070302-分析化学

超灵敏磁共振分子探针与分子影像

2012-09--2017-06   中国科学院大学   博士学位
2008-09--2012-06   华中师范大学   学士学位

   

2020-12~现在, 中国科学院精密测量科学与技术创新研究院, 副研究员
2017-07~2020-11,中国科学院精密测量科学与技术创新研究院, 博士后

   

（1） 中国分析测试协会科学技术奖青年奖, 其他, 2017

[1] 郭茜旎, 王珍, 曾庆斌, 孙献平, 周欣. 一种多组分金属有机框架材料及其在制备Hyper-CEST信号增强试剂中的应用. CN202211628161.6, 2022-12-16.
[2] 郭茜旎, 乐曲儿, 曾庆斌, 孙献平, 周欣. 一种微孔水的制备方法及其在制备惰性气体磁共振信号增强试剂中的应用. CN202211494290.0., 2022-11-25.
[3] 郭茜旎, 杨鑫鑫, 曾庆斌, 周欣. 一种超极化129Xe MRI的可显影介入导丝及其制备方法. CN202211486304.4, 2022-11-24.
[4] 周欣, 郭茜旎, 肖忠宇, 曾庆斌. 一种超极化129Xe 磁共振分子探针及其制备方法. CN202210211056.6, 2022-03-04.
[5] 周欣, 曾庆斌, 郭茜旎, 王珍, 孙献平. 一种多组分金属有机框架材料及其应用. CN202111651962.X, 2021-12-30.
[6] 周欣, 乐曲儿, 曾庆斌, 郭茜旎, 孙献平. 一种硫化铜与金属有机框架复合纳米材料的应用. CN202111613615.8, 2021-12-27.
[7] 周欣, 曾庆斌, 郭茜旎, 孙献平, 刘买利. 一种沸石咪唑骨架材料在磁共振成像中的应用. 中国: CN108578715A, 2018-09-28.
[8] 周欣, 曾庆斌, 郭茜旎, 袁亚平, 孙献平, 刘买利. 一种多功能穴番‑卟啉化合物及其合成方法和应用. CN: CN107880061A, 2018-04-06.

   

