083001-环境科学

环境毒理学

2011-07--2017-06   中国科学院大学   理学博士学位
2007-09--2011-06   山东大学   学士学位

   

2022-02~现在, 中国科学院生态环境研究中心, 副研究员
2017-07~2022-01,中国科学院生态环境研究中心, 助理研究员
2011-07~2017-06,中国科学院大学, 理学博士学位
2007-09~2011-06,山东大学, 学士学位

2022-07-01-2026-07-01,中国毒理学会分析毒理专业委员会青年委员,
2021-07-01-2025-07-01,中国毒理学会计算毒理专业委员会青年委员,
2018-11-01-2022-07-01,中国毒理学会分析毒理专业委员会青年委员,

环境科学实验

   

（1） 中国分析测试协会科学技术奖 CAIA奖, 特等奖, 其他, 2022
（2） 青年人才托举工程项目, , 部委级, 2021
（3） RSC Environmental Science Best Oral Presentation Prize, 其他, 2021

（ 1 ） 一种可穿戴产品皮肤安全性评价的离体分析方法, 2023, 第 4 作者, 专利号: CN 202310408584.5

（ 2 ） 基于MCF-7细胞系构建的RARa效应物体外筛选方法, 2022, 第 4 作者, 专利号: CN202210133063.9

（ 3 ） 核壳型纳米金棒-金属有机框架纳米材料及其制备方法, 2021, 第 4 作者, 专利号: CN111390161B

（ 4 ） 一种物质的血液毒性效应的高通量筛选方法, 2020, 第 1 作者, 专利号: CN111057745A

   

（1） The perturbation of parabens on the neuroendocrine system in zebrafish larvae, SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 
（2） 3-tert-Butyl-4-hydroxyanisole perturbs renal lipid metabolismin vitro by targeting androgen receptor-regulated de novo lipogenesis, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 
（3） Studying paraben-induced estrogen receptor- and steroid hormone-related endocrine disruption effects via multi-level approaches, SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 
（4） Silica nanoparticles trigger phosphatidylserine exposure in red blood cells and induce thrombosis risk, ENVIRONMENTAL POLLUTION, 2023, 
（5） 3-tert-Butyl-4-hydroxyanisole impairs hepatic lipid metabolism in male mice fed with a high-fat diet, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 
（6） Perfluorinated iodine alkanes promoted neural differentiation of mESCs by targeting miRNA-34a-5p in Notch-Hes signaling, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 
（7） Assessment of thyroid endocrine disruption effects of parabens using in vivo, in vitro, and in silico approaches, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 
（8） A high-throughput assay for screening the abilities of per- and polyfluoroalkyl substances in inducing plasma kallikrein-like activity, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2022, 
（9） Constructing an MCF-7 breast cancer cell-based transient transfection assay for screening RARα (Ant)agonistic activities of emerging phenolic compounds, JOURNAL OF HAZARDOUS MATERIALS, 2022, 
（10） Environmental obesogen: More considerations about the potential cause of obesity epidemic, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2022, 
（11） Abnormal neural differentiation in response to graphene quantum dots through histone modification interference, ENVIRONMENT INTERNATIONAL, 2022, 
（12） Environmental pollution,a hidden culprit for health issues, Environmental pollution,a hidden culprit for health issues, 生态环境与健康(英文), 2022, 
（13） Evidence of foodborne transmission of the coronavirus (COVID-19) through the animal products food supply chain, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 
（14） Chirality of gold nanocluster affects its interaction with coagulation factor XII, NANOIMPACT, 2021, 
（15） Graphene Quantum Dots Disrupt Embryonic Stem Cell Differentiation by Interfering with the Methylation Level of Sox2, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 
（16） Interaction of mercury ion (Hg2+) with blood and cytotoxicity attenuation by serum albumin binding, JOURNAL OF HAZARDOUS MATERIALS, 2021, 
（17） Perfluorinated iodine alkanes induce tissue-specific expression of estrogen receptor and its phosphorylation, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 
（18） Airborne particulate matters induce thrombopoiesis from megakaryocytes through regulating mitochondrial oxidative phosphorylation, PARTICLE AND FIBRE TOXICOLOGY, 2021, 
（19） 4-Hexylphenol influences adipogenic differentiation and hepatic lipid accumulation invitro, ENVIRONMENTAL POLLUTION, 2021, 
（20） 大气细颗粒物引发的神经毒性和分子机理, Neurotoxicity Induced by Atmospheric Fine Particulate Matters and the Underlying Molecular Mechanism, 化学进展, 2021, 第 3 作者
（21） Chemical Structure-Related Adipogenic Effects of Tetrabromobisphenol A and Its Analogues on 3T3-L1 Preadipocytes, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 
（22） Silver nanoparticles induce size-dependent and particle-specific neurotoxicity to primary cultures of rat cerebral cortical neurons, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 
（23） Environmental impacts on the transmission and evolution of COVID-19 combing the knowledge of pathogenic respiratory coronaviruses, ENVIRONMENTAL POLLUTION, 2020, 
（24） 典型人冠状病毒的环境行为及传播方式, Environmental behavior and transmission of representative human coronaviruses, 环境化学, 2020, 第 3 作者
（25） 新型冠状病毒2019-nCoV的一些初步认识, Preliminary understanding of the novel coronavirus 2019-nCoV, 环境化学, 2020, 第 2 作者
（26） Gold nanoparticles disturb small extracellular vesicle attributes of mouse embryonic stem cells [J], Nanoscale, 2020, 12, 15631-15637, 2020, 
（27） Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo, Toxicology Letters, 2019, 
（28） Exploring the Heterogeneity of Nanoparticles in Their Interactions with Plasma Coagulation Factor XII, ACS NANO, 2019, 
（29） Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells, JOURNAL OF HAZARDOUS MATERIALS, 2019, 
（30） Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes on neonatal SD rats, 环境科学学报(英文版), 2018, 第 1 作者
（31） Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms, ENVIRONMENTAL POLLUTION, 2018, 
（32） 纳米银的神经毒理学效应, Neurotoxicological Effects of Nanosilver, 化学进展, 2018, 第 4 作者
（33） Perfluorohexadecanoic acid increases permeability in endothelial cells through the activation of plasma kallikrein-kinin system, Chemosphere, 2018, 
（34） Synthetic Phenolic Antioxidants Cause Perturbation in Steroidogenesis in Vitro and in Vivo, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 
（35） Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: Implications from proteomic and post-transcriptional responses, ENVIRONMENTAL POLLUTION, 2018, 
（36） Adipogenic effects of tetrabromobisphenol A analogs in 3T3-L1 adipocytes, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 1 作者
（37） 对二甲苯及其代谢物对HepG2的细胞毒性效应研究, The cellular toxicities of p-xylene and its metabolites based on HepG2 cell model, 环境科学学报, 2018, 第 2 作者
（38） Epidermal penetration of gold nanoparticles and its underlying mechanism based on human reconstructed 3d episkin model, ACS APPLIED MATERIALS & INTERFACES, 2017, 
（39） Structure-dependent hematological effects of per- and. polyfluoroalkyl substances on activation of plasma kallikrein-kinin system cascade, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 
（40） Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes, ADVANCED SCIENCE, 2017, 
（41） 高效液相色谱-电喷雾-串联质谱研究四溴双酚A双（2-羟乙基醚）诱导大鼠嗜铬细胞瘤细胞呼吸链氧化磷酸化和能量代谢紊乱, Tetrabromobisphenol A bis (2-hydroxyethyl ether) induced dysfunction of the respiratory chain oxidative phosphorylation and energy metabolism in rat pheochromocytoma cells by high performance liquid chromatography-electrospray ionization-tandem mass spect, 色谱, 2017, 第 1 作者
（42） The potential neurotoxicity of emerging tetrabromobisphenol A derivatives based on rat pheochromocytoma cells, CHEMOSPHERE, 2016, 第 1 作者
（43） Silver nanoparticle exposure induces rat motor dysfunction through decrease in expression of calcium channel protein in cerebellum, TOXICOLOGY LETTERS, 2015, 第 4 作者
（44） 四溴双酚-A衍生物神经毒性效应筛选与毒性机制研究, 第十届全国生物医药色谱及相关技术学术交流会, 2014, 第 1 作者

