving the way for the establishment of microbial technology for pest control.

Ph.D.

Ronger Zheng

Ying Li

Jianqiu Chen

Tingting Zhang

M.S.

Xi Guo

Zhengyu Zhu

Jiahui Wu

Longyang Wang

Hongxin Wu

2021 The 10th Youth Science and technology award, The Entomological Society of China

2018 ASM Microbe Travel Award ($500), American Society for Microbiology 

2016 Excellent Students Awards, University of Chinese Academy of Sciences 

2015 Scholarship of Joint Ph.D. Training Program in Yale University ($12000) 

2015 Excellent Students Awards, University of Chinese Academy of Sciences 

2014 National Scholarship for Graduate Students ($5000) 

2014 The National Virology Graduate Forum Awards ($200), Wuhan Institute of Virology, University of Chinese Academy of Sciences 

2014 Excellent Students Awards, University of Chinese Academy of Sciences 

2014 Youth Science and Technology Outstanding Paper, Beijing Entomological Society