[1] Qingbin Zeng, Qianni Guo, Yaping Yuan, Lei Zhang, Weiping Jiang, Yuqi Yang, Xin Zhou. Protocol for detecting substrates in living cells by targeted molecular probes through hyperpolarized 129Xe MRI. STAR PROTOCOLS. 2022, 3(3): http://dx.doi.org/10.1016/j.xpro.2022.101499.
[2] Qingbin Zeng, Qianni Guo, Yaping Yuan, Baolong Wang, Meiju Sui, Xin Lou, LouisS Bouchard, Xin Zhou. Ultrasensitive molecular building block for biothiol NMR detection at picomolar concentrations. ISCIENCE[J]. 2021, 24(12): 103515-, [3] Zhao, Longhui, Guo, Qianni, Yuan, Chenlu, Li, Sha, Yuan, Yaping, Zeng, Qingbin, Zhang, Xu, Ye, Chaohui, Zhou, Xin. Photosensitive MRI biosensor for BCRP-Targeted uptake and light-induced inhibition of tumor cells. TALANTA[J]. 2021, 233: 122501-, https://www.sciencedirect.com/science/article/pii/S0039914021004227?via%3Dihub.
[4] Zeng, Qingbin, Bie, Binglin, Guo, Qianni, Yuan, Yaping, Han, Qi, Han, Xiaocang, Chen, Mingwei, Zhang, Xu, Yang, Yunhuang, Liu, Maili, Liu, Pan, Deng, Hexiang, Zhou, Xin. Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(30): 17558-17563, https://www.pnas.org/doi/10.1073/pnas.2004121117.
[5] Zeng, Qingbin, Guo, Qianni, Yuan, Yaping, Zhang, Xiaoxiao, Jiang, Weiping, Xiao, Sa, Zhang, Bin, Lou, Xin, Ye, Chaohui, Liu, Maili, Bouchard, Louis-S., Zhou, Xin. A Small Molecular Multifunctional Tool for pH Detection, Fluorescence Imaging, and Photodynamic Therapy. ACS APPLIED BIO MATERIALS[J]. 2020, 3(3): 1779-1786, https://pubs.acs.org/doi/10.1021/acsabm.9b01080.
[6] Ren, Lili, Chen, Shizhen, Jiang, Weiping, Zeng, Qingbin, Zhang, Xu, Xiao, Long, McMahon, Michael T, Xin, Lou, Zhou, Xin. Efficient temperature-feedback liposome for F-19 MRI signal enhancement. CHEMICAL COMMUNICATIONS[J]. 2020, 56(92): 14427-14430, http://xlink.rsc.org/?DOI=D0CC05809B.
[7] Zhang, Xiaoxiao, Yuan, Yaping, Li, Sha, Zeng, Qingbin, Guo, Qianni, Liu, Na, Yang, Minghui, Yang, Yunhuang, Liu, Maili, McMahon, Michael T, Zhou, Xin. Free-base porphyrins as CEST MRI contrast agents with highly upfield shifted labile protons. MAGNETIC RESONANCE IN MEDICINE[J]. 2019, 82(2): 577-585, https://www.webofscience.com/wos/woscc/full-record/WOS:000471308300006.
[8] Zhang, Bin, Guo, Qianni, Luo, Qing, Zhang, Xiaoxiao, Zeng, QingBin, Zhao, Longhui, Yuan, Yaping, Jiang, Weiping, Yang, Yunhuang, Liu, Maili, Ye, Chaohui, Zhou, Xin. An intracellular diamine oxidase triggered hyperpolarized Xe-129 magnetic resonance biosensor. CHEMICAL COMMUNICATIONS[J]. 2018, 54(97): http://xlink.rsc.org/?DOI=C8CC07822J.
[9] Yang, Shengjun, Zeng, Qingbin, Guo, Qianni, Chen, Shizhen, Liu, Hongbin, Liu, Maili, McMahon, Michael T, Zhou, Xin. Detection and differentiation of Cys, Hcy and GSH mixtures by F-19 NMR probe. TALANTA[J]. 2018, 184: 513-519, https://www.webofscience.com/wos/woscc/full-record/WOS:000432234900066.
[10] Zeng, Qingbin, Guo, Qianni, Yuan, Yaping, Yang, Yuqi, Zhang, Bin, Ren, Lili, Zhang, Xiaoxiao, Luo, Qing, Liu, Maili, Bouchard, LouisS, Zhou, Xin. Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized Xe-129 Magnetofluorescent Biosensor. ANALYTICAL CHEMISTRY[J]. 2017, 89(4): 2288-2295, https://pubs.acs.org/doi/10.1021/acs.analchem.6b03742.
[11] Yang, Yuqi, Chen, Shizhen, Liu, Lianhua, Li, Sha, Zeng, Qingbin, Zhao, Xiuchao, Li, Haidong, Zhang, Zhiying, Bouchard, Louis-S., Liu, Maili, Zhou, Xin. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(28): 23400-23408, https://www.webofscience.com/wos/woscc/full-record/WOS:000406172700014.
[12] Guo, Qianni, Zeng, Qingbin, Jiang, Weiping, Luo, Qing, Zhang, Xu, Bouchard, Louis-S., Liu, Maili, Zhou, Xin. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp Probe. CHEMISTRY – A EUROPEAN JOURNAL[J]. 2016, 22(12): 3967-3970, http://dx.doi.org/10.1002/chem.201600193.
[13] Guo, Qianni, Zeng, Qingbin, Zhang, Xiaoxiao, Zhou, Xin. Highly sensitive detection of mercury (II) in aqueous media by tetraphenylporphyrin with a metal ion receptor. SUPRAMOLECULAR CHEMISTRY[J]. 2014, 26(10-12): 836-842, http://ir.wipm.ac.cn/handle/112942/1398.
[14] 曾庆斌, 郭茜旎, 罗晴, 吴光耀, 周欣. 锰对比剂在MRI中的应用. 磁共振成像[J]. 2014, 5(4): 315-, http://lib.cqvip.com/Qikan/Article/Detail?id=661908143.

   

（ 1 ） 荧光标记MOF用于非小细胞肺癌的超灵敏磁共振分子影像传感, 主持, 国家级, 2021-01--2023-12
（ 2 ） 外泌体介导的129Xe/19F双核MRI用于肺癌早期探测及其演进机制的研究, 参与, 国家级, 2019-01--2022-12
（ 3 ） 肺的异构功能性数据获取与智能融合, 参与, 部委级, 2019-09--2029-08
（ 4 ） 肺癌的超高灵敏谱学与成像新技术研究, 参与, 国家级, 2019-09--2024-08