   

（ 1 ） 全氟碘烷类化合物调控雌激素受体介导的神经发育毒理学效应与分子机制, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 持久性有毒污染物的生物识别调控机制子课题7, 负责人, 国家任务, 2019-07--2024-06
（ 3 ） 基于血管舒缓素-激肽系统研究新型全氟及多氟烷基化合物致肥胖效应的血液调控机制, 负责人, 国家任务, 2022-01--2025-12
（ 4 ） 外源污染物的毒性与生理扰动分子机制子课题2, 负责人, 国家任务, 2022-01--2026-12
（ 5 ） 新型污染物致肥胖作用及机制研究, 负责人, 其他国际合作项目, 2021-02--2023-05
（ 6 ） 医疗卫生三名工程—公共健康与精准预防控制创新研究, 参与, 地方任务, 2018-01--2022-12
（ 7 ） 穿戴产品毒理研究合作项目, 参与, 境内委托项目, 2021-04--2023-09
（ 8 ） 基20220193新型环境有害因素神经毒性效应新标志物及其作用机制研究, 参与, 地方任务, 2023-01--2025-12

（1）新型酚类化合物的致肥胖作用与机制研究   中国毒理学会第十次全国毒理学大会   2023-04-08
（2）红细胞介导的纳米二氧化硅颗粒诱发血栓形成的风险及机理研究   第十一届全国环境化学大会   2022-07-25
（3）四溴双酚A类化合物的脂代谢干扰效应研究   第十二次全国分析毒理学大会   2022-07-13
（4）Polyfluorinated iodine alkanes mediate secretion of cytokines in rat cerebral astrocytes   The 41st International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2021)   2021-11-08
（5）全氟碘烷对大脑皮层神经元中N-甲基-D-天冬氨酸受体表达的调控   第四次全国计算毒理学学术研讨会   2021-07-21
（6）全氟碘烷对大脑皮层神经元雌激素受体表达的调控作用   第十届全国环境化学大会   2019-08-15
（7）Adipogenic effects of tetrabromobisphenol A analogs in 3T3-L1 adipocytes   The 256th ACS National Meeting   2018-08-19
（8）全氟或多氟烷基化合物激活血管舒缓素-激肽系统的构效关系研究   第九届全国环境化学大会   2017-10-19